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Protein

SLIT and NTRK-like protein 1

Gene

Slitrk1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Enhances neuronal dendrite outgrowth.1 Publication

GO - Biological processi

  • adult behavior Source: MGI
  • axonogenesis Source: MGI
  • homeostatic process Source: MGI
  • multicellular organism growth Source: MGI
  • nervous system development Source: MGI
  • positive regulation of synapse assembly Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
SLIT and NTRK-like protein 1
Gene namesi
Name:Slitrk1
Synonyms:Sltk1
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:2679446. Slitrk1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini18 – 622605ExtracellularSequence analysisAdd
BLAST
Transmembranei623 – 64321HelicalSequence analysisAdd
BLAST
Topological domaini644 – 69653CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence analysisAdd
BLAST
Chaini18 – 696679SLIT and NTRK-like protein 1Sequence analysisPRO_0000032674Add
BLAST

Proteomic databases

MaxQBiQ810C1.
PaxDbiQ810C1.
PRIDEiQ810C1.

PTM databases

iPTMnetiQ810C1.
PhosphoSiteiQ810C1.

Expressioni

Tissue specificityi

In the adult, significant expression is detected only in the brain. Broadly expressed in embryonic brain with highest expression in subventricular zone, subplate, cortical plate, pyramidal cell layer of hippocampus, thalamus and hypothalamus where levels are highest in ventromedial hypothalamus and medial part of periaqueductal gray matter. Also expressed in mantle layer of spinal cord and in lateral and medial motor columns.1 Publication

Developmental stagei

In the embryo, expressed from day 10-12 and continues through later gestational development and into adulthood.1 Publication

Gene expression databases

BgeeiQ810C1.
CleanExiMM_SLITRK1.
ExpressionAtlasiQ810C1. baseline and differential.
GenevisibleiQ810C1. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000097897.

Structurei

3D structure databases

ProteinModelPortaliQ810C1.
SMRiQ810C1. Positions 22-579.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 5740LRRNT 1Add
BLAST
Repeati59 – 8022LRR 1Add
BLAST
Repeati83 – 10422LRR 2Add
BLAST
Repeati106 – 12823LRR 3Add
BLAST
Repeati131 – 15222LRR 4Add
BLAST
Repeati155 – 17622LRR 5Add
BLAST
Repeati178 – 19922LRR 6Add
BLAST
Domaini212 – 26352LRRCT 1Add
BLAST
Domaini332 – 37342LRRNT 2Add
BLAST
Repeati376 – 39722LRR 7Add
BLAST
Repeati400 – 42122LRR 8Add
BLAST
Repeati424 – 44522LRR 9Add
BLAST
Repeati448 – 46922LRR 10Add
BLAST
Repeati472 – 49322LRR 11Add
BLAST
Repeati495 – 51622LRR 12Add
BLAST
Domaini529 – 58052LRRCT 2Add
BLAST

Sequence similaritiesi

Belongs to the SLITRK family.Curated
Contains 12 LRR (leucine-rich) repeats.Curated
Contains 2 LRRCT domains.Curated
Contains 2 LRRNT domains.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGN5. Eukaryota.
ENOG4111D19. LUCA.
GeneTreeiENSGT00790000122963.
HOVERGENiHBG056407.
InParanoidiQ810C1.
OMAiVICEAPT.
OrthoDBiEOG7W9RT2.
PhylomeDBiQ810C1.
TreeFamiTF351826.

