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Protein

Retinol dehydrogenase 10

Gene

Rdh10

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal.1 Publication

Catalytic activityi

All-trans-retinol + NADP+ = all-trans-retinal + NADPH.

Pathwayi: retinol metabolism

This protein is involved in the pathway retinol metabolism, which is part of Cofactor metabolism.
View all proteins of this organism that are known to be involved in the pathway retinol metabolism and in Cofactor metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei197 – 1971SubstrateBy similarity
Active sitei210 – 2101Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi40 – 6425NADPBy similarityAdd
BLAST

GO - Molecular functioni

  • NADP-retinol dehydrogenase activity Source: RGD
  • retinol dehydrogenase activity Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Enzyme and pathway databases

ReactomeiR-RNO-2453902. The canonical retinoid cycle in rods (twilight vision).
R-RNO-5365859. RA biosynthesis pathway.
UniPathwayiUPA00912.

Names & Taxonomyi

Protein namesi
Recommended name:
Retinol dehydrogenase 10 (EC:1.1.1.300)
Gene namesi
Name:Rdh10
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi727793. Rdh10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei3 – 2321Helical; Signal-anchorSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell body Source: RGD
  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 341341Retinol dehydrogenase 10PRO_0000307684Add
BLAST

Proteomic databases

PaxDbiQ80ZF7.
PRIDEiQ80ZF7.

Expressioni

Tissue specificityi

Detected in retina, entire eyecups and in liver (at protein level).1 Publication

Gene expression databases

BgeeiENSRNOG00000006681.
GenevisibleiQ80ZF7. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009096.

Structurei

3D structure databases

ProteinModelPortaliQ80ZF7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1201. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00540000069900.
HOVERGENiHBG051352.
InParanoidiQ80ZF7.
KOiK11151.
OMAiQRKEAMN.
OrthoDBiEOG091G0825.
PhylomeDBiQ80ZF7.
TreeFamiTF312837.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR032970. RDH10.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 3 hits.
PTHR24322:SF466. PTHR24322:SF466. 3 hits.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80ZF7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIVVEFFLV TFKVLWAFVL AAARWLVRPK EKSVAGQVCL ITGAGSGLGR
60 70 80 90 100
LFALEFARRR ALLVLWDINT QSNEETAGMV RHIYRDLEAA DAAALQAGNG
110 120 130 140 150
EEEILPPCNL QVFTYTCDVG KRENVYLTAE RVRKEVGEVS VLVNNAGVVS
160 170 180 190 200
GHHLLECPDE LIERTMMVNC HAHFWTTKAF LPTMLEINHG HIVTVASSLG
210 220 230 240 250
LFSTAGVEDY CASKFGVVGF HESLSHELKA AEKDGIKTTL VCPYLVDTGM
260 270 280 290 300
FRGCRIRKEI EPFLPPLKPD YCVKQAMKAI LTDQPMICTP RLMYIVTFMK
310 320 330 340
SILPFEAVVC MYRFLGADKC MYPFIAQRKQ ATNNNEAKNG I
Length:341
Mass (Da):38,061
Last modified:June 1, 2003 - v1
Checksum:i4DEFBE03B3561690
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY178865 mRNA. Translation: AAO31688.1.
RefSeqiNP_852143.1. NM_181478.2.
UniGeneiRn.16968.

Genome annotation databases

EnsembliENSRNOT00000009096; ENSRNOP00000009096; ENSRNOG00000006681.
GeneIDi353252.
KEGGirno:353252.
UCSCiRGD:727793. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY178865 mRNA. Translation: AAO31688.1.
RefSeqiNP_852143.1. NM_181478.2.
UniGeneiRn.16968.

3D structure databases

ProteinModelPortaliQ80ZF7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009096.

Proteomic databases

PaxDbiQ80ZF7.
PRIDEiQ80ZF7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000009096; ENSRNOP00000009096; ENSRNOG00000006681.
GeneIDi353252.
KEGGirno:353252.
UCSCiRGD:727793. rat.

Organism-specific databases

CTDi157506.
RGDi727793. Rdh10.

Phylogenomic databases

eggNOGiKOG1201. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00540000069900.
HOVERGENiHBG051352.
InParanoidiQ80ZF7.
KOiK11151.
OMAiQRKEAMN.
OrthoDBiEOG091G0825.
PhylomeDBiQ80ZF7.
TreeFamiTF312837.

Enzyme and pathway databases

UniPathwayiUPA00912.
ReactomeiR-RNO-2453902. The canonical retinoid cycle in rods (twilight vision).
R-RNO-5365859. RA biosynthesis pathway.

Miscellaneous databases

PROiQ80ZF7.

Gene expression databases

BgeeiENSRNOG00000006681.
GenevisibleiQ80ZF7. RN.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR032970. RDH10.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 3 hits.
PTHR24322:SF466. PTHR24322:SF466. 3 hits.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRDH10_RAT
AccessioniPrimary (citable) accession number: Q80ZF7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: June 1, 2003
Last modified: September 7, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.