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Q80ZB2

- Q80ZB2_RAT

UniProt

Q80ZB2 - Q80ZB2_RAT

Protein
Submitted name:

ATP-binding cassette 1

Gene

Abca1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. ATPase activity, coupled to transmembrane movement of substances Source: RGD
    2. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. cellular response to cholesterol Source: RGD
    2. cholesterol transport Source: RGD
    3. lipoprotein biosynthetic process Source: RGD
    4. phospholipid transport Source: RGD
    5. response to drug Source: RGD
    6. response to nutrient Source: RGD
    7. transmembrane transport Source: GOC

    Keywords - Ligandi

    ATP-bindingUniRule annotationImported, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    ATP-binding cassette 1Imported
    Gene namesi
    Name:Abca1Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

    Organism-specific databases

    RGDi631344. Abca1.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: RGD

    PTM / Processingi

    Proteomic databases

    PRIDEiQ80ZB2.

    PTM databases

    PhosphoSiteiQ80ZB2.

    Expressioni

    Gene expression databases

    GenevestigatoriQ80ZB2.

    Structurei

    3D structure databases

    ProteinModelPortaliQ80ZB2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ABC transporter superfamily.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000231547.
    HOVERGENiHBG050436.
    InParanoidiQ80ZB2.
    KOiK05641.
    PhylomeDBiQ80ZB2.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    InterProiIPR003593. AAA+_ATPase.
    IPR026082. ABC_A.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PANTHERiPTHR19229. PTHR19229. 1 hit.
    PfamiPF00005. ABC_tran. 2 hits.
    [Graphical view]
    SMARTiSM00382. AAA. 2 hits.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 2 hits.
    PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
    PS50893. ABC_TRANSPORTER_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q80ZB2-1 [UniParc]FASTAAdd to Basket

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    MPSAGTLPWV QGIICNANNP CFRYPTPGEA PGVVGNFNKS IVSRLFSDAQ     50
    RILLYSQKDT SIRDMHKVLR TLQQIKHPNS NLKLQDFLVD NETFSGFLQH 100
    SLSLPRSAVD NLLQADVSLQ KVFLQGYQLH LASLCNGSKL EEIIRPEDLK 150
    VSALCSLPRE KLDAPERELR SNMDILKPVM TKLNSTSLLP TQHLAEATTT 200
    LLDSLGGLAQ ELFSTKSWSD MRQEVMFLTN VNNSGSSTQI YQAVSRIVCG 250
    HPEGGGLKIK SLNWYEDNNY KALFGGNGTE EDTDTFYDNS TTPYCNDLMK 300
    NLESSPLSRI IWKALKPLLI GKILYTPDTP ATRQVMAEVN KTFQELALFP 350
    DLEGMWEELS PQIWTFMESS QEMDLVRPML DLRGNDQFWE RKLDGLYWTA 400
    QDIMAFLAKN PEDVQSPNGS VYTWREAFNE TNQAIQTISR FMECVNLNKL 450
    EPIPTEVTLI NKSMDLLDAR KFSAGIDFTG ITPDSVELPH HVKDKIRMDI 500
    DNVERTNKIK DGYWDPGPRA DPFEDMRYVW GGFAYLQDVV EQAIIRVLTG 550
    TEKKTGVYVQ QMPYPCYVDD IFLRVMSRSM PLFMTLAWIY SVAVIIKSIV 600
    YEKEARLKET MRIMGLDNGI LWFSWFISSL IPLLVSAGLL VIILKLGDLL 650
    PYSDPSVVFV FLSVFAVVTI LQCFLISTLF SRXNLAAACG GIIYFTLYLP 700
    YVLCVAWQDY VGFSIKIFAS LLSPVAFGFG CEYFALFEEQ GIGVQWDNLF 750
    KSPVEEDGFN LTTSVSMMLF DTFIYGVMTW YIEAVFPGQY GIPRPWYFPC 800
    TKSYWFGEEI DEKSHPGSSQ KGASEICMEE EPTHLKLGVS IQNLVKVYRD 850
    GMKVAVDGLA LNFYEGQITS FLGHNGAGKT TTMSILTGLF PPTSGTAYIL 900
    GKDIRSEMNS IRQNLGVCPQ HNVLFDMLTV EEHIWFYARL KGLSEKHVKA 950
    EMEQMALDVG LPPSKLKSKT SQLSGGMQRK LSVALAFVGG SKVVILDEPT 1000
    AGVDPYSRRG IWELLLKYRQ GRTIILSTHH MDEADILGDR IAIISHGKLC 1050
    CVGSSLFLKN QLGTGYYLTL VKKDVESSLS SCRNSSSTVS CLKKEDSVSQ 1100
    SSSDAGLGSD HESDTLTIDV SAISNLIRKH VSEARLVEDI GHELTYVLPY 1150
    EAAKEGAFVE LFHEIDDRLS DLGISSYGIS ETTLEEIFLK VAEESGVDAE 1200
    TSDGTLPARR NRRAFGDKQS CLHPFTEDDA VDPNDSDLDP ESRETDLLSG 1250
    MDGKGSYQLK GWKLTQQQFV ALLWKRLLIA RRSRKGFFAQ IVLPAVFVCI 1300
    ALVFSLIVPP FGKYPNLELQ PWMYNEQYTF VSNDAPEDMG TQELLNALTK 1350
    DPGFGTRCME GNPIPNTPCL VGEEDWTTGP VPQTLMDLFQ NGNWTMKNPS 1400
    PSCQCSSDKI KKMLPVCPPG AGGLPPPQRK QKTADILQNL TGRNNSDYLV 1450
    KTYVQIIAKS LKNKVWVNEF RYGGFSLGVS DSQALPPSQE VNNAIKQMKK 1500
    LLKLTKDSSA DRFLSSLGRF MTGLDTKNNV KVWFNNKGWH AISSFLNVIN 1550
    NAILRANLQK GENPSQYGIT AFNHPLNLTK QQLSEVALMT TSVDVLVSIC 1600
    VIFAMSFVPA SFVVFLIQER VSKAKHLQFI CGVKPVIYWL SNFVWDMCNY 1650
    VVPATLVVII FICFQQKSYV SSTNLPVLAL LLLLYGWSIT PLMYPASFVF 1700
    KIPSTAYVVL TSVNLFIGIN GSVATFVLEL FTNNKFNDIN DILKSVFLIF 1750
    PHFCLGRGLI DMVKNQAMAD ALERFGENRF VSPLSWDLVG RNLFAMAVEG 1800
    VVFFLVTVLI QYRFFIRPRP VKARLPPLND EDEDVRRERQ RILEGGGQND 1850
    ILEIKELTKI YRRKRKPAVD RICVGIPPGE CFGLLGVNGA GKTSTFKMLT 1900
    GDTAVTRGDA LLNKNSILSN IHEVHQNMGY CPQFDAITEL LTGREHLEFF 1950
    ALLRGVPEKE VGKVGEWAIR KLGLVKYGEK YASNYSGGNK RKLSTAIALI 2000
    GGPPVVFLDE PTTGMDPKAR RFLWNCALSI IKEGRSVVLT SHSMEECEAL 2050
    CTRMAIMVNG RFRCLGSVQH LKNRFGDGYT IVVRIAGSNP DLKPVQEFFG 2100
    LAFPGSVLKE KHRNMLQYQL PSSLSSLARI FSILSQSKKR LHIEDYSVSQ 2150
    TTLDQVFVNF AKDQSDDDHL KDLSLHKNQT VVDVAVLTSF LQDEKVKESY 2200
    V 2201
    Length:2,201
    Mass (Da):246,556
    Last modified:June 1, 2003 - v1
    Checksum:iB1472978BFC3E6B8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY208182 mRNA. Translation: AAO53557.1.
    RefSeqiNP_835196.1. NM_178095.2.
    UniGeneiRn.148916.
    Rn.231131.

    Genome annotation databases

    GeneIDi313210.
    KEGGirno:313210.
    UCSCiRGD:631344. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY208182 mRNA. Translation: AAO53557.1 .
    RefSeqi NP_835196.1. NM_178095.2.
    UniGenei Rn.148916.
    Rn.231131.

    3D structure databases

    ProteinModelPortali Q80ZB2.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q80ZB2.

    Proteomic databases

    PRIDEi Q80ZB2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 313210.
    KEGGi rno:313210.
    UCSCi RGD:631344. rat.

    Organism-specific databases

    CTDi 19.
    RGDi 631344. Abca1.

    Phylogenomic databases

    HOGENOMi HOG000231547.
    HOVERGENi HBG050436.
    InParanoidi Q80ZB2.
    KOi K05641.
    PhylomeDBi Q80ZB2.

    Miscellaneous databases

    NextBioi 665805.
    PROi Q80ZB2.

    Gene expression databases

    Genevestigatori Q80ZB2.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    InterProi IPR003593. AAA+_ATPase.
    IPR026082. ABC_A.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    PANTHERi PTHR19229. PTHR19229. 1 hit.
    Pfami PF00005. ABC_tran. 2 hits.
    [Graphical view ]
    SMARTi SM00382. AAA. 2 hits.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 2 hits.
    PROSITEi PS00211. ABC_TRANSPORTER_1. 1 hit.
    PS50893. ABC_TRANSPORTER_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and Characterization of Rat Liver Abca1."
      Ananthanarayanan M., Mirza M.F.
      Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Sprague-DawleyImported.

    Entry informationi

    Entry nameiQ80ZB2_RAT
    AccessioniPrimary (citable) accession number: Q80ZB2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)