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Protein

TMF-regulated nuclear protein 1

Gene

Trnp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

DNA-binding factor that regulates the expression of a subset of genes and plays a key role in tangential, radial, and lateral expansion of the brain neocortex. Regulates neural stem cells proliferation and the production of intermediate neural progenitors and basal radial glial cells affecting the process of cerebral cortex gyrification. May control the proliferation rate of cells by regulating their progression through key cell-cycle transition points.2 Publications

GO - Molecular functioni

  1. DNA binding Source: UniProtKB

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cerebellar cortex morphogenesis Source: UniProtKB
  3. neural precursor cell proliferation Source: UniProtKB
  4. regulation of cell cycle Source: UniProtKB
  5. regulation of cell proliferation Source: UniProtKB
  6. regulation of transcription, DNA-templated Source: UniProtKB-KW
  7. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Cell cycle, Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
TMF-regulated nuclear protein 1
Gene namesi
Name:Trnp1
Synonyms:Trnp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1916789. Trnp1.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 223223TMF-regulated nuclear protein 1PRO_0000336089Add
BLAST

Post-translational modificationi

Ubiquitinated, leading to its degradation by the proteasome.1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

PRIDEiQ80ZI1.

PTM databases

PhosphoSiteiQ80ZI1.

Expressioni

Tissue specificityi

Expressed in brain and kidney (at protein level). Also detected in spleen and intestine.2 Publications

Developmental stagei

Expression is highly restricted to the phase of neurogenesis with high levels in all cells in the ventricular zone (VZ) at 10 dpc. Expression disappears at the end of neurogenesis (18 dpc). However, it remains present in a specific adult neurogenic region with the highest amplification and neuronal output, the subependymal zone of the lateral ventricle from where newborn neurons migrate to the olfactory bulb (at protein level).1 Publication

Gene expression databases

BgeeiQ80ZI1.
GenevestigatoriQ80ZI1.

Interactioni

Subunit structurei

Interacts with TMF1; may regulate TRNP1 proteasomal degradation.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000068322.

Structurei

3D structure databases

ProteinModelPortaliQ80ZI1.
SMRiQ80ZI1. Positions 92-170.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi20 – 5435Pro-richAdd
BLAST

Phylogenomic databases

eggNOGiNOG76098.
GeneTreeiENSGT00390000017418.
HOGENOMiHOG000154686.
InParanoidiQ80ZI1.
OMAiCVPWGAG.
OrthoDBiEOG7FZ024.
PhylomeDBiQ80ZI1.
TreeFamiTF338814.

Sequencei

Sequence statusi: Complete.

Q80ZI1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGCRISACG PGAQEGTAEP GSPPPPPREP LPSLQPPSPS PTSTPTPTKS
60 70 80 90 100
PPLPEAAETP VEGQELQRWR QGASGGSGGA GPAGIAGAAA GAGGRALELA
110 120 130 140 150
EARRRLLEVE GRRRLVSELE SRVLQLHRVF LAAELRLAHR AESLSRLSGG
160 170 180 190 200
VAQAELYLAA HGSRLKKGAR RGRRGRPPAL LASALGLGSC VPWGAGRLRR
210 220
GQGPEPDSPF RRSPPRGPAS PQR
Length:223
Mass (Da):23,086
Last modified:June 1, 2003 - v1
Checksum:iF7BF3F085B025DDE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC049168 mRNA. Translation: AAH49168.1.
CCDSiCCDS38904.1.
RefSeqiNP_001074625.1. NM_001081156.2.
XP_006539218.1. XM_006539155.1.
UniGeneiMm.151594.

Genome annotation databases

EnsembliENSMUST00000125541; ENSMUSP00000129613; ENSMUSG00000056596.
GeneIDi69539.
KEGGimmu:69539.
UCSCiuc008vcu.1. mouse.

Cross-referencesi

Web resourcesi

Protein Spotlight

the geometry of intelligence - Issue 152 of August 2013

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC049168 mRNA. Translation: AAH49168.1.
CCDSiCCDS38904.1.
RefSeqiNP_001074625.1. NM_001081156.2.
XP_006539218.1. XM_006539155.1.
UniGeneiMm.151594.

3D structure databases

ProteinModelPortaliQ80ZI1.
SMRiQ80ZI1. Positions 92-170.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000068322.

PTM databases

PhosphoSiteiQ80ZI1.

Proteomic databases

PRIDEiQ80ZI1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000125541; ENSMUSP00000129613; ENSMUSG00000056596.
GeneIDi69539.
KEGGimmu:69539.
UCSCiuc008vcu.1. mouse.

Organism-specific databases

CTDi388610.
MGIiMGI:1916789. Trnp1.

Phylogenomic databases

eggNOGiNOG76098.
GeneTreeiENSGT00390000017418.
HOGENOMiHOG000154686.
InParanoidiQ80ZI1.
OMAiCVPWGAG.
OrthoDBiEOG7FZ024.
PhylomeDBiQ80ZI1.
TreeFamiTF338814.

Miscellaneous databases

ChiTaRSiTrnp1. mouse.
NextBioi329712.
PROiQ80ZI1.
SOURCEiSearch...

Gene expression databases

BgeeiQ80ZI1.
GenevestigatoriQ80ZI1.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  2. "TRNP: a conserved mammalian gene encoding a nuclear protein that accelerates cell-cycle progression."
    Volpe M., Shpungin S., Barbi C., Abrham G., Malovani H., Wides R., Nir U.
    DNA Cell Biol. 25:331-339(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH TMF1, UBIQUITINATION, TISSUE SPECIFICITY.
  3. "Trnp1 regulates expansion and folding of the mammalian cerebral cortex by control of radial glial fate."
    Stahl R., Walcher T., De Juan Romero C., Pilz G.A., Cappello S., Irmler M., Sanz-Aquela J.M., Beckers J., Blum R., Borrell V., Goetz M.
    Cell 153:535-549(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN CEREBRAL CORTEX EXPANSION, DNA-BINDING, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiTRNP1_MOUSE
AccessioniPrimary (citable) accession number: Q80ZI1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 1, 2003
Last modified: January 7, 2015
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.