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Q80ZF8

- BAI3_MOUSE

UniProt

Q80ZF8 - BAI3_MOUSE

Protein

Brain-specific angiogenesis inhibitor 3

Gene

Bai3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 2 (03 Oct 2012)
      Previous versions | rss
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    Functioni

    May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses. Might be involved in angiogenesis inhibition and suppression of glioblastoma By similarity.By similarity

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. protein binding Source: MGI

    GO - Biological processi

    1. negative regulation of angiogenesis Source: InterPro
    2. neuropeptide signaling pathway Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Brain-specific angiogenesis inhibitor 3
    Gene namesi
    Name:Bai3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:2441837. Bai3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 15221497Brain-specific angiogenesis inhibitor 3PRO_0000012866Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi51 – 511N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi54 – 541N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi82 – 821N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi105 – 1051N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi241 – 2411N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi303 ↔ 336PROSITE-ProRule annotation
    Disulfide bondi307 ↔ 342PROSITE-ProRule annotation
    Disulfide bondi318 ↔ 326PROSITE-ProRule annotation
    Glycosylationi337 – 3371N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi357 ↔ 392PROSITE-ProRule annotation
    Disulfide bondi361 ↔ 397PROSITE-ProRule annotation
    Disulfide bondi372 ↔ 382PROSITE-ProRule annotation
    Disulfide bondi412 ↔ 447PROSITE-ProRule annotation
    Disulfide bondi416 ↔ 452PROSITE-ProRule annotation
    Glycosylationi418 – 4181N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi427 ↔ 437PROSITE-ProRule annotation
    Disulfide bondi467 ↔ 502PROSITE-ProRule annotation
    Disulfide bondi471 ↔ 507PROSITE-ProRule annotation
    Disulfide bondi482 ↔ 492PROSITE-ProRule annotation
    Disulfide bondi514 ↔ 549PROSITE-ProRule annotation
    Disulfide bondi537 ↔ 567PROSITE-ProRule annotation
    Glycosylationi540 – 5401N-linked (GlcNAc...)Sequence Analysis
    Modified residuei619 – 6191PhosphoserineBy similarity
    Glycosylationi625 – 6251N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi779 – 7791N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi812 – 8121N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi819 ↔ 851PROSITE-ProRule annotation
    Glycosylationi828 – 8281N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi839 ↔ 853PROSITE-ProRule annotation
    Glycosylationi937 – 9371N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    The endogenous protein is proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit. Does not undergo autocatalytic cleavage (in vitro) By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiQ80ZF8.
    PRIDEiQ80ZF8.

    PTM databases

    PhosphoSiteiQ80ZF8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ80ZF8.
    CleanExiMM_BAI3.
    GenevestigatoriQ80ZF8.

    Interactioni

    Subunit structurei

    Interacts with C1QL1, C1QL2, C1QL3 and C1QL4.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ80ZF8.
    SMRiQ80ZF8. Positions 508-866.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini26 – 880855ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini902 – 9109CytoplasmicSequence Analysis
    Topological domaini932 – 9398ExtracellularSequence Analysis
    Topological domaini961 – 98121CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1003 – 102321ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1045 – 109854CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1120 – 11256ExtracellularSequence Analysis
    Topological domaini1147 – 1522376CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei881 – 90121Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei911 – 93121Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei940 – 96021Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei982 – 100221Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei1024 – 104421Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei1099 – 111921Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei1126 – 114621Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini30 – 159130CUBAdd
    BLAST
    Domaini291 – 34353TSP type-1 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini345 – 39854TSP type-1 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini400 – 45354TSP type-1 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini455 – 50854TSP type-1 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini816 – 86853GPSPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 CUB domain.Curated
    Contains 1 GPS domain.PROSITE-ProRule annotation
    Contains 4 TSP type-1 domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG146816.
    GeneTreeiENSGT00690000101769.
    HOGENOMiHOG000230916.
    HOVERGENiHBG004813.
    InParanoidiQ80ZF8.
    KOiK04598.
    OMAiWDDSKTN.
    TreeFamiTF331634.

    Family and domain databases

    InterProiIPR022624. DUF3497.
    IPR017981. GPCR_2-like.
    IPR008077. GPCR_2_brain-spec_angio_inhib.
    IPR001879. GPCR_2_extracellular_dom.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    IPR000203. GPS.
    IPR000884. Thrombospondin_1_rpt.
    [Graphical view]
    PfamiPF00002. 7tm_2. 1 hit.
    PF12003. DUF3497. 1 hit.
    PF01825. GPS. 1 hit.
    PF02793. HRM. 1 hit.
    PF00090. TSP_1. 4 hits.
    [Graphical view]
    PRINTSiPR01694. BAIPRECURSOR.
    PR00249. GPCRSECRETIN.
    SMARTiSM00303. GPS. 1 hit.
    SM00008. HormR. 1 hit.
    SM00209. TSP1. 4 hits.
    [Graphical view]
    SUPFAMiSSF82895. SSF82895. 4 hits.
    PROSITEiPS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    PS50221. GPS. 1 hit.
    PS50092. TSP1. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q80ZF8-1 [UniParc]FASTAAdd to Basket

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    MKAVRNLLIY IFSTYLLVMF GFNAAQDFWC STLVKGVIYG SYSVSEMFPK     50
    NFTNCTWTLE NPDPTKYSIY LKFSKKDLSC SNFSLLAYQF DHFSHEKIKD 100
    LLRKNHSIMQ LCSSKNAFVF LQYDKNFIQI RRVFPTDFPG LQKKVEEDQK 150
    SFFEFLVLNK VSPSQFGCHV LCTWLESCLK SENGRTESCG IMYTKCTCPQ 200
    HLGEWGIDDQ SLVLLNNVVL PLNEQTEGCL TQELQTTQVC NLTREAKRPP 250
    KEEFGMMGDH TIKSQRPRSV HEKRVPQEQA DAAKFMAQTG ESGVEEWSQW 300
    SACSVTCGQG SQVRTRTCVS PYGTHCSGPL RESRVCNNTA LCPVHGVWEE 350
    WSPWSLCSFT CGRGQRTRTR SCTPPQYGGR PCEGPETHHK PCNIALCPVD 400
    GQWQEWSSWS HCSVTCSNGT QQRSRQCTAA AHGGSECRGP WAESRECYNP 450
    ECTANGQWNQ WGHWSGCSKS CDGGWERRMR TCQGAAVTGQ QCEGTGEEVR 500
    RCSEQRCPAP YEICPEDYLI SMVWKRTPAG DLAFNQCPLN ATGTTSRRCS 550
    LSLHGVASWE QPSFARCISN EYRHLQHSIK EHLAKGQRML AGDGMSQVTK 600
    TLLDLTQRKN FYAGDLLVSV EILRNVTDTF KRASYIPASD GVQNFFQIVS 650
    NLLDEENKEK WEDAQQIYPG SIELMQVIED FIHIVGMGMM DFQNSYLMTG 700
    NVVASIQKLP AASVLTDINF PMKGRKGMVD WARNSEDRVV IPKSIFTPVS 750
    SKELDESSVF VLGAVLYKNL DLILPTLRNY TVVNSKVIVV TIRPEPKTTD 800
    SFLEIELAHL ANGTLNPYCV LWDDSKSNES LGTWSTQGCK TVLTDASHTK 850
    CLCDRLSTFA ILAQQPREIV MESSGTPSVT LIVGSGLSCL ALITLAVVYA 900
    ALWRYIRSER SIILINFCLS IISSNILILV GQTQTHNKSI CTTTTAFLHF 950
    FFLASFCWVL TEAWQSYMAV TGKIRTRLIR KRFLCLGWGL PALVVATSVG 1000
    FTRTKGYGTD HYCWLSLEGG LLYAFVGPAA AVVLVNMVIG ILVFNKLVSR 1050
    DGILDKKLKH RAGQMSEPHS GLTLKCAKCG VVSTTALSAT TASNAMASLW 1100
    SSCVVLPLLA LTWMSAVLAM TDKRSILFQI LFAVFDSLQG FVIVMVHCIL 1150
    RREVQDAFRC RLRNCQDPIN ADSSSSFPNG HAQIMTDFEK DVDIACRSVL 1200
    HKDIGPCRAA TITGTLSRIS LNDDEEEKGT NPEGLSYSTL PGNVISKVII 1250
    QQPTGLHMPM SMNELSNPCL KKENTELRRT VYLCTDDNLR GADMDIVHPQ 1300
    ERMMESDYIV MPRSSVSTQP SMKEESKMNI GMETLPHERL LHYKVNPEFN 1350
    MNPPVMDQFN MNLDQHLAPQ EHMQNLPFEP RTAVKNFMAS ELDDNVGLSR 1400
    SETGSTISMS SLERRKSRYS DLDFEKVMHT RKRHMELFQE LNQKFQTLDR 1450
    FRDIPNTSSM ENPAPNKNPW DTFKPPSEYQ HYTTINVLDT EAKDTLELRP 1500
    AEWEKCLNLP LDVQEGDFQT EV 1522
    Length:1,522
    Mass (Da):171,314
    Last modified:October 3, 2012 - v2
    Checksum:i787882AC3F2B54EB
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti215 – 2151L → V in AAO27431. 1 PublicationCurated
    Sequence conflicti683 – 6831H → Y in AAO27431. 1 PublicationCurated
    Sequence conflicti783 – 7831V → I in AAO27431. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY168406 mRNA. Translation: AAO27431.1.
    AC116556 Genomic DNA. No translation available.
    AC117221 Genomic DNA. No translation available.
    AC121828 Genomic DNA. No translation available.
    AC122187 Genomic DNA. No translation available.
    AC129314 Genomic DNA. No translation available.
    AC140308 Genomic DNA. No translation available.
    CH466536 Genomic DNA. Translation: EDL14414.1.
    CCDSiCCDS14855.1.
    RefSeqiNP_783573.4. NM_175642.4.
    UniGeneiMm.336569.

    Genome annotation databases

    EnsembliENSMUST00000041838; ENSMUSP00000035612; ENSMUSG00000033569.
    ENSMUST00000135518; ENSMUSP00000119804; ENSMUSG00000033569.
    ENSMUST00000151309; ENSMUSP00000116231; ENSMUSG00000033569.
    GeneIDi210933.
    KEGGimmu:210933.
    UCSCiuc007amw.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY168406 mRNA. Translation: AAO27431.1 .
    AC116556 Genomic DNA. No translation available.
    AC117221 Genomic DNA. No translation available.
    AC121828 Genomic DNA. No translation available.
    AC122187 Genomic DNA. No translation available.
    AC129314 Genomic DNA. No translation available.
    AC140308 Genomic DNA. No translation available.
    CH466536 Genomic DNA. Translation: EDL14414.1 .
    CCDSi CCDS14855.1.
    RefSeqi NP_783573.4. NM_175642.4.
    UniGenei Mm.336569.

    3D structure databases

    ProteinModelPortali Q80ZF8.
    SMRi Q80ZF8. Positions 508-866.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q80ZF8.

    Proteomic databases

    PaxDbi Q80ZF8.
    PRIDEi Q80ZF8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000041838 ; ENSMUSP00000035612 ; ENSMUSG00000033569 .
    ENSMUST00000135518 ; ENSMUSP00000119804 ; ENSMUSG00000033569 .
    ENSMUST00000151309 ; ENSMUSP00000116231 ; ENSMUSG00000033569 .
    GeneIDi 210933.
    KEGGi mmu:210933.
    UCSCi uc007amw.2. mouse.

    Organism-specific databases

    CTDi 577.
    MGIi MGI:2441837. Bai3.

    Phylogenomic databases

    eggNOGi NOG146816.
    GeneTreei ENSGT00690000101769.
    HOGENOMi HOG000230916.
    HOVERGENi HBG004813.
    InParanoidi Q80ZF8.
    KOi K04598.
    OMAi WDDSKTN.
    TreeFami TF331634.

    Miscellaneous databases

    NextBioi 373087.
    PROi Q80ZF8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q80ZF8.
    CleanExi MM_BAI3.
    Genevestigatori Q80ZF8.

    Family and domain databases

    InterProi IPR022624. DUF3497.
    IPR017981. GPCR_2-like.
    IPR008077. GPCR_2_brain-spec_angio_inhib.
    IPR001879. GPCR_2_extracellular_dom.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    IPR000203. GPS.
    IPR000884. Thrombospondin_1_rpt.
    [Graphical view ]
    Pfami PF00002. 7tm_2. 1 hit.
    PF12003. DUF3497. 1 hit.
    PF01825. GPS. 1 hit.
    PF02793. HRM. 1 hit.
    PF00090. TSP_1. 4 hits.
    [Graphical view ]
    PRINTSi PR01694. BAIPRECURSOR.
    PR00249. GPCRSECRETIN.
    SMARTi SM00303. GPS. 1 hit.
    SM00008. HormR. 1 hit.
    SM00209. TSP1. 4 hits.
    [Graphical view ]
    SUPFAMi SSF82895. SSF82895. 4 hits.
    PROSITEi PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    PS50221. GPS. 1 hit.
    PS50092. TSP1. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mouse brain-specific angiogenesis inhibitor 3."
      Kim K.K., Kee H.J., Koh J.T.
      Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: ICR.
      Tissue: Brain.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
      Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
      Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain.

    Entry informationi

    Entry nameiBAI3_MOUSE
    AccessioniPrimary (citable) accession number: Q80ZF8
    Secondary accession number(s): G3XA05
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2004
    Last sequence update: October 3, 2012
    Last modified: October 1, 2014
    This is version 93 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3