Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q80ZA3

- Q80ZA3_RAT

UniProt

Q80ZA3 - Q80ZA3_RAT

Protein
Submitted name:

Alpha-2 antiplasmin

Gene

Serpinf1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GO - Molecular functioni

    1. serine-type endopeptidase inhibitor activity Source: RefGenome

    GO - Biological processi

    1. aging Source: RGD
    2. cellular response to cobalt ion Source: RGD
    3. cellular response to dexamethasone stimulus Source: RGD
    4. cellular response to glucose stimulus Source: RGD
    5. cellular response to retinoic acid Source: RGD
    6. kidney development Source: RGD
    7. negative regulation of angiogenesis Source: RGD
    8. negative regulation of endopeptidase activity Source: RefGenome
    9. negative regulation of endothelial cell migration Source: RGD
    10. negative regulation of epithelial cell proliferation involved in prostate gland development Source: Ensembl
    11. negative regulation of gene expression Source: RGD
    12. negative regulation of inflammatory response Source: RGD
    13. negative regulation of neuron death Source: RGD
    14. ovulation cycle Source: RGD
    15. positive regulation of neurogenesis Source: Ensembl
    16. positive regulation of neuron projection development Source: RGD
    17. regulation of proteolysis Source: RefGenome
    18. response to acidic pH Source: RGD
    19. response to arsenic-containing substance Source: RGD
    20. retina development in camera-type eye Source: RGD
    21. short-term memory Source: RGD

    Protein family/group databases

    MEROPSiI04.979.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Alpha-2 antiplasminImported
    Submitted name:
    Protein Serpinf1Imported
    Submitted name:
    Serine (Or cysteine) peptidase inhibitor, clade F, member 1Imported
    Submitted name:
    Serine (Or cysteine) peptidase inhibitor, clade F, member 1, isoform CRA_cImported
    Gene namesi
    Name:Serpinf1Imported
    Synonyms:Dmrs91Imported
    ORF Names:rCG_34442Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 10

    Organism-specific databases

    RGDi631369. Serpinf1.

    Subcellular locationi

    GO - Cellular componenti

    1. axon Source: RGD
    2. axon hillock Source: RGD
    3. basement membrane Source: RGD
    4. extracellular region Source: RGD
    5. extracellular space Source: RGD
    6. neuronal cell body Source: RGD
    7. perinuclear region of cytoplasm Source: RGD

    Expressioni

    Gene expression databases

    GenevestigatoriQ80ZA3.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000004313.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the serpin family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG4826.
    GeneTreeiENSGT00750000117478.
    HOGENOMiHOG000115489.
    HOVERGENiHBG106911.
    OMAiLNCKIAQ.
    OrthoDBiEOG7K3TMD.
    TreeFamiTF317350.

    Family and domain databases

    InterProiIPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view]
    PANTHERiPTHR11461. PTHR11461. 1 hit.
    PfamiPF00079. Serpin. 1 hit.
    [Graphical view]
    SMARTiSM00093. SERPIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF56574. SSF56574. 1 hit.
    PROSITEiPS00284. SERPIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q80ZA3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQTLVLLLWT GALLGHGSSQ NVPDSSQDSP APDSTGEPVV EEDDPFFKAP    50
    VNKLAAAVSN FGYDLYRLRS GAVSTGNILL SPLSVATALS ALSLGAEQRT 100
    ESVIHRALYY DLINNPDIHS TYKELLASVT APEKNFKSAS RIVFERKLRV 150
    KSSFVAPLEK SYGTRPRILT GNPRIDLQEI NNWVQAQMKG KIARSTREMP 200
    SALSILLLGV AYFKGQWATK FDSRKTTLQD FHLDEDRTVR VPMMSDPKAI 250
    LRYGLDSDLN CKIAQLPLTG SMSIIFFLPL TVTQNLTMIE ESLTSEFVHD 300
    IDRELKTIQA VLTVPKLKLS YEGDVTNSLQ DMKLQSLFES PDFSKITGKP 350
    VKLTQVEHRA AFEWNEEGAG TSSNPDLQPV RLTFPLDYHL NRPFIFVLRD 400
    TDTGALLFIG RILDPSST 418
    Length:418
    Mass (Da):46,465
    Last modified:June 1, 2003 - v1
    Checksum:i5C7CAFBD5199880F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06064587 Genomic DNA. No translation available.
    AABR06064588 Genomic DNA. No translation available.
    AABR06064589 Genomic DNA. No translation available.
    BC078686 mRNA. Translation: AAH78686.1.
    AY216659 mRNA. Translation: AAO60104.1.
    CH473948 Genomic DNA. Translation: EDM05209.1.
    RefSeqiNP_808788.1. NM_177927.2.
    UniGeneiRn.16993.

    Genome annotation databases

    EnsembliENSRNOT00000004313; ENSRNOP00000004313; ENSRNOG00000003172.
    GeneIDi287526.
    KEGGirno:287526.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06064587 Genomic DNA. No translation available.
    AABR06064588 Genomic DNA. No translation available.
    AABR06064589 Genomic DNA. No translation available.
    BC078686 mRNA. Translation: AAH78686.1 .
    AY216659 mRNA. Translation: AAO60104.1 .
    CH473948 Genomic DNA. Translation: EDM05209.1 .
    RefSeqi NP_808788.1. NM_177927.2.
    UniGenei Rn.16993.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000004313.

    Protein family/group databases

    MEROPSi I04.979.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000004313 ; ENSRNOP00000004313 ; ENSRNOG00000003172 .
    GeneIDi 287526.
    KEGGi rno:287526.

    Organism-specific databases

    CTDi 5176.
    RGDi 631369. Serpinf1.

    Phylogenomic databases

    eggNOGi COG4826.
    GeneTreei ENSGT00750000117478.
    HOGENOMi HOG000115489.
    HOVERGENi HBG106911.
    OMAi LNCKIAQ.
    OrthoDBi EOG7K3TMD.
    TreeFami TF317350.

    Miscellaneous databases

    NextBioi 626411.
    PROi Q80ZA3.

    Gene expression databases

    Genevestigatori Q80ZA3.

    Family and domain databases

    InterProi IPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view ]
    PANTHERi PTHR11461. PTHR11461. 1 hit.
    Pfami PF00079. Serpin. 1 hit.
    [Graphical view ]
    SMARTi SM00093. SERPIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56574. SSF56574. 1 hit.
    PROSITEi PS00284. SERPIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Yang J.L., Yang Y.S., Li G., Luo M.
      Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Sprague-DawleyImported.
      Tissue: KidneyImported.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: KidneyImported.
    3. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    4. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    5. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    6. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiQ80ZA3_RAT
    AccessioniPrimary (citable) accession number: Q80ZA3
    Secondary accession number(s): F1LSW0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3