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Protein

DNA ligase

Gene

Lig3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported
Biological processDNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-110381. Resolution of AP sites via the single-nucleotide replacement pathway.
R-MMU-5649702. APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway.
R-MMU-5685939. HDR through MMEJ (alt-NHEJ).
R-MMU-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
Name:Lig3Imported
ORF Names:mCG_8187Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:109152. Lig3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSMUSG00000020697.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini94 – 186PARP-typeInterPro annotationAdd BLAST93
Domaini585 – 719DNA_LIGASE_A3InterPro annotationAdd BLAST135
Domaini936 – 1012BRCTInterPro annotationAdd BLAST77

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG4437. Eukaryota.
COG1793. LUCA.
GeneTreeiENSGT00860000133792.
HOGENOMiHOG000007653.
HOVERGENiHBG005515.
KOiK10776.
TreeFamiTF316220.

Family and domain databases

CDDicd00027. BRCT. 1 hit.
Gene3Di1.10.3260.10. 1 hit.
3.30.1740.10. 1 hit.
3.40.50.10190. 1 hit.
InterProiView protein in InterPro
IPR001357. BRCT_dom.
IPR036420. BRCT_dom_sf.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR036599. DNA_ligase_N_sf.
IPR031916. LIG3_BRCT.
IPR012340. NA-bd_OB-fold.
IPR001510. Znf_PARP.
IPR036957. Znf_PARP_sf.
PfamiView protein in Pfam
PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
PF16759. LIG3_BRCT. 1 hit.
PF00645. zf-PARP. 1 hit.
SMARTiView protein in SMART
SM00292. BRCT. 1 hit.
SM01336. zf-PARP. 1 hit.
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF52113. SSF52113. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiView protein in PROSITE
PS50172. BRCT. 1 hit.
PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
PS00347. PARP_ZN_FINGER_1. 1 hit.
PS50064. PARP_ZN_FINGER_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q80ZH7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLAFKILFP RNLCALGRKE LCLFPEQNRW AAISQFSQWS ETNLLGGCCL
60 70 80 90 100
LQRRKPVLAL QRGHLRPRAT HLTFWPGSHV GLCTGPCAMA EQRFCVDYAK
110 120 130 140 150
RGTAGCKKCK EKIVKGVCRI GKVVPNPFSE SGGDMKEWYH IKCMFEKLER
160 170 180 190 200
ARATTKKIED LTELEGWEEL EDNEKEQISQ HIADLSSKAA ATPKKKAAVQ
210 220 230 240 250
AKLTTTGQVT SPVKGASFIT STNPRKFSGF SAAKPNNSEQ APSSPAPGTS
260 270 280 290 300
LSASKCDPKH KDCLLREFRK LCAMVAENPS YNTKTQIIHD FLQKGSTGDG
310 320 330 340 350
FHGDVYLTVK LLLPGVIKSV YNLNDKQIVK LFSRIFNCNP DDMARDLEQG
360 370 380 390 400
DVSETIRIFF EQSKSFPPAA KSLLTIQEVD AFLLHLSKLT KEDEQQQALQ
410 420 430 440 450
DIASRCTAND LKCIIRLIKH DLKMNSGAKH VLDALDPNAY EAFKASRNLQ
460 470 480 490 500
DVVERVLHNE QEVEKDPGRR RALRVQASLM TPVQPMLAEA CKSIEYAMKK
510 520 530 540 550
CPNGMFSEIK YDGERVQVHK KGDHFSYFSR SLKPVLPHKV AHFKDYIPKA
560 570 580 590 600
FPGGQSMILD SEVLLIDNNT GKPLPFGTLG VHKKAAFQDA NVCLFVFDCI
610 620 630 640 650
YFNDVSLMDR PLCERRKFLH DNMVEIRNRI MFSEMKQVTK ASDLADMINR
660 670 680 690 700
VIREGLEGLV LKDVKGTYEP GKRHWLKVKK DYLNEGAMAD TADLVVLGAF
710 720 730 740 750
YGQGSKGGMM SIFLMGCYDP DSQKWCTVTK CAGGHDDATL ARLQKELVMV
760 770 780 790 800
KISKDPSKIP SWLKINKIYY PDFIVPDPKK AAVWEITGAE FSRSEAHTAD
810 820 830 840 850
GISIRFPRCT RIRDDKDWKS ATNLPQLKEL YQLSKDKADF AVVAGDEASP
860 870 880 890 900
TTGGSSGENE GTAGSAGPCK GPPSKSSASA KTTEQKLNSP SSRGGIKPIP
910 920 930 940 950
KHSPMKPGEK LAVKSSPVKV GMKRKATDET PCLKKVLLDV FTGVRLYLPP
960 970 980 990 1000
STPDFKRLKR YFVAFDGDLV QEFDMGSATH VLGNREKNTD AQLVSSEWIW
1010
ACIRKRRLIA PC
Length:1,012
Mass (Da):112,781
Last modified:June 1, 2003 - v1
Checksum:i189B786E0092A504
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL645594 Genomic DNA. No translation available.
BC049240 mRNA. Translation: AAH49240.1.
AK143531 mRNA. Translation: BAE25421.1.
CH466556 Genomic DNA. Translation: EDL15669.1.
RefSeqiNP_001278174.1. NM_001291245.1.
NP_001278175.1. NM_001291246.1.
NP_001278176.1. NM_001291247.1.
NP_034846.2. NM_010716.3.
XP_006532413.1. XM_006532350.3.
UniGeneiMm.277136.

Genome annotation databases

EnsembliENSMUST00000092849; ENSMUSP00000090525; ENSMUSG00000020697.
ENSMUST00000173722; ENSMUSP00000133805; ENSMUSG00000020697.
GeneIDi16882.
KEGGimmu:16882.
UCSCiuc007kna.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiQ80ZH7_MOUSE
AccessioniPrimary (citable) accession number: Q80ZH7
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: November 22, 2017
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported