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Protein

SLIT and NTRK-like protein 4

Gene

Slitrk4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Suppresses neurite outgrowth.1 Publication

GO - Biological processi

  • axonogenesis Source: MGI
  • positive regulation of synapse assembly Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
SLIT and NTRK-like protein 4
Gene namesi
Name:Slitrk4
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:2442509. Slitrk4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 618ExtracellularSequence analysisAdd BLAST600
Transmembranei619 – 639HelicalSequence analysisAdd BLAST21
Topological domaini640 – 837CytoplasmicSequence analysisAdd BLAST198

GO - Cellular componenti

  • integral component of membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000003268019 – 837SLIT and NTRK-like protein 4Sequence analysisAdd BLAST819

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi81N-linked (GlcNAc...)Sequence analysis1
Glycosylationi325N-linked (GlcNAc...)Sequence analysis1
Glycosylationi423N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ810B8.
MaxQBiQ810B8.
PaxDbiQ810B8.
PRIDEiQ810B8.

PTM databases

iPTMnetiQ810B8.
PhosphoSitePlusiQ810B8.

Expressioni

Tissue specificityi

In the adult, significant expression is detected only in the brain. Broadly expressed in embryonic brain with highest expression in subventricular zone, subplate, cortical plate, pyramidal cell layer of hippocampus, thalamus and hypothalamus.1 Publication

Developmental stagei

In the embryo, expressed from day 10-12 and continues through later gestational development and into adulthood.1 Publication

Gene expression databases

BgeeiENSMUSG00000046699.
CleanExiMM_SLITRK4.
ExpressionAtlasiQ810B8. baseline and differential.
GenevisibleiQ810B8. MM.

Interactioni

Protein-protein interaction databases

BioGridi232771. 1 interactor.
IntActiQ810B8. 1 interactor.
MINTiMINT-4997619.
STRINGi10090.ENSMUSP00000064443.

Structurei

3D structure databases

ProteinModelPortaliQ810B8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati60 – 81LRR 1Add BLAST22
Repeati84 – 105LRR 2Add BLAST22
Repeati108 – 129LRR 3Add BLAST22
Repeati132 – 153LRR 4Add BLAST22
Repeati156 – 177LRR 5Add BLAST22
Repeati179 – 200LRR 6Add BLAST22
Domaini213 – 264LRRCT 1Add BLAST52
Domaini333 – 375LRRNTAdd BLAST43
Repeati378 – 399LRR 7Add BLAST22
Repeati402 – 423LRR 8Add BLAST22
Repeati426 – 447LRR 9Add BLAST22
Repeati450 – 471LRR 10Add BLAST22
Repeati474 – 495LRR 11Add BLAST22
Repeati497 – 518LRR 12Add BLAST22
Domaini531 – 582LRRCT 2Add BLAST52

Sequence similaritiesi

Belongs to the SLITRK family.Curated
Contains 12 LRR (leucine-rich) repeats.Curated
Contains 2 LRRCT domains.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGN5. Eukaryota.
ENOG4111D19. LUCA.
GeneTreeiENSGT00790000122963.
HOGENOMiHOG000290667.
HOVERGENiHBG056407.
InParanoidiQ810B8.
OMAiRYPEKQQ.
OrthoDBiEOG091G02AI.
PhylomeDBiQ810B8.
TreeFamiTF326378.

Family and domain databases

Gene3Di3.80.10.10. 3 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 9 hits.
SM00082. LRRCT. 2 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
PROSITEiPS51450. LRR. 12 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q810B8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLWLFLIVS ALISSTNADS DISVEICNVC SCVSVENVLY VNCEKVSVYR
60 70 80 90 100
PNQLKPPWSN FYHLNFQNNF LNILYPNTFV NFSHAVSLHL GNNKLQNIEG
110 120 130 140 150
GAFLGLSALK QLHLNNNELK ILRADTFLGI ENLEYLQADY NLIKYIERGA
160 170 180 190 200
FNKLHKLKVL ILNDNLISFL PDNIFRFASL THLDIRGNRI QKLPYIGVLE
210 220 230 240 250
HIGRVVELQL EDNPWNCSCD LLPLKAWLEN MPYNIYIGEA ICETPSDLYG
260 270 280 290 300
RLLKETNKQE LCPMGTGSDF DVRILPPSQQ ENGFTTPNGH TTQTTLHRLV
310 320 330 340 350
TKPPKTTNPS KISGIVAGKA LSNRNLSQIV SYQTRVPPLT PCPVPCFCKT
360 370 380 390 400
HPSDLGLSVN CQEKNIQSMS ELTPKPLNAK KLHVNGNNIK DVDISDFTEF
410 420 430 440 450
EGLDLLHLGS NQITLIKGEV FHNLTNLRRL YLNGNQIERL YPEIFSGLHN
460 470 480 490 500
LQYLYLEYNL IKEILAGTFD SMPNLQLLYL NNNLLKSLPV YIFSGAPLAR
510 520 530 540 550
LNLRNNKFMY LPVSGVLDQL QSLTQIDLEG NPWDCTCDLV ALKLWLEKLN
560 570 580 590 600
DGIVVKELKC ETPVQFANIE LKSLKNEILC PKLLNKPSAT FTSPAPAITF
610 620 630 640 650
TTPLGPIRSP PGGPVPLSIL ILSILVVLIL TVFVAFCLLV FVLRRNKKPT
660 670 680 690 700
VKHEGLGNSE CGSMQLQLRK HDHKTNKKDG LSTEAFIPQT IEQMSKSHTC
710 720 730 740 750
GLKESETGFM FSDPPGQKVM MRNAADKDKD LLHVDTRKRL STIDELDELF
760 770 780 790 800
PSRDSNVFIQ NFLESKKEYN SIGVSGFEIR YPEKQQDKKN KKSLIGGNHS
810 820 830
KIVVEQRKSE YFELKAKLQS SPDYLQVLEE QTALNKI
Length:837
Mass (Da):94,538
Last modified:March 29, 2004 - v2
Checksum:iCCD3897E86B95ABC
GO

Sequence cautioni

The sequence BAC67207 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti429R → G in BAC27786 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB097573 Genomic DNA. Translation: BAC67207.1. Different initiation.
AK032263 mRNA. Translation: BAC27786.1.
AK039763 mRNA. Translation: BAC30442.1.
AK053065 mRNA. Translation: BAC35254.1.
CCDSiCCDS30167.1.
RefSeqiNP_848855.2. NM_178740.4.
XP_006528074.1. XM_006528011.1.
XP_006528076.1. XM_006528013.3.
XP_017173974.1. XM_017318485.1.
XP_017173975.1. XM_017318486.1.
XP_017173976.1. XM_017318487.1.
UniGeneiMm.101707.
Mm.226989.

Genome annotation databases

EnsembliENSMUST00000069926; ENSMUSP00000064443; ENSMUSG00000046699.
ENSMUST00000114679; ENSMUSP00000110327; ENSMUSG00000046699.
GeneIDi245446.
KEGGimmu:245446.
UCSCiuc009tio.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB097573 Genomic DNA. Translation: BAC67207.1. Different initiation.
AK032263 mRNA. Translation: BAC27786.1.
AK039763 mRNA. Translation: BAC30442.1.
AK053065 mRNA. Translation: BAC35254.1.
CCDSiCCDS30167.1.
RefSeqiNP_848855.2. NM_178740.4.
XP_006528074.1. XM_006528011.1.
XP_006528076.1. XM_006528013.3.
XP_017173974.1. XM_017318485.1.
XP_017173975.1. XM_017318486.1.
XP_017173976.1. XM_017318487.1.
UniGeneiMm.101707.
Mm.226989.

3D structure databases

ProteinModelPortaliQ810B8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi232771. 1 interactor.
IntActiQ810B8. 1 interactor.
MINTiMINT-4997619.
STRINGi10090.ENSMUSP00000064443.

PTM databases

iPTMnetiQ810B8.
PhosphoSitePlusiQ810B8.

Proteomic databases

EPDiQ810B8.
MaxQBiQ810B8.
PaxDbiQ810B8.
PRIDEiQ810B8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000069926; ENSMUSP00000064443; ENSMUSG00000046699.
ENSMUST00000114679; ENSMUSP00000110327; ENSMUSG00000046699.
GeneIDi245446.
KEGGimmu:245446.
UCSCiuc009tio.1. mouse.

Organism-specific databases

CTDi139065.
MGIiMGI:2442509. Slitrk4.

Phylogenomic databases

eggNOGiENOG410IGN5. Eukaryota.
ENOG4111D19. LUCA.
GeneTreeiENSGT00790000122963.
HOGENOMiHOG000290667.
HOVERGENiHBG056407.
InParanoidiQ810B8.
OMAiRYPEKQQ.
OrthoDBiEOG091G02AI.
PhylomeDBiQ810B8.
TreeFamiTF326378.

Miscellaneous databases

ChiTaRSiSlitrk4. mouse.
PROiQ810B8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000046699.
CleanExiMM_SLITRK4.
ExpressionAtlasiQ810B8. baseline and differential.
GenevisibleiQ810B8. MM.

Family and domain databases

Gene3Di3.80.10.10. 3 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 9 hits.
SM00082. LRRCT. 2 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
PROSITEiPS51450. LRR. 12 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSLIK4_MOUSE
AccessioniPrimary (citable) accession number: Q810B8
Secondary accession number(s): Q8BL56
, Q8BWB0, Q8BYG4, Q8C056
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: March 29, 2004
Last modified: November 2, 2016
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.