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Q80ZF8 (BAI3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Brain-specific angiogenesis inhibitor 3
Gene names
Name:Bai3
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length1522 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Might be involved in angiogenesis inhibition and suppression of glioblastoma By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.

Contains 1 CUB domain.

Contains 1 GPS domain.

Contains 4 TSP type-1 domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 15221497Brain-specific angiogenesis inhibitor 3
PRO_0000012866

Regions

Topological domain26 – 880855Extracellular Potential
Transmembrane881 – 90121Helical; Name=1; Potential
Topological domain902 – 9109Cytoplasmic Potential
Transmembrane911 – 93121Helical; Name=2; Potential
Topological domain932 – 9398Extracellular Potential
Transmembrane940 – 96021Helical; Name=3; Potential
Topological domain961 – 98121Cytoplasmic Potential
Transmembrane982 – 100221Helical; Name=4; Potential
Topological domain1003 – 102321Extracellular Potential
Transmembrane1024 – 104421Helical; Name=5; Potential
Topological domain1045 – 109854Cytoplasmic Potential
Transmembrane1099 – 111921Helical; Name=6; Potential
Topological domain1120 – 11256Extracellular Potential
Transmembrane1126 – 114621Helical; Name=7; Potential
Topological domain1147 – 1522376Cytoplasmic Potential
Domain30 – 159130CUB
Domain291 – 34353TSP type-1 1
Domain345 – 39854TSP type-1 2
Domain400 – 45354TSP type-1 3
Domain455 – 50854TSP type-1 4
Domain816 – 86853GPS

Amino acid modifications

Modified residue6191Phosphoserine By similarity
Modified residue12201Phosphoserine Ref.2
Modified residue14111Phosphoserine Ref.2
Glycosylation511N-linked (GlcNAc...) Potential
Glycosylation541N-linked (GlcNAc...) Potential
Glycosylation821N-linked (GlcNAc...) Potential
Glycosylation1051N-linked (GlcNAc...) Potential
Glycosylation2411N-linked (GlcNAc...) Potential
Glycosylation3371N-linked (GlcNAc...) Potential
Glycosylation4181N-linked (GlcNAc...) Potential
Glycosylation5401N-linked (GlcNAc...) Potential
Glycosylation6251N-linked (GlcNAc...) Potential
Glycosylation7791N-linked (GlcNAc...) Potential
Glycosylation8121N-linked (GlcNAc...) Potential
Glycosylation8281N-linked (GlcNAc...) Potential
Glycosylation9371N-linked (GlcNAc...) Potential
Disulfide bond303 ↔ 336 By similarity
Disulfide bond307 ↔ 342 By similarity
Disulfide bond318 ↔ 326 By similarity
Disulfide bond357 ↔ 392 By similarity
Disulfide bond361 ↔ 397 By similarity
Disulfide bond372 ↔ 382 By similarity
Disulfide bond412 ↔ 447 By similarity
Disulfide bond416 ↔ 452 By similarity
Disulfide bond427 ↔ 437 By similarity
Disulfide bond467 ↔ 502 By similarity
Disulfide bond471 ↔ 507 By similarity
Disulfide bond482 ↔ 492 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q80ZF8 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 5E18196D6043C2F4

FASTA1,522171,340
        10         20         30         40         50         60 
MKAVRNLLIY IFSTYLLVMF GFNAAQDFWC STLVKGVIYG SYSVSEMFPK NFTNCTWTLE 

        70         80         90        100        110        120 
NPDPTKYSIY LKFSKKDLSC SNFSLLAYQF DHFSHEKIKD LLRKNHSIMQ LCSSKNAFVF 

       130        140        150        160        170        180 
LQYDKNFIQI RRVFPTDFPG LQKKVEEDQK SFFEFLVLNK VSPSQFGCHV LCTWLESCLK 

       190        200        210        220        230        240 
SENGRTESCG IMYTKCTCPQ HLGEWGIDDQ SLVLVNNVVL PLNEQTEGCL TQELQTTQVC 

       250        260        270        280        290        300 
NLTREAKRPP KEEFGMMGDH TIKSQRPRSV HEKRVPQEQA DAAKFMAQTG ESGVEEWSQW 

       310        320        330        340        350        360 
SACSVTCGQG SQVRTRTCVS PYGTHCSGPL RESRVCNNTA LCPVHGVWEE WSPWSLCSFT 

       370        380        390        400        410        420 
CGRGQRTRTR SCTPPQYGGR PCEGPETHHK PCNIALCPVD GQWQEWSSWS HCSVTCSNGT 

       430        440        450        460        470        480 
QQRSRQCTAA AHGGSECRGP WAESRECYNP ECTANGQWNQ WGHWSGCSKS CDGGWERRMR 

       490        500        510        520        530        540 
TCQGAAVTGQ QCEGTGEEVR RCSEQRCPAP YEICPEDYLI SMVWKRTPAG DLAFNQCPLN 

       550        560        570        580        590        600 
ATGTTSRRCS LSLHGVASWE QPSFARCISN EYRHLQHSIK EHLAKGQRML AGDGMSQVTK 

       610        620        630        640        650        660 
TLLDLTQRKN FYAGDLLVSV EILRNVTDTF KRASYIPASD GVQNFFQIVS NLLDEENKEK 

