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UniProtKB - Q80ZD7 (AMGO1_RAT)

UniProt

Q80ZD7 - AMGO1_RAT

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Protein

Amphoterin-induced protein 1

Gene

Amigo1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Promotes growth and fasciculation of neurites from cultured hippocampal neurons. May be involved in fasciculation as well as myelination of developing neural axons. May have a role in regeneration as well as neural plasticity in the adult nervous system. May mediate homophilic as well as heterophilic cell-cell interaction and contribute to signal transduction through its intracellular domain (PubMed:12629050). Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 (By similarity).1 PublicationBy similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • axonal fasciculation Source: UniProtKB
  • axonogenesis Source: RGD
  • cell adhesion Source: RGD
  • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: UniProtKB
  • myelination Source: UniProtKB
  • positive regulation of axonogenesis Source: UniProtKB
  • positive regulation of potassium ion transmembrane transport Source: UniProtKB
  • positive regulation of synapse assembly Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Cell adhesion, Differentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Amphoterin-induced protein 1
Alternative name(s):
AMIGO-1
Alivin-2
Gene namesi
Name:Amigo1By similarity
Synonyms:Ali2By similarity, Amigo1 Publication
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1303079. Amigo1.

Subcellular locationi

  • Cell membrane By similarity; Single-pass type I membrane protein By similarity
  • Perikaryon By similarity
  • Cell projection › dendrite By similarity
  • Cell projection › axon 1 Publication

    • Note: Associated with axons of neuronal cells (PubMed:12629050). Colocalizes with KCNB1 at high-density somatodendritic clusters on the surface of hippocampal and cortical neurons (By similarity).By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini28 – 372345ExtracellularSequence analysisAdd
BLAST
Transmembranei373 – 39321HelicalSequence analysisAdd
BLAST
Topological domaini394 – 493100CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • axon Source: UniProtKB-SubCell
  • dendrite Source: UniProtKB
  • integral component of membrane Source: RGD
  • integral component of plasma membrane Source: UniProtKB
  • neuronal cell body membrane Source: UniProtKB
  • perikaryon Source: UniProtKB-SubCell
  • voltage-gated potassium channel complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence analysisAdd
BLAST
Chaini28 – 493466Amphoterin-induced protein 1Sequence analysisPRO_0000014508Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi34 ↔ 40PROSITE-ProRule annotation
Disulfide bondi38 ↔ 47PROSITE-ProRule annotation
Glycosylationi72 – 721N-linked (GlcNAc...)Sequence analysis
Disulfide bondi225 ↔ 253PROSITE-ProRule annotation
Disulfide bondi227 ↔ 270PROSITE-ProRule annotation
Glycosylationi269 – 2691N-linked (GlcNAc...)Sequence analysis
Disulfide bondi290 ↔ 341PROSITE-ProRule annotation
Glycosylationi315 – 3151N-linked (GlcNAc...)Sequence analysis
Glycosylationi349 – 3491N-linked (GlcNAc...)Sequence analysis
Glycosylationi360 – 3601N-linked (GlcNAc...)Sequence analysis
Modified residuei477 – 4771PhosphoserineCombined sources
Modified residuei481 – 4811PhosphoserineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ80ZD7.
PRIDEiQ80ZD7.

PTM databases

iPTMnetiQ80ZD7.
PhosphoSiteiQ80ZD7.

Expressioni

Developmental stagei

Expressed at moderate levels in the central nervous system of stage 13-14 embryos. Highest levels at this stage in fiber tracts from dorsal root ganglia and trigeminal ganglion to the spinal chord as well as in fibers on both sides of the Purkinje cell layer of the cerebellum. Expression is down-regulated during postnatal stages P6 to P10 followed by up-regulation at the onset of myelination. High level expression in most myelinated axon tracts of the adult including cerebellum, pons, medulla, and spinal chord as well as in nonmyelinated fiber tracts in the striatum lucidum CA3 region of the hippocampus.1 Publication

Inductioni

By HMGB1/amphoterin; in cultured hippocampal neurons.1 Publication

Gene expression databases

BgeeiENSRNOG00000045665.
GenevisibleiQ80ZD7. RN.

Interactioni

Subunit structurei

Homodimer, and heterodimer with AMIGO2 and AMIGO3 (PubMed:12629050). Interacts with KCNB1 (By similarity).By similarity1 Publication

Protein-protein interaction databases

IntActiQ80ZD7. 1 interaction.
MINTiMINT-8298625.
STRINGi10116.ENSRNOP00000066608.

