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Protein

WD and tetratricopeptide repeats protein 1

Gene

Wdtc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

  • enzyme inhibitor activity Source: MGI
  • histone binding Source: MGI
  • histone deacetylase binding Source: MGI

GO - Biological processi

  • cellular chemical homeostasis Source: MGI
  • cellular response to insulin stimulus Source: MGI
  • glucose metabolic process Source: MGI
  • in utero embryonic development Source: MGI
  • multicellular organism growth Source: MGI
  • negative regulation of fatty acid biosynthetic process Source: MGI
  • negative regulation of transcription by RNA polymerase II Source: MGI
  • protein ubiquitination Source: UniProtKB-UniPathway
  • regulation of cell size Source: MGI

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-8951664 Neddylation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
WD and tetratricopeptide repeats protein 1
Gene namesi
Name:Wdtc1
Synonyms:Gm695
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2685541 Wdtc1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000514351 – 677WD and tetratricopeptide repeats protein 1Add BLAST677

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei352PhosphoserineBy similarity1
Modified residuei511PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ80ZK9
MaxQBiQ80ZK9
PaxDbiQ80ZK9
PeptideAtlasiQ80ZK9
PRIDEiQ80ZK9

PTM databases

iPTMnetiQ80ZK9
PhosphoSitePlusiQ80ZK9

Expressioni

Gene expression databases

BgeeiENSMUSG00000037622
CleanExiMM_WDTC1
ExpressionAtlasiQ80ZK9 baseline and differential
GenevisibleiQ80ZK9 MM

Interactioni

GO - Molecular functioni

  • histone binding Source: MGI
  • histone deacetylase binding Source: MGI

Protein-protein interaction databases

BioGridi231030, 3 interactors
IntActiQ80ZK9, 1 interactor
STRINGi10090.ENSMUSP00000040647

Structurei

3D structure databases

ProteinModelPortaliQ80ZK9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati45 – 84WD 1Add BLAST40
Repeati88 – 129WD 2Add BLAST42
Repeati132 – 172WD 3Add BLAST41
Repeati182 – 222WD 4Add BLAST41
Repeati265 – 305WD 5Add BLAST41
Repeati361 – 394TPR 1Add BLAST34
Repeati396 – 431TPR 2Add BLAST36
Repeati535 – 575WD 6Add BLAST41
Repeati578 – 617WD 7Add BLAST40

Keywords - Domaini

Repeat, TPR repeat, WD repeat

Phylogenomic databases

eggNOGiKOG1310 Eukaryota
KOG1334 Eukaryota
ENOG410XWAR LUCA
GeneTreeiENSGT00530000062951
HOGENOMiHOG000231334
HOVERGENiHBG059105
InParanoidiQ80ZK9
KOiK11807
OMAiSFFIWDR
OrthoDBiEOG091G08IE
PhylomeDBiQ80ZK9
TreeFamiTF320710

Family and domain databases

Gene3Di1.25.40.10, 1 hit
2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 3 hits
SMARTiView protein in SMART
SM00028 TPR, 3 hits
SM00320 WD40, 6 hits
SUPFAMiSSF48452 SSF48452, 1 hit
SSF50978 SSF50978, 3 hits
PROSITEiView protein in PROSITE
PS50293 TPR_REGION, 1 hit
PS50082 WD_REPEATS_2, 4 hits
PS50294 WD_REPEATS_REGION, 2 hits

Sequencei

Sequence statusi: Complete.

Q80ZK9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKVNITRDL IRRQVKERGA LSFERRYHVT DPFIRRLGLE AELQGHSGCV
60 70 80 90 100
NCLEWNEKGD LLASGSDDQH TIVWDPLHHK KLLSMHTGHT ANIFSVKFLP
110 120 130 140 150
HAGDRILITG AADSKVHVHD LTVKETIHMF GDHTNRVKRI ATAPMWPNTF
160 170 180 190 200
WSAAEDGLIR QYDLRENSKH SEVLIDLTEY CGPMVEAKCL TVNPQDNNCL
210 220 230 240 250
AVGASGPFVR LYDIRMIHNH RKSMRQSPSA GVHTFCDRQK PLPDGAAQYY
260 270 280 290 300
VAGHLPVKLP DYNSRLRVLV ATYVTFSPNG TELLVNMGGE QVYLFDLTYK
310 320 330 340 350
QRPYTFLLPR KCHSVEVQNG KMSTNGVSNG VSNGLHLHSN GFRLPESKGC
360 370 380 390 400
ISPQVELPPY LERVKQQANE AFACQQWTQA IQLYSQAVQK APHNAMLYGN
410 420 430 440 450
RAAAYMKRKW DGDHYDALRD CLKAISLNPC HLKAHFRLAR CLFELKYVAE
460 470 480 490 500
ALECLDDFKG KFPEQAHSSA CDALGRDITA ALFSKSDGEE KKAAGGGGGP
510 520 530 540 550
VRLRSTSRKD SISEDEMVLR ERSYDYQFRY CGHCNTTTDI KEANFFGSNA
560 570 580 590 600
QYIVSGSDDG SFFIWEKETT NLVRVLQGDE SIVNCLQPHP SYCFLATSGI
610 620 630 640 650
DPVVRLWNPR PESEDLTGRV VEDMEGASQA NQRRMNANPL EAMLLDMGYR
660 670
ITGLSSGGAG ASDDEDSAEG QVQCRPS
Length:677
Mass (Da):75,733
Last modified:June 1, 2003 - v1
Checksum:iCDB5F09E80E6C625
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC048824 mRNA Translation: AAH48824.1
BC057107 mRNA Translation: AAH57107.1
CCDSiCCDS18746.1
RefSeqiNP_955010.1, NM_199306.4
XP_006538806.1, XM_006538743.3
XP_006538807.1, XM_006538744.3
UniGeneiMm.226576
Mm.413761

Genome annotation databases

EnsembliENSMUST00000043305; ENSMUSP00000040647; ENSMUSG00000037622
GeneIDi230796
KEGGimmu:230796
UCSCiuc008vcr.2 mouse

Similar proteinsi

Entry informationi

Entry nameiWDTC1_MOUSE
AccessioniPrimary (citable) accession number: Q80ZK9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: June 1, 2003
Last modified: March 28, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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