ID   BPIB3_MOUSE             Reviewed;         473 AA.
AC   Q80ZU7; A2APD1;
DT   29-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 2.
DT   24-JAN-2024, entry version 121.
DE   RecName: Full=BPI fold-containing family B member 3 {ECO:0000305};
DE   AltName: Full=Ligand-binding protein RYA3;
DE   AltName: Full=Long palate, lung and nasal epithelium carcinoma-associated protein 3;
DE   Flags: Precursor;
GN   Name=Bpifb3 {ECO:0000312|MGI:MGI:2675077}; Synonyms=Lplunc3, Rya3;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Olfactory epithelium;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May have the capacity to recognize and bind specific classes
CC       of odorants. May act as a carrier molecule, transporting odorants
CC       across the mucus layer to access receptor sites. May serve as a primary
CC       defense mechanism by recognizing and removing potentially harmful
CC       odorants or pathogenic microorganisms from the mucosa or clearing
CC       excess odorant from mucus to enable new odorant stimuli to be received
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
CC       {ECO:0000305}.
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DR   EMBL; AL833803; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC048084; AAH48084.2; -; mRNA.
DR   CCDS; CCDS16921.1; -.
DR   RefSeq; NP_919338.2; NM_194357.1.
DR   RefSeq; XP_006499875.1; XM_006499812.1.
DR   AlphaFoldDB; Q80ZU7; -.
DR   SMR; Q80ZU7; -.
DR   STRING; 10090.ENSMUSP00000086342; -.
DR   GlyCosmos; Q80ZU7; 1 site, No reported glycans.
DR   GlyGen; Q80ZU7; 1 site.
DR   PhosphoSitePlus; Q80ZU7; -.
DR   PaxDb; 10090-ENSMUSP00000086342; -.
DR   ProteomicsDB; 281703; -.
DR   Antibodypedia; 59271; 70 antibodies from 15 providers.
DR   DNASU; 378700; -.
DR   Ensembl; ENSMUST00000088950.8; ENSMUSP00000086342.2; ENSMUSG00000068008.9.
DR   Ensembl; ENSMUST00000109760.2; ENSMUSP00000105382.2; ENSMUSG00000068008.9.
DR   GeneID; 378700; -.
DR   KEGG; mmu:378700; -.
DR   UCSC; uc008nip.1; mouse.
DR   AGR; MGI:2675077; -.
DR   CTD; 359710; -.
DR   MGI; MGI:2675077; Bpifb3.
DR   VEuPathDB; HostDB:ENSMUSG00000068008; -.
DR   eggNOG; KOG4160; Eukaryota.
DR   GeneTree; ENSGT01100000263546; -.
DR   HOGENOM; CLU_031635_1_0_1; -.
DR   InParanoid; Q80ZU7; -.
DR   OMA; EWLSHVV; -.
DR   OrthoDB; 5263773at2759; -.
DR   PhylomeDB; Q80ZU7; -.
DR   TreeFam; TF315617; -.
DR   BioGRID-ORCS; 378700; 3 hits in 78 CRISPR screens.
DR   ChiTaRS; Bpifb3; mouse.
DR   PRO; PR:Q80ZU7; -.
DR   Proteomes; UP000000589; Chromosome 2.
DR   RNAct; Q80ZU7; Protein.
DR   Bgee; ENSMUSG00000068008; Expressed in olfactory epithelium and 15 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR   InterPro; IPR017943; Bactericidal_perm-incr_a/b_dom.
DR   InterPro; IPR001124; Lipid-bd_serum_glycop_C.
DR   InterPro; IPR017942; Lipid-bd_serum_glycop_N.
DR   PANTHER; PTHR46019:SF5; BPI FOLD-CONTAINING FAMILY B MEMBER 3; 1.
DR   PANTHER; PTHR46019; BPI FOLD-CONTAINING FAMILY B MEMBER 4-RELATED; 1.
DR   Pfam; PF01273; LBP_BPI_CETP; 1.
DR   Pfam; PF02886; LBP_BPI_CETP_C; 1.
DR   SMART; SM00328; BPI1; 1.
DR   SMART; SM00329; BPI2; 1.
DR   SUPFAM; SSF55394; Bactericidal permeability-increasing protein, BPI; 2.
DR   Genevisible; Q80ZU7; MM.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..473
FT                   /note="BPI fold-containing family B member 3"
FT                   /id="PRO_0000017171"
FT   CARBOHYD        139
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        161..196
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   473 AA;  49885 MW;  246BF7BAEB328913 CRC64;
     MMLGVYTLLL LWGLATPCLG LLETVGTLAR IDKDELGKAI QNSLVGGPIL QNVLGTVTSV
     NQGLLGAGGL LGGGGLLSYG GIFSLVEELS GLKIEELTLP KVSLKLLPGV GVQLNLHTKV
     SLHGSGPLVG LLQLAAEVNV SSKVALGMSP RGTPILVLKR CSTLLGHISL MSGLLPTPIF
     GLVEQTLCKV LPGLLCPVVD SVLSVVNELL GATLSLVPLG PLGSVEFTLA TLPLISNQYI
     ELDINPIVKS IAGDVIDFPK PRIPVKVPPK EDHTSQVTVP LYLFSTVFGL LQTNGALDLD
     ITPEMVPRNV PLTTTDLAAL APEALGKLPP AQHLLLSLRV TKSPMVLLQN KKATVSIPVT
     IHVLSSVPQG TPVALFQLNG VMTLNAHLAP SSTKLHISLS LERLSVQLAS SFPQPFDASR
     LEEWLSDVVR AAYMQRLNEH LEVGIPLPKI LNVNFANSVV DIIENAVVLT VAP
//