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Protein

Transcription initiation factor IIA subunit 2

Gene

Gtf2a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-674695 RNA Polymerase II Pre-transcription Events
R-MMU-6807505 RNA polymerase II transcribes snRNA genes
R-MMU-73776 RNA Polymerase II Promoter Escape
R-MMU-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-MMU-75953 RNA Polymerase II Transcription Initiation
R-MMU-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance
R-MMU-9018519 Estrogen-dependent gene expression

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription initiation factor IIA subunit 2
Alternative name(s):
General transcription factor IIA subunit 2
Transcription initiation factor IIA gamma chain
Short name:
TFIIA-gamma
Gene namesi
Name:Gtf2a2
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1933289 Gtf2a2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001940431 – 109Transcription initiation factor IIA subunit 2Add BLAST109

Proteomic databases

MaxQBiQ80ZM7
PaxDbiQ80ZM7
PRIDEiQ80ZM7

PTM databases

iPTMnetiQ80ZM7
PhosphoSitePlusiQ80ZM7

Expressioni

Gene expression databases

BgeeiENSMUSG00000033543
CleanExiMM_GTF2A2
ExpressionAtlasiQ80ZM7 baseline and differential
GenevisibleiQ80ZM7 MM

Interactioni

Subunit structurei

TFIIA is a heterodimer of the large unprocessed subunit 1 and a small subunit gamma. It was originally believed to be a heterotrimer of an alpha (p35), a beta (p19) and a gamma subunit (p12). Interacts with NCOA6 general coactivator. TFIIA forms a complex with TBP. Interacts with HSF1 (via transactivation domain). Interacts with HSF1 (via transactivation domain). Interacts with HSF1 (via transactivation domain).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000113501

Structurei

3D structure databases

ProteinModelPortaliQ80ZM7
SMRiQ80ZM7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TFIIA subunit 2 family.Curated

Phylogenomic databases

eggNOGiKOG3463 Eukaryota
COG5123 LUCA
GeneTreeiENSGT00390000014572
HOGENOMiHOG000167251
HOVERGENiHBG000826
InParanoidiQ80ZM7
KOiK03123
OMAiFKMESNE
OrthoDBiEOG091G0X1Z
PhylomeDBiQ80ZM7
TreeFamiTF315131

Family and domain databases

CDDicd10014 TFIIA_gamma_C, 1 hit
cd10145 TFIIA_gamma_N, 1 hit
Gene3Di1.10.287.190, 1 hit
2.30.18.10, 1 hit
InterProiView protein in InterPro
IPR009083 TFIIA_a-hlx
IPR009088 TFIIA_b-brl
IPR003194 TFIIA_gsu
IPR015871 TFIIA_gsu_C
IPR015872 TFIIA_gsu_N
PANTHERiPTHR10966 PTHR10966, 1 hit
PfamiView protein in Pfam
PF02751 TFIIA_gamma_C, 1 hit
PF02268 TFIIA_gamma_N, 1 hit
PIRSFiPIRSF009415 Hum_TFIIA_gamma, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD009224 TFIIA_gsu_N, 1 hit
SUPFAMiSSF50784 SSF50784, 1 hit

Sequencei

Sequence statusi: Complete.

Q80ZM7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYQLYRNTT LGNSLQESLD ELIQSQQITP QLALQVLLQF DKAINSALAQ
60 70 80 90 100
RVRNRVNFRG SLNTYRFCDN VWTFVLNDVE FREVTELIKV DKVKIVACDG

KNTGSNTTE
Length:109
Mass (Da):12,473
Last modified:May 10, 2004 - v2
Checksum:i8BEE65B0D9982AFA
GO

Sequence cautioni

The sequence AAH48705 differs from that shown. Intron retention.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC048705 mRNA Translation: AAH48705.1 Sequence problems.
CCDSiCCDS52851.1
RefSeqiNP_001034608.1, NM_001039519.2
NP_001269012.1, NM_001282083.1
XP_006511179.1, XM_006511116.2
UniGeneiMm.293117

Genome annotation databases

EnsembliENSMUST00000118198; ENSMUSP00000113501; ENSMUSG00000033543
ENSMUST00000119413; ENSMUSP00000113697; ENSMUSG00000033543
GeneIDi235459
KEGGimmu:235459
UCSCiuc009qnr.2 mouse

Similar proteinsi

Entry informationi

Entry nameiT2AG_MOUSE
AccessioniPrimary (citable) accession number: Q80ZM7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: May 23, 2018
This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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