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Q80ZU7 (BPIB3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
BPI fold-containing family B member 3
Alternative name(s):
Ligand-binding protein RYA3
Long palate, lung and nasal epithelium carcinoma-associated protein 3
Gene names
Name:Bpifb3
Synonyms:Lplunc3, Rya3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length473 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received By similarity.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from sequence or structural similarity. Source: UniProtKB

extracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionlipid binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 473453BPI fold-containing family B member 3
PRO_0000017171

Amino acid modifications

Glycosylation1391N-linked (GlcNAc...) Potential
Disulfide bond161 ↔ 196 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q80ZU7 [UniParc].

Last modified May 24, 2005. Version 2.
Checksum: 246BF7BAEB328913

FASTA47349,885
        10         20         30         40         50         60 
MMLGVYTLLL LWGLATPCLG LLETVGTLAR IDKDELGKAI QNSLVGGPIL QNVLGTVTSV 

        70         80         90        100        110        120 
NQGLLGAGGL LGGGGLLSYG GIFSLVEELS GLKIEELTLP KVSLKLLPGV GVQLNLHTKV 

       130        140        150        160        170        180 
SLHGSGPLVG LLQLAAEVNV SSKVALGMSP RGTPILVLKR CSTLLGHISL MSGLLPTPIF 

       190        200        210        220        230        240 
GLVEQTLCKV LPGLLCPVVD SVLSVVNELL GATLSLVPLG PLGSVEFTLA TLPLISNQYI 

       250        260        270        280        290        300 
ELDINPIVKS IAGDVIDFPK PRIPVKVPPK EDHTSQVTVP LYLFSTVFGL LQTNGALDLD 

       310        320        330        340        350        360 
ITPEMVPRNV PLTTTDLAAL APEALGKLPP AQHLLLSLRV TKSPMVLLQN KKATVSIPVT 

       370        380        390        400        410        420 
IHVLSSVPQG TPVALFQLNG VMTLNAHLAP SSTKLHISLS LERLSVQLAS SFPQPFDASR 

       430        440        450        460        470 
LEEWLSDVVR AAYMQRLNEH LEVGIPLPKI LNVNFANSVV DIIENAVVLT VAP 

« Hide

References

[1]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Olfactory epithelium.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL833803 Genomic DNA. Translation: CAM18460.1.
BC048084 mRNA. Translation: AAH48084.2.
RefSeqNP_919338.2. NM_194357.1.
XP_006499875.1. XM_006499812.1.
UniGeneMm.55392.

3D structure databases

ProteinModelPortalQ80ZU7.
SMRQ80ZU7. Positions 88-448.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ80ZU7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000088950; ENSMUSP00000086342; ENSMUSG00000068008.
ENSMUST00000109760; ENSMUSP00000105382; ENSMUSG00000068008.
GeneID378700.
KEGGmmu:378700.
UCSCuc008nip.1. mouse.

Organism-specific databases

CTD359710.
MGIMGI:2675077. Bpifb3.

Phylogenomic databases

eggNOGNOG317196.
GeneTreeENSGT00730000110772.
HOGENOMHOG000231741.
HOVERGENHBG050718.
InParanoidA2APD1.
OMAPLISNQY.
OrthoDBEOG715Q45.
PhylomeDBQ80ZU7.
TreeFamTF315617.

Gene expression databases

BgeeQ80ZU7.
GenevestigatorQ80ZU7.

Family and domain databases

InterProIPR017943. Bactericidal_perm-incr_a/b_dom.
IPR001124. Lipid-bd_serum_glycop_C.
IPR017942. Lipid-bd_serum_glycop_N.
[Graphical view]
PfamPF01273. LBP_BPI_CETP. 1 hit.
PF02886. LBP_BPI_CETP_C. 1 hit.
[Graphical view]
SMARTSM00328. BPI1. 1 hit.
SM00329. BPI2. 1 hit.
[Graphical view]
SUPFAMSSF55394. SSF55394. 2 hits.
ProtoNetSearch...

Other

NextBio400991.
PROQ80ZU7.
SOURCESearch...

Entry information

Entry nameBPIB3_MOUSE
AccessionPrimary (citable) accession number: Q80ZU7
Secondary accession number(s): A2APD1
Entry history
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: May 24, 2005
Last modified: April 16, 2014
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot