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Protein

Sodium-driven chloride bicarbonate exchanger

Gene

Slc4a10

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Electrogenic sodium/bicarbonate cotransporter in exchange for intracellular chloride. Plays an important role in regulating intracellular pH.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Antiport, Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-driven chloride bicarbonate exchanger
Alternative name(s):
Solute carrier family 4 member 10
Gene namesi
Name:Slc4a10
Synonyms:Ncbe
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi631407. Slc4a10.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 508CytoplasmicSequence analysisAdd BLAST508
Transmembranei509 – 529HelicalSequence analysisAdd BLAST21
Topological domaini530 – 537ExtracellularSequence analysis8
Transmembranei538 – 558HelicalSequence analysisAdd BLAST21
Topological domaini559 – 561CytoplasmicSequence analysis3
Transmembranei562 – 582HelicalSequence analysisAdd BLAST21
Topological domaini583 – 595ExtracellularSequence analysisAdd BLAST13
Transmembranei596 – 616HelicalSequence analysisAdd BLAST21
Topological domaini617 – 625CytoplasmicSequence analysis9
Transmembranei626 – 646HelicalSequence analysisAdd BLAST21
Topological domaini647 – 719ExtracellularSequence analysisAdd BLAST73
Transmembranei720 – 740HelicalSequence analysisAdd BLAST21
Topological domaini741 – 761CytoplasmicSequence analysisAdd BLAST21
Transmembranei762 – 782HelicalSequence analysisAdd BLAST21
Topological domaini783 – 808ExtracellularSequence analysisAdd BLAST26
Transmembranei809 – 829HelicalSequence analysisAdd BLAST21
Topological domaini830 – 854CytoplasmicSequence analysisAdd BLAST25
Transmembranei855 – 875HelicalSequence analysisAdd BLAST21
Topological domaini876 – 911ExtracellularSequence analysisAdd BLAST36
Transmembranei912 – 932HelicalSequence analysisAdd BLAST21
Topological domaini933 – 934CytoplasmicSequence analysis2
Transmembranei935 – 955HelicalSequence analysisAdd BLAST21
Topological domaini956 – 997ExtracellularSequence analysisAdd BLAST42
Transmembranei998 – 1018HelicalSequence analysisAdd BLAST21
Topological domaini1019 – 1117CytoplasmicSequence analysisAdd BLAST99

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002452421 – 1117Sodium-driven chloride bicarbonate exchangerAdd BLAST1117

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei89PhosphoserineCombined sources1
Modified residuei94PhosphothreonineBy similarity1
Modified residuei275PhosphoserineBy similarity1
Modified residuei1056PhosphoserineBy similarity1
Modified residuei1084PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ80ZA5.
PRIDEiQ80ZA5.

PTM databases

iPTMnetiQ80ZA5.
PhosphoSitePlusiQ80ZA5.

Expressioni

Tissue specificityi

Expressed in the brain, in the hippocampus as well as in dentate gyrus, cortical layers, cerebellum, olfactory bulb and in the epithelial cells of the choroid plexus. Detected in pituitary, testis, kidney and ileum. Detected also in spleen and lung.3 Publications

Developmental stagei

Expressed in spinal cord and brain at E19 through adulthood.1 Publication

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Slc9a3r1P704413EBI-8613086,EBI-1184085From a different organism.

Protein-protein interaction databases

IntActiQ80ZA5. 1 interactor.
STRINGi10116.ENSRNOP00000059155.

Structurei

3D structure databases

ProteinModelPortaliQ80ZA5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1172. Eukaryota.
ENOG410XPHD. LUCA.
HOVERGENiHBG004326.
InParanoidiQ80ZA5.
KOiK13861.
PhylomeDBiQ80ZA5.

Family and domain databases

Gene3Di3.40.1100.10. 2 hits.
InterProiIPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR003024. Na/HCO3_transpt.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERiPTHR11453. PTHR11453. 1 hit.
PfamiPF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view]
PRINTSiPR01231. HCO3TRNSPORT.
PR01232. NAHCO3TRSPRT.
SUPFAMiSSF55804. SSF55804. 2 hits.
TIGRFAMsiTIGR00834. ae. 1 hit.

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q80ZA5-1) [UniParc]FASTAAdd to basket
Also known as: rb1NCBE

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEIKDQGAQM EPLLPTRNDE EAVVDRGGTR SILKTHFEKE DLEGHRTLFI
60 70 80 90 100
GVHVPLGGRK SHRRHRHRGH KHRKRDRERD SGLEDGGESP SFDTPSQRVQ
110 120 130 140 150
FILGTEDDDE EHIPHDLFTE LDEICWREGE DAEWRETARW LKFEEDVEDG
160 170 180 190 200
GERWSKPYVA TLSLHSLFEL RSCILNGTVL LDMHANTLEE IADMVLDQQV
210 220 230 240 250
SSGQLNEDVR HRVHEALMKQ HHHQSQKKLT NRIPIVRSFA DIGKKQSEPN
260 270 280 290 300
SMDKNGQVVS PQSAPACAEN KNDVSRENST VDFSKGLGGQ QKGHTSPCGM
310 320 330 340 350
KQRLDKGPPH QQEREVDLHF MKKIPPGAEA SNILVGELEF LDRTVVAFVR
360 370 380 390 400
LSPAVLLQGL AEVPIPSRFL FILLGPLGKG QQYHEIGRSI ATLMTDEVFH
410 420 430 440 450
DVAYKAKDRN DLVSGIDEFL DQVTVLPPGE WDPSIRIEPP KNVPSQEKRK
460 470 480 490 500
TPSLPNGTAA HGGPEQHGGH SGPELQRTGR IFGGLILDIK RKAPFFWSDF
510 520 530 540 550
RDAFSLQCLA SFLFLYCACM SPVITFGGLL GEATEGRISA IESLFGASMT
560 570 580 590 600
GIAYSLFGGQ PLTILGSTGP VLVFEKILFK FCKEYGLSYL SLRASIGLWT
610 620 630 640 650
ATLCIILVAT DASSLVCYIT RFTEEAFASL ICIIFIYEAL EKLFELSESY
660 670 680 690 700
PINMHNDLEL LTQYSCNCME PHSPSNDTLK EWRESNISAS DIIWGNLTVS
710 720 730 740 750
ECRSLHGEYV GRACGHGHPY VPDVLFWSVI LFFSTVTMSA TLKQFKTSRY
760 770 780 790 800
FPTKVRSIVS DFAVFLTILC MVLIDYAIGI PSPKLQVPSV FKPTRDDRGW
810 820 830 840 850
FVTPLGPNPW WTIIAAIIPA LLCTILIFMD QQITAVIINR KEHKLKKGCG
860 870 880 890 900
YHLDLLMVAV MLGVCSIMGL PWFVAATVLS ITHVNSLKLE SECSAPGEQP
910 920 930 940 950
KFLGIREQRV TGLMIFILMG SSVFMTSILK FIPMPVLYGV FLYMGASSLK
960 970 980 990 1000
GIQLFDRIKL FWMPAKHQPD FIYLRHVPLR KVHLFTVIQM SCLGLLWIIK
1010 1020 1030 1040 1050
VSRAAIVFPM MVLALVFVRK LMDFLFTKRE LSWLDDLMPE SKKKKLEDAE
1060 1070 1080 1090 1100
KEEEQSMLAM EDEGTVQLPL EGHYRDDPSV INISDEMSKT AMWGNLLVTA
1110
DNSKEKESRF PSKSSPS
Length:1,117
Mass (Da):125,639
Last modified:June 1, 2003 - v1
Checksum:i51A27EFE653C3232
GO
Isoform 2 (identifier: Q80ZA5-2) [UniParc]FASTAAdd to basket
Also known as: rb4NCBE

The sequence of this isoform differs from the canonical sequence as follows:
     255-255: N → NA
     286-315: Missing.
     1115-1117: SPS → IESRKEKKADSGKGVDRETCL

Show »
Length:1,106
Mass (Da):124,503
Checksum:iCAB2CBDFB0876AC5
GO
Isoform 3 (identifier: Q80ZA5-3) [UniParc]FASTAAdd to basket
Also known as: rb2NCBE

The sequence of this isoform differs from the canonical sequence as follows:
     286-315: Missing.
     1115-1117: SPS → IESRKEKKADSGKGVDRETCL

Show »
Length:1,105
Mass (Da):124,432
Checksum:i50357AD41747F888
GO
Isoform 4 (identifier: Q80ZA5-4) [UniParc]FASTAAdd to basket
Also known as: rb5NCBE

The sequence of this isoform differs from the canonical sequence as follows:
     255-255: N → NA
     286-315: Missing.

Show »
Length:1,088
Mass (Da):122,442
Checksum:iF676A4A5382C6F94
GO
Isoform 5 (identifier: Q80ZA5-5) [UniParc]FASTAAdd to basket
Also known as: rb3NCBE

The sequence of this isoform differs from the canonical sequence as follows:
     255-255: N → NA
     1053-1053: E → H
     1054-1117: Missing.

Show »
Length:1,054
Mass (Da):118,620
Checksum:i2B28DC19A9796AC7
GO
Isoform 6 (identifier: Q80ZA5-6) [UniParc]FASTAAdd to basket
Also known as: rb6NCBE

The sequence of this isoform differs from the canonical sequence as follows:
     255-255: N → NA
     286-315: Missing.
     603-607: LCIIL → FLPLT
     608-1117: Missing.

Show »
Length:578
Mass (Da):64,626
Checksum:iB2CCECF7A9D82529
GO
Isoform 7 (identifier: Q80ZA5-7) [UniParc]FASTAAdd to basket
Also known as: rb7NCBE

The sequence of this isoform differs from the canonical sequence as follows:
     255-255: N → NA
     286-315: Missing.
     481-498: IFGGLILDIKRKAPFFWS → SPISGIFASPEFFHRLCG
     499-1117: Missing.

Show »
Length:469
Mass (Da):52,759
Checksum:iC527F48F7343A7E0
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_019655255N → NA in isoform 2, isoform 4, isoform 5, isoform 6 and isoform 7. 1 Publication1
Alternative sequenceiVSP_019656286 – 315Missing in isoform 2, isoform 3, isoform 4, isoform 6 and isoform 7. 2 PublicationsAdd BLAST30
Alternative sequenceiVSP_019657481 – 498IFGGL…PFFWS → SPISGIFASPEFFHRLCG in isoform 7. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_019658499 – 1117Missing in isoform 7. 1 PublicationAdd BLAST619
Alternative sequenceiVSP_019659603 – 607LCIIL → FLPLT in isoform 6. 1 Publication5
Alternative sequenceiVSP_019660608 – 1117Missing in isoform 6. 1 PublicationAdd BLAST510
Alternative sequenceiVSP_0196611053E → H in isoform 5. 1 Publication1
Alternative sequenceiVSP_0196621054 – 1117Missing in isoform 5. 1 PublicationAdd BLAST64
Alternative sequenceiVSP_0196631115 – 1117SPS → IESRKEKKADSGKGVDRETC L in isoform 2 and isoform 3. 2 Publications3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF439855 mRNA. Translation: AAO59639.1.
AF439856 mRNA. Translation: AAO59640.1.
AY579373 mRNA. Translation: AAS89262.1.
AY579374 mRNA. Translation: AAS89263.1.
AY579375 mRNA. Translation: AAS89264.1.
AY579376 mRNA. Translation: AAS89265.1.
AY579377 mRNA. Translation: AAS89266.1.
RefSeqiNP_835193.1. NM_178092.2. [Q80ZA5-1]
XP_006234344.1. XM_006234282.3. [Q80ZA5-2]
XP_006234345.1. XM_006234283.3. [Q80ZA5-3]
XP_006234347.1. XM_006234285.3. [Q80ZA5-4]
UniGeneiRn.15193.
Rn.205129.

Genome annotation databases

GeneIDi295645.
KEGGirno:295645.
UCSCiRGD:631407. rat. [Q80ZA5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF439855 mRNA. Translation: AAO59639.1.
AF439856 mRNA. Translation: AAO59640.1.
AY579373 mRNA. Translation: AAS89262.1.
AY579374 mRNA. Translation: AAS89263.1.
AY579375 mRNA. Translation: AAS89264.1.
AY579376 mRNA. Translation: AAS89265.1.
AY579377 mRNA. Translation: AAS89266.1.
RefSeqiNP_835193.1. NM_178092.2. [Q80ZA5-1]
XP_006234344.1. XM_006234282.3. [Q80ZA5-2]
XP_006234345.1. XM_006234283.3. [Q80ZA5-3]
XP_006234347.1. XM_006234285.3. [Q80ZA5-4]
UniGeneiRn.15193.
Rn.205129.

3D structure databases

ProteinModelPortaliQ80ZA5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ80ZA5. 1 interactor.
STRINGi10116.ENSRNOP00000059155.

PTM databases

iPTMnetiQ80ZA5.
PhosphoSitePlusiQ80ZA5.

Proteomic databases

PaxDbiQ80ZA5.
PRIDEiQ80ZA5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi295645.
KEGGirno:295645.
UCSCiRGD:631407. rat. [Q80ZA5-1]

Organism-specific databases

CTDi57282.
RGDi631407. Slc4a10.

Phylogenomic databases

eggNOGiKOG1172. Eukaryota.
ENOG410XPHD. LUCA.
HOVERGENiHBG004326.
InParanoidiQ80ZA5.
KOiK13861.
PhylomeDBiQ80ZA5.

Miscellaneous databases

PROiQ80ZA5.

Family and domain databases

Gene3Di3.40.1100.10. 2 hits.
InterProiIPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR003024. Na/HCO3_transpt.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERiPTHR11453. PTHR11453. 1 hit.
PfamiPF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view]
PRINTSiPR01231. HCO3TRNSPORT.
PR01232. NAHCO3TRSPRT.
SUPFAMiSSF55804. SSF55804. 2 hits.
TIGRFAMsiTIGR00834. ae. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiS4A10_RAT
AccessioniPrimary (citable) accession number: Q80ZA5
Secondary accession number(s): Q6PU70
, Q6PU71, Q6PU72, Q6PU73, Q6PU74, Q80ZA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.