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Protein

Juxtaposed with another zinc finger protein 1

Gene

Jazf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a transcriptional corepressor of orphan nuclear receptor NR2C2 (By similarity). Inhibits expression of the gluconeogenesis enzyme PCK2 through inhibition of NR2C2 activity (PubMed:24380856). Also involved in transcriptional activation of NAMPT by promoting expression of PPARA and PPARD (PubMed:24930994). Plays a role in lipid metabolism by suppressing lipogenesis, increasing lipolysis and decreasing lipid accumulation in adipose tissue (PubMed:24380856, PubMed:25614086). Plays a role in glucose homeostasis by improving glucose metabolism and insulin sensitivity (PubMed:25614086, PubMed:24380856).By similarity3 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri12 – 3726C2H2-type 1Add
BLAST
Zinc fingeri173 – 19826C2H2-type 2Add
BLAST
Zinc fingeri208 – 23023C2H2-type 3; degenerateAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Lipid metabolism, Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Juxtaposed with another zinc finger protein 1
Gene namesi
Name:Jazf1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2141450. Jazf1.

Subcellular locationi

  • Nucleus By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 243243Juxtaposed with another zinc finger protein 1PRO_0000046986Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei109 – 1091PhosphothreonineCombined sources
Modified residuei113 – 1131PhosphothreonineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ80ZQ5.
PaxDbiQ80ZQ5.
PRIDEiQ80ZQ5.

PTM databases

PhosphoSiteiQ80ZQ5.

Expressioni

Tissue specificityi

Expressed in range of tissues with highest expression levels in testis, liver, muscle and fat and lowest levels in kidney (PubMed:25614086). Detected in liver and white adipose tissue (at protein level) (PubMed:24380856).2 Publications

Developmental stagei

Expression is gradually but significantly up-regulated during adipocyte differentiation.1 Publication

Gene expression databases

BgeeiQ80ZQ5.
CleanExiMM_JAZF1.
GenevisibleiQ80ZQ5. MM.

Interactioni

Subunit structurei

Interacts with NR2C2 (via ligand-binding region).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074129.

Structurei

3D structure databases

ProteinModelPortaliQ80ZQ5.
SMRiQ80ZQ5. Positions 9-46, 142-230.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni39 – 7941Required for interaction with NR2C2By similarityAdd
BLAST

Sequence similaritiesi

Contains 3 C2H2-type zinc fingers.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri12 – 3726C2H2-type 1Add
BLAST
Zinc fingeri173 – 19826C2H2-type 2Add
BLAST
Zinc fingeri208 – 23023C2H2-type 3; degenerateAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG4124. Eukaryota.
COG5189. LUCA.
GeneTreeiENSGT00390000003635.
HOGENOMiHOG000252946.
HOVERGENiHBG052161.
InParanoidiQ80ZQ5.
KOiK19495.
OMAiQPTYIAL.
OrthoDBiEOG7CCBS8.
PhylomeDBiQ80ZQ5.
TreeFamiTF324161.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q80ZQ5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTGIAAASFF SNTCRFGGCG LHFPTLADLI EHIEDNHIDT DPRVLEKQEL
60 70 80 90 100
QQPTYVALSY INRFMTDAAR REQESLKKKI QPKLSLTLSS SVSRGNVSTP
110 120 130 140 150
PRHSSGSLTP PVTPPITPSS SFRSSTPTGS EYDEEEVDYE ESDSDESWTT
160 170 180 190 200
ESAISSEAIL SSMCMNGGEE KPFACPVPGC KKRYKNVNGI KYHAKNGHRT
210 220 230 240
QIRVRKPFKC RCGKSYKTAQ GLRHHTINFH PPVSAEMIRK MQQ
Length:243
Mass (Da):27,098
Last modified:July 11, 2003 - v2
Checksum:i878A6EE3D82C0348
GO
Isoform 2 (identifier: Q80ZQ5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     64-64: Missing.

