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Q80ZI1

- TRNP1_MOUSE

UniProt

Q80ZI1 - TRNP1_MOUSE

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Protein

TMF-regulated nuclear protein 1

Gene

Trnp1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

DNA-binding factor that regulates the expression of a subset of genes and plays a key role in tangential, radial, and lateral expansion of the brain neocortex. Regulates neural stem cells proliferation and the production of intermediate neural progenitors and basal radial glial cells affecting the process of cerebral cortex gyrification. May control the proliferation rate of cells by regulating their progression through key cell-cycle transition points.2 Publications

GO - Molecular functioni

  1. DNA binding Source: UniProtKB

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cerebellar cortex morphogenesis Source: UniProtKB
  3. neural precursor cell proliferation Source: UniProtKB
  4. regulation of cell cycle Source: UniProtKB
  5. regulation of cell proliferation Source: UniProtKB
  6. regulation of transcription, DNA-templated Source: UniProtKB-KW
  7. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Cell cycle, Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
TMF-regulated nuclear protein 1
Gene namesi
Name:Trnp1
Synonyms:Trnp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1916789. Trnp1.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 223223TMF-regulated nuclear protein 1PRO_0000336089Add
BLAST

Post-translational modificationi

Ubiquitinated, leading to its degradation by the proteasome.1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

PRIDEiQ80ZI1.

PTM databases

PhosphoSiteiQ80ZI1.

Expressioni

Tissue specificityi

Expressed in brain and kidney (at protein level). Also detected in spleen and intestine.2 Publications

Developmental stagei

Expression is highly restricted to the phase of neurogenesis with high levels in all cells in the ventricular zone (VZ) at 10 dpc. Expression disappears at the end of neurogenesis (18 dpc). However, it remains present in a specific adult neurogenic region with the highest amplification and neuronal output, the subependymal zone of the lateral ventricle from where newborn neurons migrate to the olfactory bulb (at protein level).1 Publication

Gene expression databases

BgeeiQ80ZI1.
GenevestigatoriQ80ZI1.

Interactioni

Subunit structurei

Interacts with TMF1; may regulate TRNP1 proteasomal degradation.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000068322.

Structurei

3D structure databases

ProteinModelPortaliQ80ZI1.
SMRiQ80ZI1. Positions 92-170.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi20 – 5435Pro-richAdd
BLAST

Phylogenomic databases

eggNOGiNOG76098.
GeneTreeiENSGT00390000017418.
HOGENOMiHOG000154686.
InParanoidiQ80ZI1.
OMAiCVPWGAG.
OrthoDBiEOG7FZ024.
PhylomeDBiQ80ZI1.
TreeFamiTF338814.

Sequencei

Sequence statusi: Complete.

Q80ZI1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPGCRISACG PGAQEGTAEP GSPPPPPREP LPSLQPPSPS PTSTPTPTKS
60 70 80 90 100
PPLPEAAETP VEGQELQRWR QGASGGSGGA GPAGIAGAAA GAGGRALELA
110 120 130 140 150
EARRRLLEVE GRRRLVSELE SRVLQLHRVF LAAELRLAHR AESLSRLSGG
160 170 180 190 200
VAQAELYLAA HGSRLKKGAR RGRRGRPPAL LASALGLGSC VPWGAGRLRR
210 220
GQGPEPDSPF RRSPPRGPAS PQR
Length:223
Mass (Da):23,086
Last modified:June 1, 2003 - v1
Checksum:iF7BF3F085B025DDE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC049168 mRNA. Translation: AAH49168.1.
CCDSiCCDS38904.1.
RefSeqiNP_001074625.1. NM_001081156.2.
XP_006539218.1. XM_006539155.1.
UniGeneiMm.151594.

Genome annotation databases

EnsembliENSMUST00000125541; ENSMUSP00000129613; ENSMUSG00000056596.
GeneIDi69539.
KEGGimmu:69539.
UCSCiuc008vcu.1. mouse.

Cross-referencesi

Web resourcesi

Protein Spotlight

the geometry of intelligence - Issue 152 of August 2013

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC049168 mRNA. Translation: AAH49168.1 .
CCDSi CCDS38904.1.
RefSeqi NP_001074625.1. NM_001081156.2.
XP_006539218.1. XM_006539155.1.
UniGenei Mm.151594.

3D structure databases

ProteinModelPortali Q80ZI1.
SMRi Q80ZI1. Positions 92-170.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000068322.

PTM databases

PhosphoSitei Q80ZI1.

Proteomic databases

PRIDEi Q80ZI1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000125541 ; ENSMUSP00000129613 ; ENSMUSG00000056596 .
GeneIDi 69539.
KEGGi mmu:69539.
UCSCi uc008vcu.1. mouse.

Organism-specific databases

CTDi 388610.
MGIi MGI:1916789. Trnp1.

Phylogenomic databases

eggNOGi NOG76098.
GeneTreei ENSGT00390000017418.
HOGENOMi HOG000154686.
InParanoidi Q80ZI1.
OMAi CVPWGAG.
OrthoDBi EOG7FZ024.
PhylomeDBi Q80ZI1.
TreeFami TF338814.

Miscellaneous databases

ChiTaRSi TRNP1. mouse.
NextBioi 329712.
PROi Q80ZI1.
SOURCEi Search...

Gene expression databases

Bgeei Q80ZI1.
Genevestigatori Q80ZI1.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  2. "TRNP: a conserved mammalian gene encoding a nuclear protein that accelerates cell-cycle progression."
    Volpe M., Shpungin S., Barbi C., Abrham G., Malovani H., Wides R., Nir U.
    DNA Cell Biol. 25:331-339(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH TMF1, UBIQUITINATION, TISSUE SPECIFICITY.
  3. "Trnp1 regulates expansion and folding of the mammalian cerebral cortex by control of radial glial fate."
    Stahl R., Walcher T., De Juan Romero C., Pilz G.A., Cappello S., Irmler M., Sanz-Aquela J.M., Beckers J., Blum R., Borrell V., Goetz M.
    Cell 153:535-549(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN CEREBRAL CORTEX EXPANSION, DNA-BINDING, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiTRNP1_MOUSE
AccessioniPrimary (citable) accession number: Q80ZI1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

External Data

Dasty 3