Structurei

3D structure databases

ProteinModelPortaliQ80ZD7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 6134LRRNTAdd
BLAST
Repeati62 – 8322LRR 1Add
BLAST
Repeati87 – 10822LRR 2Add
BLAST
Repeati111 – 13222LRR 3Add
BLAST
Repeati135 – 15622LRR 4Add
BLAST
Repeati159 – 17921LRR 5Add
BLAST
Repeati186 – 20621LRR 6Add
BLAST
Domaini221 – 27252LRRCTAdd
BLAST
Domaini269 – 35385Ig-like C2-typeSequence analysisAdd
BLAST

Domaini

The LRR repeat region mediates homodimerization.By similarity

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. AMIGO family.Curated
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.Sequence analysis
Contains 6 LRR (leucine-rich) repeats.Sequence analysis
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGN4. Eukaryota.
ENOG410ZZH4. LUCA.
GeneTreeiENSGT00530000063545.
HOGENOMiHOG000231327.
HOVERGENiHBG080231.
InParanoidiQ80ZD7.
OMAiCSEYKER.
OrthoDBiEOG091G06PG.
PhylomeDBiQ80ZD7.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR031283. AMIGO.
IPR031284. AMIGO1.
IPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PANTHERiPTHR24368. PTHR24368. 1 hit.
PTHR24368:SF1. PTHR24368:SF1. 1 hit.
PfamiPF07679. I-set. 1 hit.
PF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00369. LRR_TYP. 5 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51450. LRR. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q80ZD7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPQRDLRGL WLLLLSLFLL LFEVARAGRP VVSCPANCLC ASNILSCSKQ 
        60         70         80         90        100
QLPNVPQSLP GYTALLDLSH NNLSRLKAEW TPTRLTNLHS LLLSHNHLNF 
       110        120        130        140        150
ISSEAFVPVP NLRYLDLSSN HLHTLDEFLF SGLQALEVLL LYNNHIVVVD 
       160        170        180        190        200
RNAFEDMAQL QKLYLSQNMI SRFPLELIKD ANRLPKLTLL DLSSNKLKKL 
       210        220        230        240        250
PLTDLQKLPA WVKNGLYLHN NPLECDCKLY QLFSHWQYRQ LSSVMDFQED 
       260        270        280        290        300
LYCVHSKKLH NVFSLDFFNC SEYKESAWEA HLGDTLTITC DTKQQGMTKV 
       310        320        330        340        350
WVTPSNEQVL NQGANGTVTV SEDGNLHFKE VQVEDGGVYT CYAMGETFNE 
       360        370        380        390        400
TLSVELKVYN FTLHGHHDTL NTAYTTLVGC ILSVVLVLIY LYLTPCRCWC 
       410        420        430        440        450
RGVEKPSSHQ GDSLSSSMLS TTPNHDPMAG GDKDDGFDRR VAFLEPAGPG 
       460        470        480        490 
QGQNGKLKPG NTLPVPEATG KGQRRMSDPE SVSSVFSDTP IVV
Length:493
Mass (Da):55,283
Last modified:June 1, 2003 - v1
Checksum:iF7FAAE936B2337D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY237729 mRNA. Translation: AAO48950.1.
RefSeqiNP_996764.1. NM_206881.1.
XP_006233202.1. XM_006233140.2.
XP_008759613.1. XM_008761391.1.
UniGeneiRn.116338.

Genome annotation databases

EnsembliENSRNOT00000074725; ENSRNOP00000066608; ENSRNOG00000045665.
GeneIDi295365.
KEGGirno:295365.
UCSCiRGD:1303079. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY237729 mRNA. Translation: AAO48950.1.
RefSeqiNP_996764.1. NM_206881.1.
XP_006233202.1. XM_006233140.2.
XP_008759613.1. XM_008761391.1.
UniGeneiRn.116338.

3D structure databases

ProteinModelPortaliQ80ZD7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ80ZD7. 1 interaction.
MINTiMINT-8298625.
STRINGi10116.ENSRNOP00000066608.

PTM databases

iPTMnetiQ80ZD7.
PhosphoSiteiQ80ZD7.

Proteomic databases

PaxDbiQ80ZD7.
PRIDEiQ80ZD7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000074725; ENSRNOP00000066608; ENSRNOG00000045665.
GeneIDi295365.
KEGGirno:295365.
UCSCiRGD:1303079. rat.

Organism-specific databases

CTDi57463.
RGDi1303079. Amigo1.

Phylogenomic databases

eggNOGiENOG410IGN4. Eukaryota.
ENOG410ZZH4. LUCA.
GeneTreeiENSGT00530000063545.
HOGENOMiHOG000231327.
HOVERGENiHBG080231.
InParanoidiQ80ZD7.
OMAiCSEYKER.
OrthoDBiEOG091G06PG.
PhylomeDBiQ80ZD7.

Miscellaneous databases

PROiQ80ZD7.

Gene expression databases

BgeeiENSRNOG00000045665.
GenevisibleiQ80ZD7. RN.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR031283. AMIGO.
IPR031284. AMIGO1.
IPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PANTHERiPTHR24368. PTHR24368. 1 hit.
PTHR24368:SF1. PTHR24368:SF1. 1 hit.
PfamiPF07679. I-set. 1 hit.
PF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00369. LRR_TYP. 5 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51450. LRR. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAMGO1_RAT
AccessioniPrimary (citable) accession number: Q80ZD7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 1, 2003
Last modified: September 7, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.