Q80ZU7 (BPIB3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
BPI fold-containing family B member 3

Alternative name(s):
Ligand-binding protein RYA3
Long palate, lung and nasal epithelium carcinoma-associated protein 3

Gene names

Name:	Bpifb3
Synonyms:	Lplunc3, Rya3

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	473 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received By similarity.
Subcellular location	Secreted By similarity.
Sequence similarities	Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from sequence or structural similarity. Source: UniProtKB extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	lipid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Chain	21 – 473	453	BPI fold-containing family B member 3		PRO_0000017171
Amino acid modifications
	Glycosylation	139	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q80ZU7 [UniParc]. Last modified May 24, 2005. Version 2. Checksum: 246BF7BAEB328913	FASTA	473	49,885
	10 20 30 40 50 60 MMLGVYTLLL LWGLATPCLG LLETVGTLAR IDKDELGKAI QNSLVGGPIL QNVLGTVTSV 70 80 90 100 110 120 NQGLLGAGGL LGGGGLLSYG GIFSLVEELS GLKIEELTLP KVSLKLLPGV GVQLNLHTKV 130 140 150 160 170 180 SLHGSGPLVG LLQLAAEVNV SSKVALGMSP RGTPILVLKR CSTLLGHISL MSGLLPTPIF 190 200 210 220 230 240 GLVEQTLCKV LPGLLCPVVD SVLSVVNELL GATLSLVPLG PLGSVEFTLA TLPLISNQYI 250 260 270 280 290 300 ELDINPIVKS IAGDVIDFPK PRIPVKVPPK EDHTSQVTVP LYLFSTVFGL LQTNGALDLD 310 320 330 340 350 360 ITPEMVPRNV PLTTTDLAAL APEALGKLPP AQHLLLSLRV TKSPMVLLQN KKATVSIPVT 370 380 390 400 410 420 IHVLSSVPQG TPVALFQLNG VMTLNAHLAP SSTKLHISLS LERLSVQLAS SFPQPFDASR 430 440 450 460 470 LEEWLSDVVR AAYMQRLNEH LEVGIPLPKI LNVNFANSVV DIIENAVVLT VAP

References

[1]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6. Tissue: Olfactory epithelium.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL833803 Genomic DNA. Translation: CAM18460.1. BC048084 mRNA. Translation: AAH48084.2.
IPI	IPI00331009.
RefSeq	NP_919338.2. NM_194357.1.
UniGene	Mm.55392.
3D structure databases
ProteinModelPortal	Q80ZU7.
SMR	Q80ZU7. Positions 92-465.
ModBase	Search...
Proteomic databases
PRIDE	Q80ZU7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000088950; ENSMUSP00000086342; ENSMUSG00000068008. ENSMUST00000109760; ENSMUSP00000105382; ENSMUSG00000068008.
GeneID	378700.
KEGG	mmu:378700.
UCSC	uc008nip.1. mouse.
Organism-specific databases
CTD	359710.
MGI	MGI:2675077. Bpifb3.
Phylogenomic databases
eggNOG	NOG317196.
GeneTree	ENSGT00620000087589.
HOGENOM	HOG000231741.
HOVERGEN	HBG050718.
InParanoid	A2APD1.
OMA	PLISNQY.
OrthoDB	EOG4C5CJM.
Gene expression databases
ArrayExpress	Q80ZU7.
Bgee	Q80ZU7.
Genevestigator	Q80ZU7.
GermOnline	ENSMUSG00000068008. Mus musculus.
Family and domain databases
InterPro	IPR017943. Bactericidal_perm-incr_a/b_dom. IPR001124. Lipid-bd_serum_glycop_C. IPR017942. Lipid-bd_serum_glycop_N. [Graphical view]
Pfam	PF01273. LBP_BPI_CETP. 1 hit. PF02886. LBP_BPI_CETP_C. 1 hit. [Graphical view]
SMART	SM00328. BPI1. 1 hit. SM00329. BPI2. 1 hit. [Graphical view]
SUPFAM	SSF55394. Bactericidal_perm-incr_a/b_dom. 2 hits.
PROSITE	PS00400. LBP_BPI_CETP. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	400991.
SOURCE	Search...

Entry information

Entry name

BPIB3_MOUSE

Accession

Primary (citable) accession number: Q80ZU7
Secondary accession number(s): A2APD1

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 29, 2003
Last sequence update:	May 24, 2005
Last modified:	May 1, 2013
This is version 67 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program