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Protein

Protein zer-1 homolog

Gene

Zer1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably acts as target recruitment subunit in the E3 ubiquitin ligase complex ZER1-CUL2-Elongin BC.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Protein zer-1 homolog
Alternative name(s):
Zyg-11 homolog B-like protein
Gene namesi
Name:Zer1
Synonyms:Zyg, Zyg11bl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2442511 Zer1

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000665992 – 779Protein zer-1 homologAdd BLAST778

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ80ZJ6
PRIDEiQ80ZJ6

PTM databases

iPTMnetiQ80ZJ6
PhosphoSitePlusiQ80ZJ6

Expressioni

Gene expression databases

BgeeiENSMUSG00000039686
CleanExiMM_ZER1
ExpressionAtlasiQ80ZJ6 baseline and differential

Interactioni

Subunit structurei

Interacts with the ELOC-ELOB/Elongin BC complex. Part of an E3 ubiquitin ligase complex including ZER1, CUL2 and Elongin BC (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046441

Structurei

3D structure databases

ProteinModelPortaliQ80ZJ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati226 – 245LRR 1Add BLAST20
Repeati246 – 281LRR 2Add BLAST36
Repeati291 – 315LRR 3Add BLAST25
Repeati440 – 480ARM 1Add BLAST41
Repeati524 – 569ARM 2Add BLAST46
Repeati571 – 613ARM 3Add BLAST43
Repeati615 – 656ARM 4Add BLAST42
Repeati727 – 769ARM 5Add BLAST43

Sequence similaritiesi

Belongs to the zyg-11 family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG3665 Eukaryota
ENOG410XPSX LUCA
GeneTreeiENSGT00530000063187
HOGENOMiHOG000232098
HOVERGENiHBG052709
InParanoidiQ80ZJ6
KOiK10350
OMAiQLMTSQF
OrthoDBiEOG091G020B
PhylomeDBiQ80ZJ6
TreeFamiTF313007

Family and domain databases

Gene3Di1.25.10.10, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000225 Armadillo
IPR032675 LRR_dom_sf
SMARTiView protein in SMART
SM00185 ARM, 5 hits
SUPFAMiSSF48371 SSF48371, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q80ZJ6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASDTPESLM ALCTDFCLRN LDGTLGYLLD KETLRLHPDI FLPSEICDQL
60 70 80 90 100
VNEYVELVSA ACTFEPHETF FSLFSDPRST RLTRIHLRED LVQDQDLEAI
110 120 130 140 150
RKQDLVELYL TNCEKLSAKS LQTLRSFRHS LVSLSLSGCA NIFYEEDNPG
160 170 180 190 200
GCEDECLVNP TCQVLVKDFT FEGFSRLRFL NLGRMIDGIP VESLLRPLNS
210 220 230 240 250
LAALDLSGIQ TSDATFLTQW KDSLMSLVLY NMDLSDDHIR VIVQLHKLRS
260 270 280 290 300
KILTCGPHLI SSHLDISRDR LSSYYKFKLT RKVLSLLVQK LGNLMSLDIS
310 320 330 340 350
GHMILENCSI SKTDEEAGQT STEPSKSSIM PFRALKRPLQ FLGLFETSLC
360 370 380 390 400
RLTHIPAYKV SGDKNEEQVL NAIEAYTEHR PEITSRAINL LFDIARIERC
410 420 430 440 450
NQLLRALKLV ITALKCHKYD KNIQVTGSAA LFYLTNSEYR SEQSVKLRRQ
460 470 480 490 500
VIQVVLNGME SYQEVTVQRN CCLTLCNFSI PEELEFQYRR VNELLLGILS
510 520 530 540 550
PTRQDESIQR IAVHLCNALV CQVDNDHKEA VGKMGFVVTM LKLIQKKLLD
560 570 580 590 600
KTCDQVMEFS WSALWNITDE TPDNCEMFLN FNGMKLFLDC LKEFPEKQEL
610 620 630 640 650
HRNMLGLLGN VAEVKELRPQ LMTSQFISVF SNLLESKADG IEVSYNACGV
660 670 680 690 700
LSHIMFDGPE AWGVCEPQRA EVEDRMWAAI QSWDINSRRN INYRSFEPIL
710 720 730 740 750
RLLPQGISPV SQHWATWALY NLVSVYPDKY CPLLIKEGGM PLLRDLIKMA
760 770
TARQETKEMA RKVIEHCSNF REENMDTSR
Length:779
Mass (Da):89,076
Last modified:June 1, 2003 - v1
Checksum:i825D4B2E2E47A16D
GO
Isoform 2 (identifier: Q80ZJ6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     250-262: Missing.

Show »
Length:766
Mass (Da):87,738
Checksum:i5AA2669BB54E984F
GO
Isoform 3 (identifier: Q80ZJ6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     250-262: Missing.
     468-490: QRNCCLTLCNFSIPEELEFQYRR → SPCLLRPACLGPVSLPAPQAPQA
     491-779: Missing.

Show »
Length:477
Mass (Da):53,978
Checksum:iCC27C851C2D56EB8
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_014425250 – 262Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST13
Alternative sequenceiVSP_014426468 – 490QRNCC…FQYRR → SPCLLRPACLGPVSLPAPQA PQA in isoform 3. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_014427491 – 779Missing in isoform 3. 1 PublicationAdd BLAST289

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029290 mRNA Translation: BAC26374.1
AK032318 mRNA Translation: BAC27811.1
AK048853 mRNA Translation: BAC33474.1
AK087046 mRNA Translation: BAC39788.1
BX005298 Genomic DNA No translation available.
BC048924 mRNA Translation: AAH48924.1
BC057021 mRNA Translation: AAH57021.1
CCDSiCCDS15870.1 [Q80ZJ6-1]
CCDS71017.1 [Q80ZJ6-2]
RefSeqiNP_001277432.1, NM_001290503.1 [Q80ZJ6-2]
NP_848809.2, NM_178694.4 [Q80ZJ6-1]
UniGeneiMm.44526
Mm.491263

Genome annotation databases

EnsembliENSMUST00000044751; ENSMUSP00000046441; ENSMUSG00000039686 [Q80ZJ6-1]
ENSMUST00000113677; ENSMUSP00000109307; ENSMUSG00000039686 [Q80ZJ6-2]
GeneIDi227693
KEGGimmu:227693
UCSCiuc008jbf.2 mouse [Q80ZJ6-1]
uc008jbh.2 mouse [Q80ZJ6-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiZER1_MOUSE
AccessioniPrimary (citable) accession number: Q80ZJ6
Secondary accession number(s): A2BEA2, Q6PGH5, Q8BG38
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health