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Protein

Synembryn-B

Gene

Ric8b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP. Able to potentiate G(olf)-alpha-dependent cAMP accumulation suggesting that it may be an important component for odorant signal transduction (Probable).Curated

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Names & Taxonomyi

Protein namesi
Recommended name:
Synembryn-B
Alternative name(s):
Protein Ric-8B
Gene namesi
Name:Ric8b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi631419. Ric8b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 520520Synembryn-BPRO_0000235901Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei468 – 4681PhosphoserineCombined sources
Modified residuei473 – 4731PhosphothreonineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ80ZG0.
PRIDEiQ80ZG0.

PTM databases

iPTMnetiQ80ZG0.

Expressioni

Gene expression databases

ExpressionAtlasiQ80ZG0. baseline.

Interactioni

Subunit structurei

Interacts with GDP-bound G alpha proteins GNAI1, GNAL, GNAS and GNAQ. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma.1 Publication

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009625.

Family & Domainsi

Sequence similaritiesi

Belongs to the synembryn family.Curated

Phylogenomic databases

eggNOGiKOG4464. Eukaryota.
ENOG410XSCJ. LUCA.
GeneTreeiENSGT00390000014700.
HOGENOMiHOG000236345.
HOVERGENiHBG054867.
InParanoidiQ80ZG0.
OMAiYKSAKPN.
OrthoDBiEOG72JWG4.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR019318. Gua_nucleotide_exch_fac_Ric8.
IPR008376. Synembryn.
[Graphical view]
PfamiPF10165. Ric8. 1 hit.
[Graphical view]
PRINTSiPR01802. SYNEMBRYN.
SUPFAMiSSF48371. SSF48371. 2 hits.

Sequencei

Sequence statusi: Complete.

Q80ZG0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEERALYIV RAGEAGAIER VLRDYSDKHR ATFKFESADE DKRKKLCEGI
60 70 80 90 100
FKVLVKGVPT TCQVPCLEVL RILSRDKKIL APVTTEENMQ ILLRLAKLHE
110 120 130 140 150
SDDSLEKVSE FPVIVESLKC LCNIVFNSQV AQQLSLELNL AAKLCNLLRK
160 170 180 190 200
CKDRKFINDI KCFDLRLLFV LSLLHTDIRS QLRYELQGLP LLTQILESAF
210 220 230 240 250
SIKWTDEYES AIDHSGPPLS PQETDCAIEA LKALFNVTVD SWKVHKESDS
260 270 280 290 300
HQFRVMAAVL RHCLLIVGPT EDKTEELHSN AVNLLSNVPV SCLDVLICPL
310 320 330 340 350
THEETAQEAA TLDELPGDKT AEKDTALKSS AMVYNGMNME AIHVLLSFME
360 370 380 390 400
KRIDKGSSYR EGLTPVLSLL TECSRAHRNI RKFLKDQVLP PLRDVTNRPE
410 420 430 440 450
VGSTVRNKLV RLMTHVDLGV KQIAAEFLFV LCKERVDSLL KYTGYGNAAG
460 470 480 490 500
LLAARGLLAG GRGDNWYSED EDTDTEEYKN AKPKEELLKP MGLKPDGTIT
510 520
PLEEALSQYS VIEETSSDTD
Length:520
Mass (Da):58,390
Last modified:June 1, 2003 - v1
Checksum:i9A0166AD61385DA0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY177755 mRNA. Translation: AAO23337.1.
RefSeqiNP_783188.1. NM_175598.2.
UniGeneiRn.214039.

Genome annotation databases

EnsembliENSRNOT00000009625; ENSRNOP00000009625; ENSRNOG00000007323.
GeneIDi314681.
KEGGirno:314681.
UCSCiRGD:631419. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY177755 mRNA. Translation: AAO23337.1.
RefSeqiNP_783188.1. NM_175598.2.
UniGeneiRn.214039.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009625.

PTM databases

iPTMnetiQ80ZG0.

Proteomic databases

PaxDbiQ80ZG0.
PRIDEiQ80ZG0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000009625; ENSRNOP00000009625; ENSRNOG00000007323.
GeneIDi314681.
KEGGirno:314681.
UCSCiRGD:631419. rat.

Organism-specific databases

CTDi55188.
RGDi631419. Ric8b.

Phylogenomic databases

eggNOGiKOG4464. Eukaryota.
ENOG410XSCJ. LUCA.
GeneTreeiENSGT00390000014700.
HOGENOMiHOG000236345.
HOVERGENiHBG054867.
InParanoidiQ80ZG0.
OMAiYKSAKPN.
OrthoDBiEOG72JWG4.

Miscellaneous databases

PROiQ80ZG0.

Gene expression databases

ExpressionAtlasiQ80ZG0. baseline.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR019318. Gua_nucleotide_exch_fac_Ric8.
IPR008376. Synembryn.
[Graphical view]
PfamiPF10165. Ric8. 1 hit.
[Graphical view]
PRINTSiPR01802. SYNEMBRYN.
SUPFAMiSSF48371. SSF48371. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor."
    Tall G.G., Krumins A.M., Gilman A.G.
    J. Biol. Chem. 278:8356-8362(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH GNAI1; GNAS AND GNAQ.
    Strain: Sprague-Dawley.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-468 AND THR-473, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRIC8B_RAT
AccessioniPrimary (citable) accession number: Q80ZG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: June 1, 2003
Last modified: June 8, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.