Family and domain databases

Gene3Di3.80.10.10. 3 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 11 hits.
SM00082. LRRCT. 2 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
PROSITEiPS51450. LRR. 12 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q810C1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLWILLLET SLCFAAGNVT GDVCKEKICS CNEIEGDLHV DCEKKGFTSL
60 70 80 90 100
QRFTAPTSQF YHLFLHGNSL TRLFPNEFAN FYNAVSLHME NNGLHEIVPG
110 120 130 140 150
AFLGLQLVKR LHINNNKIKS FRKQTFLGLD DLEYLQADFN LLRDIDPGAF
160 170 180 190 200
QDLNKLEVLI LNDNLISTLP ANVFQYVPIT HLDLRGNRLK TLPYEEVLEQ
210 220 230 240 250
IPGIAEILLE DNPWDCTCDL LSLKEWLENI PKNALIGRVV CEAPTRLQGK
260 270 280 290 300
DLNETTEQDL CPLKNRVDSS LPAPPAQEET FAPGPLPTPF KTNGQDEHAT
310 320 330 340 350
PGAVPNGGTK IPGNWQLKIK PTPPIATGSA RNKPPVHGLP CPGGCSCDHI
360 370 380 390 400
PGSGLKMNCN NRNVSSLADL KPKLSNVQEL FLRDNKIHSI RKSHFVDYKN
410 420 430 440 450
LILLDLGNNN IANIENNTFK NLLDLRWLYM DSNYLDTLSR EKFAGLQNLE
460 470 480 490 500
YLNVEYNAIQ LILPGTFNAM PKLRILILNN NLLRSLPVDV FAGVSLSKLS
510 520 530 540 550
LHNNYFMYLP VAGVLDQLTS IIQIDLHGNP WECSCTIVPF KQWAERLGSE
560 570 580 590 600
VLMSDLKCET PVNFFRKDFM LLSNEEICPQ LYARISPTLT SHSKNSTGLA
610 620 630 640 650
ETGTHSNSYL DTSRVSISVL VPGLLLVFVT SAFTVVGMLV FILRNRKRSK
660 670 680 690
RRDANSSASE INSLQTVCDS SYWHNGPYNA DGSHRVYDCG SHSLSD
Length:696
Mass (Da):77,817
Last modified:June 1, 2003 - v1
Checksum:iB3F23AF1A28B9E1B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB097570 Genomic DNA. Translation: BAC67204.1.
AK014285 mRNA. Translation: BAB29244.2.
CCDSiCCDS27325.1.
RefSeqiNP_951020.1. NM_199065.2.
UniGeneiMm.257268.

Genome annotation databases

EnsembliENSMUST00000100322; ENSMUSP00000097897; ENSMUSG00000075478.
GeneIDi76965.
KEGGimmu:76965.
UCSCiuc007uyc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB097570 Genomic DNA. Translation: BAC67204.1.
AK014285 mRNA. Translation: BAB29244.2.
CCDSiCCDS27325.1.
RefSeqiNP_951020.1. NM_199065.2.
UniGeneiMm.257268.

3D structure databases

ProteinModelPortaliQ810C1.
SMRiQ810C1. Positions 22-579.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000097897.

PTM databases

iPTMnetiQ810C1.
PhosphoSiteiQ810C1.

Proteomic databases

MaxQBiQ810C1.
PaxDbiQ810C1.
PRIDEiQ810C1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000100322; ENSMUSP00000097897; ENSMUSG00000075478.
GeneIDi76965.
KEGGimmu:76965.
UCSCiuc007uyc.1. mouse.

Organism-specific databases

CTDi114798.
MGIiMGI:2679446. Slitrk1.

Phylogenomic databases

eggNOGiENOG410IGN5. Eukaryota.
ENOG4111D19. LUCA.
GeneTreeiENSGT00790000122963.
HOVERGENiHBG056407.
InParanoidiQ810C1.
OMAiVICEAPT.
OrthoDBiEOG7W9RT2.
PhylomeDBiQ810C1.
TreeFamiTF351826.

Miscellaneous databases

PROiQ810C1.
SOURCEiSearch...

Gene expression databases

BgeeiQ810C1.
CleanExiMM_SLITRK1.
ExpressionAtlasiQ810C1. baseline and differential.
GenevisibleiQ810C1. MM.

Family and domain databases

Gene3Di3.80.10.10. 3 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 11 hits.
SM00082. LRRCT. 2 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
PROSITEiPS51450. LRR. 12 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of Slitrk, a novel neuronal transmembrane protein family controlling neurite outgrowth."
    Aruga J., Mikoshiba K.
    Mol. Cell. Neurosci. 24:117-129(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 369-696.
    Strain: C57BL/6J.
    Tissue: Head.

Entry informationi

Entry nameiSLIK1_MOUSE
AccessioniPrimary (citable) accession number: Q810C1
Secondary accession number(s): Q9CXL0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 1, 2003
Last modified: June 8, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.