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Q80ZI1

- TRNP1_MOUSE

UniProt

Q80ZI1 - TRNP1_MOUSE

Protein

TMF-regulated nuclear protein 1

Gene

Trnp1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    DNA-binding factor that regulates the expression of a subset of genes and plays a key role in tangential, radial, and lateral expansion of the brain neocortex. Regulates neural stem cells proliferation and the production of intermediate neural progenitors and basal radial glial cells affecting the process of cerebral cortex gyrification. May control the proliferation rate of cells by regulating their progression through key cell-cycle transition points.2 Publications

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB
    2. protein binding Source: UniProtKB

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cerebellar cortex morphogenesis Source: UniProtKB
    3. neural precursor cell proliferation Source: UniProtKB
    4. regulation of cell cycle Source: UniProtKB
    5. regulation of cell proliferation Source: UniProtKB
    6. regulation of transcription, DNA-templated Source: UniProtKB-KW
    7. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Cell cycle, Neurogenesis, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    TMF-regulated nuclear protein 1
    Gene namesi
    Name:Trnp1
    Synonyms:Trnp
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:1916789. Trnp1.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 223223TMF-regulated nuclear protein 1PRO_0000336089Add
    BLAST

    Post-translational modificationi

    Ubiquitinated, leading to its degradation by the proteasome.1 Publication

    Keywords - PTMi

    Ubl conjugation

    Proteomic databases

    PRIDEiQ80ZI1.

    PTM databases

    PhosphoSiteiQ80ZI1.

    Expressioni

    Tissue specificityi

    Expressed in brain and kidney (at protein level). Also detected in spleen and intestine.2 Publications

    Developmental stagei

    Expression is highly restricted to the phase of neurogenesis with high levels in all cells in the ventricular zone (VZ) at 10 dpc. Expression disappears at the end of neurogenesis (18 dpc). However, it remains present in a specific adult neurogenic region with the highest amplification and neuronal output, the subependymal zone of the lateral ventricle from where newborn neurons migrate to the olfactory bulb (at protein level).1 Publication

    Gene expression databases

    BgeeiQ80ZI1.
    GenevestigatoriQ80ZI1.

    Interactioni

    Subunit structurei

    Interacts with TMF1; may regulate TRNP1 proteasomal degradation.1 Publication

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000068322.

    Structurei

    3D structure databases

    ProteinModelPortaliQ80ZI1.
    SMRiQ80ZI1. Positions 92-170.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi20 – 5435Pro-richAdd
    BLAST

    Phylogenomic databases

    eggNOGiNOG76098.
    GeneTreeiENSGT00390000017418.
    HOGENOMiHOG000154686.
    InParanoidiQ80ZI1.
    OMAiCVPWGAG.
    OrthoDBiEOG7FZ024.
    PhylomeDBiQ80ZI1.
    TreeFamiTF338814.

    Sequencei

    Sequence statusi: Complete.

    Q80ZI1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPGCRISACG PGAQEGTAEP GSPPPPPREP LPSLQPPSPS PTSTPTPTKS    50
    PPLPEAAETP VEGQELQRWR QGASGGSGGA GPAGIAGAAA GAGGRALELA 100
    EARRRLLEVE GRRRLVSELE SRVLQLHRVF LAAELRLAHR AESLSRLSGG 150
    VAQAELYLAA HGSRLKKGAR RGRRGRPPAL LASALGLGSC VPWGAGRLRR 200
    GQGPEPDSPF RRSPPRGPAS PQR 223
    Length:223
    Mass (Da):23,086
    Last modified:June 1, 2003 - v1
    Checksum:iF7BF3F085B025DDE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC049168 mRNA. Translation: AAH49168.1.
    CCDSiCCDS38904.1.
    RefSeqiNP_001074625.1. NM_001081156.2.
    XP_006539218.1. XM_006539155.1.
    UniGeneiMm.151594.

    Genome annotation databases

    EnsembliENSMUST00000125541; ENSMUSP00000129613; ENSMUSG00000056596.
    GeneIDi69539.
    KEGGimmu:69539.
    UCSCiuc008vcu.1. mouse.

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    the geometry of intelligence - Issue 152 of August 2013

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC049168 mRNA. Translation: AAH49168.1 .
    CCDSi CCDS38904.1.
    RefSeqi NP_001074625.1. NM_001081156.2.
    XP_006539218.1. XM_006539155.1.
    UniGenei Mm.151594.

    3D structure databases

    ProteinModelPortali Q80ZI1.
    SMRi Q80ZI1. Positions 92-170.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000068322.

    PTM databases

    PhosphoSitei Q80ZI1.

    Proteomic databases

    PRIDEi Q80ZI1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000125541 ; ENSMUSP00000129613 ; ENSMUSG00000056596 .
    GeneIDi 69539.
    KEGGi mmu:69539.
    UCSCi uc008vcu.1. mouse.

    Organism-specific databases

    CTDi 388610.
    MGIi MGI:1916789. Trnp1.

    Phylogenomic databases

    eggNOGi NOG76098.
    GeneTreei ENSGT00390000017418.
    HOGENOMi HOG000154686.
    InParanoidi Q80ZI1.
    OMAi CVPWGAG.
    OrthoDBi EOG7FZ024.
    PhylomeDBi Q80ZI1.
    TreeFami TF338814.

    Miscellaneous databases

    ChiTaRSi TRNP1. mouse.
    NextBioi 329712.
    PROi Q80ZI1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q80ZI1.
    Genevestigatori Q80ZI1.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.
    2. "TRNP: a conserved mammalian gene encoding a nuclear protein that accelerates cell-cycle progression."
      Volpe M., Shpungin S., Barbi C., Abrham G., Malovani H., Wides R., Nir U.
      DNA Cell Biol. 25:331-339(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH TMF1, UBIQUITINATION, TISSUE SPECIFICITY.
    3. "Trnp1 regulates expansion and folding of the mammalian cerebral cortex by control of radial glial fate."
      Stahl R., Walcher T., De Juan Romero C., Pilz G.A., Cappello S., Irmler M., Sanz-Aquela J.M., Beckers J., Blum R., Borrell V., Goetz M.
      Cell 153:535-549(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN CEREBRAL CORTEX EXPANSION, DNA-BINDING, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiTRNP1_MOUSE
    AccessioniPrimary (citable) accession number: Q80ZI1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

    External Data

    Dasty 3