Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Alpha-2 antiplasmin

Gene

Serpinf1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • serine-type endopeptidase inhibitor activity Source: RGD

GO - Biological processi

  • aging Source: RGD
  • cellular response to cobalt ion Source: RGD
  • cellular response to dexamethasone stimulus Source: RGD
  • cellular response to glucose stimulus Source: RGD
  • cellular response to retinoic acid Source: RGD
  • kidney development Source: RGD
  • negative regulation of angiogenesis Source: RGD
  • negative regulation of endothelial cell migration Source: RGD
  • negative regulation of epithelial cell proliferation involved in prostate gland development Source: Ensembl
  • negative regulation of gene expression Source: RGD
  • negative regulation of inflammatory response Source: RGD
  • negative regulation of neuron death Source: RGD
  • ovulation cycle Source: RGD
  • positive regulation of neuron projection development Source: RGD
  • response to acidic pH Source: RGD
  • response to arsenic-containing substance Source: RGD
  • retina development in camera-type eye Source: RGD
  • short-term memory Source: RGD
Complete GO annotation...

Protein family/group databases

MEROPSiI04.979.

Names & Taxonomyi

Protein namesi
Submitted name:
Alpha-2 antiplasminImported
Submitted name:
Protein Serpinf1Imported
Submitted name:
Serine (Or cysteine) peptidase inhibitor, clade F, member 1Imported
Submitted name:
Serine (Or cysteine) peptidase inhibitor, clade F, member 1, isoform CRA_cImported
Gene namesi
Name:Serpinf1Imported
Synonyms:Dmrs91Imported
ORF Names:rCG_34442Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi631369. Serpinf1.

Subcellular locationi

GO - Cellular componenti

  • axon Source: RGD
  • axon hillock Source: RGD
  • basement membrane Source: RGD
  • extracellular exosome Source: Ensembl
  • extracellular region Source: RGD
  • extracellular space Source: RGD
  • neuronal cell body Source: RGD
  • perinuclear region of cytoplasm Source: RGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 418399Sequence analysisPRO_5007927031Add
BLAST

PTM databases

PhosphoSiteiQ80ZA3.

Expressioni

Gene expression databases

BgeeiENSRNOG00000003172.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004313.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini63 – 415353SERPINInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the serpin family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG2392. Eukaryota.
COG4826. LUCA.
GeneTreeiENSGT00760000118839.
HOGENOMiHOG000115489.
HOVERGENiHBG106911.
KOiK19614.
OMAiLQDFHLD.
OrthoDBiEOG091G09UU.
TreeFamiTF317350.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80ZA3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQTLVLLLWT GALLGHGSSQ NVPDSSQDSP APDSTGEPVV EEDDPFFKAP
60 70 80 90 100
VNKLAAAVSN FGYDLYRLRS GAVSTGNILL SPLSVATALS ALSLGAEQRT
110 120 130 140 150
ESVIHRALYY DLINNPDIHS TYKELLASVT APEKNFKSAS RIVFERKLRV
160 170 180 190 200
KSSFVAPLEK SYGTRPRILT GNPRIDLQEI NNWVQAQMKG KIARSTREMP
210 220 230 240 250
SALSILLLGV AYFKGQWATK FDSRKTTLQD FHLDEDRTVR VPMMSDPKAI
260 270 280 290 300
LRYGLDSDLN CKIAQLPLTG SMSIIFFLPL TVTQNLTMIE ESLTSEFVHD
310 320 330 340 350
IDRELKTIQA VLTVPKLKLS YEGDVTNSLQ DMKLQSLFES PDFSKITGKP
360 370 380 390 400
VKLTQVEHRA AFEWNEEGAG TSSNPDLQPV RLTFPLDYHL NRPFIFVLRD
410
TDTGALLFIG RILDPSST
Length:418
Mass (Da):46,465
Last modified:June 1, 2003 - v1
Checksum:i5C7CAFBD5199880F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC120096 Genomic DNA. No translation available.
BC078686 mRNA. Translation: AAH78686.1.
AY216659 mRNA. Translation: AAO60104.1.
CH473948 Genomic DNA. Translation: EDM05209.1.
RefSeqiNP_808788.1. NM_177927.2.
UniGeneiRn.16993.

Genome annotation databases

EnsembliENSRNOT00000004313; ENSRNOP00000004313; ENSRNOG00000003172.
GeneIDi287526.
KEGGirno:287526.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC120096 Genomic DNA. No translation available.
BC078686 mRNA. Translation: AAH78686.1.
AY216659 mRNA. Translation: AAO60104.1.
CH473948 Genomic DNA. Translation: EDM05209.1.
RefSeqiNP_808788.1. NM_177927.2.
UniGeneiRn.16993.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004313.

Protein family/group databases

MEROPSiI04.979.

PTM databases

PhosphoSiteiQ80ZA3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000004313; ENSRNOP00000004313; ENSRNOG00000003172.
GeneIDi287526.
KEGGirno:287526.

Organism-specific databases

CTDi5176.
RGDi631369. Serpinf1.

Phylogenomic databases

eggNOGiKOG2392. Eukaryota.
COG4826. LUCA.
GeneTreeiENSGT00760000118839.
HOGENOMiHOG000115489.
HOVERGENiHBG106911.
KOiK19614.
OMAiLQDFHLD.
OrthoDBiEOG091G09UU.
TreeFamiTF317350.

Gene expression databases

BgeeiENSRNOG00000003172.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ80ZA3_RAT
AccessioniPrimary (citable) accession number: Q80ZA3
Secondary accession number(s): F1LSW0
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: September 7, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.