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Q80ZB2

- Q80ZB2_RAT

UniProt

Q80ZB2 - Q80ZB2_RAT

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Protein
Submitted name:

ATP-binding cassette 1

Gene

Abca1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. ATPase activity, coupled to transmembrane movement of substances Source: RGD
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. cellular response to cholesterol Source: RGD
  2. cholesterol transport Source: RGD
  3. lipoprotein biosynthetic process Source: RGD
  4. phospholipid transport Source: RGD
  5. response to drug Source: RGD
  6. response to nutrient Source: RGD
  7. transmembrane transport Source: GOC
Complete GO annotation...

Keywords - Ligandi

ATP-bindingUniRule annotationImported, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
ATP-binding cassette 1Imported
Gene namesi
Name:Abca1Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi631344. Abca1.

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: RGD
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ80ZB2.

PTM databases

PhosphoSiteiQ80ZB2.

Expressioni

Gene expression databases

GenevestigatoriQ80ZB2.

Structurei

3D structure databases

ProteinModelPortaliQ80ZB2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ABC transporter superfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000231547.
HOVERGENiHBG050436.
KOiK05641.
PhylomeDBiQ80ZB2.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR026082. ABC_A.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR19229. PTHR19229. 1 hit.
PfamiPF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80ZB2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPSAGTLPWV QGIICNANNP CFRYPTPGEA PGVVGNFNKS IVSRLFSDAQ
60 70 80 90 100
RILLYSQKDT SIRDMHKVLR TLQQIKHPNS NLKLQDFLVD NETFSGFLQH
110 120 130 140 150
SLSLPRSAVD NLLQADVSLQ KVFLQGYQLH LASLCNGSKL EEIIRPEDLK
160 170 180 190 200
VSALCSLPRE KLDAPERELR SNMDILKPVM TKLNSTSLLP TQHLAEATTT
210 220 230 240 250
LLDSLGGLAQ ELFSTKSWSD MRQEVMFLTN VNNSGSSTQI YQAVSRIVCG
260 270 280 290 300
HPEGGGLKIK SLNWYEDNNY KALFGGNGTE EDTDTFYDNS TTPYCNDLMK
310 320 330 340 350
NLESSPLSRI IWKALKPLLI GKILYTPDTP ATRQVMAEVN KTFQELALFP
360 370 380 390 400
DLEGMWEELS PQIWTFMESS QEMDLVRPML DLRGNDQFWE RKLDGLYWTA
410 420 430 440 450
QDIMAFLAKN PEDVQSPNGS VYTWREAFNE TNQAIQTISR FMECVNLNKL
460 470 480 490 500
EPIPTEVTLI NKSMDLLDAR KFSAGIDFTG ITPDSVELPH HVKDKIRMDI
510 520 530 540 550
DNVERTNKIK DGYWDPGPRA DPFEDMRYVW GGFAYLQDVV EQAIIRVLTG
560 570 580 590 600
TEKKTGVYVQ QMPYPCYVDD IFLRVMSRSM PLFMTLAWIY SVAVIIKSIV
610 620 630 640 650
YEKEARLKET MRIMGLDNGI LWFSWFISSL IPLLVSAGLL VIILKLGDLL
660 670 680 690 700
PYSDPSVVFV FLSVFAVVTI LQCFLISTLF SRXNLAAACG GIIYFTLYLP
710 720 730 740 750
YVLCVAWQDY VGFSIKIFAS LLSPVAFGFG CEYFALFEEQ GIGVQWDNLF
760 770 780 790 800
KSPVEEDGFN LTTSVSMMLF DTFIYGVMTW YIEAVFPGQY GIPRPWYFPC
810 820 830 840 850
TKSYWFGEEI DEKSHPGSSQ KGASEICMEE EPTHLKLGVS IQNLVKVYRD
860 870 880 890 900
GMKVAVDGLA LNFYEGQITS FLGHNGAGKT TTMSILTGLF PPTSGTAYIL
910 920 930 940 950
GKDIRSEMNS IRQNLGVCPQ HNVLFDMLTV EEHIWFYARL KGLSEKHVKA
960 970 980 990 1000
EMEQMALDVG LPPSKLKSKT SQLSGGMQRK LSVALAFVGG SKVVILDEPT
1010 1020 1030 1040 1050
AGVDPYSRRG IWELLLKYRQ GRTIILSTHH MDEADILGDR IAIISHGKLC
1060 1070 1080 1090 1100
CVGSSLFLKN QLGTGYYLTL VKKDVESSLS SCRNSSSTVS CLKKEDSVSQ
1110 1120 1130 1140 1150
SSSDAGLGSD HESDTLTIDV SAISNLIRKH VSEARLVEDI GHELTYVLPY
1160 1170 1180 1190 1200
EAAKEGAFVE LFHEIDDRLS DLGISSYGIS ETTLEEIFLK VAEESGVDAE
1210 1220 1230 1240 1250
TSDGTLPARR NRRAFGDKQS CLHPFTEDDA VDPNDSDLDP ESRETDLLSG
1260 1270 1280 1290 1300
MDGKGSYQLK GWKLTQQQFV ALLWKRLLIA RRSRKGFFAQ IVLPAVFVCI
1310 1320 1330 1340 1350
ALVFSLIVPP FGKYPNLELQ PWMYNEQYTF VSNDAPEDMG TQELLNALTK
1360 1370 1380 1390 1400
DPGFGTRCME GNPIPNTPCL VGEEDWTTGP VPQTLMDLFQ NGNWTMKNPS
1410 1420 1430 1440 1450
PSCQCSSDKI KKMLPVCPPG AGGLPPPQRK QKTADILQNL TGRNNSDYLV
1460 1470 1480 1490 1500
KTYVQIIAKS LKNKVWVNEF RYGGFSLGVS DSQALPPSQE VNNAIKQMKK
1510 1520 1530 1540 1550
LLKLTKDSSA DRFLSSLGRF MTGLDTKNNV KVWFNNKGWH AISSFLNVIN
1560 1570 1580 1590 1600
NAILRANLQK GENPSQYGIT AFNHPLNLTK QQLSEVALMT TSVDVLVSIC
1610 1620 1630 1640 1650
VIFAMSFVPA SFVVFLIQER VSKAKHLQFI CGVKPVIYWL SNFVWDMCNY
1660 1670 1680 1690 1700
VVPATLVVII FICFQQKSYV SSTNLPVLAL LLLLYGWSIT PLMYPASFVF
1710 1720 1730 1740 1750
KIPSTAYVVL TSVNLFIGIN GSVATFVLEL FTNNKFNDIN DILKSVFLIF
1760 1770 1780 1790 1800
PHFCLGRGLI DMVKNQAMAD ALERFGENRF VSPLSWDLVG RNLFAMAVEG
1810 1820 1830 1840 1850
VVFFLVTVLI QYRFFIRPRP VKARLPPLND EDEDVRRERQ RILEGGGQND
1860 1870 1880 1890 1900
ILEIKELTKI YRRKRKPAVD RICVGIPPGE CFGLLGVNGA GKTSTFKMLT
1910 1920 1930 1940 1950
GDTAVTRGDA LLNKNSILSN IHEVHQNMGY CPQFDAITEL LTGREHLEFF
1960 1970 1980 1990 2000
ALLRGVPEKE VGKVGEWAIR KLGLVKYGEK YASNYSGGNK RKLSTAIALI
2010 2020 2030 2040 2050
GGPPVVFLDE PTTGMDPKAR RFLWNCALSI IKEGRSVVLT SHSMEECEAL
2060 2070 2080 2090 2100
CTRMAIMVNG RFRCLGSVQH LKNRFGDGYT IVVRIAGSNP DLKPVQEFFG
2110 2120 2130 2140 2150
LAFPGSVLKE KHRNMLQYQL PSSLSSLARI FSILSQSKKR LHIEDYSVSQ
2160 2170 2180 2190 2200
TTLDQVFVNF AKDQSDDDHL KDLSLHKNQT VVDVAVLTSF LQDEKVKESY

V
Length:2,201
Mass (Da):246,556
Last modified:June 1, 2003 - v1
Checksum:iB1472978BFC3E6B8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY208182 mRNA. Translation: AAO53557.1.
RefSeqiNP_835196.1. NM_178095.2.
UniGeneiRn.148916.
Rn.231131.

Genome annotation databases

GeneIDi313210.
KEGGirno:313210.
UCSCiRGD:631344. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY208182 mRNA. Translation: AAO53557.1 .
RefSeqi NP_835196.1. NM_178095.2.
UniGenei Rn.148916.
Rn.231131.

3D structure databases

ProteinModelPortali Q80ZB2.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q80ZB2.

Proteomic databases

PRIDEi Q80ZB2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 313210.
KEGGi rno:313210.
UCSCi RGD:631344. rat.

Organism-specific databases

CTDi 19.
RGDi 631344. Abca1.

Phylogenomic databases

HOGENOMi HOG000231547.
HOVERGENi HBG050436.
KOi K05641.
PhylomeDBi Q80ZB2.

Miscellaneous databases

NextBioi 665805.
PROi Q80ZB2.

Gene expression databases

Genevestigatori Q80ZB2.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR003593. AAA+_ATPase.
IPR026082. ABC_A.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR19229. PTHR19229. 1 hit.
Pfami PF00005. ABC_tran. 2 hits.
[Graphical view ]
SMARTi SM00382. AAA. 2 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
PROSITEi PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and Characterization of Rat Liver Abca1."
    Ananthanarayanan M., Mirza M.F.
    Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Sprague-DawleyImported.

Entry informationi

Entry nameiQ80ZB2_RAT
AccessioniPrimary (citable) accession number: Q80ZB2
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)