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Protein

WD and tetratricopeptide repeats protein 1

Gene

Wdtc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

  • enzyme inhibitor activity Source: MGI
  • histone binding Source: MGI
  • histone deacetylase binding Source: MGI

GO - Biological processi

  • cellular chemical homeostasis Source: MGI
  • cellular response to insulin stimulus Source: MGI
  • glucose metabolic process Source: MGI
  • in utero embryonic development Source: MGI
  • multicellular organism growth Source: MGI
  • negative regulation of catalytic activity Source: GOC
  • negative regulation of fatty acid biosynthetic process Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • protein ubiquitination Source: UniProtKB-UniPathway
  • regulation of cell size Source: MGI
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
WD and tetratricopeptide repeats protein 1
Gene namesi
Name:Wdtc1
Synonyms:Gm695
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2685541. Wdtc1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 677677WD and tetratricopeptide repeats protein 1PRO_0000051435Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei511 – 5111PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ80ZK9.
MaxQBiQ80ZK9.
PaxDbiQ80ZK9.
PRIDEiQ80ZK9.

PTM databases

iPTMnetiQ80ZK9.
PhosphoSiteiQ80ZK9.

Expressioni

Gene expression databases

BgeeiQ80ZK9.
CleanExiMM_WDTC1.
ExpressionAtlasiQ80ZK9. baseline and differential.
GenevisibleiQ80ZK9. MM.

Interactioni

GO - Molecular functioni

  • histone binding Source: MGI
  • histone deacetylase binding Source: MGI

Protein-protein interaction databases

BioGridi231030. 3 interactions.
IntActiQ80ZK9. 1 interaction.
STRINGi10090.ENSMUSP00000040647.

Structurei

3D structure databases

ProteinModelPortaliQ80ZK9.
SMRiQ80ZK9. Positions 39-356, 358-470, 473-501, 530-607.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati45 – 8440WD 1Add
BLAST
Repeati88 – 12942WD 2Add
BLAST
Repeati132 – 17241WD 3Add
BLAST
Repeati182 – 22241WD 4Add
BLAST
Repeati265 – 30541WD 5Add
BLAST
Repeati361 – 39434TPR 1Add
BLAST
Repeati396 – 43136TPR 2Add
BLAST
Repeati535 – 57541WD 6Add
BLAST
Repeati578 – 61740WD 7Add
BLAST

Sequence similaritiesi

Contains 2 TPR repeats.Curated
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat, WD repeat

Phylogenomic databases

eggNOGiKOG1310. Eukaryota.
KOG1334. Eukaryota.
ENOG410XWAR. LUCA.
GeneTreeiENSGT00530000062951.
HOGENOMiHOG000231334.
HOVERGENiHBG059105.
InParanoidiQ80ZK9.
KOiK11807.
OMAiHRYCGHC.
OrthoDBiEOG7CRTPK.
PhylomeDBiQ80ZK9.
TreeFamiTF320710.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
2.130.10.10. 3 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 3 hits.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
SM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
SSF50978. SSF50978. 3 hits.
PROSITEiPS50293. TPR_REGION. 1 hit.
PS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80ZK9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKVNITRDL IRRQVKERGA LSFERRYHVT DPFIRRLGLE AELQGHSGCV
60 70 80 90 100
NCLEWNEKGD LLASGSDDQH TIVWDPLHHK KLLSMHTGHT ANIFSVKFLP
110 120 130 140 150
HAGDRILITG AADSKVHVHD LTVKETIHMF GDHTNRVKRI ATAPMWPNTF
160 170 180 190 200
WSAAEDGLIR QYDLRENSKH SEVLIDLTEY CGPMVEAKCL TVNPQDNNCL
210 220 230 240 250
AVGASGPFVR LYDIRMIHNH RKSMRQSPSA GVHTFCDRQK PLPDGAAQYY
260 270 280 290 300
VAGHLPVKLP DYNSRLRVLV ATYVTFSPNG TELLVNMGGE QVYLFDLTYK
310 320 330 340 350
QRPYTFLLPR KCHSVEVQNG KMSTNGVSNG VSNGLHLHSN GFRLPESKGC
360 370 380 390 400
ISPQVELPPY LERVKQQANE AFACQQWTQA IQLYSQAVQK APHNAMLYGN
410 420 430 440 450
RAAAYMKRKW DGDHYDALRD CLKAISLNPC HLKAHFRLAR CLFELKYVAE
460 470 480 490 500
ALECLDDFKG KFPEQAHSSA CDALGRDITA ALFSKSDGEE KKAAGGGGGP
510 520 530 540 550
VRLRSTSRKD SISEDEMVLR ERSYDYQFRY CGHCNTTTDI KEANFFGSNA
560 570 580 590 600
QYIVSGSDDG SFFIWEKETT NLVRVLQGDE SIVNCLQPHP SYCFLATSGI
610 620 630 640 650
DPVVRLWNPR PESEDLTGRV VEDMEGASQA NQRRMNANPL EAMLLDMGYR
660 670
ITGLSSGGAG ASDDEDSAEG QVQCRPS
Length:677
Mass (Da):75,733
Last modified:June 1, 2003 - v1
Checksum:iCDB5F09E80E6C625
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC048824 mRNA. Translation: AAH48824.1.
BC057107 mRNA. Translation: AAH57107.1.
CCDSiCCDS18746.1.
RefSeqiNP_955010.1. NM_199306.4.
XP_006538806.1. XM_006538743.2.
XP_006538807.1. XM_006538744.2.
UniGeneiMm.226576.
Mm.413761.

