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Protein

Bcl-2-binding component 3

Gene

Bbc3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis. Functions by promoting partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53 (By similarity). Essential for ER stress-induced cell death (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Bcl-2-binding component 3
Alternative name(s):
p53 up-regulated modulator of apoptosis
Gene namesi
Name:Bbc3
Synonyms:Puma
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi631434. Bbc3.

Subcellular locationi

  • Mitochondrion

  • Note: Localized to the mitochondria in order to induce cytochrome c release.By similarity

GO - Cellular componenti

  • mitochondrion Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 193193Bcl-2-binding component 3PRO_0000143085Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei10 – 101PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ80ZG6.

PTM databases

PhosphoSiteiQ80ZG6.

Expressioni

Inductioni

By DNA damage, glucocorticoid treatment, growth factor deprivation and p53.By similarity

Interactioni

Subunit structurei

Interacts with BCL2, BCL2L1/BCL-XL, MCL1 and BCL2A1 (By similarity). Interacts (via BH3 domain) with NOL3 (via CARD domain); preventing the association of BBC3 with BCL2 and resulting in activation of CASP8.By similarity1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ80ZG6.
SMRiQ80ZG6. Positions 130-155.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi137 – 15115BH3Add
BLAST

Domaini

The BH3 motif is intrinsically disordered.By similarity

Sequence similaritiesi

Belongs to the Bcl-2 family.Curated

Phylogenomic databases

HOVERGENiHBG050671.
InParanoidiQ80ZG6.
KOiK10132.
PhylomeDBiQ80ZG6.

Family and domain databases

InterProiIPR031661. Bbc3.
[Graphical view]
PANTHERiPTHR28639. PTHR28639. 1 hit.
PfamiPF15826. PUMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80ZG6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARARQEGSS PEPVEGLARD SPRPFPLGRL MPSAVSCGLC EPGLPAAPAA
60 70 80 90 100
PALLPAAYLC APTAPPAVTA ALGGPRWPGG HRSRPRGPRP DGPQPSLSPA
110 120 130 140 150
QQHLESPVPS APEALAGGPT QAAPGVRVEE EEWAREIGAQ LRRMADDLNA
160 170 180 190
QYERRRQEEQ HRHRPSPWRV MYNLFMGLLP LPRDPGAPEM EPN
Length:193
Mass (Da):20,718
Last modified:June 1, 2003 - v1
Checksum:i39B5994F66065372
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY157758 mRNA. Translation: AAO16862.1.
RefSeqiNP_776209.1. NM_173837.2.
UniGeneiRn.25176.

Genome annotation databases

GeneIDi317673.
KEGGirno:317673.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY157758 mRNA. Translation: AAO16862.1.
RefSeqiNP_776209.1. NM_173837.2.
UniGeneiRn.25176.

3D structure databases

ProteinModelPortaliQ80ZG6.
SMRiQ80ZG6. Positions 130-155.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ80ZG6.

Proteomic databases

PaxDbiQ80ZG6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi317673.
KEGGirno:317673.

Organism-specific databases

CTDi27113.
RGDi631434. Bbc3.

Phylogenomic databases

HOVERGENiHBG050671.
InParanoidiQ80ZG6.
KOiK10132.
PhylomeDBiQ80ZG6.

Miscellaneous databases

PROiQ80ZG6.

Family and domain databases

InterProiIPR031661. Bbc3.
[Graphical view]
PANTHERiPTHR28639. PTHR28639. 1 hit.
PfamiPF15826. PUMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBBC3_RAT
AccessioniPrimary (citable) accession number: Q80ZG6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: June 1, 2003
Last modified: July 6, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.