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Protein

Sodium-independent sulfate anion transporter

Gene

Slc26a11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Exhibits sodium-independent sulfate anion transporter activity that may cooperate with SLC26A2 to mediate DIDS-sensitive sulfate uptake into high endothelial venules endothelial cells (HEVEC).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Anion exchange, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-independent sulfate anion transporter
Alternative name(s):
Solute carrier family 26 member 11
Gene namesi
Name:Slc26a11Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2444589. Slc26a11.

Subcellular locationi

  • Cell membrane By similarity; Multi-pass membrane protein By similarity
  • Lysosome membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3434ExtracellularSequence analysisAdd
BLAST
Transmembranei35 – 5521HelicalSequence analysisAdd
BLAST
Topological domaini56 – 561CytoplasmicSequence analysis
Transmembranei57 – 7721HelicalSequence analysisAdd
BLAST
Topological domaini78 – 825ExtracellularSequence analysis
Transmembranei83 – 10018HelicalSequence analysisAdd
BLAST
Topological domaini101 – 1066CytoplasmicSequence analysis
Transmembranei107 – 12721HelicalSequence analysisAdd
BLAST
Topological domaini128 – 17649ExtracellularSequence analysisAdd
BLAST
Transmembranei177 – 19721HelicalSequence analysisAdd
BLAST
Topological domaini198 – 23336CytoplasmicSequence analysisAdd
BLAST
Transmembranei234 – 25421HelicalSequence analysisAdd
BLAST
Topological domaini255 – 28733ExtracellularSequence analysisAdd
BLAST
Transmembranei288 – 30821HelicalSequence analysisAdd
BLAST
Topological domaini309 – 32416CytoplasmicSequence analysisAdd
BLAST
Transmembranei325 – 34521HelicalSequence analysisAdd
BLAST
Topological domaini346 – 36116ExtracellularSequence analysisAdd
BLAST
Transmembranei362 – 38221HelicalSequence analysisAdd
BLAST
Topological domaini383 – 3831CytoplasmicSequence analysis
Transmembranei384 – 40421HelicalSequence analysisAdd
BLAST
Topological domaini405 – 41713ExtracellularSequence analysisAdd
BLAST
Transmembranei418 – 43821HelicalSequence analysisAdd
BLAST
Topological domaini439 – 593155CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 593593Sodium-independent sulfate anion transporterPRO_0000320687Add
BLAST

Proteomic databases

EPDiQ80ZD3.
MaxQBiQ80ZD3.
PaxDbiQ80ZD3.
PeptideAtlasiQ80ZD3.
PRIDEiQ80ZD3.

PTM databases

iPTMnetiQ80ZD3.
PhosphoSiteiQ80ZD3.
SwissPalmiQ80ZD3.

Expressioni

Gene expression databases

BgeeiQ80ZD3.
CleanExiMM_SLC26A11.
GenevisibleiQ80ZD3. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000050999.

Structurei

3D structure databases

ProteinModelPortaliQ80ZD3.
SMRiQ80ZD3. Positions 32-158.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini453 – 566114STASPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 STAS domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0236. Eukaryota.
COG0659. LUCA.
GeneTreeiENSGT00760000119026.
HOGENOMiHOG000031187.
HOVERGENiHBG054728.
InParanoidiQ80ZD3.
KOiK14708.
OMAiHTFLHIG.
OrthoDBiEOG7BZVSR.
PhylomeDBiQ80ZD3.
TreeFamiTF323537.

Family and domain databases

Gene3Di3.30.750.24. 1 hit.
InterProiIPR018045. S04_transporter_CS.
IPR011547. SLC26A/SulP_dom.
IPR001902. SLC26A/SulP_fam.
IPR002645. STAS_dom.
[Graphical view]
PANTHERiPTHR11814. PTHR11814. 1 hit.
PfamiPF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view]
SUPFAMiSSF52091. SSF52091. 1 hit.
PROSITEiPS01130. SLC26A. 1 hit.
PS50801. STAS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 13 Publications (identifier: Q80ZD3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPDTCCCSA TALRRRLPVL AWVPDYSLQW LRLDFIAGLS VGLTVIPQAL
60 70 80 90 100
AYAEVAGLPP QYGLYSAFMG CFVYFFLGTS RDVTLGPTAI MSLLVSFYTF
110 120 130 140 150
REPAYAVLLA FLSGCIQLAM GLLHLGFLLD FISCPVIKGF TSAASITIGF
160 170 180 190 200
GQIKNLLGLQ KIPRQFFLQV YHTFLHIGET RVGDAVLGLA SMLLLLVLKC
210 220 230 240 250
MREHMPPPHP EMPLAVKFSR GLVWTVTTAR NALVVSSAAL IAYAFEVTGS
260 270 280 290 300
HPFVLTGKIA EGLPPVRIPP FSVTRDNKTI SFSEMVQDMG AGLAVVPLMG
310 320 330 340 350
LLESIAVAKS FASQNNYRID ANQELLAIGL TNVLGSLVSS YPVTGSFGRT
360 370 380 390 400
AVNAQTGVCT PAGGLVTGAL VLLSLNYLTS LFSYIPKSAL AAVIITAVTP
410 420 430 440 450
LFDVKIFRSL WRVQRLDLLP LCVTFLLSFW EIQYGILAGS LVSLLILLHS
460 470 480 490 500
VARPKTQVSE GQIFVLQPAS GLYFPAIDAL REAITNRALE ASPPRSAVLE
510 520 530 540 550
CTHISSVDYT VIVGLGELLE DFQKKGVALA FVGLQVPVLR TLLAADLKGF
560 570 580 590
RYFTTLEEAE KFLQQEPGTE PNSIHEDAVP EQRSSLLKSP SGP
Length:593
Mass (Da):64,109
Last modified:February 26, 2008 - v2
Checksum:iB073D040EAA77DDE
GO
Isoform 22 Publications (identifier: Q80ZD3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-8: MAPDTCCC → MHAPTPVC
     9-180: Missing.

