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Q80ZU7

- BPIB3_MOUSE

UniProt

Q80ZU7 - BPIB3_MOUSE

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Protein
BPI fold-containing family B member 3
Gene
Bpifb3, Lplunc3, Rya3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received By similarity.

GO - Molecular functioni

  1. lipid binding Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
BPI fold-containing family B member 3
Alternative name(s):
Ligand-binding protein RYA3
Long palate, lung and nasal epithelium carcinoma-associated protein 3
Gene namesi
Name:Bpifb3
Synonyms:Lplunc3, Rya3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:2675077. Bpifb3.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed prediction
Add
BLAST
Chaini21 – 473453BPI fold-containing family B member 3
PRO_0000017171Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi139 – 1391N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi161 ↔ 196 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ80ZU7.

Expressioni

Gene expression databases

BgeeiQ80ZU7.
GenevestigatoriQ80ZU7.

Structurei

3D structure databases

ProteinModelPortaliQ80ZU7.
SMRiQ80ZU7. Positions 88-448.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG317196.
GeneTreeiENSGT00730000110772.
HOGENOMiHOG000231741.
HOVERGENiHBG050718.
InParanoidiA2APD1.
OMAiPLISNQY.
OrthoDBiEOG715Q45.
PhylomeDBiQ80ZU7.
TreeFamiTF315617.

Family and domain databases

InterProiIPR017943. Bactericidal_perm-incr_a/b_dom.
IPR001124. Lipid-bd_serum_glycop_C.
IPR017942. Lipid-bd_serum_glycop_N.
[Graphical view]
PfamiPF01273. LBP_BPI_CETP. 1 hit.
PF02886. LBP_BPI_CETP_C. 1 hit.
[Graphical view]
SMARTiSM00328. BPI1. 1 hit.
SM00329. BPI2. 1 hit.
[Graphical view]
SUPFAMiSSF55394. SSF55394. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q80ZU7-1 [UniParc]FASTAAdd to Basket

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MMLGVYTLLL LWGLATPCLG LLETVGTLAR IDKDELGKAI QNSLVGGPIL    50
QNVLGTVTSV NQGLLGAGGL LGGGGLLSYG GIFSLVEELS GLKIEELTLP 100
KVSLKLLPGV GVQLNLHTKV SLHGSGPLVG LLQLAAEVNV SSKVALGMSP 150
RGTPILVLKR CSTLLGHISL MSGLLPTPIF GLVEQTLCKV LPGLLCPVVD 200
SVLSVVNELL GATLSLVPLG PLGSVEFTLA TLPLISNQYI ELDINPIVKS 250
IAGDVIDFPK PRIPVKVPPK EDHTSQVTVP LYLFSTVFGL LQTNGALDLD 300
ITPEMVPRNV PLTTTDLAAL APEALGKLPP AQHLLLSLRV TKSPMVLLQN 350
KKATVSIPVT IHVLSSVPQG TPVALFQLNG VMTLNAHLAP SSTKLHISLS 400
LERLSVQLAS SFPQPFDASR LEEWLSDVVR AAYMQRLNEH LEVGIPLPKI 450
LNVNFANSVV DIIENAVVLT VAP 473
Length:473
Mass (Da):49,885
Last modified:May 24, 2005 - v2
Checksum:i246BF7BAEB328913
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL833803 Genomic DNA. Translation: CAM18460.1.
BC048084 mRNA. Translation: AAH48084.2.
CCDSiCCDS16921.1.
RefSeqiNP_919338.2. NM_194357.1.
XP_006499875.1. XM_006499812.1.
UniGeneiMm.55392.

Genome annotation databases

EnsembliENSMUST00000088950; ENSMUSP00000086342; ENSMUSG00000068008.
ENSMUST00000109760; ENSMUSP00000105382; ENSMUSG00000068008.
GeneIDi378700.
KEGGimmu:378700.
UCSCiuc008nip.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL833803 Genomic DNA. Translation: CAM18460.1 .
BC048084 mRNA. Translation: AAH48084.2 .
CCDSi CCDS16921.1.
RefSeqi NP_919338.2. NM_194357.1.
XP_006499875.1. XM_006499812.1.
UniGenei Mm.55392.

3D structure databases

ProteinModelPortali Q80ZU7.
SMRi Q80ZU7. Positions 88-448.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q80ZU7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000088950 ; ENSMUSP00000086342 ; ENSMUSG00000068008 .
ENSMUST00000109760 ; ENSMUSP00000105382 ; ENSMUSG00000068008 .
GeneIDi 378700.
KEGGi mmu:378700.
UCSCi uc008nip.1. mouse.

Organism-specific databases

CTDi 359710.
MGIi MGI:2675077. Bpifb3.

Phylogenomic databases

eggNOGi NOG317196.
GeneTreei ENSGT00730000110772.
HOGENOMi HOG000231741.
HOVERGENi HBG050718.
InParanoidi A2APD1.
OMAi PLISNQY.
OrthoDBi EOG715Q45.
PhylomeDBi Q80ZU7.
TreeFami TF315617.

Miscellaneous databases

NextBioi 400991.
PROi Q80ZU7.
SOURCEi Search...

Gene expression databases

Bgeei Q80ZU7.
Genevestigatori Q80ZU7.

Family and domain databases

InterProi IPR017943. Bactericidal_perm-incr_a/b_dom.
IPR001124. Lipid-bd_serum_glycop_C.
IPR017942. Lipid-bd_serum_glycop_N.
[Graphical view ]
Pfami PF01273. LBP_BPI_CETP. 1 hit.
PF02886. LBP_BPI_CETP_C. 1 hit.
[Graphical view ]
SMARTi SM00328. BPI1. 1 hit.
SM00329. BPI2. 1 hit.
[Graphical view ]
SUPFAMi SSF55394. SSF55394. 2 hits.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Olfactory epithelium.

Entry informationi

Entry nameiBPIB3_MOUSE
AccessioniPrimary (citable) accession number: Q80ZU7
Secondary accession number(s): A2APD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: May 24, 2005
Last modified: July 9, 2014
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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