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Protein

Membrane progestin receptor beta

Gene

Paqr8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Plasma membrane progesterone (P4) receptor coupled to G proteins. Seems to act through a G(i) mediated pathway (By similarity). May be involved in oocyte maturation (PubMed:12601167). Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone (By similarity).By similarity1 Publication

Miscellaneous

Non-classical progesterone receptors involved in extranuclear signaling are classified in 2 groups: the class II progestin and adipoQ receptor (PAQR) family (also called mPRs) (PAQR5, PAQR6, PAQR7, PAQR8 and PAQR9) and the b5-like heme/steroid-binding protein family (also called MAPRs) (PGRMC1, PGRMC2, NENF and CYB5D2).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Receptor
Biological processDifferentiation, Oogenesis
LigandLipid-binding, Steroid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane progestin receptor betaBy similarity
Short name:
mPR betaBy similarity
Alternative name(s):
Lysosomal membrane protein in brain 11 Publication
Membrane progesterone P4 receptor betaBy similarity
Membrane progesterone receptor betaBy similarity
Progesterone and adipoQ receptor family member 8
Progestin and adipoQ receptor family member 8By similarity
Progestin and adipoQ receptor family member VIII
Gene namesi
Name:Paqr8Imported
Synonyms:Mprb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1921479. Paqr8.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 76CytoplasmicSequence analysisAdd BLAST76
Transmembranei77 – 97Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini98 – 111ExtracellularSequence analysisAdd BLAST14
Transmembranei112 – 132Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini133 – 173CytoplasmicSequence analysisAdd BLAST41
Transmembranei174 – 194Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini195 – 213ExtracellularSequence analysisAdd BLAST19
Transmembranei214 – 234Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini235 – 243CytoplasmicSequence analysis9
Transmembranei244 – 264Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini265 – 283ExtracellularSequence analysisAdd BLAST19
Transmembranei284 – 304Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini305 – 315CytoplasmicSequence analysisAdd BLAST11
Transmembranei316 – 336Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini337 – 354ExtracellularSequence analysisAdd BLAST18

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002188411 – 354Membrane progestin receptor betaAdd BLAST354

Proteomic databases

MaxQBiQ80ZE5.
PaxDbiQ80ZE5.
PRIDEiQ80ZE5.

PTM databases

iPTMnetiQ80ZE5.
PhosphoSitePlusiQ80ZE5.

Expressioni

Tissue specificityi

Expressed in brain and testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000025931.
CleanExiMM_PAQR8.
GenevisibleiQ80ZE5. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000069127.

Structurei

3D structure databases

ProteinModelPortaliQ80ZE5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ADIPOR family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0748. Eukaryota.
COG1272. LUCA.
GeneTreeiENSGT00530000062965.
HOGENOMiHOG000230872.
HOVERGENiHBG052504.
InParanoidiQ80ZE5.
OMAiREPYIHA.
OrthoDBiEOG091G0QDA.
PhylomeDBiQ80ZE5.
TreeFamiTF319738.

Family and domain databases

InterProiView protein in InterPro
IPR004254. AdipoR/HlyIII-related.
PANTHERiPTHR20855. PTHR20855. 1 hit.
PfamiView protein in Pfam
PF03006. HlyIII. 1 hit.

Sequencei

Sequence statusi: Complete.

Q80ZE5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTAILERLS TLSMSGQQLR RLPKILEEGL PKMPCTVPET DVPQLFREPY
60 70 80 90 100
IHAGYRPTGH EWRYYFFSLF QKHNEVVNVW THLLAALAVL LRFWAFVEAG
110 120 130 140 150
ALQWASPHTL PLLLFILSSI TYLTCSLLAH LLQSKSELSH YTFYFVDYVG
160 170 180 190 200
VSVYQYGSAL AHFFYSSDQA WYELFWIFFL PAAAFCGWLS CAGCCYAKYR
210 220 230 240 250
YRRPYPVMRK ICQVVPAGLA FVLDISPVAH RVALCHLAGC QEQAAWYHTL
260 270 280 290 300
QILFFLVSAY FFSCPVPEKY FPGSCDIVGH GHQIFHAFLS VCTLSQLEAI
310 320 330 340 350
LLDYQGRHEI FLQRHGPLSV YSACLSFFVL AACSAATATL LRHKVKDRLI

KKDS
Length:354
Mass (Da):40,430
Last modified:August 16, 2004 - v2
Checksum:i14544CBB3338B538
GO

Sequence cautioni

The sequence BAC27629 differs from that shown. Reason: Frameshift at position 324.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti41D → G in AAR08385 (PubMed:16141072).Curated1
Sequence conflicti41D → G in BAC33221 (PubMed:16141072).Curated1
Sequence conflicti116I → V in AAO47230 (PubMed:12601167).Curated1
Sequence conflicti177I → L in AAO47230 (PubMed:12601167).Curated1
Sequence conflicti339T → S in AAO47230 (PubMed:12601167).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF313617 mRNA. Translation: AAO47230.1.
AY424297 mRNA. Translation: AAR08385.1.
AK006107 mRNA. Translation: BAB24412.1.
AK029772 mRNA. Translation: BAC26609.1.
AK031969 mRNA. Translation: BAC27629.1. Frameshift.
AK048045 mRNA. Translation: BAC33221.1.
AK147376 mRNA. Translation: BAE27872.1.
BC059813 mRNA. Translation: AAH59813.1.
CCDSiCCDS14844.1.
RefSeqiNP_083105.3. NM_028829.3.
XP_006495640.1. XM_006495577.2.
XP_006495641.1. XM_006495578.3.
UniGeneiMm.40780.

Genome annotation databases

EnsembliENSMUST00000068880; ENSMUSP00000069127; ENSMUSG00000025931.
ENSMUST00000167119; ENSMUSP00000128781; ENSMUSG00000025931.
ENSMUST00000187651; ENSMUSP00000140913; ENSMUSG00000025931.
ENSMUST00000189400; ENSMUSP00000141054; ENSMUSG00000025931.
GeneIDi74229.
KEGGimmu:74229.
UCSCiuc007ald.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiPAQR8_MOUSE
AccessioniPrimary (citable) accession number: Q80ZE5
Secondary accession number(s): Q3UHI5
, Q8C891, Q8CCW9, Q9DA71
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: October 25, 2017
This is version 102 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families