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Protein

Retinol dehydrogenase 10

Gene

Rdh10

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal.1 Publication

Catalytic activityi

All-trans-retinol + NADP+ = all-trans-retinal + NADPH.

Pathwayi: retinol metabolism

This protein is involved in the pathway retinol metabolism, which is part of Cofactor metabolism.
View all proteins of this organism that are known to be involved in the pathway retinol metabolism and in Cofactor metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei197SubstrateBy similarity1
Active sitei210Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi40 – 64NADPBy similarityAdd BLAST25

GO - Molecular functioni

  • NADP-retinol dehydrogenase activity Source: RGD
  • retinol dehydrogenase activity Source: RGD

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNADP

Enzyme and pathway databases

ReactomeiR-RNO-2453902 The canonical retinoid cycle in rods (twilight vision)
R-RNO-5365859 RA biosynthesis pathway
UniPathwayiUPA00912

Names & Taxonomyi

Protein namesi
Recommended name:
Retinol dehydrogenase 10 (EC:1.1.1.300)
Gene namesi
Name:Rdh10
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi727793 Rdh10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei3 – 23Helical; Signal-anchorSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003076841 – 341Retinol dehydrogenase 10Add BLAST341

Proteomic databases

PaxDbiQ80ZF7
PRIDEiQ80ZF7

Expressioni

Tissue specificityi

Detected in retina, entire eyecups and in liver (at protein level).1 Publication

Gene expression databases

BgeeiENSRNOG00000006681
GenevisibleiQ80ZF7 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009096

Structurei

3D structure databases

ProteinModelPortaliQ80ZF7
SMRiQ80ZF7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1201 Eukaryota
COG1028 LUCA
GeneTreeiENSGT00910000143991
HOVERGENiHBG051352
InParanoidiQ80ZF7
KOiK11151
OMAiAKMCWEL
OrthoDBiEOG091G0825
PhylomeDBiQ80ZF7
TreeFamiTF312837

Family and domain databases

InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR032970 RDH10
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PANTHERiPTHR24322:SF731 PTHR24322:SF731, 1 hit
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit

Sequencei

Sequence statusi: Complete.

Q80ZF7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIVVEFFLV TFKVLWAFVL AAARWLVRPK EKSVAGQVCL ITGAGSGLGR
60 70 80 90 100
LFALEFARRR ALLVLWDINT QSNEETAGMV RHIYRDLEAA DAAALQAGNG
110 120 130 140 150
EEEILPPCNL QVFTYTCDVG KRENVYLTAE RVRKEVGEVS VLVNNAGVVS
160 170 180 190 200
GHHLLECPDE LIERTMMVNC HAHFWTTKAF LPTMLEINHG HIVTVASSLG
210 220 230 240 250
LFSTAGVEDY CASKFGVVGF HESLSHELKA AEKDGIKTTL VCPYLVDTGM
260 270 280 290 300
FRGCRIRKEI EPFLPPLKPD YCVKQAMKAI LTDQPMICTP RLMYIVTFMK
310 320 330 340
SILPFEAVVC MYRFLGADKC MYPFIAQRKQ ATNNNEAKNG I
Length:341
Mass (Da):38,061
Last modified:June 1, 2003 - v1
Checksum:i4DEFBE03B3561690
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY178865 mRNA Translation: AAO31688.1
RefSeqiNP_852143.1, NM_181478.2
UniGeneiRn.16968

Genome annotation databases

EnsembliENSRNOT00000009096; ENSRNOP00000009096; ENSRNOG00000006681
GeneIDi353252
KEGGirno:353252
UCSCiRGD:727793 rat

Similar proteinsi

Entry informationi

Entry nameiRDH10_RAT
AccessioniPrimary (citable) accession number: Q80ZF7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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