Q80ZB2 (Q80ZB2_RAT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
ATP-binding cassette 1 EMBL AAO53557.1

Gene names

Name:

Abca1 RGD 631344

Organism

Rattus norvegicus (Rat) EMBL AAO53557.1

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	2201 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the ABC transporter superfamily. RuleBase RU000684

Ontologies

Keywords
Ligand	ATP-binding RuleBase RU000684 EMBL AAO53557.1 Nucleotide-binding
Gene Ontology (GO)
Biological_process	cellular response to cholesterol Inferred from expression pattern PubMed 15907796. Source: RGD cholesterol transport Inferred from direct assay PubMed 12909583. Source: RGD lipoprotein biosynthetic process Inferred from mutant phenotype PubMed 14993246. Source: RGD phospholipid transport Inferred from direct assay PubMed 12909583. Source: RGD response to drug Inferred from expression pattern PubMed 14690017. Source: RGD response to nutrient Inferred from expression pattern PubMed 15710224. Source: RGD
Cellular_component	cell surface Inferred from direct assay PubMed 15907796. Source: RGD
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity, coupled to transmembrane movement of substances Inferred from direct assay PubMed 12909583. Source: RGD
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q80ZB2 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: B1472978BFC3E6B8	FASTA	2,201	246,556
	10 20 30 40 50 60 MPSAGTLPWV QGIICNANNP CFRYPTPGEA PGVVGNFNKS IVSRLFSDAQ RILLYSQKDT 70 80 90 100 110 120 SIRDMHKVLR TLQQIKHPNS NLKLQDFLVD NETFSGFLQH SLSLPRSAVD NLLQADVSLQ 130 140 150 160 170 180 KVFLQGYQLH LASLCNGSKL EEIIRPEDLK VSALCSLPRE KLDAPERELR SNMDILKPVM 190 200 210 220 230 240 TKLNSTSLLP TQHLAEATTT LLDSLGGLAQ ELFSTKSWSD MRQEVMFLTN VNNSGSSTQI 250 260 270 280 290 300 YQAVSRIVCG HPEGGGLKIK SLNWYEDNNY KALFGGNGTE EDTDTFYDNS TTPYCNDLMK 310 320 330 340 350 360 NLESSPLSRI IWKALKPLLI GKILYTPDTP ATRQVMAEVN KTFQELALFP DLEGMWEELS 370 380 390 400 410 420 PQIWTFMESS QEMDLVRPML DLRGNDQFWE RKLDGLYWTA QDIMAFLAKN PEDVQSPNGS 430 440 450 460 470 480 VYTWREAFNE TNQAIQTISR FMECVNLNKL EPIPTEVTLI NKSMDLLDAR KFSAGIDFTG 490 500 510 520 530 540 ITPDSVELPH HVKDKIRMDI DNVERTNKIK DGYWDPGPRA DPFEDMRYVW GGFAYLQDVV 550 560 570 580 590 600 EQAIIRVLTG TEKKTGVYVQ QMPYPCYVDD IFLRVMSRSM PLFMTLAWIY SVAVIIKSIV 610 620 630 640 650 660 YEKEARLKET MRIMGLDNGI LWFSWFISSL IPLLVSAGLL VIILKLGDLL PYSDPSVVFV 670 680 690 700 710 720 FLSVFAVVTI LQCFLISTLF SRXNLAAACG GIIYFTLYLP YVLCVAWQDY VGFSIKIFAS 730 740 750 760 770 780 LLSPVAFGFG CEYFALFEEQ GIGVQWDNLF KSPVEEDGFN LTTSVSMMLF DTFIYGVMTW 790 800 810 820 830 840 YIEAVFPGQY GIPRPWYFPC TKSYWFGEEI DEKSHPGSSQ KGASEICMEE EPTHLKLGVS 850 860 870 880 890 900 IQNLVKVYRD GMKVAVDGLA LNFYEGQITS FLGHNGAGKT TTMSILTGLF PPTSGTAYIL 910 920 930 940 950 960 GKDIRSEMNS IRQNLGVCPQ HNVLFDMLTV EEHIWFYARL KGLSEKHVKA EMEQMALDVG 970 980 990 1000 1010 1020 LPPSKLKSKT SQLSGGMQRK LSVALAFVGG SKVVILDEPT AGVDPYSRRG IWELLLKYRQ 1030 1040 1050 1060 1070 1080 GRTIILSTHH MDEADILGDR IAIISHGKLC CVGSSLFLKN QLGTGYYLTL VKKDVESSLS 1090 1100 1110 1120 1130 1140 SCRNSSSTVS CLKKEDSVSQ SSSDAGLGSD HESDTLTIDV SAISNLIRKH VSEARLVEDI 1150 1160 1170 1180 1190 1200 GHELTYVLPY EAAKEGAFVE LFHEIDDRLS DLGISSYGIS ETTLEEIFLK VAEESGVDAE 1210 1220 1230 1240 1250 1260 TSDGTLPARR NRRAFGDKQS CLHPFTEDDA VDPNDSDLDP ESRETDLLSG MDGKGSYQLK 1270 1280 1290 1300 1310 1320 GWKLTQQQFV ALLWKRLLIA RRSRKGFFAQ IVLPAVFVCI ALVFSLIVPP FGKYPNLELQ 1330 1340 1350 1360 1370 1380 PWMYNEQYTF VSNDAPEDMG TQELLNALTK DPGFGTRCME GNPIPNTPCL VGEEDWTTGP 1390 1400 1410 1420 1430 1440 VPQTLMDLFQ NGNWTMKNPS PSCQCSSDKI KKMLPVCPPG AGGLPPPQRK QKTADILQNL 1450 1460 1470 1480 1490 1500 TGRNNSDYLV KTYVQIIAKS LKNKVWVNEF RYGGFSLGVS DSQALPPSQE VNNAIKQMKK 1510 1520 1530 1540 1550 1560 LLKLTKDSSA DRFLSSLGRF MTGLDTKNNV KVWFNNKGWH AISSFLNVIN NAILRANLQK 1570 1580 1590 1600 1610 1620 GENPSQYGIT AFNHPLNLTK QQLSEVALMT TSVDVLVSIC VIFAMSFVPA SFVVFLIQER 1630 1640 1650 1660 1670 1680 VSKAKHLQFI CGVKPVIYWL SNFVWDMCNY VVPATLVVII FICFQQKSYV SSTNLPVLAL 1690 1700 1710 1720 1730 1740 LLLLYGWSIT PLMYPASFVF KIPSTAYVVL TSVNLFIGIN GSVATFVLEL FTNNKFNDIN 1750 1760 1770 1780 1790 1800 DILKSVFLIF PHFCLGRGLI DMVKNQAMAD ALERFGENRF VSPLSWDLVG RNLFAMAVEG 1810 1820 1830 1840 1850 1860 VVFFLVTVLI QYRFFIRPRP VKARLPPLND EDEDVRRERQ RILEGGGQND ILEIKELTKI 1870 1880 1890 1900 1910 1920 YRRKRKPAVD RICVGIPPGE CFGLLGVNGA GKTSTFKMLT GDTAVTRGDA LLNKNSILSN 1930 1940 1950 1960 1970 1980 IHEVHQNMGY CPQFDAITEL LTGREHLEFF ALLRGVPEKE VGKVGEWAIR KLGLVKYGEK 1990 2000 2010 2020 2030 2040 YASNYSGGNK RKLSTAIALI GGPPVVFLDE PTTGMDPKAR RFLWNCALSI IKEGRSVVLT 2050 2060 2070 2080 2090 2100 SHSMEECEAL CTRMAIMVNG RFRCLGSVQH LKNRFGDGYT IVVRIAGSNP DLKPVQEFFG 2110 2120 2130 2140 2150 2160 LAFPGSVLKE KHRNMLQYQL PSSLSSLARI FSILSQSKKR LHIEDYSVSQ TTLDQVFVNF 2170 2180 2190 2200 AKDQSDDDHL KDLSLHKNQT VVDVAVLTSF LQDEKVKESY V

References

[1]	"Cloning and Characterization of Rat Liver Abca1." Ananthanarayanan M., Mirza M.F. Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Sprague-Dawley EMBL AAO53557.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY208182 mRNA. Translation: AAO53557.1.
IPI	IPI00949022.
RefSeq	NP_835196.1. NM_178095.2.
UniGene	Rn.231131. Rn.231992.
3D structure databases
ProteinModelPortal	Q80ZB2.
ModBase	Search...
PTM databases
PhosphoSite	Q80ZB2.
Proteomic databases
PRIDE	Q80ZB2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	313210.
KEGG	rno:313210.
UCSC	RGD:631344. rat.
Organism-specific databases
CTD	19.
RGD	631344. Abca1.
Phylogenomic databases
HOGENOM	HOG000231547.
HOVERGEN	HBG050436.
InParanoid	Q80ZB2.
KO	K05641.
Gene expression databases
ArrayExpress	Q80ZB2.
Genevestigator	Q80ZB2.
Family and domain databases
InterPro	IPR003593. AAA+_ATPase. IPR026082. ABC_A. IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR027417. P-loop_NTPase. [Graphical view]
PANTHER	PTHR19229. PTHR19229. 1 hit.
Pfam	PF00005. ABC_tran. 2 hits. [Graphical view]
SMART	SM00382. AAA. 2 hits. [Graphical view]
SUPFAM	SSF52540. SSF52540. 2 hits.
PROSITE	PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	665805.

Entry information

Entry name

Q80ZB2_RAT

Accession

Primary (citable) accession number: Q80ZB2

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2003
Last sequence update:	June 1, 2003
Last modified:	May 29, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)