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Protein

Amphoterin-induced protein 2

Gene

Amigo2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain (By similarity).By similarity

GO - Biological processi

  • cell adhesion Source: MGI
  • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: UniProtKB
  • negative regulation of apoptotic process Source: InterPro
  • negative regulation of programmed cell death Source: UniProtKB
  • positive regulation of synapse assembly Source: MGI

Keywordsi

Biological processCell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Amphoterin-induced protein 2
Alternative name(s):
AMIGO-2
Alivin-1
Gene namesi
Name:Amigo2Imported
Synonyms:Ali1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2145995 Amigo2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini39 – 397ExtracellularSequence analysisAdd BLAST359
Transmembranei398 – 418HelicalSequence analysisAdd BLAST21
Topological domaini419 – 519CytoplasmicSequence analysisAdd BLAST101

Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 38Sequence analysisAdd BLAST38
ChainiPRO_000001451039 – 519Amphoterin-induced protein 2Sequence analysisAdd BLAST481

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi40 ↔ 46PROSITE-ProRule annotation
Disulfide bondi44 ↔ 53PROSITE-ProRule annotation
Glycosylationi57N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi103N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi231 ↔ 259PROSITE-ProRule annotation
Disulfide bondi233 ↔ 281PROSITE-ProRule annotation
Glycosylationi280N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi287N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi309 ↔ 362PROSITE-ProRule annotation
Glycosylationi344N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi372N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi380N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi383N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi387N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ80ZD9
PaxDbiQ80ZD9
PRIDEiQ80ZD9

PTM databases

iPTMnetiQ80ZD9
PhosphoSitePlusiQ80ZD9

Expressioni

Tissue specificityi

Highest level in cerebellum, retina, liver, and lung. Lower levels in cerebrum, kidney, small intestine, spleen and testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000048218
CleanExiMM_AMIGO2
ExpressionAtlasiQ80ZD9 baseline and differential
GenevisibleiQ80ZD9 MM

Interactioni

Subunit structurei

Binds itself as well as AMIGO1 and AMIGO3.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ80ZD9
SMRiQ80ZD9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 67LRRNTAdd BLAST29
Repeati68 – 89LRR 1Add BLAST22
Repeati93 – 114LRR 2Add BLAST22
Repeati117 – 138LRR 3Add BLAST22
Repeati141 – 162LRR 4Add BLAST22
Repeati165 – 186LRR 5Add BLAST22
Repeati192 – 213LRR 6Add BLAST22
Domaini227 – 283LRRCTAdd BLAST57
Domaini288 – 378Ig-like C2-typeSequence analysisAdd BLAST91

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGN4 Eukaryota
ENOG410ZZH4 LUCA
GeneTreeiENSGT00530000063545
HOGENOMiHOG000231327
HOVERGENiHBG080231
InParanoidiQ80ZD9
KOiK22529
OMAiSCIAMNR
OrthoDBiEOG091G05D4
PhylomeDBiQ80ZD9
TreeFamiTF326838

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR031283 AMIGO
IPR031286 AMIGO2
IPR000483 Cys-rich_flank_reg_C
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013151 Immunoglobulin
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PANTHERiPTHR24368 PTHR24368, 1 hit
PTHR24368:SF209 PTHR24368:SF209, 1 hit
PfamiView protein in Pfam
PF00047 ig, 1 hit
PF13855 LRR_8, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00369 LRR_TYP, 5 hits
SM00082 LRRCT, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS51450 LRR, 6 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q80ZD9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLRFHTLPT LPRAVKPGCR ELLCLLVIAV MVSPSASGMC PTACICATDI
60 70 80 90 100
VSCTNKNLSK VPGNLFRLIK RLDLSYNRIG LLDADWIPVS FVKLSTLILR
110 120 130 140 150
HNNITSISTG SFSTTPNLKC LDLSSNRLKS VKSATFQELK ALEVLLLYNN
160 170 180 190 200
HISYLDPAAF GGLSHLQKLY LSGNFLTQFP MDLYTGRFKL ADLTFLDVSY
210 220 230 240 250
NRIPSIPMHH INLVPGRQLR GIYLHGNPFV CDCSLYSLLI FWYRRHFSSV
260 270 280 290 300
MDFKNDYTCR LWSDSRHSHQ LQLLQESFLN CSYSVINGSF HALGFIHEAQ
310 320 330 340 350
VGERAIVHCD SKTGNGNTDF IWVGPDNRLL EPDKDMGNFR VFYNGSLVIE
360 370 380 390 400
NPGFEDAGVY SCIAMNRQRL LNETVDIMIN VSNFTINRSH AHEAFNTAFT
410 420 430 440 450
TLAACVASIV LVLLYLYLTP CPCKCKAKRQ KNTLSQSSAH SSILSPGPTG
460 470 480 490 500
DASADDRKAG KRVVFLEPLK DTAAGQNGKV KLFPSETVIA EGILKSTRAK
510
SDSDSVNSVF SDTPFVAST
Length:519
Mass (Da):57,562
Last modified:June 1, 2003 - v1
Checksum:i0E9DD3FFA20C0A06
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY237006 mRNA Translation: AAO48947.1
AB078880 mRNA Translation: BAC81187.1
CCDSiCCDS27780.1
RefSeqiNP_001158035.1, NM_001164563.1
NP_001158074.1, NM_001164602.1
NP_835215.1, NM_178114.4
UniGeneiMm.24005

Genome annotation databases

EnsembliENSMUST00000053106; ENSMUSP00000059913; ENSMUSG00000048218
GeneIDi105827
KEGGimmu:105827
UCSCiuc007xks.2 mouse

Similar proteinsi

Entry informationi

Entry nameiAMGO2_MOUSE
AccessioniPrimary (citable) accession number: Q80ZD9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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