UniProtKB - Q80ZD7 (AMGO1_RAT)
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Protein
Amphoterin-induced protein 1
Gene
Amigo1
Organism
Rattus norvegicus (Rat)
Status
Functioni
Promotes growth and fasciculation of neurites from cultured hippocampal neurons. May be involved in fasciculation as well as myelination of developing neural axons. May have a role in regeneration as well as neural plasticity in the adult nervous system. May mediate homophilic as well as heterophilic cell-cell interaction and contribute to signal transduction through its intracellular domain (PubMed:12629050). Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 (By similarity).1 PublicationBy similarity1 Publication
GO - Molecular functioni
- potassium channel regulator activity Source: UniProtKB
GO - Biological processi
- axonal fasciculation Source: UniProtKB
- axonogenesis Source: RGD
- cell adhesion Source: RGD
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
- homophilic cell adhesion via plasma membrane adhesion molecules Source: UniProtKB
- myelination Source: UniProtKB
- positive regulation of axonogenesis Source: UniProtKB
- positive regulation of potassium ion transmembrane transport Source: UniProtKB
- positive regulation of synapse assembly Source: RGD
Keywordsi
Molecular function | Developmental protein |
Biological process | Cell adhesion, Differentiation, Neurogenesis |
Names & Taxonomyi
Protein namesi | Recommended name: Amphoterin-induced protein 1Alternative name(s): AMIGO-1 Alivin-2 |
Gene namesi | |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1303079 Amigo1 |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 28 – 372 | ExtracellularSequence analysisAdd BLAST | 345 | |
Transmembranei | 373 – 393 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 394 – 493 | CytoplasmicSequence analysisAdd BLAST | 100 |
Keywords - Cellular componenti
Cell membrane, Cell projection, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 27 | Sequence analysisAdd BLAST | 27 | |
ChainiPRO_0000014508 | 28 – 493 | Amphoterin-induced protein 1Sequence analysisAdd BLAST | 466 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 34 ↔ 40 | PROSITE-ProRule annotation | ||
Disulfide bondi | 38 ↔ 47 | PROSITE-ProRule annotation | ||
Glycosylationi | 72 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 225 ↔ 253 | PROSITE-ProRule annotation | ||
Disulfide bondi | 227 ↔ 270 | PROSITE-ProRule annotation | ||
Glycosylationi | 269 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 290 ↔ 341 | PROSITE-ProRule annotation | ||
Glycosylationi | 315 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 349 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 360 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 477 | PhosphoserineCombined sources | 1 | |
Modified residuei | 481 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | Q80ZD7 |
PRIDEi | Q80ZD7 |
PTM databases
iPTMneti | Q80ZD7 |
PhosphoSitePlusi | Q80ZD7 |
Expressioni
Developmental stagei
Expressed at moderate levels in the central nervous system of stage 13-14 embryos. Highest levels at this stage in fiber tracts from dorsal root ganglia and trigeminal ganglion to the spinal chord as well as in fibers on both sides of the Purkinje cell layer of the cerebellum. Expression is down-regulated during postnatal stages P6 to P10 followed by up-regulation at the onset of myelination. High level expression in most myelinated axon tracts of the adult including cerebellum, pons, medulla, and spinal chord as well as in nonmyelinated fiber tracts in the striatum lucidum CA3 region of the hippocampus.1 Publication
Inductioni
By HMGB1/amphoterin; in cultured hippocampal neurons.1 Publication
Gene expression databases
Bgeei | ENSRNOG00000045665 |
Genevisiblei | Q80ZD7 RN |
Interactioni
Subunit structurei
Homodimer, and heterodimer with AMIGO2 and AMIGO3 (PubMed:12629050). Interacts with KCNB1 (By similarity).By similarity1 Publication
Protein-protein interaction databases
IntActi | Q80ZD7 1 interactor. |
MINTi | Q80ZD7 |
STRINGi | 10116.ENSRNOP00000066608 |
Structurei
3D structure databases
ProteinModelPortali | Q80ZD7 |
SMRi | Q80ZD7 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 28 – 61 | LRRNTAdd BLAST | 34 | |
Repeati | 62 – 83 | LRR 1Add BLAST | 22 | |
Repeati | 87 – 108 | LRR 2Add BLAST | 22 | |
Repeati | 111 – 132 | LRR 3Add BLAST | 22 | |
Repeati | 135 – 156 | LRR 4Add BLAST | 22 | |
Repeati | 159 – 179 | LRR 5Add BLAST | 21 | |
Repeati | 186 – 206 | LRR 6Add BLAST | 21 | |
Domaini | 221 – 272 | LRRCTAdd BLAST | 52 | |
Domaini | 269 – 353 | Ig-like C2-typeSequence analysisAdd BLAST | 85 |
Domaini
The LRR repeat region mediates homodimerization.By similarity
Sequence similaritiesi
Keywords - Domaini
Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG410IGN4 Eukaryota ENOG410ZZH4 LUCA |
GeneTreei | ENSGT00530000063545 |
HOGENOMi | HOG000231327 |
HOVERGENi | HBG080231 |
InParanoidi | Q80ZD7 |
OMAi | CSEYKER |
OrthoDBi | EOG091G06PG |
PhylomeDBi | Q80ZD7 |
Family and domain databases
Gene3Di | 2.60.40.101 hit 3.80.10.101 hit |
InterProi | View protein in InterPro IPR031283 AMIGO IPR031284 AMIGO1 IPR000483 Cys-rich_flank_reg_C IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR013098 Ig_I-set IPR003599 Ig_sub IPR003598 Ig_sub2 IPR001611 Leu-rich_rpt IPR003591 Leu-rich_rpt_typical-subtyp IPR032675 LRR_dom_sf |
PANTHERi | PTHR24368 PTHR24368, 1 hit PTHR24368:SF1 PTHR24368:SF1, 1 hit |
Pfami | View protein in Pfam PF07679 I-set, 1 hit PF13855 LRR_8, 1 hit |
SMARTi | View protein in SMART SM00409 IG, 1 hit SM00408 IGc2, 1 hit SM00369 LRR_TYP, 5 hits SM00082 LRRCT, 1 hit |
SUPFAMi | SSF48726 SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835 IG_LIKE, 1 hit PS51450 LRR, 6 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q80ZD7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQPQRDLRGL WLLLLSLFLL LFEVARAGRP VVSCPANCLC ASNILSCSKQ
60 70 80 90 100
QLPNVPQSLP GYTALLDLSH NNLSRLKAEW TPTRLTNLHS LLLSHNHLNF
110 120 130 140 150
ISSEAFVPVP NLRYLDLSSN HLHTLDEFLF SGLQALEVLL LYNNHIVVVD
160 170 180 190 200
RNAFEDMAQL QKLYLSQNMI SRFPLELIKD ANRLPKLTLL DLSSNKLKKL
210 220 230 240 250
PLTDLQKLPA WVKNGLYLHN NPLECDCKLY QLFSHWQYRQ LSSVMDFQED
260 270 280 290 300
LYCVHSKKLH NVFSLDFFNC SEYKESAWEA HLGDTLTITC DTKQQGMTKV
310 320 330 340 350
WVTPSNEQVL NQGANGTVTV SEDGNLHFKE VQVEDGGVYT CYAMGETFNE
360 370 380 390 400
TLSVELKVYN FTLHGHHDTL NTAYTTLVGC ILSVVLVLIY LYLTPCRCWC
410 420 430 440 450
RGVEKPSSHQ GDSLSSSMLS TTPNHDPMAG GDKDDGFDRR VAFLEPAGPG
460 470 480 490
QGQNGKLKPG NTLPVPEATG KGQRRMSDPE SVSSVFSDTP IVV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY237729 mRNA Translation: AAO48950.1 |
RefSeqi | NP_996764.1, NM_206881.1 XP_006233202.1, XM_006233140.2 XP_008759613.1, XM_008761391.1 |
UniGenei | Rn.116338 |
Genome annotation databases
Ensembli | ENSRNOT00000074725; ENSRNOP00000066608; ENSRNOG00000045665 |
GeneIDi | 295365 |
KEGGi | rno:295365 |
UCSCi | RGD:1303079 rat |
Similar proteinsi
Entry informationi
Entry namei | AMGO1_RAT | |
Accessioni | Q80ZD7Primary (citable) accession number: Q80ZD7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 21, 2005 |
Last sequence update: | June 1, 2003 | |
Last modified: | February 28, 2018 | |
This is version 114 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |