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Protein

Cytochrome c oxidase subunit 6B2

Gene

Cox6b2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. This protein may be one of the heme-binding subunits of the oxidase (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 6B2
Alternative name(s):
Cytochrome c oxidase subunit VIb isoform 2
Short name:
COX VIb-2
Cytochrome c oxidase subunit VIb, testis-specific isoform
Gene namesi
Name:Cox6b2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:3044182. Cox6b2.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial crista Source: MGI
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001949221 – 88Cytochrome c oxidase subunit 6B2Add BLAST88

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi32 ↔ 67PROSITE-ProRule annotation
Disulfide bondi42 ↔ 56PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ80ZN9.
PRIDEiQ80ZN9.

PTM databases

PhosphoSitePlusiQ80ZN9.

Expressioni

Tissue specificityi

Testis specific.1 Publication

Gene expression databases

BgeeiENSMUSG00000051811.
CleanExiMM_COX6B2.
ExpressionAtlasiQ80ZN9. baseline and differential.
GenevisibleiQ80ZN9. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000064988.

Structurei

3D structure databases

ProteinModelPortaliQ80ZN9.
SMRiQ80ZN9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 75CHCHPROSITE-ProRule annotationAdd BLAST47

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi32 – 42Cx9C motifPROSITE-ProRule annotationAdd BLAST11
Motifi56 – 67Cx10C motifPROSITE-ProRule annotationAdd BLAST12

Sequence similaritiesi

Contains 1 CHCH (coiled coil-helix-coiled coil-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3057. Eukaryota.
ENOG41121WM. LUCA.
GeneTreeiENSGT00390000001191.
HOGENOMiHOG000165128.
HOVERGENiHBG051090.
InParanoidiQ80ZN9.
KOiK02267.
OMAiISWVQRW.
PhylomeDBiQ80ZN9.
TreeFamiTF105065.

Family and domain databases

CDDicd00926. Cyt_c_Oxidase_VIb. 1 hit.
Gene3Di1.10.10.140. 1 hit.
InterProiIPR003213. Cyt_c_oxidase_su6B.
[Graphical view]
PfamiPF02297. COX6B. 1 hit.
[Graphical view]
PIRSFiPIRSF000278. Cyt_c_oxidase_6B. 1 hit.
SUPFAMiSSF47694. SSF47694. 1 hit.
PROSITEiPS51808. CHCH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80ZN9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGVQAQKPP PGQWTTPPFD PRFPNQNQTR NCYQNFLDYH RCVKTMNRRG
60 70 80
KSTQPCEYYF RVFHSLCPIS WVQRWNEQIK QGTFPGKI
Length:88
Mass (Da):10,521
Last modified:June 1, 2003 - v1
Checksum:iE1B539ECA9AB9A46
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY152400 mRNA. Translation: AAN46753.1.
CT010366 mRNA. Translation: CAJ18573.1.
AK160152 mRNA. Translation: BAE35659.1.
BC048670 mRNA. Translation: AAH48670.1.
BC107296 mRNA. Translation: AAI07297.1.
BC107297 mRNA. Translation: AAI07298.1.
CCDSiCCDS39738.1.
RefSeqiNP_001276777.1. NM_001289848.1.
NP_001276778.1. NM_001289849.1.
NP_001276779.1. NM_001289850.1.
NP_899664.1. NM_183405.2.
NP_899665.1. NM_183406.3.
UniGeneiMm.29625.

Genome annotation databases

EnsembliENSMUST00000063324; ENSMUSP00000064988; ENSMUSG00000051811.
ENSMUST00000182048; ENSMUSP00000138765; ENSMUSG00000051811.
ENSMUST00000182111; ENSMUSP00000138709; ENSMUSG00000051811.
GeneIDi333182.
KEGGimmu:333182.
UCSCiuc009eyl.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY152400 mRNA. Translation: AAN46753.1.
CT010366 mRNA. Translation: CAJ18573.1.
AK160152 mRNA. Translation: BAE35659.1.
BC048670 mRNA. Translation: AAH48670.1.
BC107296 mRNA. Translation: AAI07297.1.
BC107297 mRNA. Translation: AAI07298.1.
CCDSiCCDS39738.1.
RefSeqiNP_001276777.1. NM_001289848.1.
NP_001276778.1. NM_001289849.1.
NP_001276779.1. NM_001289850.1.
NP_899664.1. NM_183405.2.
NP_899665.1. NM_183406.3.
UniGeneiMm.29625.

3D structure databases

ProteinModelPortaliQ80ZN9.
SMRiQ80ZN9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000064988.

PTM databases

PhosphoSitePlusiQ80ZN9.

Proteomic databases

PaxDbiQ80ZN9.
PRIDEiQ80ZN9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000063324; ENSMUSP00000064988; ENSMUSG00000051811.
ENSMUST00000182048; ENSMUSP00000138765; ENSMUSG00000051811.
ENSMUST00000182111; ENSMUSP00000138709; ENSMUSG00000051811.
GeneIDi333182.
KEGGimmu:333182.
UCSCiuc009eyl.2. mouse.

Organism-specific databases

CTDi125965.
MGIiMGI:3044182. Cox6b2.

Phylogenomic databases

eggNOGiKOG3057. Eukaryota.
ENOG41121WM. LUCA.
GeneTreeiENSGT00390000001191.
HOGENOMiHOG000165128.
HOVERGENiHBG051090.
InParanoidiQ80ZN9.
KOiK02267.
OMAiISWVQRW.
PhylomeDBiQ80ZN9.
TreeFamiTF105065.

Miscellaneous databases

PROiQ80ZN9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000051811.
CleanExiMM_COX6B2.
ExpressionAtlasiQ80ZN9. baseline and differential.
GenevisibleiQ80ZN9. MM.

Family and domain databases

CDDicd00926. Cyt_c_Oxidase_VIb. 1 hit.
Gene3Di1.10.10.140. 1 hit.
InterProiIPR003213. Cyt_c_oxidase_su6B.
[Graphical view]
PfamiPF02297. COX6B. 1 hit.
[Graphical view]
PIRSFiPIRSF000278. Cyt_c_oxidase_6B. 1 hit.
SUPFAMiSSF47694. SSF47694. 1 hit.
PROSITEiPS51808. CHCH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCX6B2_MOUSE
AccessioniPrimary (citable) accession number: Q80ZN9
Secondary accession number(s): Q3KNG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: June 1, 2003
Last modified: November 30, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.