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Protein

Brain-specific homeobox protein homolog

Gene

Bsx

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

DNA binding protein that function as transcriptional activator. Is essentiel for normal postnatal growth and nursing. Is an essential factor for neuronal neuropeptide Y and agouti-related peptide function and locomotory behavior in the control of energy balance.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi108 – 168HomeoboxPROSITE-ProRule annotationAdd BLAST61

GO - Molecular functioni

GO - Biological processi

  • brain development Source: UniProtKB
  • eating behavior Source: MGI
  • locomotory behavior Source: MGI
  • mammary gland involution Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Brain-specific homeobox protein homolog
Gene namesi
Name:BsxImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2669849. Bsx.

Subcellular locationi

Isoform 1 :
  • Nucleus 1 Publication
Isoform 2 :
  • Cytoplasm 1 Publication

GO - Cellular componenti

  • cytoplasm Source: MGI
  • nucleus Source: MGI
  • transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi109R → G: Abolishes the nuclear localization; when associated with G-101. 1 Publication1
Mutagenesisi111R → G: Abolishes the nuclear localization; when associated with G-109. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000488441 – 232Brain-specific homeobox protein homologAdd BLAST232

Proteomic databases

PaxDbiQ810B3.
PRIDEiQ810B3.

PTM databases

PhosphoSitePlusiQ810B3.

Expressioni

Tissue specificityi

Expressed in brain. In brain, it is restricted to a few specific developing brain structures such as pineal gland, telencephalic septum, hypothalamic pre-mammillary body and arcuate nucleus.1 Publication

Developmental stagei

Expressed in early embryonic stages of epiphysis development from E9.5 onwards.1 Publication

Gene expression databases

BgeeiENSMUSG00000054360.
CleanExiMM_BSX.

Interactioni

Protein-protein interaction databases

BioGridi232691. 2 interactors.
STRINGi10090.ENSMUSP00000068057.

Structurei

3D structure databases

ProteinModelPortaliQ810B3.
SMRiQ810B3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi68 – 80His-richAdd BLAST13

Sequence similaritiesi

Belongs to the distal-less homeobox family.Sequence analysis
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0491. Eukaryota.
ENOG4111UAT. LUCA.
GeneTreeiENSGT00860000133665.
HOGENOMiHOG000231924.
HOVERGENiHBG050738.
InParanoidiQ810B3.
OMAiPHTSEAV.
OrthoDBiEOG091G0QT3.
PhylomeDBiQ810B3.
TreeFamiTF350735.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q810B3-1) [UniParc]FASTAAdd to basket
Also known as: Bsxla

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNLNFTSPLH PASSQRPTSF FIEDILLHKP KPLREVAPDH FASSLASRVP
60 70 80 90 100
LLDYGYPLMP TPTLLTPHAH HPLHKGDHHH PYFLTTSGMP VPALFPHPQH
110 120 130 140 150
AELPGKHCRR RKARTVFSDS QLSGLEKRFE IQRYLSTPER VELATALSLS
160 170 180 190 200
ETQVKTWFQN RRMKHKKQLR KSQDEPKAAD GPESPEGSPR APEGAPADAR
210 220 230
LSLPAGAFVL TEPEDEVDIG DEGELSSGPH VL
Length:232
Mass (Da):25,862
Last modified:June 1, 2003 - v1
Checksum:iFEE7C9F1574F5624
GO
Isoform 2 (identifier: Q810B3-2) [UniParc]FASTAAdd to basket
Also known as: Bsxlb

The sequence of this isoform differs from the canonical sequence as follows:
     88-131: GMPVPALFPH...LSGLEKRFEI → ALRPGEKVRN...NVVPEPADEA
     132-232: Missing.

Show »
Length:130
Mass (Da):14,323
Checksum:i7CA6FD721CB2ED1D
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02757088 – 131GMPVP…KRFEI → ALRPGEKVRNPALPVDARAC GAHCPQPLRDSGENVVPEPA DEA in isoform 2. 1 PublicationAdd BLAST44
Alternative sequenceiVSP_027571132 – 232Missing in isoform 2. 1 PublicationAdd BLAST101

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY233396 mRNA. Translation: AAO84023.1.
BC104386 mRNA. Translation: AAI04387.1.
BC104387 mRNA. Translation: AAI04388.1.
CCDSiCCDS23084.1. [Q810B3-1]
RefSeqiNP_839976.1. NM_178245.3. [Q810B3-1]
UniGeneiMm.261652.

Genome annotation databases

EnsembliENSMUST00000067375; ENSMUSP00000068057; ENSMUSG00000054360. [Q810B3-1]
GeneIDi244813.
KEGGimmu:244813.
UCSCiuc009paa.1. mouse. [Q810B3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Protein Spotlight

Of fidgets and food - Issue 85 of August 2007

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY233396 mRNA. Translation: AAO84023.1.
BC104386 mRNA. Translation: AAI04387.1.
BC104387 mRNA. Translation: AAI04388.1.
CCDSiCCDS23084.1. [Q810B3-1]
RefSeqiNP_839976.1. NM_178245.3. [Q810B3-1]
UniGeneiMm.261652.

3D structure databases

ProteinModelPortaliQ810B3.
SMRiQ810B3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi232691. 2 interactors.
STRINGi10090.ENSMUSP00000068057.

PTM databases

PhosphoSitePlusiQ810B3.

Proteomic databases

PaxDbiQ810B3.
PRIDEiQ810B3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000067375; ENSMUSP00000068057; ENSMUSG00000054360. [Q810B3-1]
GeneIDi244813.
KEGGimmu:244813.
UCSCiuc009paa.1. mouse. [Q810B3-1]

Organism-specific databases

CTDi390259.
MGIiMGI:2669849. Bsx.

Phylogenomic databases

eggNOGiKOG0491. Eukaryota.
ENOG4111UAT. LUCA.
GeneTreeiENSGT00860000133665.
HOGENOMiHOG000231924.
HOVERGENiHBG050738.
InParanoidiQ810B3.
OMAiPHTSEAV.
OrthoDBiEOG091G0QT3.
PhylomeDBiQ810B3.
TreeFamiTF350735.

Miscellaneous databases

PROiQ810B3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000054360.
CleanExiMM_BSX.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBSH_MOUSE
AccessioniPrimary (citable) accession number: Q810B3
Secondary accession number(s): Q3SXB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: June 1, 2003
Last modified: November 30, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.