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Protein

SLIT and NTRK-like protein 1

Gene

Slitrk1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

It is involved in synaptogenesis and promotes excitatory synapse differentiation (By similarity). Enhances neuronal dendrite outgrowth (PubMed:14550773).By similarity1 Publication

GO - Biological processi

  • adult behavior Source: MGI
  • axonogenesis Source: MGI
  • homeostatic process Source: MGI
  • multicellular organism growth Source: MGI
  • nervous system development Source: MGI
  • positive regulation of axonogenesis Source: UniProtKB
  • positive regulation of synapse assembly Source: MGI
  • synapse assembly Source: MGI

Enzyme and pathway databases

ReactomeiR-MMU-388844. Receptor protein tyrosine phosphatases interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
SLIT and NTRK-like protein 1
Gene namesi
Name:Slitrk1
Synonyms:Sltk1
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:2679446. Slitrk1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini18 – 622ExtracellularSequence analysisAdd BLAST605
Transmembranei623 – 643HelicalSequence analysisAdd BLAST21
Topological domaini644 – 696CytoplasmicSequence analysisAdd BLAST53

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • extracellular region Source: UniProtKB-SubCell
  • integral component of membrane Source: MGI
  • synapse Source: UniProtKB

Keywords - Cellular componenti

Cell junction, Membrane, Secreted, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000003267418 – 696SLIT and NTRK-like protein 1Sequence analysisAdd BLAST679

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei695PhosphoserineBy similarity1

Post-translational modificationi

Undergoes proteolytic cleavage that results in shedding of the ectodomain and cleavage of the C-terminal cytoplasmic tail. Glycosylated. Phosphorylation at Ser-695 is necessary for proper function in promoting neurite outgrowth.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ810C1.
PaxDbiQ810C1.
PRIDEiQ810C1.

PTM databases

iPTMnetiQ810C1.
PhosphoSitePlusiQ810C1.

Expressioni

Tissue specificityi

In the adult, significant expression is detected only in the brain. Broadly expressed in embryonic brain with highest expression in subventricular zone, subplate, cortical plate, pyramidal cell layer of hippocampus, thalamus and hypothalamus where levels are highest in ventromedial hypothalamus and medial part of periaqueductal gray matter. Also expressed in mantle layer of spinal cord and in lateral and medial motor columns.1 Publication

Developmental stagei

In the embryo, expressed from day 10-12 and continues through later gestational development and into adulthood.1 Publication

Gene expression databases

BgeeiENSMUSG00000075478.
CleanExiMM_SLITRK1.
ExpressionAtlasiQ810C1. baseline and differential.
GenevisibleiQ810C1. MM.

Interactioni

Subunit structurei

Can form homodimers; homodimerization requires repeat LRR 2 (By similarity). Interacts with YWHAB, YWHAE, YWHAG, YWHAH, SFN, YWHAQ and YWHAZ (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000097897.

Structurei

3D structure databases

ProteinModelPortaliQ810C1.
SMRiQ810C1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 57LRRNT 1Add BLAST40
Repeati59 – 80LRR 1Add BLAST22
Repeati83 – 104LRR 2Add BLAST22
Repeati106 – 128LRR 3Add BLAST23
Repeati131 – 152LRR 4Add BLAST22
Repeati155 – 176LRR 5Add BLAST22
Repeati178 – 199LRR 6Add BLAST22
Domaini212 – 263LRRCT 1Add BLAST52
Domaini332 – 373LRRNT 2Add BLAST42
Repeati376 – 397LRR 7Add BLAST22
Repeati400 – 421LRR 8Add BLAST22
Repeati424 – 445LRR 9Add BLAST22
Repeati448 – 469LRR 10Add BLAST22
Repeati472 – 493LRR 11Add BLAST22
Repeati495 – 516LRR 12Add BLAST22
Domaini529 – 580LRRCT 2Add BLAST52

Sequence similaritiesi

Belongs to the SLITRK family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGN5. Eukaryota.
ENOG4111D19. LUCA.
GeneTreeiENSGT00790000122963.
HOVERGENiHBG056407.
InParanoidiQ810C1.
OMAiDLKCESP.
OrthoDBiEOG091G02AI.
PhylomeDBiQ810C1.
TreeFamiTF351826.

Family and domain databases

Gene3Di3.80.10.10. 4 hits.
InterProiView protein in InterPro
IPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
PfamiView protein in Pfam
PF13855. LRR_8. 2 hits.
SMARTiView protein in SMART
SM00369. LRR_TYP. 11 hits.
SM00082. LRRCT. 2 hits.
SUPFAMiSSF52058. SSF52058. 2 hits.
PROSITEiView protein in PROSITE
PS51450. LRR. 12 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q810C1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLWILLLET SLCFAAGNVT GDVCKEKICS CNEIEGDLHV DCEKKGFTSL
60 70 80 90 100
QRFTAPTSQF YHLFLHGNSL TRLFPNEFAN FYNAVSLHME NNGLHEIVPG
110 120 130 140 150
AFLGLQLVKR LHINNNKIKS FRKQTFLGLD DLEYLQADFN LLRDIDPGAF
160 170 180 190 200
QDLNKLEVLI LNDNLISTLP ANVFQYVPIT HLDLRGNRLK TLPYEEVLEQ
210 220 230 240 250
IPGIAEILLE DNPWDCTCDL LSLKEWLENI PKNALIGRVV CEAPTRLQGK
260 270 280 290 300
DLNETTEQDL CPLKNRVDSS LPAPPAQEET FAPGPLPTPF KTNGQDEHAT
310 320 330 340 350
PGAVPNGGTK IPGNWQLKIK PTPPIATGSA RNKPPVHGLP CPGGCSCDHI
360 370 380 390 400
PGSGLKMNCN NRNVSSLADL KPKLSNVQEL FLRDNKIHSI RKSHFVDYKN
410 420 430 440 450
LILLDLGNNN IANIENNTFK NLLDLRWLYM DSNYLDTLSR EKFAGLQNLE
460 470 480 490 500
YLNVEYNAIQ LILPGTFNAM PKLRILILNN NLLRSLPVDV FAGVSLSKLS
510 520 530 540 550
LHNNYFMYLP VAGVLDQLTS IIQIDLHGNP WECSCTIVPF KQWAERLGSE
560 570 580 590 600
VLMSDLKCET PVNFFRKDFM LLSNEEICPQ LYARISPTLT SHSKNSTGLA
610 620 630 640 650
ETGTHSNSYL DTSRVSISVL VPGLLLVFVT SAFTVVGMLV FILRNRKRSK
660 670 680 690
RRDANSSASE INSLQTVCDS SYWHNGPYNA DGSHRVYDCG SHSLSD
Length:696
Mass (Da):77,817
Last modified:June 1, 2003 - v1
Checksum:iB3F23AF1A28B9E1B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB097570 Genomic DNA. Translation: BAC67204.1.
AK014285 mRNA. Translation: BAB29244.2.
CCDSiCCDS27325.1.
RefSeqiNP_951020.1. NM_199065.2.
UniGeneiMm.257268.

Genome annotation databases

EnsembliENSMUST00000100322; ENSMUSP00000097897; ENSMUSG00000075478.
GeneIDi76965.
KEGGimmu:76965.
UCSCiuc007uyc.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiSLIK1_MOUSE
AccessioniPrimary (citable) accession number: Q810C1
Secondary accession number(s): Q9CXL0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 1, 2003
Last modified: July 5, 2017
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families