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Protein

Amphoterin-induced protein 3

Gene

Amigo3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May mediate heterophilic cell-cell interaction. May contribute to signal transduction through its intracellular domain.1 Publication

GO - Biological processi

  • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
  • nervous system development Source: RGD
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Amphoterin-induced protein 3
Alternative name(s):
AMIGO-3
Alivin-3
Gene namesi
Name:Amigo3Imported
Synonyms:Ali3By similarity
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi631413. Amigo3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 383364ExtracellularSequence analysisAdd
BLAST
Transmembranei384 – 40421HelicalSequence analysisAdd
BLAST
Topological domaini405 – 508104CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 508489Amphoterin-induced protein 3Sequence analysisPRO_0000014515Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi34 ↔ 40PROSITE-ProRule annotation
Disulfide bondi38 ↔ 47PROSITE-ProRule annotation
Glycosylationi107 – 1071N-linked (GlcNAc...)Sequence analysis
Disulfide bondi223 ↔ 251PROSITE-ProRule annotation
Disulfide bondi225 ↔ 273PROSITE-ProRule annotation
Glycosylationi272 – 2721N-linked (GlcNAc...)Sequence analysis
Disulfide bondi300 ↔ 352PROSITE-ProRule annotation
Glycosylationi301 – 3011N-linked (GlcNAc...)Sequence analysis
Glycosylationi362 – 3621N-linked (GlcNAc...)Sequence analysis
Glycosylationi368 – 3681N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ80ZD5.

Interactioni

Subunit structurei

Binds AMIGO1 or AMIGO2.

Structurei

3D structure databases

ProteinModelPortaliQ80ZD5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 6137LRRNTAdd
BLAST
Repeati62 – 8322LRR 1Add
BLAST
Repeati86 – 10722LRR 2Add
BLAST
Repeati110 – 13122LRR 3Add
BLAST
Repeati134 – 15522LRR 4Add
BLAST
Repeati158 – 17821LRR 5Add
BLAST
Repeati184 – 20724LRR 6Add
BLAST
Domaini219 – 27557LRRCTAdd
BLAST
Domaini279 – 37092Ig-like C2-typeSequence analysisAdd
BLAST

Sequence similaritiesi

Contains 6 LRR (leucine-rich) repeats.Sequence analysis
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG080231.
InParanoidiQ80ZD5.
PhylomeDBiQ80ZD5.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR031283. AMIGO.
IPR031285. AMIGO3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PANTHERiPTHR24368. PTHR24368. 1 hit.
PTHR24368:SF62. PTHR24368:SF62. 1 hit.
PfamiPF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00369. LRR_TYP. 6 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q80ZD5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAWLVLLGLL LCMLGAGSGT SDLEGVLPPD PHNCPNKCVC AADVLSCAGR
60 70 80 90 100
GLQDLPAALP ATAAELDLSH NALKRLHPGW LAPLSRLRAL YLGYNKLDVL
110 120 130 140 150
GRGVFTNASG LRILDLSSNL LRRLRTYDLD GLEELEKLLL FNNRLMHLDL
160 170 180 190 200
DAFQGLSMLS HLYLSCNELS SFSFNHLHGL GLTRLRTLDL SSNWLGHVSV
210 220 230 240 250
PELAALPTFL KNRLYLHNNP LPCDCSLYHL LRRWHQRGLS ALHDFEREYT
260 270 280 290 300
CLAFKVAESR VRFFEHSRVF KNCSVAAAPG LELPEEELHT HVGQSLRLFC
310 320 330 340 350
NTTVPAARVA WVSPKNELLV APGSQDGSIA VLADGSLAIG RVQEQHAGLF
360 370 380 390 400
VCLASGPRLH HNQTLEYNVS VHKPRPEPEA FNTGFTTLLG CIVGLVLVLL
410 420 430 440 450
YLFAPPCRGC CRCCRRACRN RCWPRASSPL QELSAQSSVL STTPPDAPSR
460 470 480 490 500
KASVHKHVAF LEPGKKGLNG RVQLAVAEDF DLCNPMGLQL KAGSESASST

GSEGLMMS
Length:508
Mass (Da):55,565
Last modified:June 1, 2003 - v1
Checksum:iFD983CE97D83392D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY237731 mRNA. Translation: AAO48952.1.
RefSeqiNP_835280.1. NM_178144.1.
UniGeneiRn.203829.

Genome annotation databases

GeneIDi316003.
KEGGirno:316003.
UCSCiRGD:631413. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY237731 mRNA. Translation: AAO48952.1.
RefSeqiNP_835280.1. NM_178144.1.
UniGeneiRn.203829.

3D structure databases

ProteinModelPortaliQ80ZD5.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ80ZD5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi316003.
KEGGirno:316003.
UCSCiRGD:631413. rat.

Organism-specific databases

CTDi386724.
RGDi631413. Amigo3.

Phylogenomic databases

HOVERGENiHBG080231.
InParanoidiQ80ZD5.
PhylomeDBiQ80ZD5.

Miscellaneous databases

PROiQ80ZD5.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR031283. AMIGO.
IPR031285. AMIGO3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PANTHERiPTHR24368. PTHR24368. 1 hit.
PTHR24368:SF62. PTHR24368:SF62. 1 hit.
PfamiPF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00369. LRR_TYP. 6 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAMGO3_RAT
AccessioniPrimary (citable) accession number: Q80ZD5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 1, 2003
Last modified: June 8, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.