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Q80ZW0

- STK35_MOUSE

UniProt

Q80ZW0 - STK35_MOUSE

Protein

Serine/threonine-protein kinase 35

Gene

Stk35

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 3 (23 Mar 2010)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei236 – 2361ATPPROSITE-ProRule annotation
    Active sitei365 – 3651Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi213 – 2219ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein serine/threonine kinase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase 35
    Alternative name(s):
    Serine/threonine-protein kinase 35 L1 (EC:2.7.11.1)
    Gene namesi
    Name:Stk35
    Synonyms:Stk35l1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1914583. Stk35.

    Subcellular locationi

    Nucleus. Nucleusnucleolus. Cytoplasm
    Note: When associated with PDLIM1, it is mostly found in cytoplasm, localized to actin stress fibers.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleolus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 539539Serine/threonine-protein kinase 35PRO_0000277618Add
    BLAST

    Post-translational modificationi

    Autophosphorylated.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ80ZW0.
    PRIDEiQ80ZW0.

    PTM databases

    PhosphoSiteiQ80ZW0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ80ZW0.
    BgeeiQ80ZW0.
    CleanExiMM_STK35.
    GenevestigatoriQ80ZW0.

    Interactioni

    Subunit structurei

    Interacts with PDLIM1/CLP-36.By similarity

    Protein-protein interaction databases

    BioGridi212113. 3 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ80ZW0.
    SMRiQ80ZW0. Positions 203-528.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini207 – 535329Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi132 – 1354Poly-Pro
    Compositional biasi196 – 1994Poly-Gly

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00750000117533.
    HOGENOMiHOG000231155.
    HOVERGENiHBG056829.
    InParanoidiA2ANF2.
    KOiK08859.
    OMAiPRGKEGH.
    OrthoDBiEOG76DTSN.
    PhylomeDBiQ80ZW0.
    TreeFamiTF105336.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 2 hits.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q80ZW0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGHQESPLTR AAAGGAAYIK RLRKVLSWRE LGDGHGNLEA EASPGSVAVI    50
    TRAAPRRATR SARLPASRPT RLCRQARLGT DHPPARAPRG NRFARKRNSA 100
    GQITIQGPAP PHLGARRRDE ARGARAAPLL LPPPPAAMET GKENGARRGT 150
    KSPERKRRSP VQRVLCEKLR PAAQAMDPAG AEVPGEAFLA RRRPDGGGGD 200
    VPARPRYSLL AEIGRGSYGV VYEAVAGRSG ARVAVKKIRC DAPENVELAL 250
    AEFWALTSLK RRHQNIVQFE ECVLQRNGLA QRMSHGNKNS QLYLRLVETS 300
    LKGERILGYA EEPCYLWFVM EYCEGGDLNQ YVLSRRPDPA TNKSFMLQLT 350
    SAIAFLHKNH IVHRDLKPDN ILITERSGTP ILKVADFGLS KVCAGLAPRG 400
    KEGNQDNKNV NVNKYWLSSA CGSDFYMAPE VWEGHYTAKA DIFALGIIIW 450
    AMIERITFID SETKKELLGT YIKQGTEIVP VGEALLENPK MELHIPQKRR 500
    TSMSEGVKQL LKDMLAANPQ DRPDAFELET RMDQVTCAA 539
    Length:539
    Mass (Da):59,459
    Last modified:March 23, 2010 - v3
    Checksum:i66959648E99458B3
    GO

    Sequence cautioni

    The sequence BAC25152.1 differs from that shown. Reason: Frameshift at position 23.
    The sequence AAI38905.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAI38906.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAC25152.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAE38504.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAM22106.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti28 – 281W → G in BAE38504. (PubMed:16141072)Curated
    Sequence conflicti71 – 711R → G in BAE38504. (PubMed:16141072)Curated
    Sequence conflicti71 – 711R → G in BAC25152. (PubMed:16141072)Curated
    Sequence conflicti147 – 1471R → S in BAC25152. (PubMed:16141072)Curated
    Sequence conflicti304 – 32724ERILG…CEGGD → RSFGTHSLIVSRTGWQRVQV VVIS in BAE38504. (PubMed:16141072)CuratedAdd
    BLAST
    Sequence conflicti337 – 3371P → A in BAC25152. (PubMed:16141072)Curated
    Sequence conflicti345 – 3451F → V in BAC25152. (PubMed:16141072)Curated
    Sequence conflicti365 – 37713DLKPD…ITERS → RPKARQHPDHRAV in BAC25152. (PubMed:16141072)CuratedAdd
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL808137 Genomic DNA. Translation: CAM22106.1. Different initiation.
    BC047277 mRNA. Translation: AAH47277.1.
    BC138904 mRNA. Translation: AAI38905.1. Different initiation.
    BC138905 mRNA. Translation: AAI38906.1. Different initiation.
    AK006778 mRNA. Translation: BAC25152.1. Sequence problems.
    AK165988 mRNA. Translation: BAE38504.1. Different initiation.
    CCDSiCCDS16732.2.
    RefSeqiNP_899085.3. NM_183262.3.
    UniGeneiMm.389329.

    Genome annotation databases

    EnsembliENSMUST00000165413; ENSMUSP00000126541; ENSMUSG00000037885.
    GeneIDi67333.
    KEGGimmu:67333.
    UCSCiuc008mie.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL808137 Genomic DNA. Translation: CAM22106.1 . Different initiation.
    BC047277 mRNA. Translation: AAH47277.1 .
    BC138904 mRNA. Translation: AAI38905.1 . Different initiation.
    BC138905 mRNA. Translation: AAI38906.1 . Different initiation.
    AK006778 mRNA. Translation: BAC25152.1 . Sequence problems.
    AK165988 mRNA. Translation: BAE38504.1 . Different initiation.
    CCDSi CCDS16732.2.
    RefSeqi NP_899085.3. NM_183262.3.
    UniGenei Mm.389329.

    3D structure databases

    ProteinModelPortali Q80ZW0.
    SMRi Q80ZW0. Positions 203-528.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 212113. 3 interactions.

    PTM databases

    PhosphoSitei Q80ZW0.

    Proteomic databases

    PaxDbi Q80ZW0.
    PRIDEi Q80ZW0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000165413 ; ENSMUSP00000126541 ; ENSMUSG00000037885 .
    GeneIDi 67333.
    KEGGi mmu:67333.
    UCSCi uc008mie.2. mouse.

    Organism-specific databases

    CTDi 140901.
    MGIi MGI:1914583. Stk35.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00750000117533.
    HOGENOMi HOG000231155.
    HOVERGENi HBG056829.
    InParanoidi A2ANF2.
    KOi K08859.
    OMAi PRGKEGH.
    OrthoDBi EOG76DTSN.
    PhylomeDBi Q80ZW0.
    TreeFami TF105336.

    Miscellaneous databases

    NextBioi 324268.
    PROi Q80ZW0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q80ZW0.
    Bgeei Q80ZW0.
    CleanExi MM_STK35.
    Genevestigatori Q80ZW0.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 2 hits.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 25-539.
      Tissue: Olfactory epithelium.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 28-539.
      Strain: C57BL/6J.
      Tissue: Lung and Testis.

    Entry informationi

    Entry nameiSTK35_MOUSE
    AccessioniPrimary (citable) accession number: Q80ZW0
    Secondary accession number(s): A2ANF2, Q3TMD8, Q8BIC2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 6, 2007
    Last sequence update: March 23, 2010
    Last modified: October 1, 2014
    This is version 92 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3