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Q810B3 (BSH_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Brain-specific homeobox protein homolog
Gene names
Name:Bsx
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length232 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

DNA binding protein that function as transcriptional activator. Is essentiel for normal postnatal growth and nursing. Is an essential factor for neuronal neuropeptide Y and agouti-related peptide function and locomotory behavior in the control of energy balance. Ref.2 Ref.5 Ref.6

Subcellular location

Isoform 1: Nucleus Ref.2.

Isoform 2: Cytoplasm Ref.2.

Tissue specificity

Expressed in brain. In brain, it is restricted to a few specific developing brain structures such as pineal gland, telencephalic septum, hypothalamic pre-mammillary body and arcuate nucleus. Ref.4

Developmental stage

Expressed in early embryonic stages of epiphysis development from E9.5 onwards. Ref.4

Sequence similarities

Belongs to the distal-less homeobox family.

Contains 1 homeobox DNA-binding domain.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q810B3-1)

Also known as: Bsxla;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q810B3-2)

Also known as: Bsxlb;

The sequence of this isoform differs from the canonical sequence as follows:
     88-131: GMPVPALFPH...LSGLEKRFEI → ALRPGEKVRN...NVVPEPADEA
     132-232: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 232232Brain-specific homeobox protein homolog
PRO_0000048844

Regions

DNA binding108 – 16861Homeobox
Compositional bias68 – 8013His-rich

Natural variations

Alternative sequence88 – 13144GMPVP…KRFEI → ALRPGEKVRNPALPVDARAC GAHCPQPLRDSGENVVPEPA DEA in isoform 2.
VSP_027570
Alternative sequence132 – 232101Missing in isoform 2.
VSP_027571

Experimental info

Mutagenesis1091R → G: Abolishes the nuclear localization; when associated with G-101. Ref.2
Mutagenesis1111R → G: Abolishes the nuclear localization; when associated with G-109. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (Bsxla) [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: FEE7C9F1574F5624

FASTA23225,862
        10         20         30         40         50         60 
MNLNFTSPLH PASSQRPTSF FIEDILLHKP KPLREVAPDH FASSLASRVP LLDYGYPLMP 

        70         80         90        100        110        120 
TPTLLTPHAH HPLHKGDHHH PYFLTTSGMP VPALFPHPQH AELPGKHCRR RKARTVFSDS 

       130        140        150        160        170        180 
QLSGLEKRFE IQRYLSTPER VELATALSLS ETQVKTWFQN RRMKHKKQLR KSQDEPKAAD 

       190        200        210        220        230 
GPESPEGSPR APEGAPADAR LSLPAGAFVL TEPEDEVDIG DEGELSSGPH VL 

« Hide

Isoform 2 (Bsxlb) [UniParc].

Checksum: 7CA6FD721CB2ED1D
Show »

FASTA13014,323

References

« Hide 'large scale' references
[1]"Identification of vertebrate homologs of the Drosophila brain-specific homeobox gene."
Assimacopoulos S., Ragsdale C.W.
Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: CD-1.
Tissue: Hypothalamus and Pineal gland.
[2]"Cloning and functional analysis of hypothalamic homeobox gene Bsx1a and its isoform, Bsx1b."
Chu H.-Y., Ohtoshi A.
Mol. Cell. Biol. 27:3743-3749(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, MUTAGENESIS OF ARG-109 AND ARG-111, SUBCELLULAR LOCATION.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[4]"Bsx, an evolutionary conserved brain specific homeobox gene expressed in the septum, epiphysis, mammillary bodies and arcuate nucleus."
Cremona M., Colombo E., Andreazzoli M., Cossu G., Broccoli V.
Gene Expr. Patterns 4:47-51(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
[5]"A role for brain-specific homeobox factor bsx in the control of hyperphagia and locomotory behavior."
Sakkou M., Wiedmer P., Anlag K., Hamm A., Seuntjens E., Ettwiller L., Tschoep M.H., Treier M.
Cell Metab. 5:450-463(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[6]"A brain-specific homeobox gene, bsx, is essential for proper postnatal growth and nursing."
McArthur T., Ohtoshi A.
Mol. Cell. Biol. 27:5120-5127(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Web resources

Protein Spotlight

Of fidgets and food - Issue 85 of August 2007

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY233396 mRNA. Translation: AAO84023.1.
BC104386 mRNA. Translation: AAI04387.1.
BC104387 mRNA. Translation: AAI04388.1.
RefSeqNP_839976.1. NM_178245.3.
UniGeneMm.261652.

3D structure databases

ProteinModelPortalQ810B3.
SMRQ810B3. Positions 104-167.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid232691. 2 interactions.

PTM databases

PhosphoSiteQ810B3.

Proteomic databases

PRIDEQ810B3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000067375; ENSMUSP00000068057; ENSMUSG00000054360. [Q810B3-1]
GeneID244813.
KEGGmmu:244813.
UCSCuc009paa.1. mouse. [Q810B3-1]

Organism-specific databases

CTD390259.
MGIMGI:2669849. Bsx.

Phylogenomic databases

eggNOGNOG242366.
GeneTreeENSGT00740000114906.
HOGENOMHOG000231924.
HOVERGENHBG050738.
InParanoidQ3SXB1.
OMALHKPEHH.
OrthoDBEOG7QVM51.
PhylomeDBQ810B3.
TreeFamTF350735.

Gene expression databases

BgeeQ810B3.
CleanExMM_BSX.
GenevestigatorQ810B3.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio386432.
PROQ810B3.
SOURCESearch...

Entry information

Entry nameBSH_MOUSE
AccessionPrimary (citable) accession number: Q810B3
Secondary accession number(s): Q3SXB1
Entry history
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: June 1, 2003
Last modified: April 16, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot