Amigo1

Functionⁱ

Promotes growth and fasciculation of neurites from cultured hippocampal neurons. May be involved in fasciculation as well as myelination of developing neural axons. May have a role in regeneration as well as neural plasticity in the adult nervous system. May mediate homophilic as well as heterophilic cell-cell interaction and contribute to signal transduction through its intracellular domain (PubMed:12629050). Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 (By similarity).1 PublicationBy similarity1 Publication

GO - Molecular functionⁱ

potassium channel regulator activity Source: UniProtKB

Complete GO annotation...

GO - Biological processⁱ

axonal fasciculation
Source: UniProtKB
Inferred from direct assayⁱ
- 12629050
axonogenesis
Source: RGD
Inferred from direct assayⁱ
- 12629050
cell adhesion
Source: RGD
Traceable author statementⁱ
- 12629050
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
Source: UniProtKB
Inferred from physical interactionⁱ
- 12629050
homophilic cell adhesion via plasma membrane adhesion molecules
Source: UniProtKB
Inferred from physical interactionⁱ
- 12629050
myelination
Source: UniProtKB
Inferred from expression patternⁱ
- 12629050
positive regulation of axonogenesis
Source: UniProtKB
Inferred from direct assayⁱ
- 12629050
positive regulation of potassium ion transmembrane transport Source: UniProtKB
positive regulation of synapse assembly Source: Ensembl

Complete GO annotation...

Keywordsⁱ

Molecular function	Developmental protein
Biological process	Cell adhesion, Differentiation, Neurogenesis

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Amphoterin-induced protein 1 Alternative name(s): AMIGO-1 Alivin-2
Gene namesⁱ	Name:Amigo1By similarity Synonyms:Ali2By similarity, Amigo1 Publication
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 2

Organism-specific databases

Rat genome database More...RGDⁱ	1303079. Amigo1.

RGDⁱ

1303079. Amigo1.

Subcellular locationⁱ

Note:

Associated with axons of neuronal cells (PubMed:12629050). Colocalizes with KCNB1 at high-density somatodendritic clusters on the surface of hippocampal and cortical neurons (By similarity).By similarity

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	28 – 372	ExtracellularSequence analysisAdd BLAST	345
Transmembraneⁱ	373 – 393	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	394 – 493	CytoplasmicSequence analysisAdd BLAST	100

GO - Cellular componentⁱ

axon Source: UniProtKB-SubCell
dendrite Source: UniProtKB
integral component of membrane
Source: RGD
Inferred from direct assayⁱ
- 12629050
integral component of plasma membrane
Source: UniProtKB
Non-traceable author statementⁱ
- 12629050
neuronal cell body membrane Source: UniProtKB
perikaryon Source: UniProtKB-SubCell
voltage-gated potassium channel complex Source: Ensembl

Complete GO annotation...

Keywords - Cellular componentⁱ

Cell membrane, Cell projection, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 27	Sequence analysisAdd BLAST		27
ChainⁱPRO_0000014508	28 – 493	Amphoterin-induced protein 1Sequence analysisAdd BLAST		466

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	34 ↔ 40	PROSITE-ProRule annotation
Disulfide bondⁱ	38 ↔ 47	PROSITE-ProRule annotation
Glycosylationⁱ	72	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	225 ↔ 253	PROSITE-ProRule annotation
Disulfide bondⁱ	227 ↔ 270	PROSITE-ProRule annotation
Glycosylationⁱ	269	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	290 ↔ 341	PROSITE-ProRule annotation
Glycosylationⁱ	315	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	349	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	360	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	477	PhosphoserineCombined sources	1
Modified residueⁱ	481	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbⁱ	Q80ZD7.
PRIDEⁱ	Q80ZD7.

PTM databases

iPTMnetⁱ	Q80ZD7.
PhosphoSitePlusⁱ	Q80ZD7.

Expressionⁱ

Developmental stageⁱ

Expressed at moderate levels in the central nervous system of stage 13-14 embryos. Highest levels at this stage in fiber tracts from dorsal root ganglia and trigeminal ganglion to the spinal chord as well as in fibers on both sides of the Purkinje cell layer of the cerebellum. Expression is down-regulated during postnatal stages P6 to P10 followed by up-regulation at the onset of myelination. High level expression in most myelinated axon tracts of the adult including cerebellum, pons, medulla, and spinal chord as well as in nonmyelinated fiber tracts in the striatum lucidum CA3 region of the hippocampus.1 Publication

Inductionⁱ

By HMGB1/amphoterin; in cultured hippocampal neurons.1 Publication

Gene expression databases

Bgeeⁱ	ENSRNOG00000045665.
Genevisibleⁱ	Q80ZD7. RN.

Interactionⁱ

Subunit structureⁱ

Homodimer, and heterodimer with AMIGO2 and AMIGO3 (PubMed:12629050). Interacts with KCNB1 (By similarity).By similarity1 Publication

Protein-protein interaction databases

IntActⁱ	Q80ZD7. 1 interactor.
Molecular INTeraction database More...MINTⁱ	MINT-8298625.
STRINGⁱ	10116.ENSRNOP00000066608.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q80ZD7.
SMRⁱ	Q80ZD7.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	28 – 61	LRRNTAdd BLAST	34
Repeatⁱ	62 – 83	LRR 1Add BLAST	22
Repeatⁱ	87 – 108	LRR 2Add BLAST	22
Repeatⁱ	111 – 132	LRR 3Add BLAST	22
Repeatⁱ	135 – 156	LRR 4Add BLAST	22
Repeatⁱ	159 – 179	LRR 5Add BLAST	21
Repeatⁱ	186 – 206	LRR 6Add BLAST	21
Domainⁱ	221 – 272	LRRCTAdd BLAST	52
Domainⁱ	269 – 353	Ig-like C2-typeSequence analysisAdd BLAST	85

Domainⁱ

The LRR repeat region mediates homodimerization.By similarity

Sequence similaritiesⁱ

Belongs to the immunoglobulin superfamily. AMIGO family.Curated

Keywords - Domainⁱ

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IGN4. Eukaryota. ENOG410ZZH4. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063545.
HOGENOMⁱ	HOG000231327.
HOVERGENⁱ	HBG080231.
InParanoidⁱ	Q80ZD7.
OMAⁱ	CSEYKER.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06PG.
PhylomeDBⁱ	Q80ZD7.

Family and domain databases

Gene3Dⁱ	2.60.40.10. 1 hit. 3.80.10.10. 1 hit.
InterProⁱ	View protein in InterPro IPR031283. AMIGO. IPR031284. AMIGO1. IPR000483. Cys-rich_flank_reg_C. IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR013098. Ig_I-set. IPR003599. Ig_sub. IPR003598. Ig_sub2. IPR032675. L_dom-like. IPR001611. Leu-rich_rpt. IPR003591. Leu-rich_rpt_typical-subtyp.
PANTHERⁱ	PTHR24368. PTHR24368. 1 hit. PTHR24368:SF213. PTHR24368:SF213. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07679. I-set. 1 hit. PF13855. LRR_8. 1 hit.
SMARTⁱ	View protein in SMART SM00409. IG. 1 hit. SM00408. IGc2. 1 hit. SM00369. LRR_TYP. 5 hits. SM00082. LRRCT. 1 hit.
SUPFAMⁱ	SSF48726. SSF48726. 1 hit. SSF52058. SSF52058. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50835. IG_LIKE. 1 hit. PS51450. LRR. 6 hits.

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q80ZD7-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MQPQRDLRGL WLLLLSLFLL LFEVARAGRP VVSCPANCLC ASNILSCSKQ 
        60         70         80         90        100
QLPNVPQSLP GYTALLDLSH NNLSRLKAEW TPTRLTNLHS LLLSHNHLNF 
       110        120        130        140        150
ISSEAFVPVP NLRYLDLSSN HLHTLDEFLF SGLQALEVLL LYNNHIVVVD 
       160        170        180        190        200
RNAFEDMAQL QKLYLSQNMI SRFPLELIKD ANRLPKLTLL DLSSNKLKKL 
       210        220        230        240        250
PLTDLQKLPA WVKNGLYLHN NPLECDCKLY QLFSHWQYRQ LSSVMDFQED 
       260        270        280        290        300
LYCVHSKKLH NVFSLDFFNC SEYKESAWEA HLGDTLTITC DTKQQGMTKV 
       310        320        330        340        350
WVTPSNEQVL NQGANGTVTV SEDGNLHFKE VQVEDGGVYT CYAMGETFNE 
       360        370        380        390        400
TLSVELKVYN FTLHGHHDTL NTAYTTLVGC ILSVVLVLIY LYLTPCRCWC 
       410        420        430        440        450
RGVEKPSSHQ GDSLSSSMLS TTPNHDPMAG GDKDDGFDRR VAFLEPAGPG 
       460        470        480        490 
QGQNGKLKPG NTLPVPEATG KGQRRMSDPE SVSSVFSDTP IVV

Length:493

Mass (Da):55,283

Last modified:June 1, 2003 - v1

Checksum:ⁱF7FAAE936B2337D4

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY237729 mRNA. Translation: AAO48950.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_996764.1. NM_206881.1. XP_006233202.1. XM_006233140.2. XP_008759613.1. XM_008761391.1.
UniGeneⁱ	Rn.116338.

Genome annotation databases

Ensemblⁱ	ENSRNOT00000074725; ENSRNOP00000066608; ENSRNOG00000045665.
GeneIDⁱ	295365.
KEGGⁱ	rno:295365.
UCSC genome browser More...UCSCⁱ	RGD:1303079. rat.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY237729 mRNA. Translation: AAO48950.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_996764.1. NM_206881.1. XP_006233202.1. XM_006233140.2. XP_008759613.1. XM_008761391.1.
UniGeneⁱ	Rn.116338.

3D structure databases

ProteinModelPortalⁱ	Q80ZD7.
SMRⁱ	Q80ZD7.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q80ZD7. 1 interactor.
Molecular INTeraction database More...MINTⁱ	MINT-8298625.
STRINGⁱ	10116.ENSRNOP00000066608.

PTM databases

iPTMnetⁱ	Q80ZD7.
PhosphoSitePlusⁱ	Q80ZD7.

Proteomic databases

PaxDbⁱ	Q80ZD7.
PRIDEⁱ	Q80ZD7.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000074725; ENSRNOP00000066608; ENSRNOG00000045665.
GeneIDⁱ	295365.
KEGGⁱ	rno:295365.
UCSC genome browser More...UCSCⁱ	RGD:1303079. rat.

Organism-specific databases

CTDⁱ	57463.
Rat genome database More...RGDⁱ	1303079. Amigo1.

Phylogenomic databases

eggNOGⁱ	ENOG410IGN4. Eukaryota. ENOG410ZZH4. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063545.
HOGENOMⁱ	HOG000231327.
HOVERGENⁱ	HBG080231.
InParanoidⁱ	Q80ZD7.
OMAⁱ	CSEYKER.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06PG.
PhylomeDBⁱ	Q80ZD7.

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q80ZD7.

PROⁱ

PR:Q80ZD7.

Gene expression databases

Bgeeⁱ	ENSRNOG00000045665.
Genevisibleⁱ	Q80ZD7. RN.

Family and domain databases

Gene3Dⁱ	2.60.40.10. 1 hit. 3.80.10.10. 1 hit.
InterProⁱ	View protein in InterPro IPR031283. AMIGO. IPR031284. AMIGO1. IPR000483. Cys-rich_flank_reg_C. IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR013098. Ig_I-set. IPR003599. Ig_sub. IPR003598. Ig_sub2. IPR032675. L_dom-like. IPR001611. Leu-rich_rpt. IPR003591. Leu-rich_rpt_typical-subtyp.
PANTHERⁱ	PTHR24368. PTHR24368. 1 hit. PTHR24368:SF213. PTHR24368:SF213. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07679. I-set. 1 hit. PF13855. LRR_8. 1 hit.
SMARTⁱ	View protein in SMART SM00409. IG. 1 hit. SM00408. IGc2. 1 hit. SM00369. LRR_TYP. 5 hits. SM00082. LRRCT. 1 hit.
SUPFAMⁱ	SSF48726. SSF48726. 1 hit. SSF52058. SSF52058. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50835. IG_LIKE. 1 hit. PS51450. LRR. 6 hits.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	AMGO1_RAT
Accessionⁱ	Q80ZD7Primary (citable) accession number: Q80ZD7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 21, 2005
	Last sequence update:	June 1, 2003
	Last modified:	May 10, 2017
	This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

UniProtKB

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Annotation systems

Supporting data

UniProtKB - Q80ZD7 (AMGO1_RAT)

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Amphoterin-induced protein 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