Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cytochrome c oxidase subunit 6B2

Gene

Cox6b2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. This protein may be one of the heme-binding subunits of the oxidase (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 6B2
Alternative name(s):
Cytochrome c oxidase subunit VIb isoform 2
Short name:
COX VIb-2
Cytochrome c oxidase subunit VIb, testis-specific isoform
Gene namesi
Name:Cox6b2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:3044182. Cox6b2.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial crista Source: MGI
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8888Cytochrome c oxidase subunit 6B2PRO_0000194922Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi32 ↔ 67By similarity
Disulfide bondi42 ↔ 56By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiQ80ZN9.
PaxDbiQ80ZN9.
PRIDEiQ80ZN9.

Expressioni

Tissue specificityi

Testis specific.1 Publication

Gene expression databases

BgeeiQ80ZN9.
CleanExiMM_COX6B2.
ExpressionAtlasiQ80ZN9. baseline and differential.
GenevisibleiQ80ZN9. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000064988.

Structurei

3D structure databases

ProteinModelPortaliQ80ZN9.
SMRiQ80ZN9. Positions 14-88.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3057. Eukaryota.
ENOG41121WM. LUCA.
GeneTreeiENSGT00390000001191.
HOGENOMiHOG000165128.
HOVERGENiHBG051090.
InParanoidiQ80ZN9.
KOiK02267.
OMAiSWVQRWN.
OrthoDBiEOG7WDN54.
PhylomeDBiQ80ZN9.
TreeFamiTF105065.

Family and domain databases

Gene3Di1.10.10.140. 1 hit.
InterProiIPR003213. Cyt_c_oxidase_su6B.
[Graphical view]
PfamiPF02297. COX6B. 1 hit.
[Graphical view]
PIRSFiPIRSF000278. Cyt_c_oxidase_6B. 1 hit.
SUPFAMiSSF47694. SSF47694. 1 hit.

Sequencei

Sequence statusi: Complete.

Q80ZN9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGVQAQKPP PGQWTTPPFD PRFPNQNQTR NCYQNFLDYH RCVKTMNRRG
60 70 80
KSTQPCEYYF RVFHSLCPIS WVQRWNEQIK QGTFPGKI
Length:88
Mass (Da):10,521
Last modified:June 1, 2003 - v1
Checksum:iE1B539ECA9AB9A46
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY152400 mRNA. Translation: AAN46753.1.
CT010366 mRNA. Translation: CAJ18573.1.
AK160152 mRNA. Translation: BAE35659.1.
BC048670 mRNA. Translation: AAH48670.1.
BC107296 mRNA. Translation: AAI07297.1.
BC107297 mRNA. Translation: AAI07298.1.
CCDSiCCDS39738.1.
RefSeqiNP_001276777.1. NM_001289848.1.
NP_001276778.1. NM_001289849.1.
NP_001276779.1. NM_001289850.1.
NP_899664.1. NM_183405.2.
NP_899665.1. NM_183406.3.
UniGeneiMm.29625.

Genome annotation databases

EnsembliENSMUST00000063324; ENSMUSP00000064988; ENSMUSG00000051811.
ENSMUST00000182048; ENSMUSP00000138765; ENSMUSG00000051811.
ENSMUST00000182111; ENSMUSP00000138709; ENSMUSG00000051811.
GeneIDi333182.
KEGGimmu:333182.
UCSCiuc009eyl.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY152400 mRNA. Translation: AAN46753.1.
CT010366 mRNA. Translation: CAJ18573.1.
AK160152 mRNA. Translation: BAE35659.1.
BC048670 mRNA. Translation: AAH48670.1.
BC107296 mRNA. Translation: AAI07297.1.
BC107297 mRNA. Translation: AAI07298.1.
CCDSiCCDS39738.1.
RefSeqiNP_001276777.1. NM_001289848.1.
NP_001276778.1. NM_001289849.1.
NP_001276779.1. NM_001289850.1.
NP_899664.1. NM_183405.2.
NP_899665.1. NM_183406.3.
UniGeneiMm.29625.

3D structure databases

ProteinModelPortaliQ80ZN9.
SMRiQ80ZN9. Positions 14-88.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000064988.

Proteomic databases

EPDiQ80ZN9.
PaxDbiQ80ZN9.
PRIDEiQ80ZN9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000063324; ENSMUSP00000064988; ENSMUSG00000051811.
ENSMUST00000182048; ENSMUSP00000138765; ENSMUSG00000051811.
ENSMUST00000182111; ENSMUSP00000138709; ENSMUSG00000051811.
GeneIDi333182.
KEGGimmu:333182.
UCSCiuc009eyl.2. mouse.

Organism-specific databases

CTDi125965.
MGIiMGI:3044182. Cox6b2.

Phylogenomic databases

eggNOGiKOG3057. Eukaryota.
ENOG41121WM. LUCA.
GeneTreeiENSGT00390000001191.
HOGENOMiHOG000165128.
HOVERGENiHBG051090.
InParanoidiQ80ZN9.
KOiK02267.
OMAiSWVQRWN.
OrthoDBiEOG7WDN54.
PhylomeDBiQ80ZN9.
TreeFamiTF105065.

Miscellaneous databases

PROiQ80ZN9.
SOURCEiSearch...

Gene expression databases

BgeeiQ80ZN9.
CleanExiMM_COX6B2.
ExpressionAtlasiQ80ZN9. baseline and differential.
GenevisibleiQ80ZN9. MM.

Family and domain databases

Gene3Di1.10.10.140. 1 hit.
InterProiIPR003213. Cyt_c_oxidase_su6B.
[Graphical view]
PfamiPF02297. COX6B. 1 hit.
[Graphical view]
PIRSFiPIRSF000278. Cyt_c_oxidase_6B. 1 hit.
SUPFAMiSSF47694. SSF47694. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cytochrome c oxidase of mammals contains a testes-specific isoform of subunit VIb -- the counterpart to testes-specific cytochrome c?"
    Huttemann M., Jaradat S., Grossman L.I.
    Mol. Reprod. Dev. 66:8-16(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Testis.
  2. "Cloning of mouse full open reading frames in Gateway(R) system entry vector (pDONR201)."
    Ebert L., Muenstermann E., Schatten R., Henze S., Bohn E., Mollenhauer J., Wiemann S., Schick M., Korn B.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Testis.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Testis.

Entry informationi

Entry nameiCX6B2_MOUSE
AccessioniPrimary (citable) accession number: Q80ZN9
Secondary accession number(s): Q3KNG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: June 1, 2003
Last modified: June 8, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.