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Protein

SLIT and NTRK-like protein 4

Gene

Slitrk4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Suppresses neurite outgrowth.1 Publication

GO - Biological processi

  • axonogenesis Source: MGI
  • positive regulation of synapse assembly Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
SLIT and NTRK-like protein 4
Gene namesi
Name:Slitrk4
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:2442509. Slitrk4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 618600ExtracellularSequence analysisAdd
BLAST
Transmembranei619 – 63921HelicalSequence analysisAdd
BLAST
Topological domaini640 – 837198CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 837819SLIT and NTRK-like protein 4Sequence analysisPRO_0000032680Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi81 – 811N-linked (GlcNAc...)Sequence analysis
Glycosylationi325 – 3251N-linked (GlcNAc...)Sequence analysis
Glycosylationi423 – 4231N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ810B8.
MaxQBiQ810B8.
PaxDbiQ810B8.
PRIDEiQ810B8.

PTM databases

iPTMnetiQ810B8.
PhosphoSiteiQ810B8.

Expressioni

Tissue specificityi

In the adult, significant expression is detected only in the brain. Broadly expressed in embryonic brain with highest expression in subventricular zone, subplate, cortical plate, pyramidal cell layer of hippocampus, thalamus and hypothalamus.1 Publication

Developmental stagei

In the embryo, expressed from day 10-12 and continues through later gestational development and into adulthood.1 Publication

Gene expression databases

BgeeiENSMUSG00000046699.
CleanExiMM_SLITRK4.
ExpressionAtlasiQ810B8. baseline and differential.
GenevisibleiQ810B8. MM.

Interactioni

Protein-protein interaction databases

BioGridi232771. 1 interaction.
IntActiQ810B8. 1 interaction.
MINTiMINT-4997619.
STRINGi10090.ENSMUSP00000064443.

Structurei

3D structure databases

ProteinModelPortaliQ810B8.
SMRiQ810B8. Positions 29-581.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati60 – 8122LRR 1Add
BLAST
Repeati84 – 10522LRR 2Add
BLAST
Repeati108 – 12922LRR 3Add
BLAST
Repeati132 – 15322LRR 4Add
BLAST
Repeati156 – 17722LRR 5Add
BLAST
Repeati179 – 20022LRR 6Add
BLAST
Domaini213 – 26452LRRCT 1Add
BLAST
Domaini333 – 37543LRRNTAdd
BLAST
Repeati378 – 39922LRR 7Add
BLAST
Repeati402 – 42322LRR 8Add
BLAST
Repeati426 – 44722LRR 9Add
BLAST
Repeati450 – 47122LRR 10Add
BLAST
Repeati474 – 49522LRR 11Add
BLAST
Repeati497 – 51822LRR 12Add
BLAST
Domaini531 – 58252LRRCT 2Add
BLAST

Sequence similaritiesi

Belongs to the SLITRK family.Curated
Contains 12 LRR (leucine-rich) repeats.Curated
Contains 2 LRRCT domains.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGN5. Eukaryota.
ENOG4111D19. LUCA.
GeneTreeiENSGT00790000122963.
HOGENOMiHOG000290667.
HOVERGENiHBG056407.
InParanoidiQ810B8.
OMAiRYPEKQQ.
OrthoDBiEOG091G02AI.
PhylomeDBiQ810B8.
TreeFamiTF326378.

Family and domain databases

Gene3Di3.80.10.10. 3 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 9 hits.
SM00082. LRRCT. 2 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
PROSITEiPS51450. LRR. 12 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q810B8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLWLFLIVS ALISSTNADS DISVEICNVC SCVSVENVLY VNCEKVSVYR
60 70 80 90 100
PNQLKPPWSN FYHLNFQNNF LNILYPNTFV NFSHAVSLHL GNNKLQNIEG
110 120 130 140 150
GAFLGLSALK QLHLNNNELK ILRADTFLGI ENLEYLQADY NLIKYIERGA
160 170 180 190 200
FNKLHKLKVL ILNDNLISFL PDNIFRFASL THLDIRGNRI QKLPYIGVLE
210 220 230 240 250
HIGRVVELQL EDNPWNCSCD LLPLKAWLEN MPYNIYIGEA ICETPSDLYG
260 270 280 290 300
RLLKETNKQE LCPMGTGSDF DVRILPPSQQ ENGFTTPNGH TTQTTLHRLV
310 320 330 340 350
TKPPKTTNPS KISGIVAGKA LSNRNLSQIV SYQTRVPPLT PCPVPCFCKT
360 370 380 390 400
HPSDLGLSVN CQEKNIQSMS ELTPKPLNAK KLHVNGNNIK DVDISDFTEF
410 420 430 440 450
EGLDLLHLGS NQITLIKGEV FHNLTNLRRL YLNGNQIERL YPEIFSGLHN
460 470 480 490 500
LQYLYLEYNL IKEILAGTFD SMPNLQLLYL NNNLLKSLPV YIFSGAPLAR
510 520 530 540 550
LNLRNNKFMY LPVSGVLDQL QSLTQIDLEG NPWDCTCDLV ALKLWLEKLN
560 570 580 590 600
DGIVVKELKC ETPVQFANIE LKSLKNEILC PKLLNKPSAT FTSPAPAITF
610 620 630 640 650
TTPLGPIRSP PGGPVPLSIL ILSILVVLIL TVFVAFCLLV FVLRRNKKPT
660 670 680 690 700
VKHEGLGNSE CGSMQLQLRK HDHKTNKKDG LSTEAFIPQT IEQMSKSHTC
710 720 730 740 750
GLKESETGFM FSDPPGQKVM MRNAADKDKD LLHVDTRKRL STIDELDELF
760 770 780 790 800
PSRDSNVFIQ NFLESKKEYN SIGVSGFEIR YPEKQQDKKN KKSLIGGNHS
810 820 830
KIVVEQRKSE YFELKAKLQS SPDYLQVLEE QTALNKI
Length:837
Mass (Da):94,538
Last modified:March 29, 2004 - v2
Checksum:iCCD3897E86B95ABC
GO

