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Q810B3

- BSH_MOUSE

UniProt

Q810B3 - BSH_MOUSE

Protein

Brain-specific homeobox protein homolog

Gene

Bsx

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    DNA binding protein that function as transcriptional activator. Is essentiel for normal postnatal growth and nursing. Is an essential factor for neuronal neuropeptide Y and agouti-related peptide function and locomotory behavior in the control of energy balance.3 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi108 – 16861HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. protein binding Source: MGI
    2. sequence-specific DNA binding Source: MGI
    3. sequence-specific DNA binding transcription factor activity Source: MGI

    GO - Biological processi

    1. brain development Source: UniProtKB
    2. eating behavior Source: MGI
    3. locomotory behavior Source: MGI
    4. mammary gland involution Source: MGI
    5. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    6. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Brain-specific homeobox protein homolog
    Gene namesi
    Name:BsxImported
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:2669849. Bsx.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. nucleus Source: MGI
    3. transcription factor complex Source: MGI

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi109 – 1091R → G: Abolishes the nuclear localization; when associated with G-101. 1 Publication
    Mutagenesisi111 – 1111R → G: Abolishes the nuclear localization; when associated with G-109. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 232232Brain-specific homeobox protein homologPRO_0000048844Add
    BLAST

    Proteomic databases

    PRIDEiQ810B3.

    PTM databases

    PhosphoSiteiQ810B3.

    Expressioni

    Tissue specificityi

    Expressed in brain. In brain, it is restricted to a few specific developing brain structures such as pineal gland, telencephalic septum, hypothalamic pre-mammillary body and arcuate nucleus.1 Publication

    Developmental stagei

    Expressed in early embryonic stages of epiphysis development from E9.5 onwards.1 Publication

    Gene expression databases

    BgeeiQ810B3.
    CleanExiMM_BSX.
    GenevestigatoriQ810B3.

    Interactioni

    Protein-protein interaction databases

    BioGridi232691. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ810B3.
    SMRiQ810B3. Positions 104-167.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi68 – 8013His-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the distal-less homeobox family.Sequence Analysis
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG242366.
    GeneTreeiENSGT00740000114906.
    HOGENOMiHOG000231924.
    HOVERGENiHBG050738.
    InParanoidiQ3SXB1.
    OMAiLHKPEHH.
    OrthoDBiEOG7QVM51.
    PhylomeDBiQ810B3.
    TreeFamiTF350735.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q810B3-1) [UniParc]FASTAAdd to Basket

    Also known as: Bsxla

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNLNFTSPLH PASSQRPTSF FIEDILLHKP KPLREVAPDH FASSLASRVP    50
    LLDYGYPLMP TPTLLTPHAH HPLHKGDHHH PYFLTTSGMP VPALFPHPQH 100
    AELPGKHCRR RKARTVFSDS QLSGLEKRFE IQRYLSTPER VELATALSLS 150
    ETQVKTWFQN RRMKHKKQLR KSQDEPKAAD GPESPEGSPR APEGAPADAR 200
    LSLPAGAFVL TEPEDEVDIG DEGELSSGPH VL 232
    Length:232
    Mass (Da):25,862
    Last modified:June 1, 2003 - v1
    Checksum:iFEE7C9F1574F5624
    GO
    Isoform 2 (identifier: Q810B3-2) [UniParc]FASTAAdd to Basket

    Also known as: Bsxlb

    The sequence of this isoform differs from the canonical sequence as follows:
         88-131: GMPVPALFPH...LSGLEKRFEI → ALRPGEKVRN...NVVPEPADEA
         132-232: Missing.

    Show »
    Length:130
    Mass (Da):14,323
    Checksum:i7CA6FD721CB2ED1D
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei88 – 13144GMPVP…KRFEI → ALRPGEKVRNPALPVDARAC GAHCPQPLRDSGENVVPEPA DEA in isoform 2. 1 PublicationVSP_027570Add
    BLAST
    Alternative sequencei132 – 232101Missing in isoform 2. 1 PublicationVSP_027571Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY233396 mRNA. Translation: AAO84023.1.
    BC104386 mRNA. Translation: AAI04387.1.
    BC104387 mRNA. Translation: AAI04388.1.
    CCDSiCCDS23084.1. [Q810B3-1]
    RefSeqiNP_839976.1. NM_178245.3. [Q810B3-1]
    UniGeneiMm.261652.

    Genome annotation databases

    EnsembliENSMUST00000067375; ENSMUSP00000068057; ENSMUSG00000054360. [Q810B3-1]
    GeneIDi244813.
    KEGGimmu:244813.
    UCSCiuc009paa.1. mouse. [Q810B3-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    Of fidgets and food - Issue 85 of August 2007

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY233396 mRNA. Translation: AAO84023.1 .
    BC104386 mRNA. Translation: AAI04387.1 .
    BC104387 mRNA. Translation: AAI04388.1 .
    CCDSi CCDS23084.1. [Q810B3-1 ]
    RefSeqi NP_839976.1. NM_178245.3. [Q810B3-1 ]
    UniGenei Mm.261652.

    3D structure databases

    ProteinModelPortali Q810B3.
    SMRi Q810B3. Positions 104-167.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 232691. 2 interactions.

    PTM databases

    PhosphoSitei Q810B3.

    Proteomic databases

    PRIDEi Q810B3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000067375 ; ENSMUSP00000068057 ; ENSMUSG00000054360 . [Q810B3-1 ]
    GeneIDi 244813.
    KEGGi mmu:244813.
    UCSCi uc009paa.1. mouse. [Q810B3-1 ]

    Organism-specific databases

    CTDi 390259.
    MGIi MGI:2669849. Bsx.

    Phylogenomic databases

    eggNOGi NOG242366.
    GeneTreei ENSGT00740000114906.
    HOGENOMi HOG000231924.
    HOVERGENi HBG050738.
    InParanoidi Q3SXB1.
    OMAi LHKPEHH.
    OrthoDBi EOG7QVM51.
    PhylomeDBi Q810B3.
    TreeFami TF350735.

    Miscellaneous databases

    NextBioi 386432.
    PROi Q810B3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q810B3.
    CleanExi MM_BSX.
    Genevestigatori Q810B3.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of vertebrate homologs of the Drosophila brain-specific homeobox gene."
      Assimacopoulos S., Ragsdale C.W.
      Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: CD-1Imported.
      Tissue: Hypothalamus1 Publication and Pineal gland1 Publication.
    2. "Cloning and functional analysis of hypothalamic homeobox gene Bsx1a and its isoform, Bsx1b."
      Chu H.-Y., Ohtoshi A.
      Mol. Cell. Biol. 27:3743-3749(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, MUTAGENESIS OF ARG-109 AND ARG-111, SUBCELLULAR LOCATION.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    4. "Bsx, an evolutionary conserved brain specific homeobox gene expressed in the septum, epiphysis, mammillary bodies and arcuate nucleus."
      Cremona M., Colombo E., Andreazzoli M., Cossu G., Broccoli V.
      Gene Expr. Patterns 4:47-51(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    5. "A role for brain-specific homeobox factor bsx in the control of hyperphagia and locomotory behavior."
      Sakkou M., Wiedmer P., Anlag K., Hamm A., Seuntjens E., Ettwiller L., Tschoep M.H., Treier M.
      Cell Metab. 5:450-463(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. "A brain-specific homeobox gene, bsx, is essential for proper postnatal growth and nursing."
      McArthur T., Ohtoshi A.
      Mol. Cell. Biol. 27:5120-5127(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiBSH_MOUSE
    AccessioniPrimary (citable) accession number: Q810B3
    Secondary accession number(s): Q3SXB1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 31, 2004
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3