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Protein

Pre-mRNA-splicing factor SLU7

Gene

Slu7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri118 – 135CCHC-typeAdd BLAST18

GO - Molecular functioni

  • pre-mRNA 3'-splice site binding Source: HGNC
  • second spliceosomal transesterification activity Source: HGNC
  • zinc ion binding Source: HGNC

GO - Biological processi

  • alternative mRNA splicing, via spliceosome Source: HGNC
  • cellular response to heat Source: UniProtKB
  • intracellular protein transport Source: UniProtKB
  • mRNA 3'-splice site recognition Source: HGNC
  • RNA splicing, via transesterification reactions Source: HGNC

Keywordsi

Biological processmRNA processing, mRNA splicing
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-109688. Cleavage of Growing Transcript in the Termination Region.
R-RNO-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-RNO-72187. mRNA 3'-end processing.

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-mRNA-splicing factor SLU7
Gene namesi
Name:Slu7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi631432. Slu7.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002891972 – 586Pre-mRNA-splicing factor SLU7Add BLAST585

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei215PhosphoserineCombined sources1
Modified residuei227PhosphoserineBy similarity1
Modified residuei235PhosphoserineCombined sources1
Cross-linki349Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki408Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ80ZG5.
PRIDEiQ80ZG5.

PTM databases

iPTMnetiQ80ZG5.
PhosphoSitePlusiQ80ZG5.

Expressioni

Gene expression databases

BgeeiENSRNOG00000003822.
ExpressionAtlasiQ80ZG5. baseline and differential.
GenevisibleiQ80ZG5. RN.

Interactioni

Subunit structurei

Component of late spliceosomal complexes. Associates with the spliceosome prior to recognition of the 3'-splice site for step II, probably during catalysis of step I (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005132.

Structurei

3D structure databases

SMRiQ80ZG5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi129 – 169Bipartite nuclear localization signalBy similarityAdd BLAST41

Domaini

The CCHC-type zinc finger is required to retain the protein within the nucleus and prevent its shuttle back to the cytoplasm via the CRM1 pathway.By similarity

Sequence similaritiesi

Belongs to the SLU7 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri118 – 135CCHC-typeAdd BLAST18

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2560. Eukaryota.
ENOG410XPPP. LUCA.
GeneTreeiENSGT00390000002292.
HOGENOMiHOG000194391.
HOVERGENiHBG053287.
InParanoidiQ80ZG5.
KOiK12819.
OMAiKPQTLME.
OrthoDBiEOG091G05PK.
PhylomeDBiQ80ZG5.
TreeFamiTF105691.

Family and domain databases

Gene3Di4.10.60.10. 1 hit.
InterProiView protein in InterPro
IPR021715. Slu7.
IPR036875. Znf_CCHC_sf.
PfamiView protein in Pfam
PF11708. Slu7. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q80ZG5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAAAVDPVS ATPMTGSKEM NLEEPKKMTR EDWRKKKELE EQRKLGNAPA
60 70 80 90 100
EVDEEGKDIN PHIPQYISSV PWYIDPSKRP TLKHQRPQPE KQKQFSSSGE
110 120 130 140 150
WYKRGVKENS ITTKYRKGAC ENCGAMTHKR KDCFERPRRV GAKFTGTNIA
160 170 180 190 200
PDEHIQPQLM FDYDGKRDRW NGYNPEEHMK IVEEYAKVDL AKRTLKAQKL
210 220 230 240 250
QEELASGKLV EQANSPKHQW GEEEPNSQME KDHNSEDEDE DKYADDIDMP
260 270 280 290 300
GQNFDSKRRI TVRNLRIRED IAKYLRNLDP NSAYYDPKTR AMRENPYANA
310 320 330 340 350
GKNPDEVSYA GDNFVRYTGD TISMAQTQLF AWEAYDKGSE VHLQADPTKL
360 370 380 390 400
ELLYKSFKVK KEDFKEQQKE SILEKYGGQE HLDAPPAELL LAQTEDYVEY
410 420 430 440 450
SRHGTVIKGQ ERAVACSKYE EDVKINNHTH IWGSYWKEGR WGYKCCHSFF
460 470 480 490 500
KYSYCTGEAG KESVNSEECI INDATGEEPV KKPQTLMELH QEKLKEEKKK
510 520 530 540 550
KKKKKKHRKS SSDSDDDEER KQEKLKKALN AEEARLLHVK EIMQVDERKR
560 570 580
PYNSIYETRE PTEEEMEAYR MKRQRPDDPM ASFLGQ
Length:586
Mass (Da):68,337
Last modified:May 29, 2007 - v2
Checksum:iDBDBFBCDE5DC571A
GO

Sequence cautioni

The sequence AAO17154 differs from that shown. Many sequencing errors.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY207315 mRNA. Translation: AAO17154.2. Sequence problems.
AABR03074285 Genomic DNA. No translation available.
AABR03076495 Genomic DNA. No translation available.
BC062243 mRNA. Translation: AAH62243.1. Different termination.
RefSeqiNP_001094020.1. NM_001100550.1.
XP_008765864.1. XM_008767642.2.
UniGeneiRn.137183.

Genome annotation databases

EnsembliENSRNOT00000005132; ENSRNOP00000005132; ENSRNOG00000003822.
GeneIDi303057.
KEGGirno:303057.
UCSCiRGD:631432. rat.

Similar proteinsi

Entry informationi

Entry nameiSLU7_RAT
AccessioniPrimary (citable) accession number: Q80ZG5
Secondary accession number(s): Q6P6G1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: November 22, 2017
This is version 102 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families