Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q80ZI6 (LRSM1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
E3 ubiquitin-protein ligase LRSAM1

EC=6.3.2.-
Alternative name(s):
Leucine-rich repeat and sterile alpha motif-containing protein 1
Tsg101-associated ligase
Gene names
Name:Lrsam1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length727 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) cargos By similarity.

Pathway

Protein modification; protein ubiquitination.

Subunit structure

Interacts with TSG101 By similarity.

Subcellular location

Cytoplasm By similarity. Note: Displays a punctuate distribution and localizes to a submembranal ring By similarity.

Tissue specificity

Widely expressed. Ref.2

Domain

The coiled coil domains interact with the SB domain of TSG101 By similarity.

The PTAP motifs mediate the binding to UEV domains By similarity.

Sequence similarities

Contains 6 LRR (leucine-rich) repeats.

Contains 1 RING-type zinc finger.

Contains 1 SAM (sterile alpha motif) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 727727E3 ubiquitin-protein ligase LRSAM1
PRO_0000055924

Regions

Repeat30 – 5122LRR 1
Repeat56 – 7722LRR 2
Repeat82 – 10322LRR 3
Repeat105 – 12622LRR 4
Repeat128 – 15023LRR 5
Repeat151 – 17222LRR 6
Domain569 – 63264SAM
Zinc finger679 – 71436RING-type
Coiled coil241 – 382142 Potential
Coiled coil469 – 54779 Potential
Motif653 – 6564PTAP motif 1
Motif665 – 6684PTAP motif 2

Amino acid modifications

Modified residue2341Phosphoserine By similarity
Modified residue6041Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q80ZI6 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 561B6FE6F730ADAE

FASTA72783,976
        10         20         30         40         50         60 
MPLFFRKRKP SEEARKRLEY QMCLAKEAGA DDILDISKCE LSEIPFGAFA TCKVLQKKVL 

        70         80         90        100        110        120 
IVHTNHLTSL LPKSCSLLSL VTIKVLDLHE NQLTALPDDM GQLTVLQVLN VERNQLTHLP 

       130        140        150        160        170        180 
RSIGNLLQLQ TLNVKDNKLK ELPDTLGELR SLRTLDISEN EIQRLPQMLA HVRTLETLSL 

       190        200        210        220        230        240 
NALAMVYPPP EVCGAGTAAV QQFLCKESGL DYYPPSQYLL PVLEQDGAEN TQDSPDGPAS 

       250        260        270        280        290        300 
RFSREEAEWQ NRFSDYEKRK EQKMLEKLEF ERRLDLGQRE HAELLQQSHS HKDEILQTVK 

       310        320        330        340        350        360 
QEQTRLEQDL SERQRCLDAE RQQLQEQLKQ TEQSIASRIQ RLLQDNQRQK KSSEILKSLE 

       370        380        390        400        410        420 
NERIRMEQLM SITQEETENL RQREIAAAMQ QMLTESCKSR LIQMAYESQR QSLAQQACSS 

       430        440        450        460        470        480 
MAEMDKRFQQ ILSWQQMDQN KAISQILQES VMQKAAFEAL QVKKDLMHRQ IRNQIRLIET 

       490        500        510        520        530        540 
ELLQLTQLEL KRKSLDTETL QEMVSEQRWA LSNLLQQLLK EKKQREEELH GILAELEAKS 

       550        560        570        580        590        600 
ETKQENYWLI QYQRLLNQKP LSLKLQEEGM ERRLVALLVE LSAEHYLPLF AHHRISLDML 

       610        620        630        640        650        660 
SRMSPGDLAK VGVSEAGLQH EILRRAQDLL AVPRVQPELK PLENEVLGAL EPPTAPRELQ 

       670        680        690        700        710        720 
ESVRPSAPPA ELDMPTSECV VCLEREAQMV FLTCGHVCCC QQCCQPLRTC PLCRQEISQR 


LRIYHSS 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Olfactory epithelium.
[2]"Tal, a Tsg101-specific E3 ubiquitin ligase, regulates receptor endocytosis and retrovirus budding."
Amit I., Yakir L., Katz M., Zwang Y., Marmor M.D., Citri A., Shtiegman K., Alroy I., Tuvia S., Reiss Y., Roubini E., Cohen M., Wides R., Bacharach E., Schubert U., Yarden Y.
Genes Dev. 18:1737-1752(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC049146 mRNA. Translation: AAH49146.1.
RefSeqNP_955006.1. NM_199302.2.
XP_006498032.1. XM_006497969.1.
XP_006498033.1. XM_006497970.1.
XP_006498034.1. XM_006497971.1.
XP_006498035.1. XM_006497972.1.
UniGeneMm.248037.

3D structure databases

ProteinModelPortalQ80ZI6.
SMRQ80ZI6. Positions 34-216, 679-724.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ80ZI6. 1 interaction.

PTM databases

PhosphoSiteQ80ZI6.

Proteomic databases

PaxDbQ80ZI6.
PRIDEQ80ZI6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000028132; ENSMUSP00000028132; ENSMUSG00000026792.
ENSMUST00000113200; ENSMUSP00000108825; ENSMUSG00000026792.
GeneID227738.
KEGGmmu:227738.
UCSCuc008jhd.2. mouse.

Organism-specific databases

CTD90678.
MGIMGI:2684789. Lrsam1.

Phylogenomic databases

eggNOGCOG4886.
GeneTreeENSGT00750000117546.
HOGENOMHOG000231972.
HOVERGENHBG052363.
InParanoidQ80ZI6.
KOK10641.
OMAIFLNCGH.
OrthoDBEOG77T149.
PhylomeDBQ80ZI6.
TreeFamTF329645.

Enzyme and pathway databases

UniPathwayUPA00143.

Gene expression databases

BgeeQ80ZI6.
GenevestigatorQ80ZI6.

Family and domain databases

Gene3D1.10.150.50. 1 hit.
3.30.40.10. 1 hit.
InterProIPR001611. Leu-rich_rpt.
IPR025875. Leu-rich_rpt_4.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR011510. SAM_2.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamPF12799. LRR_4. 2 hits.
PF07647. SAM_2. 1 hit.
[Graphical view]
SMARTSM00184. RING. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMSSF47769. SSF47769. 1 hit.
PROSITEPS51450. LRR. 4 hits.
PS50105. SAM_DOMAIN. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio378812.
PROQ80ZI6.
SOURCESearch...

Entry information

Entry nameLRSM1_MOUSE
AccessionPrimary (citable) accession number: Q80ZI6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: June 1, 2003
Last modified: April 16, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot