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Protein
Submitted name:

Alpha-2 antiplasmin

Gene

Serpinf1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. serine-type endopeptidase inhibitor activity Source: RGD

GO - Biological processi

  1. aging Source: RGD
  2. cellular response to cobalt ion Source: RGD
  3. cellular response to dexamethasone stimulus Source: RGD
  4. cellular response to glucose stimulus Source: RGD
  5. cellular response to retinoic acid Source: RGD
  6. kidney development Source: RGD
  7. negative regulation of angiogenesis Source: RGD
  8. negative regulation of endopeptidase activity Source: GO_Central
  9. negative regulation of endothelial cell migration Source: RGD
  10. negative regulation of epithelial cell proliferation involved in prostate gland development Source: Ensembl
  11. negative regulation of gene expression Source: RGD
  12. negative regulation of inflammatory response Source: RGD
  13. negative regulation of neuron death Source: RGD
  14. ovulation cycle Source: RGD
  15. positive regulation of neuron projection development Source: RGD
  16. response to acidic pH Source: RGD
  17. response to arsenic-containing substance Source: RGD
  18. retina development in camera-type eye Source: RGD
  19. short-term memory Source: RGD
Complete GO annotation...

Protein family/group databases

MEROPSiI04.979.

Names & Taxonomyi

Protein namesi
Submitted name:
Alpha-2 antiplasminImported
Submitted name:
Protein Serpinf1Imported
Submitted name:
Serine (Or cysteine) peptidase inhibitor, clade F, member 1Imported
Submitted name:
Serine (Or cysteine) peptidase inhibitor, clade F, member 1, isoform CRA_cImported
Gene namesi
Name:Serpinf1Imported
Synonyms:Dmrs91Imported
ORF Names:rCG_34442Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi631369. Serpinf1.

Subcellular locationi

GO - Cellular componenti

  1. axon Source: RGD
  2. axon hillock Source: RGD
  3. basement membrane Source: RGD
  4. extracellular region Source: RGD
  5. extracellular space Source: RGD
  6. extracellular vesicular exosome Source: Ensembl
  7. neuronal cell body Source: RGD
  8. perinuclear region of cytoplasm Source: RGD
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ80ZA3.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004313.

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family.UniRule annotation

Phylogenomic databases

eggNOGiCOG4826.
GeneTreeiENSGT00770000120524.
HOGENOMiHOG000115489.
HOVERGENiHBG106911.
OMAiLNCKIAQ.
OrthoDBiEOG7K3TMD.
TreeFamiTF317350.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80ZA3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQTLVLLLWT GALLGHGSSQ NVPDSSQDSP APDSTGEPVV EEDDPFFKAP
60 70 80 90 100
VNKLAAAVSN FGYDLYRLRS GAVSTGNILL SPLSVATALS ALSLGAEQRT
110 120 130 140 150
ESVIHRALYY DLINNPDIHS TYKELLASVT APEKNFKSAS RIVFERKLRV
160 170 180 190 200
KSSFVAPLEK SYGTRPRILT GNPRIDLQEI NNWVQAQMKG KIARSTREMP
210 220 230 240 250
SALSILLLGV AYFKGQWATK FDSRKTTLQD FHLDEDRTVR VPMMSDPKAI
260 270 280 290 300
LRYGLDSDLN CKIAQLPLTG SMSIIFFLPL TVTQNLTMIE ESLTSEFVHD
310 320 330 340 350
IDRELKTIQA VLTVPKLKLS YEGDVTNSLQ DMKLQSLFES PDFSKITGKP
360 370 380 390 400
VKLTQVEHRA AFEWNEEGAG TSSNPDLQPV RLTFPLDYHL NRPFIFVLRD
410
TDTGALLFIG RILDPSST
Length:418
Mass (Da):46,465
Last modified:June 1, 2003 - v1
Checksum:i5C7CAFBD5199880F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06064587 Genomic DNA. No translation available.
AABR06064588 Genomic DNA. No translation available.
AABR06064589 Genomic DNA. No translation available.
BC078686 mRNA. Translation: AAH78686.1.
AY216659 mRNA. Translation: AAO60104.1.
CH473948 Genomic DNA. Translation: EDM05209.1.
RefSeqiNP_808788.1. NM_177927.2.
UniGeneiRn.16993.

Genome annotation databases

EnsembliENSRNOT00000004313; ENSRNOP00000004313; ENSRNOG00000003172.
GeneIDi287526.
KEGGirno:287526.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06064587 Genomic DNA. No translation available.
AABR06064588 Genomic DNA. No translation available.
AABR06064589 Genomic DNA. No translation available.
BC078686 mRNA. Translation: AAH78686.1.
AY216659 mRNA. Translation: AAO60104.1.
CH473948 Genomic DNA. Translation: EDM05209.1.
RefSeqiNP_808788.1. NM_177927.2.
UniGeneiRn.16993.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004313.

Protein family/group databases

MEROPSiI04.979.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000004313; ENSRNOP00000004313; ENSRNOG00000003172.
GeneIDi287526.
KEGGirno:287526.

Organism-specific databases

CTDi5176.
RGDi631369. Serpinf1.

Phylogenomic databases

eggNOGiCOG4826.
GeneTreeiENSGT00770000120524.
HOGENOMiHOG000115489.
HOVERGENiHBG106911.
OMAiLNCKIAQ.
OrthoDBiEOG7K3TMD.
TreeFamiTF317350.

Miscellaneous databases

NextBioi35577206.
PROiQ80ZA3.

Gene expression databases

GenevestigatoriQ80ZA3.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Yang J.L., Yang Y.S., Li G., Luo M.
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Sprague-DawleyImported.
    Tissue: KidneyImported.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: KidneyImported.
  3. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  5. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  6. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiQ80ZA3_RAT
AccessioniPrimary (citable) accession number: Q80ZA3
Secondary accession number(s): F1LSW0
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: April 29, 2015
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.