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Q80ZW0 (STK35_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein kinase 35
Alternative name(s):
Serine/threonine-protein kinase 35 L1
EC=2.7.11.1
Gene names
Name:Stk35
Synonyms:Stk35l1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length539 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Subunit structure

Interacts with PDLIM1/CLP-36 By similarity.

Subcellular location

Nucleus. Nucleusnucleolus. Cytoplasm. Note: When associated with PDLIM1, it is mostly found in cytoplasm, localized to actin stress fibers By similarity.

Post-translational modification

Autophosphorylated By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

Contains 1 protein kinase domain.

Sequence caution

The sequence AAI38905.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAI38906.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAC25152.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence BAC25152.1 differs from that shown. Reason: Frameshift at position 23.

The sequence BAE38504.1 differs from that shown. Reason: Erroneous initiation.

The sequence CAM22106.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentCytoplasm
Nucleus
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Serine/threonine-protein kinase
Transferase
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleolus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

protein serine/threonine kinase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 539539Serine/threonine-protein kinase 35
PRO_0000277618

Regions

Domain207 – 535329Protein kinase
Nucleotide binding213 – 2219ATP By similarity
Compositional bias132 – 1354Poly-Pro
Compositional bias196 – 1994Poly-Gly

Sites

Active site3651Proton acceptor By similarity
Binding site2361ATP By similarity

Experimental info

Sequence conflict281W → G in BAE38504. Ref.3
Sequence conflict711R → G in BAE38504. Ref.3
Sequence conflict711R → G in BAC25152. Ref.3
Sequence conflict1471R → S in BAC25152. Ref.3
Sequence conflict304 – 32724ERILG…CEGGD → RSFGTHSLIVSRTGWQRVQV VVIS in BAE38504. Ref.3
Sequence conflict3371P → A in BAC25152. Ref.3
Sequence conflict3451F → V in BAC25152. Ref.3
Sequence conflict365 – 37713DLKPD…ITERS → RPKARQHPDHRAV in BAC25152. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q80ZW0 [UniParc].

Last modified March 23, 2010. Version 3.
Checksum: 66959648E99458B3

FASTA53959,459
        10         20         30         40         50         60 
MGHQESPLTR AAAGGAAYIK RLRKVLSWRE LGDGHGNLEA EASPGSVAVI TRAAPRRATR 

        70         80         90        100        110        120 
SARLPASRPT RLCRQARLGT DHPPARAPRG NRFARKRNSA GQITIQGPAP PHLGARRRDE 

       130        140        150        160        170        180 
ARGARAAPLL LPPPPAAMET GKENGARRGT KSPERKRRSP VQRVLCEKLR PAAQAMDPAG 

       190        200        210        220        230        240 
AEVPGEAFLA RRRPDGGGGD VPARPRYSLL AEIGRGSYGV VYEAVAGRSG ARVAVKKIRC 

       250        260        270        280        290        300 
DAPENVELAL AEFWALTSLK RRHQNIVQFE ECVLQRNGLA QRMSHGNKNS QLYLRLVETS 

       310        320        330        340        350        360 
LKGERILGYA EEPCYLWFVM EYCEGGDLNQ YVLSRRPDPA TNKSFMLQLT SAIAFLHKNH 

       370        380        390        400        410        420 
IVHRDLKPDN ILITERSGTP ILKVADFGLS KVCAGLAPRG KEGNQDNKNV NVNKYWLSSA 

       430        440        450        460        470        480 
CGSDFYMAPE VWEGHYTAKA DIFALGIIIW AMIERITFID SETKKELLGT YIKQGTEIVP 

       490        500        510        520        530 
VGEALLENPK MELHIPQKRR TSMSEGVKQL LKDMLAANPQ DRPDAFELET RMDQVTCAA 

« Hide

References

[1]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 25-539.
Tissue: Olfactory epithelium.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 28-539.
Strain: C57BL/6J.
Tissue: Lung and Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL808137 Genomic DNA. Translation: CAM22106.1. Different initiation.
BC047277 mRNA. Translation: AAH47277.1.
BC138904 mRNA. Translation: AAI38905.1. Different initiation.
BC138905 mRNA. Translation: AAI38906.1. Different initiation.
AK006778 mRNA. Translation: BAC25152.1. Sequence problems.
AK165988 mRNA. Translation: BAE38504.1. Different initiation.
CCDSCCDS16732.2.
RefSeqNP_899085.3. NM_183262.3.
UniGeneMm.389329.

3D structure databases

ProteinModelPortalQ80ZW0.
SMRQ80ZW0. Positions 203-528.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid212113. 3 interactions.

PTM databases

PhosphoSiteQ80ZW0.

Proteomic databases

PaxDbQ80ZW0.
PRIDEQ80ZW0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000165413; ENSMUSP00000126541; ENSMUSG00000037885.
GeneID67333.
KEGGmmu:67333.
UCSCuc008mie.2. mouse.

Organism-specific databases

CTD140901.
MGIMGI:1914583. Stk35.

Phylogenomic databases

eggNOGCOG0515.
GeneTreeENSGT00750000117533.
HOGENOMHOG000231155.
HOVERGENHBG056829.
InParanoidA2ANF2.
KOK08859.
OMAPRGKEGH.
OrthoDBEOG76DTSN.
PhylomeDBQ80ZW0.
TreeFamTF105336.

Gene expression databases

ArrayExpressQ80ZW0.
BgeeQ80ZW0.
CleanExMM_STK35.
GenevestigatorQ80ZW0.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 2 hits.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio324268.
PROQ80ZW0.
SOURCESearch...

Entry information

Entry nameSTK35_MOUSE
AccessionPrimary (citable) accession number: Q80ZW0
Secondary accession number(s): A2ANF2, Q3TMD8, Q8BIC2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: March 23, 2010
Last modified: July 9, 2014
This is version 91 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot