Q80ZF5 (Q80ZF5_RAT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Obscurin EMBL AAO34127.1

Gene names

Name:	Obscn RGD 631335
Synonyms:	Obscurin EMBL AAO34127.1

Organism

Rattus norvegicus (Rat) EMBL AAO34127.1

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	803 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 DH (DBL-homology) domain. Contains 1 PH domain. SAAS SAAS000219

Ontologies

Gene Ontology (GO)
Biological_process	cellular protein localization Inferred from mutant phenotype PubMed 18782775. Source: BHF-UCL regulation of Rho protein signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	M band Inferred from direct assay PubMed 11717165. Source: BHF-UCL Z disc Inferred from direct assay PubMed 11717165. Source: BHF-UCL
Molecular_function	Rho guanyl-nucleotide exchange factor activity Non-traceable author statement Ref.1. Source: RGD phospholipid binding Inferred from electronic annotation. Source: InterPro structural constituent of muscle Non-traceable author statement PubMed 11717165. Source: BHF-UCL
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL AAO34127.1

Sequences

	Sequence		Length	Mass (Da)
	Q80ZF5 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: A1BC0789EBF277D6	FASTA	803	88,463
	10 20 30 40 50 60 GTSKDPTQPP PPPLQHYLEQ PVERVQKYQA LLKELIRNKA RNRQNCALLE QAYAVVSALP 70 80 90 100 110 120 QRAENKLHVS LMENYPGTLE ALGEPIRQGH FIVWEGAPGA RMPWKGHNRH VFLFRNHLVI 130 140 150 160 170 180 CKPRRDSRTD TFSYVFRNMM KLNSIDLNDQ VEGDDRAFEV WHEREDSVRK YLLQARTVII 190 200 210 220 230 240 KNSWVKEICG IQQRLAQPVW CPPEFEEELA DCTAELGETV KLACRVTGTP KPIVSWYKDG 250 260 270 280 290 300 KPVEVDPHHI LIEDPDGSCT LILDNLTGID SGQYMCFAAS AAGNASTLGK ILVQVPPRFV 310 320 330 340 350 360 NKVRATPFVE GEDAQITCTV EGAPYPQIRW YKDGALLTLG NRYRMVNEPR SGMLVLVIQA 370 380 390 400 410 420 ASKEDLGHYE CELVNRLGST RCGGELYMQS PALRAWDQHH REQLVAAVEV TEQETKVPKK 430 440 450 460 470 480 TVIIEETITT VVKSPRGRRQ SPSKSPSRSP SRRSASPRRP GLLAPEMLYP PGTSPSRRLE 490 500 510 520 530 540 VEQGRKAPVP ALYVTEAEAH TPASQPQPKW LEVEETIEVR VKKTGSRGAS PVREMTSHGE 550 560 570 580 590 600 GILFTLPGAI PARDPNANNS NNKSVYQGAR TWGPAVVHVG EPFVFQVDSV GNVDWAAAGP 610 620 630 640 650 660 ESEEVRASQE EENVEKEEGG SDGDENTFLM EEPQDTDSLQ GRDPKILTHN GRVLTLADLE 670 680 690 700 710 720 DYVPQEGETF GCGDPTPSAP DEPPCEVSVL QREIGELTVG QPVLLNVGRP PGPSATPSFF 730 740 750 760 770 780 RPSSQVHSPE SVSFLLREAW TGPASAAPWT SSFHTHVQSS VDGGHGSFKT EVSTQTVSFG 790 800 AVGETVTLHI DPDGGEAPGP SQG

References

[1]	"Obscurin is a ligand for small ankyrin 1 in skeletal muscle." Kontrogianni-Konstantopoulos A., Jones E.M., Van Rossum D.B., Bloch R.J. Mol. Biol. Cell 14:1138-1148(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Sprague-Dawley EMBL AAO34127.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY167411 mRNA. Translation: AAO34127.1.
IPI	IPI00476408.
UniGene	Rn.232158. Rn.40889.
3D structure databases
HSSP	HSSP built from PDB template 3NCM based on UniProtKB P13594.
ProteinModelPortal	Q80ZF5.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000029928. Q80ZF5.
PTM databases
PhosphoSite	Q80ZF5.
Proteomic databases
PaxDb	Q80ZF5.
PRIDE	Q80ZF5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
UCSC	RGD:631335. rat.
Organism-specific databases
RGD	631335. Obscn.
Phylogenomic databases
eggNOG	COG0515.
HOGENOM	HOG000202800.
HOVERGEN	HBG099610.
InParanoid	Q80ZF5.
Gene expression databases
ArrayExpress	Q80ZF5.
Genevestigator	Q80ZF5.
Family and domain databases
Gene3D	1.20.900.10. 1 hit. 2.30.29.30. 1 hit. 2.60.40.10. 2 hits.
InterPro	IPR000219. DH-domain. IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR013098. Ig_I-set. IPR003598. Ig_sub2. IPR011993. PH_like_dom. IPR001849. Pleckstrin_homology. [Graphical view]
Pfam	PF07679. I-set. 2 hits. PF00621. RhoGEF. 1 hit. [Graphical view]
SMART	SM00408. IGc2. 2 hits. SM00233. PH. 1 hit. [Graphical view]
SUPFAM	SSF48065. DH-domain. 1 hit.
PROSITE	PS50010. DH_2. 1 hit. PS50835. IG_LIKE. 2 hits. PS50003. PH_DOMAIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q80ZF5_RAT

Accession

Primary (citable) accession number: Q80ZF5

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2003
Last sequence update:	June 1, 2003
Last modified:	April 3, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)