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Protein

Amphoterin-induced protein 2

Gene

Amigo2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain (By similarity).By similarity

GO - Biological processi

  • cell adhesion Source: MGI
  • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: UniProtKB
  • negative regulation of apoptotic process Source: InterPro
  • negative regulation of programmed cell death Source: UniProtKB
  • positive regulation of synapse assembly Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Amphoterin-induced protein 2
Alternative name(s):
AMIGO-2
Alivin-1
Gene namesi
Name:Amigo2Imported
Synonyms:Ali1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2145995. Amigo2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini39 – 397ExtracellularSequence analysisAdd BLAST359
Transmembranei398 – 418HelicalSequence analysisAdd BLAST21
Topological domaini419 – 519CytoplasmicSequence analysisAdd BLAST101

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 38Sequence analysisAdd BLAST38
ChainiPRO_000001451039 – 519Amphoterin-induced protein 2Sequence analysisAdd BLAST481

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi40 ↔ 46PROSITE-ProRule annotation
Disulfide bondi44 ↔ 53PROSITE-ProRule annotation
Glycosylationi57N-linked (GlcNAc...)Sequence analysis1
Glycosylationi103N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi231 ↔ 259PROSITE-ProRule annotation
Disulfide bondi233 ↔ 281PROSITE-ProRule annotation
Glycosylationi280N-linked (GlcNAc...)Sequence analysis1
Glycosylationi287N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi309 ↔ 362PROSITE-ProRule annotation
Glycosylationi344N-linked (GlcNAc...)Sequence analysis1
Glycosylationi372N-linked (GlcNAc...)Sequence analysis1
Glycosylationi380N-linked (GlcNAc...)Sequence analysis1
Glycosylationi383N-linked (GlcNAc...)Sequence analysis1
Glycosylationi387N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ80ZD9.
PRIDEiQ80ZD9.

PTM databases

iPTMnetiQ80ZD9.
PhosphoSitePlusiQ80ZD9.

Expressioni

Tissue specificityi

Highest level in cerebellum, retina, liver, and lung. Lower levels in cerebrum, kidney, small intestine, spleen and testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000048218.
CleanExiMM_AMIGO2.
ExpressionAtlasiQ80ZD9. baseline and differential.
GenevisibleiQ80ZD9. MM.

Interactioni

Subunit structurei

Binds itself as well as AMIGO1 and AMIGO3.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000059913.

Structurei

3D structure databases

ProteinModelPortaliQ80ZD9.
SMRiQ80ZD9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 67LRRNTAdd BLAST29
Repeati68 – 89LRR 1Add BLAST22
Repeati93 – 114LRR 2Add BLAST22
Repeati117 – 138LRR 3Add BLAST22
Repeati141 – 162LRR 4Add BLAST22
Repeati165 – 186LRR 5Add BLAST22
Repeati192 – 213LRR 6Add BLAST22
Domaini227 – 283LRRCTAdd BLAST57
Domaini288 – 378Ig-like C2-typeSequence analysisAdd BLAST91

Sequence similaritiesi

Contains 6 LRR (leucine-rich) repeats.Sequence analysis
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGN4. Eukaryota.
ENOG410ZZH4. LUCA.
GeneTreeiENSGT00530000063545.
HOGENOMiHOG000231327.
HOVERGENiHBG080231.
InParanoidiQ80ZD9.
OMAiSCIAMNR.
OrthoDBiEOG091G05D4.
PhylomeDBiQ80ZD9.
TreeFamiTF326838.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR031283. AMIGO.
IPR031286. AMIGO2.
IPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013151. Immunoglobulin.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PANTHERiPTHR24368. PTHR24368. 1 hit.
PTHR24368:SF209. PTHR24368:SF209. 1 hit.
PfamiPF00047. ig. 1 hit.
PF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00369. LRR_TYP. 5 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51450. LRR. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q80ZD9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLRFHTLPT LPRAVKPGCR ELLCLLVIAV MVSPSASGMC PTACICATDI
60 70 80 90 100
VSCTNKNLSK VPGNLFRLIK RLDLSYNRIG LLDADWIPVS FVKLSTLILR
110 120 130 140 150
HNNITSISTG SFSTTPNLKC LDLSSNRLKS VKSATFQELK ALEVLLLYNN
160 170 180 190 200
HISYLDPAAF GGLSHLQKLY LSGNFLTQFP MDLYTGRFKL ADLTFLDVSY
210 220 230 240 250
NRIPSIPMHH INLVPGRQLR GIYLHGNPFV CDCSLYSLLI FWYRRHFSSV
260 270 280 290 300
MDFKNDYTCR LWSDSRHSHQ LQLLQESFLN CSYSVINGSF HALGFIHEAQ
310 320 330 340 350
VGERAIVHCD SKTGNGNTDF IWVGPDNRLL EPDKDMGNFR VFYNGSLVIE
360 370 380 390 400
NPGFEDAGVY SCIAMNRQRL LNETVDIMIN VSNFTINRSH AHEAFNTAFT
410 420 430 440 450
TLAACVASIV LVLLYLYLTP CPCKCKAKRQ KNTLSQSSAH SSILSPGPTG
460 470 480 490 500
DASADDRKAG KRVVFLEPLK DTAAGQNGKV KLFPSETVIA EGILKSTRAK
510
SDSDSVNSVF SDTPFVAST
Length:519
Mass (Da):57,562
Last modified:June 1, 2003 - v1
Checksum:i0E9DD3FFA20C0A06
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY237006 mRNA. Translation: AAO48947.1.
AB078880 mRNA. Translation: BAC81187.1.
CCDSiCCDS27780.1.
RefSeqiNP_001158035.1. NM_001164563.1.
NP_001158074.1. NM_001164602.1.
NP_835215.1. NM_178114.4.
UniGeneiMm.24005.

Genome annotation databases

EnsembliENSMUST00000053106; ENSMUSP00000059913; ENSMUSG00000048218.
GeneIDi105827.
KEGGimmu:105827.
UCSCiuc007xks.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY237006 mRNA. Translation: AAO48947.1.
AB078880 mRNA. Translation: BAC81187.1.
CCDSiCCDS27780.1.
RefSeqiNP_001158035.1. NM_001164563.1.
NP_001158074.1. NM_001164602.1.
NP_835215.1. NM_178114.4.
UniGeneiMm.24005.

3D structure databases

ProteinModelPortaliQ80ZD9.
SMRiQ80ZD9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000059913.

PTM databases

iPTMnetiQ80ZD9.
PhosphoSitePlusiQ80ZD9.

Proteomic databases

PaxDbiQ80ZD9.
PRIDEiQ80ZD9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000053106; ENSMUSP00000059913; ENSMUSG00000048218.
GeneIDi105827.
KEGGimmu:105827.
UCSCiuc007xks.2. mouse.

Organism-specific databases

CTDi347902.
MGIiMGI:2145995. Amigo2.

Phylogenomic databases

eggNOGiENOG410IGN4. Eukaryota.
ENOG410ZZH4. LUCA.
GeneTreeiENSGT00530000063545.
HOGENOMiHOG000231327.
HOVERGENiHBG080231.
InParanoidiQ80ZD9.
OMAiSCIAMNR.
OrthoDBiEOG091G05D4.
PhylomeDBiQ80ZD9.
TreeFamiTF326838.

Miscellaneous databases

ChiTaRSiAmigo2. mouse.
PROiQ80ZD9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000048218.
CleanExiMM_AMIGO2.
ExpressionAtlasiQ80ZD9. baseline and differential.
GenevisibleiQ80ZD9. MM.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR031283. AMIGO.
IPR031286. AMIGO2.
IPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013151. Immunoglobulin.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PANTHERiPTHR24368. PTHR24368. 1 hit.
PTHR24368:SF209. PTHR24368:SF209. 1 hit.
PfamiPF00047. ig. 1 hit.
PF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00369. LRR_TYP. 5 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51450. LRR. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAMGO2_MOUSE
AccessioniPrimary (citable) accession number: Q80ZD9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.