Show »
Length:421
Mass (Da):45,204
Checksum:i7404536D669503E1
GO

Sequence cautioni

The sequence AAH38604.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti37 – 371A → S in AAH38604 (PubMed:15489334).Curated
Sequence conflicti205 – 2051M → V in AAO49173 (Ref. 1) Curated
Sequence conflicti369 – 3691A → T in AAO49173 (Ref. 1) Curated
Sequence conflicti396 – 3961T → A in AAO49173 (Ref. 1) Curated
Sequence conflicti500 – 5001E → G in BAC40782 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 88MAPDTCCC → MHAPTPVC in isoform 2. 2 PublicationsVSP_052687
Alternative sequencei9 – 180172Missing in isoform 2. 2 PublicationsVSP_052688Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF345196 mRNA. Translation: AAO49173.1.
AK052202 mRNA. Translation: BAC34882.1.
AK089182 mRNA. Translation: BAC40782.1.
BC038604 mRNA. Translation: AAH38604.1. Different initiation.
BC132493 mRNA. Translation: AAI32494.1.
BC137897 mRNA. Translation: AAI37898.1.
CCDSiCCDS25717.1. [Q80ZD3-1]
RefSeqiNP_848858.2. NM_178743.3. [Q80ZD3-1]
XP_006533484.1. XM_006533421.1. [Q80ZD3-2]
UniGeneiMm.31869.

Genome annotation databases

EnsembliENSMUST00000050880; ENSMUSP00000050999; ENSMUSG00000039908. [Q80ZD3-1]
GeneIDi268512.
KEGGimmu:268512.
UCSCiuc007mqm.1. mouse. [Q80ZD3-1]
uc007mqn.1. mouse. [Q80ZD3-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF345196 mRNA. Translation: AAO49173.1.
AK052202 mRNA. Translation: BAC34882.1.
AK089182 mRNA. Translation: BAC40782.1.
BC038604 mRNA. Translation: AAH38604.1. Different initiation.
BC132493 mRNA. Translation: AAI32494.1.
BC137897 mRNA. Translation: AAI37898.1.
CCDSiCCDS25717.1. [Q80ZD3-1]
RefSeqiNP_848858.2. NM_178743.3. [Q80ZD3-1]
XP_006533484.1. XM_006533421.1. [Q80ZD3-2]
UniGeneiMm.31869.

3D structure databases

ProteinModelPortaliQ80ZD3.
SMRiQ80ZD3. Positions 32-158.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000050999.

PTM databases

iPTMnetiQ80ZD3.
PhosphoSiteiQ80ZD3.
SwissPalmiQ80ZD3.

Proteomic databases

EPDiQ80ZD3.
MaxQBiQ80ZD3.
PaxDbiQ80ZD3.
PeptideAtlasiQ80ZD3.
PRIDEiQ80ZD3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000050880; ENSMUSP00000050999; ENSMUSG00000039908. [Q80ZD3-1]
GeneIDi268512.
KEGGimmu:268512.
UCSCiuc007mqm.1. mouse. [Q80ZD3-1]
uc007mqn.1. mouse. [Q80ZD3-2]

Organism-specific databases

CTDi284129.
MGIiMGI:2444589. Slc26a11.

Phylogenomic databases

eggNOGiKOG0236. Eukaryota.
COG0659. LUCA.
GeneTreeiENSGT00760000119026.
HOGENOMiHOG000031187.
HOVERGENiHBG054728.
InParanoidiQ80ZD3.
KOiK14708.
OMAiHTFLHIG.
OrthoDBiEOG7BZVSR.
PhylomeDBiQ80ZD3.
TreeFamiTF323537.

Miscellaneous databases

PROiQ80ZD3.
SOURCEiSearch...

Gene expression databases

BgeeiQ80ZD3.
CleanExiMM_SLC26A11.
GenevisibleiQ80ZD3. MM.

Family and domain databases

Gene3Di3.30.750.24. 1 hit.
InterProiIPR018045. S04_transporter_CS.
IPR011547. SLC26A/SulP_dom.
IPR001902. SLC26A/SulP_fam.
IPR002645. STAS_dom.
[Graphical view]
PANTHERiPTHR11814. PTHR11814. 1 hit.
PfamiPF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view]
SUPFAMiSSF52091. SSF52091. 1 hit.
PROSITEiPS01130. SLC26A. 1 hit.
PS50801. STAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of Mus musculus Slc26a11, a putative anion exchanger."
    Mount D.B.
    Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: C57BL/6JImported.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6JImported and NODImported.
    Tissue: Dendritic cellImported and Embryonic heartImported.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: FVB/NImported.
    Tissue: BrainImported and Salivary glandImported.

Entry informationi

Entry nameiS2611_MOUSE
AccessioniPrimary (citable) accession number: Q80ZD3
Secondary accession number(s): B2RQF3
, Q8BTP1, Q8BWL3, Q8CHW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: July 6, 2016
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.