Note: No experimental confirmation available.
Show »
Length:242
Mass (Da):26,950
Checksum:iFB1567AEEFE1A4AB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti211 – 2111R → L in BAC34275 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei64 – 641Missing in isoform 2. 1 PublicationVSP_007756

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK043767 mRNA. Translation: BAC31649.1.
AK050474 mRNA. Translation: BAC34275.1.
BC048577 mRNA. Translation: AAH48577.1.
CCDSiCCDS20152.1. [Q80ZQ5-1]
RefSeqiNP_001161749.1. NM_001168277.1.
NP_775582.2. NM_173406.3. [Q80ZQ5-1]
XP_011239597.1. XM_011241295.1.
UniGeneiMm.386865.

Genome annotation databases

EnsembliENSMUST00000074541; ENSMUSP00000074129; ENSMUSG00000063568. [Q80ZQ5-1]
GeneIDi231986.
KEGGimmu:231986.
UCSCiuc009bza.2. mouse. [Q80ZQ5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK043767 mRNA. Translation: BAC31649.1.
AK050474 mRNA. Translation: BAC34275.1.
BC048577 mRNA. Translation: AAH48577.1.
CCDSiCCDS20152.1. [Q80ZQ5-1]
RefSeqiNP_001161749.1. NM_001168277.1.
NP_775582.2. NM_173406.3. [Q80ZQ5-1]
XP_011239597.1. XM_011241295.1.
UniGeneiMm.386865.

3D structure databases

ProteinModelPortaliQ80ZQ5.
SMRiQ80ZQ5. Positions 9-46, 142-230.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074129.

PTM databases

PhosphoSiteiQ80ZQ5.

Proteomic databases

MaxQBiQ80ZQ5.
PaxDbiQ80ZQ5.
PRIDEiQ80ZQ5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000074541; ENSMUSP00000074129; ENSMUSG00000063568. [Q80ZQ5-1]
GeneIDi231986.
KEGGimmu:231986.
UCSCiuc009bza.2. mouse. [Q80ZQ5-1]

Organism-specific databases

CTDi221895.
MGIiMGI:2141450. Jazf1.

Phylogenomic databases

eggNOGiKOG4124. Eukaryota.
COG5189. LUCA.
GeneTreeiENSGT00390000003635.
HOGENOMiHOG000252946.
HOVERGENiHBG052161.
InParanoidiQ80ZQ5.
KOiK19495.
OMAiQPTYIAL.
OrthoDBiEOG7CCBS8.
PhylomeDBiQ80ZQ5.
TreeFamiTF324161.

Miscellaneous databases

ChiTaRSiJazf1. mouse.
NextBioi380891.
PROiQ80ZQ5.
SOURCEiSearch...

Gene expression databases

BgeeiQ80ZQ5.
CleanExiMM_JAZF1.
GenevisibleiQ80ZQ5. MM.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Brain cortex and Pancreas.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-109 AND THR-113, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  4. "Overexpression of Jazf1 reduces body weight gain and regulates lipid metabolism in high fat diet."
    Jang W.Y., Bae K.B., Kim S.H., Yu D.H., Kim H.J., Ji Y.R., Park S.J., Park S.J., Kang M.C., Jeong J.I., Park S.J., Lee S.G., Lee I., Kim M.O., Yoon D., Ryoo Z.Y.
    Biochem. Biophys. Res. Commun. 444:296-301(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  5. "JAZF1 regulates visfatin expression in adipocytes via PPARalpha and PPARbeta/delta signaling."
    Ming G.F., Li X., Yin J.Y., Ai Y.H., Xu D.M., Ma X.H., Liu Z.Y., Liu H.X., Zhou H.H., Liu Z.Q.
    Metabolism 63:1012-1021(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DEVELOPMENTAL STAGE.
  6. "Transcription factor TIP27 regulates glucose homeostasis and insulin sensitivity in a PI3-kinase/Akt-dependent manner in mice."
    Yuan L., Luo X., Zeng M., Zhang Y., Yang M., Zhang L., Liu R., Boden G., Liu H., Ma Z.A., Li L., Yang G.
    Int. J. Obes. Relat. Metab. Disord. 39:949-958(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiJAZF1_MOUSE
AccessioniPrimary (citable) accession number: Q80ZQ5
Secondary accession number(s): Q8BLQ8, Q8BWN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: July 11, 2003
Last modified: February 17, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.