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Protein

Protein zer-1 homolog

Gene

Zer1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probably acts as target recruitment subunit in the E3 ubiquitin ligase complex ZER1-CUL2-Elongin BC.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Protein zer-1 homolog
Alternative name(s):
Zyg-11 homolog B-like protein
Gene namesi
Name:Zer1
Synonyms:Zyg, Zyg11bl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2442511. Zer1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 779778Protein zer-1 homologPRO_0000066599Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ80ZJ6.
MaxQBiQ80ZJ6.
PaxDbiQ80ZJ6.
PRIDEiQ80ZJ6.

PTM databases

iPTMnetiQ80ZJ6.
PhosphoSiteiQ80ZJ6.

Expressioni

Gene expression databases

BgeeiQ80ZJ6.
CleanExiMM_ZER1.
ExpressionAtlasiQ80ZJ6. baseline and differential.

Interactioni

Subunit structurei

Interacts with the TCEB1-TCEB2/Elongin BC complex. Part of an E3 ubiquitin ligase complex including ZER1, CUL2 and Elongin BC (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046441.

Structurei

3D structure databases

ProteinModelPortaliQ80ZJ6.
SMRiQ80ZJ6. Positions 80-140, 174-235.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati226 – 24520LRR 1Add
BLAST
Repeati246 – 28136LRR 2Add
BLAST
Repeati291 – 31525LRR 3Add
BLAST
Repeati440 – 48041ARM 1Add
BLAST
Repeati524 – 56946ARM 2Add
BLAST
Repeati571 – 61343ARM 3Add
BLAST
Repeati615 – 65642ARM 4Add
BLAST
Repeati727 – 76943ARM 5Add
BLAST

Sequence similaritiesi

Belongs to the zyg-11 family.Curated
Contains 5 ARM repeats.Curated
Contains 3 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG3665. Eukaryota.
ENOG410XPSX. LUCA.
GeneTreeiENSGT00530000063187.
HOGENOMiHOG000232098.
HOVERGENiHBG052709.
InParanoidiQ80ZJ6.
KOiK10350.
OMAiAINCKRF.
OrthoDBiEOG79W94F.
PhylomeDBiQ80ZJ6.
TreeFamiTF313007.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR032675. L_dom-like.
[Graphical view]
SMARTiSM00185. ARM. 5 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q80ZJ6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASDTPESLM ALCTDFCLRN LDGTLGYLLD KETLRLHPDI FLPSEICDQL
60 70 80 90 100
VNEYVELVSA ACTFEPHETF FSLFSDPRST RLTRIHLRED LVQDQDLEAI
110 120 130 140 150
RKQDLVELYL TNCEKLSAKS LQTLRSFRHS LVSLSLSGCA NIFYEEDNPG
160 170 180 190 200
GCEDECLVNP TCQVLVKDFT FEGFSRLRFL NLGRMIDGIP VESLLRPLNS
210 220 230 240 250
LAALDLSGIQ TSDATFLTQW KDSLMSLVLY NMDLSDDHIR VIVQLHKLRS
260 270 280 290 300
KILTCGPHLI SSHLDISRDR LSSYYKFKLT RKVLSLLVQK LGNLMSLDIS
310 320 330 340 350
GHMILENCSI SKTDEEAGQT STEPSKSSIM PFRALKRPLQ FLGLFETSLC
360 370 380 390 400
RLTHIPAYKV SGDKNEEQVL NAIEAYTEHR PEITSRAINL LFDIARIERC
410 420 430 440 450
NQLLRALKLV ITALKCHKYD KNIQVTGSAA LFYLTNSEYR SEQSVKLRRQ
460 470 480 490 500
VIQVVLNGME SYQEVTVQRN CCLTLCNFSI PEELEFQYRR VNELLLGILS
510 520 530 540 550
PTRQDESIQR IAVHLCNALV CQVDNDHKEA VGKMGFVVTM LKLIQKKLLD
560 570 580 590 600
KTCDQVMEFS WSALWNITDE TPDNCEMFLN FNGMKLFLDC LKEFPEKQEL
610 620 630 640 650
HRNMLGLLGN VAEVKELRPQ LMTSQFISVF SNLLESKADG IEVSYNACGV
660 670 680 690 700
LSHIMFDGPE AWGVCEPQRA EVEDRMWAAI QSWDINSRRN INYRSFEPIL
710 720 730 740 750
RLLPQGISPV SQHWATWALY NLVSVYPDKY CPLLIKEGGM PLLRDLIKMA
760 770
TARQETKEMA RKVIEHCSNF REENMDTSR
Length:779
Mass (Da):89,076
Last modified:June 1, 2003 - v1
Checksum:i825D4B2E2E47A16D
GO
Isoform 2 (identifier: Q80ZJ6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     250-262: Missing.

