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Q80ZI1 (TRNP1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
TMF-regulated nuclear protein 1
Gene names
Name:Trnp1
Synonyms:Trnp
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length223 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

DNA-binding factor that regulates the expression of a subset of genes and plays a key role in tangential, radial, and lateral expansion of the brain neocortex. Regulates neural stem cells proliferation and the production of intermediate neural progenitors and basal radial glial cells affecting the process of cerebral cortex gyrification. May control the proliferation rate of cells by regulating their progression through key cell-cycle transition points. Ref.2 Ref.3

Subunit structure

Interacts with TMF1; may regulate TRNP1 proteasomal degradation. Ref.2

Subcellular location

Nucleus Ref.3.

Tissue specificity

Expressed in brain and kidney (at protein level). Also detected in spleen and intestine. Ref.2 Ref.3

Developmental stage

Expression is highly restricted to the phase of neurogenesis with high levels in all cells in the ventricular zone (VZ) at 10 dpc. Expression disappears at the end of neurogenesis (18 dpc). However, it remains present in a specific adult neurogenic region with the highest amplification and neuronal output, the subependymal zone of the lateral ventricle from where newborn neurons migrate to the olfactory bulb (at protein level). Ref.3

Post-translational modification

Ubiquitinated, leading to its degradation by the proteasome. Ref.2

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 223223TMF-regulated nuclear protein 1
PRO_0000336089

Regions

Compositional bias20 – 5435Pro-rich

Sequences

Sequence LengthMass (Da)Tools
Q80ZI1 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: F7BF3F085B025DDE

FASTA22323,086
        10         20         30         40         50         60 
MPGCRISACG PGAQEGTAEP GSPPPPPREP LPSLQPPSPS PTSTPTPTKS PPLPEAAETP 

        70         80         90        100        110        120 
VEGQELQRWR QGASGGSGGA GPAGIAGAAA GAGGRALELA EARRRLLEVE GRRRLVSELE 

       130        140        150        160        170        180 
SRVLQLHRVF LAAELRLAHR AESLSRLSGG VAQAELYLAA HGSRLKKGAR RGRRGRPPAL 

       190        200        210        220 
LASALGLGSC VPWGAGRLRR GQGPEPDSPF RRSPPRGPAS PQR 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye.
[2]"TRNP: a conserved mammalian gene encoding a nuclear protein that accelerates cell-cycle progression."
Volpe M., Shpungin S., Barbi C., Abrham G., Malovani H., Wides R., Nir U.
DNA Cell Biol. 25:331-339(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH TMF1, UBIQUITINATION, TISSUE SPECIFICITY.
[3]"Trnp1 regulates expansion and folding of the mammalian cerebral cortex by control of radial glial fate."
Stahl R., Walcher T., De Juan Romero C., Pilz G.A., Cappello S., Irmler M., Sanz-Aquela J.M., Beckers J., Blum R., Borrell V., Goetz M.
Cell 153:535-549(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION IN CEREBRAL CORTEX EXPANSION, DNA-BINDING, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
+Additional computationally mapped references.

Web resources

Protein Spotlight

the geometry of intelligence - Issue 152 of August 2013

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC049168 mRNA. Translation: AAH49168.1.
CCDSCCDS38904.1.
RefSeqNP_001074625.1. NM_001081156.2.
XP_006539218.1. XM_006539155.1.
UniGeneMm.151594.

3D structure databases

ProteinModelPortalQ80ZI1.
SMRQ80ZI1. Positions 92-170.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000068322.

PTM databases

PhosphoSiteQ80ZI1.

Proteomic databases

PRIDEQ80ZI1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000125541; ENSMUSP00000129613; ENSMUSG00000056596.
GeneID69539.
KEGGmmu:69539.
UCSCuc008vcu.1. mouse.

Organism-specific databases

CTD388610.
MGIMGI:1916789. Trnp1.

Phylogenomic databases

eggNOGNOG76098.
GeneTreeENSGT00390000017418.
HOGENOMHOG000154686.
InParanoidQ80ZI1.
OMACVPWGAG.
OrthoDBEOG7FZ024.
PhylomeDBQ80ZI1.
TreeFamTF338814.

Gene expression databases

BgeeQ80ZI1.
GenevestigatorQ80ZI1.

Family and domain databases

ProtoNetSearch...

Other

ChiTaRSTRNP1. mouse.
NextBio329712.
PROQ80ZI1.
SOURCESearch...

Entry information

Entry nameTRNP1_MOUSE
AccessionPrimary (citable) accession number: Q80ZI1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 1, 2003
Last modified: July 9, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot