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Q80ZF8

- BAI3_MOUSE

UniProt

Q80ZF8 - BAI3_MOUSE

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Protein
Brain-specific angiogenesis inhibitor 3
Gene
Bai3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses. Might be involved in angiogenesis inhibition and suppression of glioblastoma By similarity.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. protein binding Source: MGI
Complete GO annotation...

GO - Biological processi

  1. negative regulation of angiogenesis Source: InterPro
  2. neuropeptide signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Brain-specific angiogenesis inhibitor 3
Gene namesi
Name:Bai3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:2441837. Bai3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 880855Extracellular Reviewed prediction
Add
BLAST
Transmembranei881 – 90121Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini902 – 9109Cytoplasmic Reviewed prediction
Transmembranei911 – 93121Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini932 – 9398Extracellular Reviewed prediction
Transmembranei940 – 96021Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini961 – 98121Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei982 – 100221Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini1003 – 102321Extracellular Reviewed prediction
Add
BLAST
Transmembranei1024 – 104421Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini1045 – 109854Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei1099 – 111921Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini1120 – 11256Extracellular Reviewed prediction
Transmembranei1126 – 114621Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini1147 – 1522376Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 Reviewed prediction
Add
BLAST
Chaini26 – 15221497Brain-specific angiogenesis inhibitor 3
PRO_0000012866Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi51 – 511N-linked (GlcNAc...) Reviewed prediction
Glycosylationi54 – 541N-linked (GlcNAc...) Reviewed prediction
Glycosylationi82 – 821N-linked (GlcNAc...) Reviewed prediction
Glycosylationi105 – 1051N-linked (GlcNAc...) Reviewed prediction
Glycosylationi241 – 2411N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi303 ↔ 336 By similarity
Disulfide bondi307 ↔ 342 By similarity
Disulfide bondi318 ↔ 326 By similarity
Glycosylationi337 – 3371N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi357 ↔ 392 By similarity
Disulfide bondi361 ↔ 397 By similarity
Disulfide bondi372 ↔ 382 By similarity
Disulfide bondi412 ↔ 447 By similarity
Disulfide bondi416 ↔ 452 By similarity
Glycosylationi418 – 4181N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi427 ↔ 437 By similarity
Disulfide bondi467 ↔ 502 By similarity
Disulfide bondi471 ↔ 507 By similarity
Disulfide bondi482 ↔ 492 By similarity
Disulfide bondi514 ↔ 549 By similarity
Disulfide bondi537 ↔ 567 By similarity
Glycosylationi540 – 5401N-linked (GlcNAc...) Reviewed prediction
Modified residuei619 – 6191Phosphoserine By similarity
Glycosylationi625 – 6251N-linked (GlcNAc...) Reviewed prediction
Glycosylationi779 – 7791N-linked (GlcNAc...) Reviewed prediction
Glycosylationi812 – 8121N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi819 ↔ 851 By similarity
Glycosylationi828 – 8281N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi839 ↔ 853 By similarity
Glycosylationi937 – 9371N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

The endogenous protein is proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit. Does not undergo autocatalytic cleavage (in vitro) By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ80ZF8.
PRIDEiQ80ZF8.

PTM databases

PhosphoSiteiQ80ZF8.

Expressioni

Gene expression databases

ArrayExpressiQ80ZF8.
CleanExiMM_BAI3.
GenevestigatoriQ80ZF8.

Interactioni

Subunit structurei

Interacts with C1QL1, C1QL2, C1QL3 and C1QL4 By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ80ZF8.
SMRiQ80ZF8. Positions 508-866.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 159130CUB
Add
BLAST
Domaini291 – 34353TSP type-1 1
Add
BLAST
Domaini345 – 39854TSP type-1 2
Add
BLAST
Domaini400 – 45354TSP type-1 3
Add
BLAST
Domaini455 – 50854TSP type-1 4
Add
BLAST
Domaini816 – 86853GPS
Add
BLAST

Sequence similaritiesi

Contains 1 CUB domain.
Contains 1 GPS domain.
Contains 4 TSP type-1 domains.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG146816.
GeneTreeiENSGT00690000101769.
HOGENOMiHOG000230916.
HOVERGENiHBG004813.
InParanoidiQ80ZF8.
KOiK04598.
OMAiWDDSKTN.
TreeFamiTF331634.

Family and domain databases

InterProiIPR022624. DUF3497.
IPR017981. GPCR_2-like.
IPR008077. GPCR_2_brain-spec_angio_inhib.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
IPR000884. Thrombospondin_1_rpt.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF12003. DUF3497. 1 hit.
PF01825. GPS. 1 hit.
PF02793. HRM. 1 hit.
PF00090. TSP_1. 4 hits.
[Graphical view]
PRINTSiPR01694. BAIPRECURSOR.
PR00249. GPCRSECRETIN.
SMARTiSM00303. GPS. 1 hit.
SM00008. HormR. 1 hit.
SM00209. TSP1. 4 hits.
[Graphical view]
SUPFAMiSSF82895. SSF82895. 4 hits.
PROSITEiPS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS50092. TSP1. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q80ZF8-1 [UniParc]FASTAAdd to Basket

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MKAVRNLLIY IFSTYLLVMF GFNAAQDFWC STLVKGVIYG SYSVSEMFPK     50
NFTNCTWTLE NPDPTKYSIY LKFSKKDLSC SNFSLLAYQF DHFSHEKIKD 100
LLRKNHSIMQ LCSSKNAFVF LQYDKNFIQI RRVFPTDFPG LQKKVEEDQK 150
SFFEFLVLNK VSPSQFGCHV LCTWLESCLK SENGRTESCG IMYTKCTCPQ 200
HLGEWGIDDQ SLVLLNNVVL PLNEQTEGCL TQELQTTQVC NLTREAKRPP 250
KEEFGMMGDH TIKSQRPRSV HEKRVPQEQA DAAKFMAQTG ESGVEEWSQW 300
SACSVTCGQG SQVRTRTCVS PYGTHCSGPL RESRVCNNTA LCPVHGVWEE 350
WSPWSLCSFT CGRGQRTRTR SCTPPQYGGR PCEGPETHHK PCNIALCPVD 400
GQWQEWSSWS HCSVTCSNGT QQRSRQCTAA AHGGSECRGP WAESRECYNP 450
ECTANGQWNQ WGHWSGCSKS CDGGWERRMR TCQGAAVTGQ QCEGTGEEVR 500
RCSEQRCPAP YEICPEDYLI SMVWKRTPAG DLAFNQCPLN ATGTTSRRCS 550
LSLHGVASWE QPSFARCISN EYRHLQHSIK EHLAKGQRML AGDGMSQVTK 600
TLLDLTQRKN FYAGDLLVSV EILRNVTDTF KRASYIPASD GVQNFFQIVS 650
NLLDEENKEK WEDAQQIYPG SIELMQVIED FIHIVGMGMM DFQNSYLMTG 700
NVVASIQKLP AASVLTDINF PMKGRKGMVD WARNSEDRVV IPKSIFTPVS 750
SKELDESSVF VLGAVLYKNL DLILPTLRNY TVVNSKVIVV TIRPEPKTTD 800
SFLEIELAHL ANGTLNPYCV LWDDSKSNES LGTWSTQGCK TVLTDASHTK 850
CLCDRLSTFA ILAQQPREIV MESSGTPSVT LIVGSGLSCL ALITLAVVYA 900
ALWRYIRSER SIILINFCLS IISSNILILV GQTQTHNKSI CTTTTAFLHF 950
FFLASFCWVL TEAWQSYMAV TGKIRTRLIR KRFLCLGWGL PALVVATSVG 1000
FTRTKGYGTD HYCWLSLEGG LLYAFVGPAA AVVLVNMVIG ILVFNKLVSR 1050
DGILDKKLKH RAGQMSEPHS GLTLKCAKCG VVSTTALSAT TASNAMASLW 1100
SSCVVLPLLA LTWMSAVLAM TDKRSILFQI LFAVFDSLQG FVIVMVHCIL 1150
RREVQDAFRC RLRNCQDPIN ADSSSSFPNG HAQIMTDFEK DVDIACRSVL 1200
HKDIGPCRAA TITGTLSRIS LNDDEEEKGT NPEGLSYSTL PGNVISKVII 1250
QQPTGLHMPM SMNELSNPCL KKENTELRRT VYLCTDDNLR GADMDIVHPQ 1300
ERMMESDYIV MPRSSVSTQP SMKEESKMNI GMETLPHERL LHYKVNPEFN 1350
MNPPVMDQFN MNLDQHLAPQ EHMQNLPFEP RTAVKNFMAS ELDDNVGLSR 1400
SETGSTISMS SLERRKSRYS DLDFEKVMHT RKRHMELFQE LNQKFQTLDR 1450
FRDIPNTSSM ENPAPNKNPW DTFKPPSEYQ HYTTINVLDT EAKDTLELRP 1500
AEWEKCLNLP LDVQEGDFQT EV 1522
Length:1,522
Mass (Da):171,314
Last modified:October 3, 2012 - v2
Checksum:i787882AC3F2B54EB
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti215 – 2151L → V in AAO27431. 1 Publication
Sequence conflicti683 – 6831H → Y in AAO27431. 1 Publication
Sequence conflicti783 – 7831V → I in AAO27431. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY168406 mRNA. Translation: AAO27431.1.
AC116556 Genomic DNA. No translation available.
AC117221 Genomic DNA. No translation available.
AC121828 Genomic DNA. No translation available.
AC122187 Genomic DNA. No translation available.
AC129314 Genomic DNA. No translation available.
AC140308 Genomic DNA. No translation available.
CH466536 Genomic DNA. Translation: EDL14414.1.
CCDSiCCDS14855.1.
RefSeqiNP_783573.4. NM_175642.4.
UniGeneiMm.336569.

