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Protein

BPI fold-containing family B member 3

Gene

Bpifb3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received (By similarity).By similarity

GO - Molecular functioni

  1. lipid binding Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
BPI fold-containing family B member 3
Alternative name(s):
Ligand-binding protein RYA3
Long palate, lung and nasal epithelium carcinoma-associated protein 3
Gene namesi
Name:Bpifb3
Synonyms:Lplunc3, Rya3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:2675077. Bpifb3.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 473453BPI fold-containing family B member 3PRO_0000017171Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi139 – 1391N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi161 ↔ 196By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ80ZU7.

Expressioni

Gene expression databases

BgeeiQ80ZU7.
ExpressionAtlasiQ80ZU7. baseline.
GenevestigatoriQ80ZU7.

Structurei

3D structure databases

ProteinModelPortaliQ80ZU7.
SMRiQ80ZU7. Positions 88-448.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG317196.
GeneTreeiENSGT00730000110772.
HOGENOMiHOG000231741.
HOVERGENiHBG050718.
InParanoidiQ80ZU7.
OMAiPIKVPPK.
OrthoDBiEOG715Q45.
PhylomeDBiQ80ZU7.
TreeFamiTF315617.

Family and domain databases

InterProiIPR017943. Bactericidal_perm-incr_a/b_dom.
IPR001124. Lipid-bd_serum_glycop_C.
IPR017942. Lipid-bd_serum_glycop_N.
[Graphical view]
PfamiPF01273. LBP_BPI_CETP. 1 hit.
PF02886. LBP_BPI_CETP_C. 1 hit.
[Graphical view]
SMARTiSM00328. BPI1. 1 hit.
SM00329. BPI2. 1 hit.
[Graphical view]
SUPFAMiSSF55394. SSF55394. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q80ZU7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMLGVYTLLL LWGLATPCLG LLETVGTLAR IDKDELGKAI QNSLVGGPIL
60 70 80 90 100
QNVLGTVTSV NQGLLGAGGL LGGGGLLSYG GIFSLVEELS GLKIEELTLP
110 120 130 140 150
KVSLKLLPGV GVQLNLHTKV SLHGSGPLVG LLQLAAEVNV SSKVALGMSP
160 170 180 190 200
RGTPILVLKR CSTLLGHISL MSGLLPTPIF GLVEQTLCKV LPGLLCPVVD
210 220 230 240 250
SVLSVVNELL GATLSLVPLG PLGSVEFTLA TLPLISNQYI ELDINPIVKS
260 270 280 290 300
IAGDVIDFPK PRIPVKVPPK EDHTSQVTVP LYLFSTVFGL LQTNGALDLD
310 320 330 340 350
ITPEMVPRNV PLTTTDLAAL APEALGKLPP AQHLLLSLRV TKSPMVLLQN
360 370 380 390 400
KKATVSIPVT IHVLSSVPQG TPVALFQLNG VMTLNAHLAP SSTKLHISLS
410 420 430 440 450
LERLSVQLAS SFPQPFDASR LEEWLSDVVR AAYMQRLNEH LEVGIPLPKI
460 470
LNVNFANSVV DIIENAVVLT VAP
Length:473
Mass (Da):49,885
Last modified:May 24, 2005 - v2
Checksum:i246BF7BAEB328913
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL833803 Genomic DNA. Translation: CAM18460.1.
BC048084 mRNA. Translation: AAH48084.2.
CCDSiCCDS16921.1.
RefSeqiNP_919338.2. NM_194357.1.
XP_006499875.1. XM_006499812.1.
UniGeneiMm.55392.

Genome annotation databases

EnsembliENSMUST00000088950; ENSMUSP00000086342; ENSMUSG00000068008.
ENSMUST00000109760; ENSMUSP00000105382; ENSMUSG00000068008.
GeneIDi378700.
KEGGimmu:378700.
UCSCiuc008nip.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL833803 Genomic DNA. Translation: CAM18460.1.
BC048084 mRNA. Translation: AAH48084.2.
CCDSiCCDS16921.1.
RefSeqiNP_919338.2. NM_194357.1.
XP_006499875.1. XM_006499812.1.
UniGeneiMm.55392.

3D structure databases

ProteinModelPortaliQ80ZU7.
SMRiQ80ZU7. Positions 88-448.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ80ZU7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000088950; ENSMUSP00000086342; ENSMUSG00000068008.
ENSMUST00000109760; ENSMUSP00000105382; ENSMUSG00000068008.
GeneIDi378700.
KEGGimmu:378700.
UCSCiuc008nip.1. mouse.

Organism-specific databases

CTDi359710.
MGIiMGI:2675077. Bpifb3.

Phylogenomic databases

eggNOGiNOG317196.
GeneTreeiENSGT00730000110772.
HOGENOMiHOG000231741.
HOVERGENiHBG050718.
InParanoidiQ80ZU7.
OMAiPIKVPPK.
OrthoDBiEOG715Q45.
PhylomeDBiQ80ZU7.
TreeFamiTF315617.

Miscellaneous databases

NextBioi400991.
PROiQ80ZU7.
SOURCEiSearch...

Gene expression databases

BgeeiQ80ZU7.
ExpressionAtlasiQ80ZU7. baseline.
GenevestigatoriQ80ZU7.

Family and domain databases

InterProiIPR017943. Bactericidal_perm-incr_a/b_dom.
IPR001124. Lipid-bd_serum_glycop_C.
IPR017942. Lipid-bd_serum_glycop_N.
[Graphical view]
PfamiPF01273. LBP_BPI_CETP. 1 hit.
PF02886. LBP_BPI_CETP_C. 1 hit.
[Graphical view]
SMARTiSM00328. BPI1. 1 hit.
SM00329. BPI2. 1 hit.
[Graphical view]
SUPFAMiSSF55394. SSF55394. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Olfactory epithelium.

Entry informationi

Entry nameiBPIB3_MOUSE
AccessioniPrimary (citable) accession number: Q80ZU7
Secondary accession number(s): A2APD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: May 24, 2005
Last modified: January 7, 2015
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.