Genome annotation databases

EnsembliENSMUST00000043305; ENSMUSP00000040647; ENSMUSG00000037622.
GeneIDi230796.
KEGGimmu:230796.
UCSCiuc008vcr.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC048824 mRNA. Translation: AAH48824.1.
BC057107 mRNA. Translation: AAH57107.1.
CCDSiCCDS18746.1.
RefSeqiNP_955010.1. NM_199306.4.
XP_006538806.1. XM_006538743.2.
XP_006538807.1. XM_006538744.2.
UniGeneiMm.226576.
Mm.413761.

3D structure databases

ProteinModelPortaliQ80ZK9.
SMRiQ80ZK9. Positions 39-356, 358-470, 473-501, 530-607.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi231030. 3 interactions.
IntActiQ80ZK9. 1 interaction.
STRINGi10090.ENSMUSP00000040647.

PTM databases

iPTMnetiQ80ZK9.
PhosphoSiteiQ80ZK9.

Proteomic databases

EPDiQ80ZK9.
MaxQBiQ80ZK9.
PaxDbiQ80ZK9.
PRIDEiQ80ZK9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043305; ENSMUSP00000040647; ENSMUSG00000037622.
GeneIDi230796.
KEGGimmu:230796.
UCSCiuc008vcr.2. mouse.

Organism-specific databases

CTDi23038.
MGIiMGI:2685541. Wdtc1.

Phylogenomic databases

eggNOGiKOG1310. Eukaryota.
KOG1334. Eukaryota.
ENOG410XWAR. LUCA.
GeneTreeiENSGT00530000062951.
HOGENOMiHOG000231334.
HOVERGENiHBG059105.
InParanoidiQ80ZK9.
KOiK11807.
OMAiHRYCGHC.
OrthoDBiEOG7CRTPK.
PhylomeDBiQ80ZK9.
TreeFamiTF320710.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

ChiTaRSiWdtc1. mouse.
NextBioi380168.
PROiQ80ZK9.
SOURCEiSearch...

Gene expression databases

BgeeiQ80ZK9.
CleanExiMM_WDTC1.
ExpressionAtlasiQ80ZK9. baseline and differential.
GenevisibleiQ80ZK9. MM.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
2.130.10.10. 3 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 3 hits.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
SM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
SSF50978. SSF50978. 3 hits.
PROSITEiPS50293. TPR_REGION. 1 hit.
PS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Brain and Salivary gland.
  2. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-511, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-511, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiWDTC1_MOUSE
AccessioniPrimary (citable) accession number: Q80ZK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: June 1, 2003
Last modified: May 11, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.