       670        680        690        700        710        720 
WEDAQQIYPG SIELMQVIED FIYIVGMGMM DFQNSYLMTG NVVASIQKLP AASVLTDINF 

       730        740        750        760        770        780 
PMKGRKGMVD WARNSEDRVV IPKSIFTPVS SKELDESSVF VLGAVLYKNL DLILPTLRNY 

       790        800        810        820        830        840 
TVINSKVIVV TIRPEPKTTD SFLEIELAHL ANGTLNPYCV LWDDSKSNES LGTWSTQGCK 

       850        860        870        880        890        900 
TVLTDASHTK CLCDRLSTFA ILAQQPREIV MESSGTPSVT LIVGSGLSCL ALITLAVVYA 

       910        920        930        940        950        960 
ALWRYIRSER SIILINFCLS IISSNILILV GQTQTHNKSI CTTTTAFLHF FFLASFCWVL 

       970        980        990       1000       1010       1020 
TEAWQSYMAV TGKIRTRLIR KRFLCLGWGL PALVVATSVG FTRTKGYGTD HYCWLSLEGG 

      1030       1040       1050       1060       1070       1080 
LLYAFVGPAA AVVLVNMVIG ILVFNKLVSR DGILDKKLKH RAGQMSEPHS GLTLKCAKCG 

      1090       1100       1110       1120       1130       1140 
VVSTTALSAT TASNAMASLW SSCVVLPLLA LTWMSAVLAM TDKRSILFQI LFAVFDSLQG 

      1150       1160       1170       1180       1190       1200 
FVIVMVHCIL RREVQDAFRC RLRNCQDPIN ADSSSSFPNG HAQIMTDFEK DVDIACRSVL 

      1210       1220       1230       1240       1250       1260 
HKDIGPCRAA TITGTLSRIS LNDDEEEKGT NPEGLSYSTL PGNVISKVII QQPTGLHMPM 

      1270       1280       1290       1300       1310       1320 
SMNELSNPCL KKENTELRRT VYLCTDDNLR GADMDIVHPQ ERMMESDYIV MPRSSVSTQP 

      1330       1340       1350       1360       1370       1380 
SMKEESKMNI GMETLPHERL LHYKVNPEFN MNPPVMDQFN MNLDQHLAPQ EHMQNLPFEP 

      1390       1400       1410       1420       1430       1440 
RTAVKNFMAS ELDDNVGLSR SETGSTISMS SLERRKSRYS DLDFEKVMHT RKRHMELFQE 

      1450       1460       1470       1480       1490       1500 
LNQKFQTLDR FRDIPNTSSM ENPAPNKNPW DTFKPPSEYQ HYTTINVLDT EAKDTLELRP 

      1510       1520 
AEWEKCLNLP LDVQEGDFQT EV

« Hide

References

« Hide 'large scale' references
[1]"Mouse brain-specific angiogenesis inhibitor 3."
Kim K.K., Kee H.J., Koh J.T.
Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: ICR.
Tissue: Brain.
[2]"Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
Mol. Cell. Proteomics 6:283-293(2007) [PubMed: 17114649] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1220 AND SER-1411, MASS SPECTROMETRY.
Tissue: Brain cortex.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY168406 mRNA. Translation: AAO27431.1.
IPIIPI00187338.
UniGeneMm.336569.

3D structure databases

ProteinModelPortalQ80ZF8.
SMRQ80ZF8. Positions 291-453, 455-568.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ80ZF8.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ80ZF8.

Proteomic databases

PRIDEQ80ZF8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCuc007amw.2. mouse.

Organism-specific databases

MGIMGI:2441837. Bai3.

Phylogenomic databases

HOGENOMHBG714232.
HOVERGENHBG004813.
InParanoidQ80ZF8.

Gene expression databases

ArrayExpressQ80ZF8.
BgeeQ80ZF8.
CleanExMM_BAI3.
GenevestigatorQ80ZF8.
GermOnlineENSMUSG00000033569. Mus musculus.

Family and domain databases

InterProIPR022624. DUF3497.
IPR017981. GPCR_2-like.
IPR008077. GPCR_2_brain-spec_angio_inhib.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS_dom.
IPR000884. Thrombospondin_1_rpt.
[Graphical view]
PfamPF00002. 7tm_2. 1 hit.
PF12003. DUF3497. 1 hit.
PF01825. GPS. 1 hit.
PF02793. HRM. 1 hit.
PF00090. TSP_1. 4 hits.
[Graphical view]
PRINTSPR01694. BAIPRECURSOR.
PR00249. GPCRSECRETIN.
SMARTSM00303. GPS. 1 hit.
SM00008. HormR. 1 hit.
SM00209. TSP1. 4 hits.
[Graphical view]
SUPFAMSSF82895. TSP1. 4 hits.
PROSITEPS01180. CUB. False negative.
PS00649. G_PROTEIN_RECEP_F2_1. False negative.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS50092. TSP1. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

SOURCESearch...

Entry information

Entry nameBAI3_MOUSE
AccessionPrimary (citable) accession number: Q80ZF8
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 1, 2003
Last modified: November 16, 2011
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents