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Protein

Serine/threonine-protein kinase 35

Gene

Stk35

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei236 – 2361ATPPROSITE-ProRule annotation
Active sitei365 – 3651Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi213 – 2219ATPPROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase 35
Alternative name(s):
Serine/threonine-protein kinase 35 L1 (EC:2.7.11.1)
Gene namesi
Name:Stk35
Synonyms:Stk35l1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1914583. Stk35.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 539539Serine/threonine-protein kinase 35PRO_0000277618Add
BLAST

Post-translational modificationi

Autophosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ80ZW0.
PRIDEiQ80ZW0.

PTM databases

PhosphoSiteiQ80ZW0.

Expressioni

Gene expression databases

BgeeiQ80ZW0.
CleanExiMM_STK35.
ExpressionAtlasiQ80ZW0. baseline and differential.
GenevisibleiQ80ZW0. MM.

Interactioni

Subunit structurei

Interacts with PDLIM1/CLP-36.By similarity

Protein-protein interaction databases

BioGridi212113. 3 interactions.
STRINGi10090.ENSMUSP00000126541.

Structurei

3D structure databases

ProteinModelPortaliQ80ZW0.
SMRiQ80ZW0. Positions 196-539.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini207 – 535329Protein kinasePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi132 – 1354Poly-Pro
Compositional biasi196 – 1994Poly-Gly

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00780000121956.
HOGENOMiHOG000231155.
HOVERGENiHBG056829.
InParanoidiQ80ZW0.
KOiK08859.
OMAiGHQEPPL.
OrthoDBiEOG76DTSN.
PhylomeDBiQ80ZW0.
TreeFamiTF105336.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80ZW0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGHQESPLTR AAAGGAAYIK RLRKVLSWRE LGDGHGNLEA EASPGSVAVI
60 70 80 90 100
TRAAPRRATR SARLPASRPT RLCRQARLGT DHPPARAPRG NRFARKRNSA
110 120 130 140 150
GQITIQGPAP PHLGARRRDE ARGARAAPLL LPPPPAAMET GKENGARRGT
160 170 180 190 200
KSPERKRRSP VQRVLCEKLR PAAQAMDPAG AEVPGEAFLA RRRPDGGGGD
210 220 230 240 250
VPARPRYSLL AEIGRGSYGV VYEAVAGRSG ARVAVKKIRC DAPENVELAL
260 270 280 290 300
AEFWALTSLK RRHQNIVQFE ECVLQRNGLA QRMSHGNKNS QLYLRLVETS
310 320 330 340 350
LKGERILGYA EEPCYLWFVM EYCEGGDLNQ YVLSRRPDPA TNKSFMLQLT
360 370 380 390 400
SAIAFLHKNH IVHRDLKPDN ILITERSGTP ILKVADFGLS KVCAGLAPRG
410 420 430 440 450
KEGNQDNKNV NVNKYWLSSA CGSDFYMAPE VWEGHYTAKA DIFALGIIIW
460 470 480 490 500
AMIERITFID SETKKELLGT YIKQGTEIVP VGEALLENPK MELHIPQKRR
510 520 530
TSMSEGVKQL LKDMLAANPQ DRPDAFELET RMDQVTCAA
Length:539
Mass (Da):59,459
Last modified:March 23, 2010 - v3
Checksum:i66959648E99458B3
GO

Sequence cautioni

The sequence AAI38905.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAI38906.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAC25152.1 differs from that shown. Reason: Frameshift at position 23. Curated
The sequence BAC25152.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAE38504.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAM22106.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti28 – 281W → G in BAE38504 (PubMed:16141072).Curated
Sequence conflicti71 – 711R → G in BAE38504 (PubMed:16141072).Curated
Sequence conflicti71 – 711R → G in BAC25152 (PubMed:16141072).Curated
Sequence conflicti147 – 1471R → S in BAC25152 (PubMed:16141072).Curated
Sequence conflicti304 – 32724ERILG…CEGGD → RSFGTHSLIVSRTGWQRVQV VVIS in BAE38504 (PubMed:16141072).CuratedAdd
BLAST
Sequence conflicti337 – 3371P → A in BAC25152 (PubMed:16141072).Curated
Sequence conflicti345 – 3451F → V in BAC25152 (PubMed:16141072).Curated
Sequence conflicti365 – 37713DLKPD…ITERS → RPKARQHPDHRAV in BAC25152 (PubMed:16141072).CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL808137 Genomic DNA. Translation: CAM22106.1. Different initiation.
BC047277 mRNA. Translation: AAH47277.1.
BC138904 mRNA. Translation: AAI38905.1. Different initiation.
BC138905 mRNA. Translation: AAI38906.1. Different initiation.
AK006778 mRNA. Translation: BAC25152.1. Sequence problems.
AK165988 mRNA. Translation: BAE38504.1. Different initiation.
CCDSiCCDS16732.2.
RefSeqiNP_899085.3. NM_183262.3.
UniGeneiMm.389329.

Genome annotation databases

EnsembliENSMUST00000165413; ENSMUSP00000126541; ENSMUSG00000037885.
GeneIDi67333.
KEGGimmu:67333.
UCSCiuc008mie.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL808137 Genomic DNA. Translation: CAM22106.1. Different initiation.
BC047277 mRNA. Translation: AAH47277.1.
BC138904 mRNA. Translation: AAI38905.1. Different initiation.
BC138905 mRNA. Translation: AAI38906.1. Different initiation.
AK006778 mRNA. Translation: BAC25152.1. Sequence problems.
AK165988 mRNA. Translation: BAE38504.1. Different initiation.
CCDSiCCDS16732.2.
RefSeqiNP_899085.3. NM_183262.3.
UniGeneiMm.389329.

3D structure databases

ProteinModelPortaliQ80ZW0.
SMRiQ80ZW0. Positions 196-539.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212113. 3 interactions.
STRINGi10090.ENSMUSP00000126541.

PTM databases

PhosphoSiteiQ80ZW0.

Proteomic databases

PaxDbiQ80ZW0.
PRIDEiQ80ZW0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000165413; ENSMUSP00000126541; ENSMUSG00000037885.
GeneIDi67333.
KEGGimmu:67333.
UCSCiuc008mie.2. mouse.

Organism-specific databases

CTDi140901.
MGIiMGI:1914583. Stk35.

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00780000121956.
HOGENOMiHOG000231155.
HOVERGENiHBG056829.
InParanoidiQ80ZW0.
KOiK08859.
OMAiGHQEPPL.
OrthoDBiEOG76DTSN.
PhylomeDBiQ80ZW0.
TreeFamiTF105336.

Miscellaneous databases

NextBioi324268.
PROiQ80ZW0.
SOURCEiSearch...

Gene expression databases

BgeeiQ80ZW0.
CleanExiMM_STK35.
ExpressionAtlasiQ80ZW0. baseline and differential.
GenevisibleiQ80ZW0. MM.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 25-539.
    Tissue: Olfactory epithelium.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 28-539.
    Strain: C57BL/6J.
    Tissue: Lung and Testis.

Entry informationi

Entry nameiSTK35_MOUSE
AccessioniPrimary (citable) accession number: Q80ZW0
Secondary accession number(s): A2ANF2, Q3TMD8, Q8BIC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: March 23, 2010
Last modified: June 24, 2015
This is version 97 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.