Show »
Length:766
Mass (Da):87,738
Checksum:i5AA2669BB54E984F
GO
Isoform 3 (identifier: Q80ZJ6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     250-262: Missing.
     468-490: QRNCCLTLCNFSIPEELEFQYRR → SPCLLRPACLGPVSLPAPQAPQA
     491-779: Missing.

Show »
Length:477
Mass (Da):53,978
Checksum:iCC27C851C2D56EB8
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei250 – 26213Missing in isoform 2 and isoform 3. 2 PublicationsVSP_014425Add
BLAST
Alternative sequencei468 – 49023QRNCC…FQYRR → SPCLLRPACLGPVSLPAPQA PQA in isoform 3. 1 PublicationVSP_014426Add
BLAST
Alternative sequencei491 – 779289Missing in isoform 3. 1 PublicationVSP_014427Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029290 mRNA. Translation: BAC26374.1.
AK032318 mRNA. Translation: BAC27811.1.
AK048853 mRNA. Translation: BAC33474.1.
AK087046 mRNA. Translation: BAC39788.1.
BX005298 Genomic DNA. Translation: CAM18958.1.
BC048924 mRNA. Translation: AAH48924.1.
BC057021 mRNA. Translation: AAH57021.1.
CCDSiCCDS15870.1. [Q80ZJ6-1]
CCDS71017.1. [Q80ZJ6-2]
RefSeqiNP_001277432.1. NM_001290503.1. [Q80ZJ6-2]
NP_848809.2. NM_178694.4. [Q80ZJ6-1]
UniGeneiMm.44526.
Mm.491263.

Genome annotation databases

EnsembliENSMUST00000044751; ENSMUSP00000046441; ENSMUSG00000039686. [Q80ZJ6-1]
ENSMUST00000113677; ENSMUSP00000109307; ENSMUSG00000039686. [Q80ZJ6-2]
GeneIDi227693.
KEGGimmu:227693.
UCSCiuc008jbf.2. mouse. [Q80ZJ6-1]
uc008jbh.2. mouse. [Q80ZJ6-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029290 mRNA. Translation: BAC26374.1.
AK032318 mRNA. Translation: BAC27811.1.
AK048853 mRNA. Translation: BAC33474.1.
AK087046 mRNA. Translation: BAC39788.1.
BX005298 Genomic DNA. Translation: CAM18958.1.
BC048924 mRNA. Translation: AAH48924.1.
BC057021 mRNA. Translation: AAH57021.1.
CCDSiCCDS15870.1. [Q80ZJ6-1]
CCDS71017.1. [Q80ZJ6-2]
RefSeqiNP_001277432.1. NM_001290503.1. [Q80ZJ6-2]
NP_848809.2. NM_178694.4. [Q80ZJ6-1]
UniGeneiMm.44526.
Mm.491263.

3D structure databases

ProteinModelPortaliQ80ZJ6.
SMRiQ80ZJ6. Positions 80-140, 174-235.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046441.

PTM databases

iPTMnetiQ80ZJ6.
PhosphoSiteiQ80ZJ6.

Proteomic databases

EPDiQ80ZJ6.
MaxQBiQ80ZJ6.
PaxDbiQ80ZJ6.
PRIDEiQ80ZJ6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044751; ENSMUSP00000046441; ENSMUSG00000039686. [Q80ZJ6-1]
ENSMUST00000113677; ENSMUSP00000109307; ENSMUSG00000039686. [Q80ZJ6-2]
GeneIDi227693.
KEGGimmu:227693.
UCSCiuc008jbf.2. mouse. [Q80ZJ6-1]
uc008jbh.2. mouse. [Q80ZJ6-3]

Organism-specific databases

CTDi10444.
MGIiMGI:2442511. Zer1.

Phylogenomic databases

eggNOGiKOG3665. Eukaryota.
ENOG410XPSX. LUCA.
GeneTreeiENSGT00530000063187.
HOGENOMiHOG000232098.
HOVERGENiHBG052709.
InParanoidiQ80ZJ6.
KOiK10350.
OMAiAINCKRF.
OrthoDBiEOG79W94F.
PhylomeDBiQ80ZJ6.
TreeFamiTF313007.

Miscellaneous databases

PROiQ80ZJ6.
SOURCEiSearch...

Gene expression databases

BgeeiQ80ZJ6.
CleanExiMM_ZER1.
ExpressionAtlasiQ80ZJ6. baseline and differential.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR032675. L_dom-like.
[Graphical view]
SMARTiSM00185. ARM. 5 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Strain: C57BL/6J.
    Tissue: Cerebellum, Head, Lung and Olfactory bulb.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Embryonic brain and Olfactory epithelium.
  4. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 504-510, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Spleen and Testis.

Entry informationi

Entry nameiZER1_MOUSE
AccessioniPrimary (citable) accession number: Q80ZJ6
Secondary accession number(s): A2BEA2, Q6PGH5, Q8BG38
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: June 1, 2003
Last modified: June 8, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.