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Q80ZA3

- Q80ZA3_RAT

UniProt

Q80ZA3 - Q80ZA3_RAT

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Protein
Submitted name:

Alpha-2 antiplasmin

Gene
Serpinf1, Dmrs91, rCG_34442
Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. serine-type endopeptidase inhibitor activity Source: RefGenome

GO - Biological processi

  1. aging Source: RGD
  2. cellular response to cobalt ion Source: RGD
  3. cellular response to dexamethasone stimulus Source: RGD
  4. cellular response to glucose stimulus Source: RGD
  5. cellular response to retinoic acid Source: RGD
  6. kidney development Source: RGD
  7. negative regulation of angiogenesis Source: RGD
  8. negative regulation of endopeptidase activity Source: RefGenome
  9. negative regulation of endothelial cell migration Source: RGD
  10. negative regulation of epithelial cell proliferation involved in prostate gland development Source: Ensembl
  11. negative regulation of gene expression Source: RGD
  12. negative regulation of inflammatory response Source: RGD
  13. negative regulation of neuron death Source: RGD
  14. ovulation cycle Source: RGD
  15. positive regulation of neurogenesis Source: Ensembl
  16. positive regulation of neuron projection development Source: RGD
  17. regulation of proteolysis Source: RefGenome
  18. response to acidity Source: RGD
  19. response to arsenic-containing substance Source: RGD
  20. retina development in camera-type eye Source: RGD
  21. short-term memory Source: RGD
Complete GO annotation...

Protein family/group databases

MEROPSiI04.979.

Names & Taxonomyi

Protein namesi
Submitted name:
Alpha-2 antiplasminImported
Submitted name:
Protein Serpinf1Imported
Submitted name:
Serine (Or cysteine) peptidase inhibitor, clade F, member 1Imported
Submitted name:
Serine (Or cysteine) peptidase inhibitor, clade F, member 1, isoform CRA_cImported
Gene namesi
Name:Serpinf1Imported
Synonyms:Dmrs91Imported
ORF Names:rCG_34442Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 10

Organism-specific databases

RGDi631369. Serpinf1.

Subcellular locationi

GO - Cellular componenti

  1. axon Source: RGD
  2. axon hillock Source: RGD
  3. basement membrane Source: RGD
  4. extracellular region Source: RGD
  5. extracellular space Source: RGD
  6. neuronal cell body Source: RGD
  7. perinuclear region of cytoplasm Source: RGD
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ80ZA3.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004313.

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family.UniRule annotation

Phylogenomic databases

eggNOGiCOG4826.
GeneTreeiENSGT00750000117478.
HOGENOMiHOG000115489.
HOVERGENiHBG106911.
OMAiLNCKIAQ.
OrthoDBiEOG7K3TMD.
TreeFamiTF317350.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80ZA3-1 [UniParc]FASTAAdd to Basket

« Hide

MQTLVLLLWT GALLGHGSSQ NVPDSSQDSP APDSTGEPVV EEDDPFFKAP    50
VNKLAAAVSN FGYDLYRLRS GAVSTGNILL SPLSVATALS ALSLGAEQRT 100
ESVIHRALYY DLINNPDIHS TYKELLASVT APEKNFKSAS RIVFERKLRV 150
KSSFVAPLEK SYGTRPRILT GNPRIDLQEI NNWVQAQMKG KIARSTREMP 200
SALSILLLGV AYFKGQWATK FDSRKTTLQD FHLDEDRTVR VPMMSDPKAI 250
LRYGLDSDLN CKIAQLPLTG SMSIIFFLPL TVTQNLTMIE ESLTSEFVHD 300
IDRELKTIQA VLTVPKLKLS YEGDVTNSLQ DMKLQSLFES PDFSKITGKP 350
VKLTQVEHRA AFEWNEEGAG TSSNPDLQPV RLTFPLDYHL NRPFIFVLRD 400
TDTGALLFIG RILDPSST 418
Length:418
Mass (Da):46,465
Last modified:June 1, 2003 - v1
Checksum:i5C7CAFBD5199880F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06064587 Genomic DNA. No translation available.
AABR06064588 Genomic DNA. No translation available.
AABR06064589 Genomic DNA. No translation available.
BC078686 mRNA. Translation: AAH78686.1.
AY216659 mRNA. Translation: AAO60104.1.
CH473948 Genomic DNA. Translation: EDM05209.1.
RefSeqiNP_808788.1. NM_177927.2.
UniGeneiRn.16993.

Genome annotation databases

EnsembliENSRNOT00000004313; ENSRNOP00000004313; ENSRNOG00000003172.
GeneIDi287526.
KEGGirno:287526.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06064587 Genomic DNA. No translation available.
AABR06064588 Genomic DNA. No translation available.
AABR06064589 Genomic DNA. No translation available.
BC078686 mRNA. Translation: AAH78686.1 .
AY216659 mRNA. Translation: AAO60104.1 .
CH473948 Genomic DNA. Translation: EDM05209.1 .
RefSeqi NP_808788.1. NM_177927.2.
UniGenei Rn.16993.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000004313.

Protein family/group databases

MEROPSi I04.979.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000004313 ; ENSRNOP00000004313 ; ENSRNOG00000003172 .
GeneIDi 287526.
KEGGi rno:287526.

Organism-specific databases

CTDi 5176.
RGDi 631369. Serpinf1.

Phylogenomic databases

eggNOGi COG4826.
GeneTreei ENSGT00750000117478.
HOGENOMi HOG000115489.
HOVERGENi HBG106911.
OMAi LNCKIAQ.
OrthoDBi EOG7K3TMD.
TreeFami TF317350.

Miscellaneous databases

NextBioi 626411.
PROi Q80ZA3.

Gene expression databases

Genevestigatori Q80ZA3.

Family and domain databases

InterProi IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view ]
PANTHERi PTHR11461. PTHR11461. 1 hit.
Pfami PF00079. Serpin. 1 hit.
[Graphical view ]
SMARTi SM00093. SERPIN. 1 hit.
[Graphical view ]
SUPFAMi SSF56574. SSF56574. 1 hit.
PROSITEi PS00284. SERPIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Yang J.L., Yang Y.S., Li G., Luo M.
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Sprague-DawleyImported.
    Tissue: KidneyImported.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: KidneyImported.
  3. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  5. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  6. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiQ80ZA3_RAT
AccessioniPrimary (citable) accession number: Q80ZA3
Secondary accession number(s): F1LSW0
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: September 3, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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