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Q80ZI6

- LRSM1_MOUSE

UniProt

Q80ZI6 - LRSM1_MOUSE

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Protein

E3 ubiquitin-protein ligase LRSAM1

Gene
Lrsam1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) cargos By similarity.

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri679 – 71436RING-typeAdd
BLAST

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. ubiquitin-protein transferase activity Source: UniProtKB
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. negative regulation of endocytosis Source: UniProtKB
  2. protein autoubiquitination Source: UniProtKB
  3. protein catabolic process Source: UniProtKB
  4. protein polyubiquitination Source: UniProtKB
  5. protein transport Source: UniProtKB-KW
  6. ubiquitin-dependent endocytosis Source: UniProtKB
  7. viral budding Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Protein transport, Transport, Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_199115. Antigen processing: Ubiquitination & Proteasome degradation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase LRSAM1 (EC:6.3.2.-)
Alternative name(s):
Leucine-rich repeat and sterile alpha motif-containing protein 1
Tsg101-associated ligase
Gene namesi
Name:Lrsam1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:2684789. Lrsam1.

Subcellular locationi

Cytoplasm By similarity
Note: Displays a punctuate distribution and localizes to a submembranal ring By similarity.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 727727E3 ubiquitin-protein ligase LRSAM1PRO_0000055924Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei234 – 2341Phosphoserine By similarity
Modified residuei604 – 6041Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ80ZI6.
PaxDbiQ80ZI6.
PRIDEiQ80ZI6.

PTM databases

PhosphoSiteiQ80ZI6.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiQ80ZI6.
GenevestigatoriQ80ZI6.

Interactioni

Subunit structurei

Interacts with TSG101 By similarity.

Protein-protein interaction databases

IntActiQ80ZI6. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ80ZI6.
SMRiQ80ZI6. Positions 34-216, 679-724.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati30 – 5122LRR 1Add
BLAST
Repeati56 – 7722LRR 2Add
BLAST
Repeati82 – 10322LRR 3Add
BLAST
Repeati105 – 12622LRR 4Add
BLAST
Repeati128 – 15023LRR 5Add
BLAST
Repeati151 – 17222LRR 6Add
BLAST
Domaini569 – 63264SAMAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili241 – 382142 Reviewed predictionAdd
BLAST
Coiled coili469 – 54779 Reviewed predictionAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi653 – 6564PTAP motif 1
Motifi665 – 6684PTAP motif 2

Domaini

The coiled coil domains interact with the SB domain of TSG101 By similarity.
The PTAP motifs mediate the binding to UEV domains By similarity.

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri679 – 71436RING-typeAdd
BLAST

Keywords - Domaini

Coiled coil, Leucine-rich repeat, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG4886.
GeneTreeiENSGT00750000117546.
HOGENOMiHOG000231972.
HOVERGENiHBG052363.
InParanoidiQ80ZI6.
KOiK10641.
OMAiIFLNCGH.
OrthoDBiEOG77T149.
PhylomeDBiQ80ZI6.
TreeFamiTF329645.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
3.30.40.10. 1 hit.
InterProiIPR001611. Leu-rich_rpt.
IPR025875. Leu-rich_rpt_4.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR011510. SAM_2.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF12799. LRR_4. 2 hits.
PF07647. SAM_2. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
PROSITEiPS51450. LRR. 4 hits.
PS50105. SAM_DOMAIN. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80ZI6-1 [UniParc]FASTAAdd to Basket

« Hide

MPLFFRKRKP SEEARKRLEY QMCLAKEAGA DDILDISKCE LSEIPFGAFA    50
TCKVLQKKVL IVHTNHLTSL LPKSCSLLSL VTIKVLDLHE NQLTALPDDM 100
GQLTVLQVLN VERNQLTHLP RSIGNLLQLQ TLNVKDNKLK ELPDTLGELR 150
SLRTLDISEN EIQRLPQMLA HVRTLETLSL NALAMVYPPP EVCGAGTAAV 200
QQFLCKESGL DYYPPSQYLL PVLEQDGAEN TQDSPDGPAS RFSREEAEWQ 250
NRFSDYEKRK EQKMLEKLEF ERRLDLGQRE HAELLQQSHS HKDEILQTVK 300
QEQTRLEQDL SERQRCLDAE RQQLQEQLKQ TEQSIASRIQ RLLQDNQRQK 350
KSSEILKSLE NERIRMEQLM SITQEETENL RQREIAAAMQ QMLTESCKSR 400
LIQMAYESQR QSLAQQACSS MAEMDKRFQQ ILSWQQMDQN KAISQILQES 450
VMQKAAFEAL QVKKDLMHRQ IRNQIRLIET ELLQLTQLEL KRKSLDTETL 500
QEMVSEQRWA LSNLLQQLLK EKKQREEELH GILAELEAKS ETKQENYWLI 550
QYQRLLNQKP LSLKLQEEGM ERRLVALLVE LSAEHYLPLF AHHRISLDML 600
SRMSPGDLAK VGVSEAGLQH EILRRAQDLL AVPRVQPELK PLENEVLGAL 650
EPPTAPRELQ ESVRPSAPPA ELDMPTSECV VCLEREAQMV FLTCGHVCCC 700
QQCCQPLRTC PLCRQEISQR LRIYHSS 727
Length:727
Mass (Da):83,976
Last modified:June 1, 2003 - v1
Checksum:i561B6FE6F730ADAE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC049146 mRNA. Translation: AAH49146.1.
CCDSiCCDS15935.1.
RefSeqiNP_955006.1. NM_199302.2.
XP_006498032.1. XM_006497969.1.
XP_006498033.1. XM_006497970.1.
XP_006498034.1. XM_006497971.1.
XP_006498035.1. XM_006497972.1.
UniGeneiMm.248037.

Genome annotation databases

EnsembliENSMUST00000028132; ENSMUSP00000028132; ENSMUSG00000026792.
ENSMUST00000113200; ENSMUSP00000108825; ENSMUSG00000026792.
GeneIDi227738.
KEGGimmu:227738.
UCSCiuc008jhd.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC049146 mRNA. Translation: AAH49146.1 .
CCDSi CCDS15935.1.
RefSeqi NP_955006.1. NM_199302.2.
XP_006498032.1. XM_006497969.1.
XP_006498033.1. XM_006497970.1.
XP_006498034.1. XM_006497971.1.
XP_006498035.1. XM_006497972.1.
UniGenei Mm.248037.

3D structure databases

ProteinModelPortali Q80ZI6.
SMRi Q80ZI6. Positions 34-216, 679-724.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q80ZI6. 1 interaction.

PTM databases

PhosphoSitei Q80ZI6.

Proteomic databases

MaxQBi Q80ZI6.
PaxDbi Q80ZI6.
PRIDEi Q80ZI6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000028132 ; ENSMUSP00000028132 ; ENSMUSG00000026792 .
ENSMUST00000113200 ; ENSMUSP00000108825 ; ENSMUSG00000026792 .
GeneIDi 227738.
KEGGi mmu:227738.
UCSCi uc008jhd.2. mouse.

Organism-specific databases

CTDi 90678.
MGIi MGI:2684789. Lrsam1.

Phylogenomic databases

eggNOGi COG4886.
GeneTreei ENSGT00750000117546.
HOGENOMi HOG000231972.
HOVERGENi HBG052363.
InParanoidi Q80ZI6.
KOi K10641.
OMAi IFLNCGH.
OrthoDBi EOG77T149.
PhylomeDBi Q80ZI6.
TreeFami TF329645.

Enzyme and pathway databases

UniPathwayi UPA00143 .
Reactomei REACT_199115. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

NextBioi 378812.
PROi Q80ZI6.
SOURCEi Search...

Gene expression databases

Bgeei Q80ZI6.
Genevestigatori Q80ZI6.

Family and domain databases

Gene3Di 1.10.150.50. 1 hit.
3.30.40.10. 1 hit.
InterProi IPR001611. Leu-rich_rpt.
IPR025875. Leu-rich_rpt_4.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR011510. SAM_2.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF12799. LRR_4. 2 hits.
PF07647. SAM_2. 1 hit.
[Graphical view ]
SMARTi SM00184. RING. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view ]
SUPFAMi SSF47769. SSF47769. 1 hit.
PROSITEi PS51450. LRR. 4 hits.
PS50105. SAM_DOMAIN. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Olfactory epithelium.
  2. "Tal, a Tsg101-specific E3 ubiquitin ligase, regulates receptor endocytosis and retrovirus budding."
    Amit I., Yakir L., Katz M., Zwang Y., Marmor M.D., Citri A., Shtiegman K., Alroy I., Tuvia S., Reiss Y., Roubini E., Cohen M., Wides R., Bacharach E., Schubert U., Yarden Y.
    Genes Dev. 18:1737-1752(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiLRSM1_MOUSE
AccessioniPrimary (citable) accession number: Q80ZI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: June 1, 2003
Last modified: September 3, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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