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Protein

Sodium-independent sulfate anion transporter

Gene

Slc26a11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Exhibits sodium-independent sulfate anion transporter activity that may cooperate with SLC26A2 to mediate DIDS-sensitive sulfate uptake into high endothelial venules endothelial cells (HEVEC).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Anion exchange, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-427601. Multifunctional anion exchangers.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-independent sulfate anion transporter
Alternative name(s):
Solute carrier family 26 member 11
Gene namesi
Name:Slc26a11Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2444589. Slc26a11.

Subcellular locationi

  • Cell membrane By similarity; Multi-pass membrane protein By similarity
  • Lysosome membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 34ExtracellularSequence analysisAdd BLAST34
Transmembranei35 – 55HelicalSequence analysisAdd BLAST21
Topological domaini56CytoplasmicSequence analysis1
Transmembranei57 – 77HelicalSequence analysisAdd BLAST21
Topological domaini78 – 82ExtracellularSequence analysis5
Transmembranei83 – 100HelicalSequence analysisAdd BLAST18
Topological domaini101 – 106CytoplasmicSequence analysis6
Transmembranei107 – 127HelicalSequence analysisAdd BLAST21
Topological domaini128 – 176ExtracellularSequence analysisAdd BLAST49
Transmembranei177 – 197HelicalSequence analysisAdd BLAST21
Topological domaini198 – 233CytoplasmicSequence analysisAdd BLAST36
Transmembranei234 – 254HelicalSequence analysisAdd BLAST21
Topological domaini255 – 287ExtracellularSequence analysisAdd BLAST33
Transmembranei288 – 308HelicalSequence analysisAdd BLAST21
Topological domaini309 – 324CytoplasmicSequence analysisAdd BLAST16
Transmembranei325 – 345HelicalSequence analysisAdd BLAST21
Topological domaini346 – 361ExtracellularSequence analysisAdd BLAST16
Transmembranei362 – 382HelicalSequence analysisAdd BLAST21
Topological domaini383CytoplasmicSequence analysis1
Transmembranei384 – 404HelicalSequence analysisAdd BLAST21
Topological domaini405 – 417ExtracellularSequence analysisAdd BLAST13
Transmembranei418 – 438HelicalSequence analysisAdd BLAST21
Topological domaini439 – 593CytoplasmicSequence analysisAdd BLAST155

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003206871 – 593Sodium-independent sulfate anion transporterAdd BLAST593

Proteomic databases

PaxDbiQ80ZD3.
PeptideAtlasiQ80ZD3.
PRIDEiQ80ZD3.

PTM databases

iPTMnetiQ80ZD3.
PhosphoSitePlusiQ80ZD3.
SwissPalmiQ80ZD3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000039908.
CleanExiMM_SLC26A11.
GenevisibleiQ80ZD3. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000050999.

Structurei

3D structure databases

ProteinModelPortaliQ80ZD3.
SMRiQ80ZD3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini453 – 566STASPROSITE-ProRule annotationAdd BLAST114

Sequence similaritiesi

Contains 1 STAS domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0236. Eukaryota.
COG0659. LUCA.
GeneTreeiENSGT00850000132388.
HOGENOMiHOG000031187.
HOVERGENiHBG054728.
InParanoidiQ80ZD3.
KOiK14708.
OMAiECTHISS.
OrthoDBiEOG091G05ML.
PhylomeDBiQ80ZD3.
TreeFamiTF323537.

Family and domain databases

Gene3Di3.30.750.24. 1 hit.
InterProiIPR018045. S04_transporter_CS.
IPR011547. SLC26A/SulP_dom.
IPR001902. SLC26A/SulP_fam.
IPR002645. STAS_dom.
[Graphical view]
PANTHERiPTHR11814. PTHR11814. 1 hit.
PfamiPF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view]
SUPFAMiSSF52091. SSF52091. 1 hit.
PROSITEiPS01130. SLC26A. 1 hit.
PS50801. STAS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 13 Publications (identifier: Q80ZD3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPDTCCCSA TALRRRLPVL AWVPDYSLQW LRLDFIAGLS VGLTVIPQAL
60 70 80 90 100
AYAEVAGLPP QYGLYSAFMG CFVYFFLGTS RDVTLGPTAI MSLLVSFYTF
110 120 130 140 150
REPAYAVLLA FLSGCIQLAM GLLHLGFLLD FISCPVIKGF TSAASITIGF
160 170 180 190 200
GQIKNLLGLQ KIPRQFFLQV YHTFLHIGET RVGDAVLGLA SMLLLLVLKC
210 220 230 240 250
MREHMPPPHP EMPLAVKFSR GLVWTVTTAR NALVVSSAAL IAYAFEVTGS
260 270 280 290 300
HPFVLTGKIA EGLPPVRIPP FSVTRDNKTI SFSEMVQDMG AGLAVVPLMG
310 320 330 340 350
LLESIAVAKS FASQNNYRID ANQELLAIGL TNVLGSLVSS YPVTGSFGRT
360 370 380 390 400
AVNAQTGVCT PAGGLVTGAL VLLSLNYLTS LFSYIPKSAL AAVIITAVTP
410 420 430 440 450
LFDVKIFRSL WRVQRLDLLP LCVTFLLSFW EIQYGILAGS LVSLLILLHS
460 470 480 490 500
VARPKTQVSE GQIFVLQPAS GLYFPAIDAL REAITNRALE ASPPRSAVLE
510 520 530 540 550
CTHISSVDYT VIVGLGELLE DFQKKGVALA FVGLQVPVLR TLLAADLKGF
560 570 580 590
RYFTTLEEAE KFLQQEPGTE PNSIHEDAVP EQRSSLLKSP SGP
Length:593
Mass (Da):64,109
Last modified:February 26, 2008 - v2
Checksum:iB073D040EAA77DDE
GO
Isoform 22 Publications (identifier: Q80ZD3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-8: MAPDTCCC → MHAPTPVC
     9-180: Missing.

Show »
Length:421
Mass (Da):45,204
Checksum:i7404536D669503E1
GO

Sequence cautioni

The sequence AAH38604 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti37A → S in AAH38604 (PubMed:15489334).Curated1
Sequence conflicti205M → V in AAO49173 (Ref. 1) Curated1
Sequence conflicti369A → T in AAO49173 (Ref. 1) Curated1
Sequence conflicti396T → A in AAO49173 (Ref. 1) Curated1
Sequence conflicti500E → G in BAC40782 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0526871 – 8MAPDTCCC → MHAPTPVC in isoform 2. 2 Publications8
Alternative sequenceiVSP_0526889 – 180Missing in isoform 2. 2 PublicationsAdd BLAST172

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF345196 mRNA. Translation: AAO49173.1.
AK052202 mRNA. Translation: BAC34882.1.
AK089182 mRNA. Translation: BAC40782.1.
BC038604 mRNA. Translation: AAH38604.1. Different initiation.
BC132493 mRNA. Translation: AAI32494.1.
BC137897 mRNA. Translation: AAI37898.1.
CCDSiCCDS25717.1. [Q80ZD3-1]
RefSeqiNP_848858.2. NM_178743.3. [Q80ZD3-1]
XP_006533484.1. XM_006533421.2. [Q80ZD3-2]
UniGeneiMm.31869.

Genome annotation databases

EnsembliENSMUST00000050880; ENSMUSP00000050999; ENSMUSG00000039908. [Q80ZD3-1]
GeneIDi268512.
KEGGimmu:268512.
UCSCiuc007mqm.1. mouse. [Q80ZD3-1]
uc007mqn.1. mouse. [Q80ZD3-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF345196 mRNA. Translation: AAO49173.1.
AK052202 mRNA. Translation: BAC34882.1.
AK089182 mRNA. Translation: BAC40782.1.
BC038604 mRNA. Translation: AAH38604.1. Different initiation.
BC132493 mRNA. Translation: AAI32494.1.
BC137897 mRNA. Translation: AAI37898.1.
CCDSiCCDS25717.1. [Q80ZD3-1]
RefSeqiNP_848858.2. NM_178743.3. [Q80ZD3-1]
XP_006533484.1. XM_006533421.2. [Q80ZD3-2]
UniGeneiMm.31869.

3D structure databases

ProteinModelPortaliQ80ZD3.
SMRiQ80ZD3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000050999.

PTM databases

iPTMnetiQ80ZD3.
PhosphoSitePlusiQ80ZD3.
SwissPalmiQ80ZD3.

Proteomic databases

PaxDbiQ80ZD3.
PeptideAtlasiQ80ZD3.
PRIDEiQ80ZD3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000050880; ENSMUSP00000050999; ENSMUSG00000039908. [Q80ZD3-1]
GeneIDi268512.
KEGGimmu:268512.
UCSCiuc007mqm.1. mouse. [Q80ZD3-1]
uc007mqn.1. mouse. [Q80ZD3-2]

Organism-specific databases

CTDi284129.
MGIiMGI:2444589. Slc26a11.

Phylogenomic databases

eggNOGiKOG0236. Eukaryota.
COG0659. LUCA.
GeneTreeiENSGT00850000132388.
HOGENOMiHOG000031187.
HOVERGENiHBG054728.
InParanoidiQ80ZD3.
KOiK14708.
OMAiECTHISS.
OrthoDBiEOG091G05ML.
PhylomeDBiQ80ZD3.
TreeFamiTF323537.

Enzyme and pathway databases

ReactomeiR-MMU-427601. Multifunctional anion exchangers.

Miscellaneous databases

PROiQ80ZD3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039908.
CleanExiMM_SLC26A11.
GenevisibleiQ80ZD3. MM.

Family and domain databases

Gene3Di3.30.750.24. 1 hit.
InterProiIPR018045. S04_transporter_CS.
IPR011547. SLC26A/SulP_dom.
IPR001902. SLC26A/SulP_fam.
IPR002645. STAS_dom.
[Graphical view]
PANTHERiPTHR11814. PTHR11814. 1 hit.
PfamiPF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view]
SUPFAMiSSF52091. SSF52091. 1 hit.
PROSITEiPS01130. SLC26A. 1 hit.
PS50801. STAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS2611_MOUSE
AccessioniPrimary (citable) accession number: Q80ZD3
Secondary accession number(s): B2RQF3
, Q8BTP1, Q8BWL3, Q8CHW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: November 30, 2016
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.