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Q80ZW0

- STK35_MOUSE

UniProt

Q80ZW0 - STK35_MOUSE

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Protein
Serine/threonine-protein kinase 35
Gene
Stk35, Stk35l1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei236 – 2361ATP By similarity
Active sitei365 – 3651Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi213 – 2219ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase 35
Alternative name(s):
Serine/threonine-protein kinase 35 L1 (EC:2.7.11.1)
Gene namesi
Name:Stk35
Synonyms:Stk35l1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1914583. Stk35.

Subcellular locationi

Nucleus. Nucleusnucleolus. Cytoplasm
Note: When associated with PDLIM1, it is mostly found in cytoplasm, localized to actin stress fibers By similarity.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleolus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 539539Serine/threonine-protein kinase 35
PRO_0000277618Add
BLAST

Post-translational modificationi

Autophosphorylated By similarity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ80ZW0.
PRIDEiQ80ZW0.

PTM databases

PhosphoSiteiQ80ZW0.

Expressioni

Gene expression databases

ArrayExpressiQ80ZW0.
BgeeiQ80ZW0.
CleanExiMM_STK35.
GenevestigatoriQ80ZW0.

Interactioni

Subunit structurei

Interacts with PDLIM1/CLP-36 By similarity.

Protein-protein interaction databases

BioGridi212113. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ80ZW0.
SMRiQ80ZW0. Positions 203-528.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini207 – 535329Protein kinase
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi132 – 1354Poly-Pro
Compositional biasi196 – 1994Poly-Gly

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00750000117533.
HOGENOMiHOG000231155.
HOVERGENiHBG056829.
InParanoidiA2ANF2.
KOiK08859.
OMAiPRGKEGH.
OrthoDBiEOG76DTSN.
PhylomeDBiQ80ZW0.
TreeFamiTF105336.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80ZW0-1 [UniParc]FASTAAdd to Basket

« Hide

MGHQESPLTR AAAGGAAYIK RLRKVLSWRE LGDGHGNLEA EASPGSVAVI    50
TRAAPRRATR SARLPASRPT RLCRQARLGT DHPPARAPRG NRFARKRNSA 100
GQITIQGPAP PHLGARRRDE ARGARAAPLL LPPPPAAMET GKENGARRGT 150
KSPERKRRSP VQRVLCEKLR PAAQAMDPAG AEVPGEAFLA RRRPDGGGGD 200
VPARPRYSLL AEIGRGSYGV VYEAVAGRSG ARVAVKKIRC DAPENVELAL 250
AEFWALTSLK RRHQNIVQFE ECVLQRNGLA QRMSHGNKNS QLYLRLVETS 300
LKGERILGYA EEPCYLWFVM EYCEGGDLNQ YVLSRRPDPA TNKSFMLQLT 350
SAIAFLHKNH IVHRDLKPDN ILITERSGTP ILKVADFGLS KVCAGLAPRG 400
KEGNQDNKNV NVNKYWLSSA CGSDFYMAPE VWEGHYTAKA DIFALGIIIW 450
AMIERITFID SETKKELLGT YIKQGTEIVP VGEALLENPK MELHIPQKRR 500
TSMSEGVKQL LKDMLAANPQ DRPDAFELET RMDQVTCAA 539
Length:539
Mass (Da):59,459
Last modified:March 23, 2010 - v3
Checksum:i66959648E99458B3
GO

Sequence cautioni

The sequence BAC25152.1 differs from that shown. Reason: Frameshift at position 23.
The sequence AAI38905.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAI38906.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAC25152.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAE38504.1 differs from that shown. Reason: Erroneous initiation.
The sequence CAM22106.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti28 – 281W → G in BAE38504. 1 Publication
Sequence conflicti71 – 711R → G in BAE38504. 1 Publication
Sequence conflicti71 – 711R → G in BAC25152. 1 Publication
Sequence conflicti147 – 1471R → S in BAC25152. 1 Publication
Sequence conflicti304 – 32724ERILG…CEGGD → RSFGTHSLIVSRTGWQRVQV VVIS in BAE38504. 1 Publication
Add
BLAST
Sequence conflicti337 – 3371P → A in BAC25152. 1 Publication
Sequence conflicti345 – 3451F → V in BAC25152. 1 Publication
Sequence conflicti365 – 37713DLKPD…ITERS → RPKARQHPDHRAV in BAC25152. 1 Publication
Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL808137 Genomic DNA. Translation: CAM22106.1. Different initiation.
BC047277 mRNA. Translation: AAH47277.1.
BC138904 mRNA. Translation: AAI38905.1. Different initiation.
BC138905 mRNA. Translation: AAI38906.1. Different initiation.
AK006778 mRNA. Translation: BAC25152.1. Sequence problems.
AK165988 mRNA. Translation: BAE38504.1. Different initiation.
CCDSiCCDS16732.2.
RefSeqiNP_899085.3. NM_183262.3.
UniGeneiMm.389329.

Genome annotation databases

EnsembliENSMUST00000165413; ENSMUSP00000126541; ENSMUSG00000037885.
GeneIDi67333.
KEGGimmu:67333.
UCSCiuc008mie.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL808137 Genomic DNA. Translation: CAM22106.1 . Different initiation.
BC047277 mRNA. Translation: AAH47277.1 .
BC138904 mRNA. Translation: AAI38905.1 . Different initiation.
BC138905 mRNA. Translation: AAI38906.1 . Different initiation.
AK006778 mRNA. Translation: BAC25152.1 . Sequence problems.
AK165988 mRNA. Translation: BAE38504.1 . Different initiation.
CCDSi CCDS16732.2.
RefSeqi NP_899085.3. NM_183262.3.
UniGenei Mm.389329.

3D structure databases

ProteinModelPortali Q80ZW0.
SMRi Q80ZW0. Positions 203-528.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 212113. 3 interactions.

PTM databases

PhosphoSitei Q80ZW0.

Proteomic databases

PaxDbi Q80ZW0.
PRIDEi Q80ZW0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000165413 ; ENSMUSP00000126541 ; ENSMUSG00000037885 .
GeneIDi 67333.
KEGGi mmu:67333.
UCSCi uc008mie.2. mouse.

Organism-specific databases

CTDi 140901.
MGIi MGI:1914583. Stk35.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00750000117533.
HOGENOMi HOG000231155.
HOVERGENi HBG056829.
InParanoidi A2ANF2.
KOi K08859.
OMAi PRGKEGH.
OrthoDBi EOG76DTSN.
PhylomeDBi Q80ZW0.
TreeFami TF105336.

Miscellaneous databases

NextBioi 324268.
PROi Q80ZW0.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q80ZW0.
Bgeei Q80ZW0.
CleanExi MM_STK35.
Genevestigatori Q80ZW0.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 2 hits.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 25-539.
    Tissue: Olfactory epithelium.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 28-539.
    Strain: C57BL/6J.
    Tissue: Lung and Testis.

Entry informationi

Entry nameiSTK35_MOUSE
AccessioniPrimary (citable) accession number: Q80ZW0
Secondary accession number(s): A2ANF2, Q3TMD8, Q8BIC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: March 23, 2010
Last modified: July 9, 2014
This is version 91 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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