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Protein

Amphoterin-induced protein 3

Gene

Amigo3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May mediate heterophilic cell-cell interaction. May contribute to signal transduction through its intracellular domain.1 Publication

GO - Biological processi

  • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
  • nervous system development Source: RGD

Keywordsi

Biological processCell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Amphoterin-induced protein 3
Alternative name(s):
AMIGO-3
Alivin-3
Gene namesi
Name:Amigo3Imported
Synonyms:Ali3By similarity
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi631413 Amigo3

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 383ExtracellularSequence analysisAdd BLAST364
Transmembranei384 – 404HelicalSequence analysisAdd BLAST21
Topological domaini405 – 508CytoplasmicSequence analysisAdd BLAST104

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001451520 – 508Amphoterin-induced protein 3Sequence analysisAdd BLAST489

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 40PROSITE-ProRule annotation
Disulfide bondi38 ↔ 47PROSITE-ProRule annotation
Glycosylationi107N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi223 ↔ 251PROSITE-ProRule annotation
Disulfide bondi225 ↔ 273PROSITE-ProRule annotation
Glycosylationi272N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi300 ↔ 352PROSITE-ProRule annotation
Glycosylationi301N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi362N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi368N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ80ZD5

Interactioni

Subunit structurei

Binds AMIGO1 or AMIGO2.

Structurei

3D structure databases

ProteinModelPortaliQ80ZD5
SMRiQ80ZD5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 61LRRNTAdd BLAST37
Repeati62 – 83LRR 1Add BLAST22
Repeati86 – 107LRR 2Add BLAST22
Repeati110 – 131LRR 3Add BLAST22
Repeati134 – 155LRR 4Add BLAST22
Repeati158 – 178LRR 5Add BLAST21
Repeati184 – 207LRR 6Add BLAST24
Domaini219 – 275LRRCTAdd BLAST57
Domaini279 – 370Ig-like C2-typeSequence analysisAdd BLAST92

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG080231
InParanoidiQ80ZD5
KOiK22529
PhylomeDBiQ80ZD5

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR031283 AMIGO
IPR031285 AMIGO3
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PANTHERiPTHR24368 PTHR24368, 1 hit
PTHR24368:SF62 PTHR24368:SF62, 1 hit
PfamiView protein in Pfam
PF13855 LRR_8, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00369 LRR_TYP, 6 hits
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q80ZD5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAWLVLLGLL LCMLGAGSGT SDLEGVLPPD PHNCPNKCVC AADVLSCAGR
60 70 80 90 100
GLQDLPAALP ATAAELDLSH NALKRLHPGW LAPLSRLRAL YLGYNKLDVL
110 120 130 140 150
GRGVFTNASG LRILDLSSNL LRRLRTYDLD GLEELEKLLL FNNRLMHLDL
160 170 180 190 200
DAFQGLSMLS HLYLSCNELS SFSFNHLHGL GLTRLRTLDL SSNWLGHVSV
210 220 230 240 250
PELAALPTFL KNRLYLHNNP LPCDCSLYHL LRRWHQRGLS ALHDFEREYT
260 270 280 290 300
CLAFKVAESR VRFFEHSRVF KNCSVAAAPG LELPEEELHT HVGQSLRLFC
310 320 330 340 350
NTTVPAARVA WVSPKNELLV APGSQDGSIA VLADGSLAIG RVQEQHAGLF
360 370 380 390 400
VCLASGPRLH HNQTLEYNVS VHKPRPEPEA FNTGFTTLLG CIVGLVLVLL
410 420 430 440 450
YLFAPPCRGC CRCCRRACRN RCWPRASSPL QELSAQSSVL STTPPDAPSR
460 470 480 490 500
KASVHKHVAF LEPGKKGLNG RVQLAVAEDF DLCNPMGLQL KAGSESASST

GSEGLMMS
Length:508
Mass (Da):55,565
Last modified:June 1, 2003 - v1
Checksum:iFD983CE97D83392D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY237731 mRNA Translation: AAO48952.1
RefSeqiNP_835280.1, NM_178144.1
UniGeneiRn.203829

Genome annotation databases

GeneIDi316003
KEGGirno:316003
UCSCiRGD:631413 rat

Similar proteinsi

Entry informationi

Entry nameiAMGO3_RAT
AccessioniPrimary (citable) accession number: Q80ZD5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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