Genome annotation databases

EnsembliENSMUST00000041838; ENSMUSP00000035612; ENSMUSG00000033569.
ENSMUST00000135518; ENSMUSP00000119804; ENSMUSG00000033569.
ENSMUST00000151309; ENSMUSP00000116231; ENSMUSG00000033569.
GeneIDi210933.
KEGGimmu:210933.
UCSCiuc007amw.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY168406 mRNA. Translation: AAO27431.1 .
AC116556 Genomic DNA. No translation available.
AC117221 Genomic DNA. No translation available.
AC121828 Genomic DNA. No translation available.
AC122187 Genomic DNA. No translation available.
AC129314 Genomic DNA. No translation available.
AC140308 Genomic DNA. No translation available.
CH466536 Genomic DNA. Translation: EDL14414.1 .
CCDSi CCDS14855.1.
RefSeqi NP_783573.4. NM_175642.4.
UniGenei Mm.336569.

3D structure databases

ProteinModelPortali Q80ZF8.
SMRi Q80ZF8. Positions 508-866.
ModBasei Search...

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q80ZF8.

Proteomic databases

PaxDbi Q80ZF8.
PRIDEi Q80ZF8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000041838 ; ENSMUSP00000035612 ; ENSMUSG00000033569 .
ENSMUST00000135518 ; ENSMUSP00000119804 ; ENSMUSG00000033569 .
ENSMUST00000151309 ; ENSMUSP00000116231 ; ENSMUSG00000033569 .
GeneIDi 210933.
KEGGi mmu:210933.
UCSCi uc007amw.2. mouse.

Organism-specific databases

CTDi 577.
MGIi MGI:2441837. Bai3.

Phylogenomic databases

eggNOGi NOG146816.
GeneTreei ENSGT00690000101769.
HOGENOMi HOG000230916.
HOVERGENi HBG004813.
InParanoidi Q80ZF8.
KOi K04598.
OMAi WDDSKTN.
TreeFami TF331634.

Miscellaneous databases

NextBioi 373087.
PROi Q80ZF8.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q80ZF8.
CleanExi MM_BAI3.
Genevestigatori Q80ZF8.

Family and domain databases

InterProi IPR022624. DUF3497.
IPR017981. GPCR_2-like.
IPR008077. GPCR_2_brain-spec_angio_inhib.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
IPR000884. Thrombospondin_1_rpt.
[Graphical view ]
Pfami PF00002. 7tm_2. 1 hit.
PF12003. DUF3497. 1 hit.
PF01825. GPS. 1 hit.
PF02793. HRM. 1 hit.
PF00090. TSP_1. 4 hits.
[Graphical view ]
PRINTSi PR01694. BAIPRECURSOR.
PR00249. GPCRSECRETIN.
SMARTi SM00303. GPS. 1 hit.
SM00008. HormR. 1 hit.
SM00209. TSP1. 4 hits.
[Graphical view ]
SUPFAMi SSF82895. SSF82895. 4 hits.
PROSITEi PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS50092. TSP1. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse brain-specific angiogenesis inhibitor 3."
    Kim K.K., Kee H.J., Koh J.T.
    Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ICR.
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiBAI3_MOUSE
AccessioniPrimary (citable) accession number: Q80ZF8
Secondary accession number(s): G3XA05
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: October 3, 2012
Last modified: July 9, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi