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Protein
Submitted name:

Protein Sec24b

Gene

Sec24b

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • aorta morphogenesis Source: MGI
  • auditory receptor cell morphogenesis Source: MGI
  • auditory receptor cell stereocilium organization Source: MGI
  • cardiovascular system development Source: MGI
  • cochlear nucleus development Source: MGI
  • coronary artery morphogenesis Source: MGI
  • ER to Golgi vesicle-mediated transport Source: InterPro
  • intracellular protein transport Source: InterPro
  • lung lobe morphogenesis Source: MGI
  • lung morphogenesis Source: MGI
  • neural tube closure Source: MGI
  • outflow tract morphogenesis Source: MGI
  • pulmonary artery morphogenesis Source: MGI
  • regulation of cargo loading into COPII-coated vesicle Source: MGI
  • regulation of establishment of planar polarity involved in neural tube closure Source: MGI
Complete GO annotation...

Keywords - Biological processi

Protein transportSAAS annotation, Transport

Enzyme and pathway databases

ReactomeiR-MMU-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-MMU-2132295. MHC class II antigen presentation.
R-MMU-5694530. Cargo concentration in the ER.
R-MMU-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein Sec24bImported
Submitted name:
Sec24 related gene family, member B (S. cerevisiae)Imported
Gene namesi
Name:Sec24bImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:2139764. Sec24b.

Subcellular locationi

GO - Cellular componenti

  • COPII vesicle coat Source: MGI
  • ER to Golgi transport vesicle Source: MGI
Complete GO annotation...

PTM / Processingi

Proteomic databases

PeptideAtlasiQ80ZX0.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000001079.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini585 – 62137zf-Sec23_Sec24InterPro annotationAdd
BLAST
Domaini658 – 897240Sec23_trunkInterPro annotationAdd
BLAST
Domaini902 – 98685Sec23_BSInterPro annotationAdd
BLAST
Domaini997 – 1097101Sec23_helicalInterPro annotationAdd
BLAST
Domaini1124 – 118966Gelsolin-likeInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiKOG1985. Eukaryota.
COG5028. LUCA.
GeneTreeiENSGT00590000082962.
HOGENOMiHOG000196365.
HOVERGENiHBG054850.
KOiK14007.
OMAiNILPMTP.
OrthoDBiEOG7R56RS.
TreeFamiTF354244.

Family and domain databases

Gene3Di3.40.20.10. 1 hit.
3.40.50.410. 1 hit.
InterProiIPR029006. ADF-H/Gelsolin-like_dom.
IPR007123. Gelsolin-like_dom.
IPR006900. Sec23/24_helical_dom.
IPR006896. Sec23/24_trunk_dom.
IPR012990. Sec23_24_beta_S.
IPR002035. VWF_A.
IPR006895. Znf_Sec23_Sec24.
[Graphical view]
PfamiPF00626. Gelsolin. 1 hit.
PF08033. Sec23_BS. 1 hit.
PF04815. Sec23_helical. 1 hit.
PF04811. Sec23_trunk. 1 hit.
PF04810. zf-Sec23_Sec24. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF81811. SSF81811. 1 hit.
SSF82754. SSF82754. 1 hit.
SSF82919. SSF82919. 1 hit.

Sequencei

Sequence statusi: Complete.

Q80ZX0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAPAGSPHP AAGARMPPKL GGAVSGLAPP QQNGPAQSPM QVPSGYGLPH
60 70 80 90 100
QNYMVPSGHY SQGPGKMTSL PLDSQCDSYY SRPYTVPTQN SGTPSSANQP
110 120 130 140 150
GAQQMYGRGP SAPHMGGSMP GSFQGIPASA SHSYSSASQP YSSLGNRYSS
160 170 180 190 200
PTTYSANASV ASQGYPSTCS HYPISTVSNV VYPNVSYPSL PASEPYGQMF
210 220 230 240 250
TSQSAPPPAR PVKESYSGPS TALTYPSRPP PPPSQHQQQQ QQQQQQQQQQ
260 270 280 290 300
QSHSGYSSLP WSGPALPPAQ DSLIRNQMGS LATANSHPTN NENVQPPKSS
310 320 330 340 350
SVVSTVLPGP SSTRMPPAPS HPVGPVPSAP PPPEQMQTKG MQYGDYGNNQ
360 370 380 390 400
ASSTATPLSS ASDDEEEQEE DEEAGVDSSS TTSSASPLPN SYDALEGGSY
410 420 430 440 450
PDMHSSSASS PVPDHALEPS PTLAQALSAA PTPPAAQPAK VAKPFGYGYP
460 470 480 490 500
ALQPAYQNAA PPPMPAAHPS GPAYTGYPQH YPGVNQLSSG LGGLSLQSSP
510 520 530 540 550
QPESLRPVNL TQEKNILPPT PIWAPVPNLS AELSKLNCSP DSFRCTLTSI
560 570 580 590 600
PQTQALLNKA KLPLGLLLHP FRDLTQLPVI TSNTIVRCRS CRTYINPFVS
610 620 630 640 650
FIDQRRWKCN LCYRVNDVPE EFLYNPLTRS YGEPHKRPEV QNSTVEFIAS
660 670 680 690 700
SDYMLRPPQP AVYLFVLDVS HNAVEAGYLT VLCQSLLENL DKLPGDSRTR
710 720 730 740 750
IGFMTFDSTI HFYNLQEGLS QPQMLIVSDI DDVFLPTPDS LLVNLYESKE
760 770 780 790 800
LIKDLLNALP SMFINTRETH SALGPALQAA FKLMSPTGGR VSVFQTQLPS
810 820 830 840 850
LGAGLLQSRE DPNQRSSTKV VHHLGPATDF YKKLALDCSG QQTAVDLFLL
860 870 880 890 900
SSQYSDLASL ACMSKYSAGC IFYYPSFHST HNPSQAEKLQ KDLKRYLTRK
910 920 930 940 950
IGFEAVMRIR CTKGLSMHTF HGNFFVRSTD LLSLANINPD AGFAVQLSIE
960 970 980 990 1000
ESLTDTALVC FQTALLYTSS KGERRIRVHT LCLPVVSSLA DVYAGVDVQA
1010 1020 1030 1040 1050
AVCLLANMAV DRSVSSSLSD ARDALVNAVV DPLSAYSSAV ASVPRSTLTA
1060 1070 1080 1090 1100
PSSLKLLPLY VLALLKQKAF RTGTSTRLDD RVYAMCQMKS QPLVHLMKMI
1110 1120 1130 1140 1150
HPNLYRIDRL TDEGAIHVND RVVPQPPLQK LSAEKLTREG AFLMDCGSVF
1160 1170 1180 1190 1200
YIWVGKGCDS NFIENVLGYP DFASIPQKMT HLPELDTLPS ERTRSFVTWL
1210 1220 1230 1240 1250
RDSRPLSPVL HLVKDESPAK TDFFQHLLED RTEAALSYYE FLIHIQQQVC

K
Length:1,251
Mass (Da):135,551
Last modified:June 1, 2003 - v1
Checksum:i4E36C4C0C0F79D25
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC118620 Genomic DNA. No translation available.
BC046776 mRNA. Translation: AAH46776.1.
RefSeqiNP_997092.1. NM_207209.2.
UniGeneiMm.192303.

Genome annotation databases

EnsembliENSMUST00000001079; ENSMUSP00000001079; ENSMUSG00000001052.
GeneIDi99683.
KEGGimmu:99683.
UCSCiuc008rit.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC118620 Genomic DNA. No translation available.
BC046776 mRNA. Translation: AAH46776.1.
RefSeqiNP_997092.1. NM_207209.2.
UniGeneiMm.192303.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000001079.

Proteomic databases

PeptideAtlasiQ80ZX0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001079; ENSMUSP00000001079; ENSMUSG00000001052.
GeneIDi99683.
KEGGimmu:99683.
UCSCiuc008rit.1. mouse.

Organism-specific databases

CTDi10427.
MGIiMGI:2139764. Sec24b.

Phylogenomic databases

eggNOGiKOG1985. Eukaryota.
COG5028. LUCA.
GeneTreeiENSGT00590000082962.
HOGENOMiHOG000196365.
HOVERGENiHBG054850.
KOiK14007.
OMAiNILPMTP.
OrthoDBiEOG7R56RS.
TreeFamiTF354244.

Enzyme and pathway databases

ReactomeiR-MMU-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-MMU-2132295. MHC class II antigen presentation.
R-MMU-5694530. Cargo concentration in the ER.
R-MMU-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Miscellaneous databases

ChiTaRSiSec24b. mouse.
SOURCEiSearch...

Family and domain databases

Gene3Di3.40.20.10. 1 hit.
3.40.50.410. 1 hit.
InterProiIPR029006. ADF-H/Gelsolin-like_dom.
IPR007123. Gelsolin-like_dom.
IPR006900. Sec23/24_helical_dom.
IPR006896. Sec23/24_trunk_dom.
IPR012990. Sec23_24_beta_S.
IPR002035. VWF_A.
IPR006895. Znf_Sec23_Sec24.
[Graphical view]
PfamiPF00626. Gelsolin. 1 hit.
PF08033. Sec23_BS. 1 hit.
PF04815. Sec23_helical. 1 hit.
PF04811. Sec23_trunk. 1 hit.
PF04810. zf-Sec23_Sec24. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF81811. SSF81811. 1 hit.
SSF82754. SSF82754. 1 hit.
SSF82919. SSF82919. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6Imported.
    Tissue: BrainImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.
  5. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiQ80ZX0_MOUSE
AccessioniPrimary (citable) accession number: Q80ZX0
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: July 6, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.