Sequence cautioni

The sequence BAC67207 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti429 – 4291R → G in BAC27786 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB097573 Genomic DNA. Translation: BAC67207.1. Different initiation.
AK032263 mRNA. Translation: BAC27786.1.
AK039763 mRNA. Translation: BAC30442.1.
AK053065 mRNA. Translation: BAC35254.1.
CCDSiCCDS30167.1.
RefSeqiNP_848855.2. NM_178740.4.
XP_006528074.1. XM_006528011.1.
XP_006528075.1. XM_006528012.1.
XP_006528076.1. XM_006528013.2.
UniGeneiMm.101707.
Mm.226989.

Genome annotation databases

EnsembliENSMUST00000069926; ENSMUSP00000064443; ENSMUSG00000046699.
ENSMUST00000114679; ENSMUSP00000110327; ENSMUSG00000046699.
GeneIDi245446.
KEGGimmu:245446.
UCSCiuc009tio.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB097573 Genomic DNA. Translation: BAC67207.1. Different initiation.
AK032263 mRNA. Translation: BAC27786.1.
AK039763 mRNA. Translation: BAC30442.1.
AK053065 mRNA. Translation: BAC35254.1.
CCDSiCCDS30167.1.
RefSeqiNP_848855.2. NM_178740.4.
XP_006528074.1. XM_006528011.1.
XP_006528075.1. XM_006528012.1.
XP_006528076.1. XM_006528013.2.
UniGeneiMm.101707.
Mm.226989.

3D structure databases

ProteinModelPortaliQ810B8.
SMRiQ810B8. Positions 29-581.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi232771. 1 interaction.
IntActiQ810B8. 1 interaction.
MINTiMINT-4997619.
STRINGi10090.ENSMUSP00000064443.

PTM databases

iPTMnetiQ810B8.
PhosphoSiteiQ810B8.

Proteomic databases

EPDiQ810B8.
MaxQBiQ810B8.
PaxDbiQ810B8.
PRIDEiQ810B8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000069926; ENSMUSP00000064443; ENSMUSG00000046699.
ENSMUST00000114679; ENSMUSP00000110327; ENSMUSG00000046699.
GeneIDi245446.
KEGGimmu:245446.
UCSCiuc009tio.1. mouse.

Organism-specific databases

CTDi139065.
MGIiMGI:2442509. Slitrk4.

Phylogenomic databases

eggNOGiENOG410IGN5. Eukaryota.
ENOG4111D19. LUCA.
GeneTreeiENSGT00790000122963.
HOGENOMiHOG000290667.
HOVERGENiHBG056407.
InParanoidiQ810B8.
OMAiRYPEKQQ.
OrthoDBiEOG091G02AI.
PhylomeDBiQ810B8.
TreeFamiTF326378.

Miscellaneous databases

ChiTaRSiSlitrk4. mouse.
PROiQ810B8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000046699.
CleanExiMM_SLITRK4.
ExpressionAtlasiQ810B8. baseline and differential.
GenevisibleiQ810B8. MM.

Family and domain databases

Gene3Di3.80.10.10. 3 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 9 hits.
SM00082. LRRCT. 2 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
PROSITEiPS51450. LRR. 12 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSLIK4_MOUSE
AccessioniPrimary (citable) accession number: Q810B8
Secondary accession number(s): Q8BL56
, Q8BWB0, Q8BYG4, Q8C056
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: March 29, 2004
Last modified: September 7, 2016
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.