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Protein

DNA ligase

Gene

Lig3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported
Biological processDNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-110381 Resolution of AP sites via the single-nucleotide replacement pathway
R-MMU-5649702 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
R-MMU-5685939 HDR through MMEJ (alt-NHEJ)
R-MMU-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
Name:Lig3Imported
ORF Names:mCG_8187Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:109152 Lig3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSMUSG00000020697

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini94 – 186PARP-typeInterPro annotationAdd BLAST93
Domaini585 – 719DNA_LIGASE_A3InterPro annotationAdd BLAST135
Domaini936 – 1012BRCTInterPro annotationAdd BLAST77

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG4437 Eukaryota
COG1793 LUCA
GeneTreeiENSGT00860000133792
HOGENOMiHOG000007653
HOVERGENiHBG005515
KOiK10776
TreeFamiTF316220

Family and domain databases

CDDicd00027 BRCT, 1 hit
Gene3Di1.10.3260.10, 1 hit
3.30.1740.10, 1 hit
3.40.50.10190, 1 hit
InterProiView protein in InterPro
IPR001357 BRCT_dom
IPR036420 BRCT_dom_sf
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR031916 LIG3_BRCT
IPR012340 NA-bd_OB-fold
IPR001510 Znf_PARP
IPR036957 Znf_PARP_sf
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
PF16759 LIG3_BRCT, 1 hit
PF00645 zf-PARP, 1 hit
SMARTiView protein in SMART
SM00292 BRCT, 1 hit
SM01336 zf-PARP, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
SSF52113 SSF52113, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS50172 BRCT, 1 hit
PS00697 DNA_LIGASE_A1, 1 hit
PS00333 DNA_LIGASE_A2, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit
PS00347 PARP_ZN_FINGER_1, 1 hit
PS50064 PARP_ZN_FINGER_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q80ZH7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLAFKILFP RNLCALGRKE LCLFPEQNRW AAISQFSQWS ETNLLGGCCL
60 70 80 90 100
LQRRKPVLAL QRGHLRPRAT HLTFWPGSHV GLCTGPCAMA EQRFCVDYAK
110 120 130 140 150
RGTAGCKKCK EKIVKGVCRI GKVVPNPFSE SGGDMKEWYH IKCMFEKLER
160 170 180 190 200
ARATTKKIED LTELEGWEEL EDNEKEQISQ HIADLSSKAA ATPKKKAAVQ
210 220 230 240 250
AKLTTTGQVT SPVKGASFIT STNPRKFSGF SAAKPNNSEQ APSSPAPGTS
260 270 280 290 300
LSASKCDPKH KDCLLREFRK LCAMVAENPS YNTKTQIIHD FLQKGSTGDG
310 320 330 340 350
FHGDVYLTVK LLLPGVIKSV YNLNDKQIVK LFSRIFNCNP DDMARDLEQG
360 370 380 390 400
DVSETIRIFF EQSKSFPPAA KSLLTIQEVD AFLLHLSKLT KEDEQQQALQ
410 420 430 440 450
DIASRCTAND LKCIIRLIKH DLKMNSGAKH VLDALDPNAY EAFKASRNLQ
460 470 480 490 500
DVVERVLHNE QEVEKDPGRR RALRVQASLM TPVQPMLAEA CKSIEYAMKK
510 520 530 540 550
CPNGMFSEIK YDGERVQVHK KGDHFSYFSR SLKPVLPHKV AHFKDYIPKA
560 570 580 590 600
FPGGQSMILD SEVLLIDNNT GKPLPFGTLG VHKKAAFQDA NVCLFVFDCI
610 620 630 640 650
YFNDVSLMDR PLCERRKFLH DNMVEIRNRI MFSEMKQVTK ASDLADMINR
660 670 680 690 700
VIREGLEGLV LKDVKGTYEP GKRHWLKVKK DYLNEGAMAD TADLVVLGAF
710 720 730 740 750
YGQGSKGGMM SIFLMGCYDP DSQKWCTVTK CAGGHDDATL ARLQKELVMV
760 770 780 790 800
KISKDPSKIP SWLKINKIYY PDFIVPDPKK AAVWEITGAE FSRSEAHTAD
810 820 830 840 850
GISIRFPRCT RIRDDKDWKS ATNLPQLKEL YQLSKDKADF AVVAGDEASP
860 870 880 890 900
TTGGSSGENE GTAGSAGPCK GPPSKSSASA KTTEQKLNSP SSRGGIKPIP
910 920 930 940 950
KHSPMKPGEK LAVKSSPVKV GMKRKATDET PCLKKVLLDV FTGVRLYLPP
960 970 980 990 1000
STPDFKRLKR YFVAFDGDLV QEFDMGSATH VLGNREKNTD AQLVSSEWIW
1010
ACIRKRRLIA PC
Length:1,012
Mass (Da):112,781
Last modified:June 1, 2003 - v1
Checksum:i189B786E0092A504
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL645594 Genomic DNA No translation available.
BC049240 mRNA Translation: AAH49240.1
AK143531 mRNA Translation: BAE25421.1
CH466556 Genomic DNA Translation: EDL15669.1
RefSeqiNP_001278174.1, NM_001291245.1
NP_001278175.1, NM_001291246.1
NP_001278176.1, NM_001291247.1
NP_034846.2, NM_010716.3
XP_006532413.1, XM_006532350.3
UniGeneiMm.277136

Genome annotation databases

EnsembliENSMUST00000092849; ENSMUSP00000090525; ENSMUSG00000020697
ENSMUST00000173722; ENSMUSP00000133805; ENSMUSG00000020697
GeneIDi16882
KEGGimmu:16882
UCSCiuc007kna.2 mouse

Similar proteinsi

Entry informationi

Entry nameiQ80ZH7_MOUSE
AccessioniPrimary (citable) accession number: Q80ZH7
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: June 20, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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