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Protein
Submitted name:

Alpha-2 antiplasmin

Gene

Serpinf1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • serine-type endopeptidase inhibitor activity Source: RGD

GO - Biological processi

  • aging Source: RGD
  • cellular response to cobalt ion Source: RGD
  • cellular response to dexamethasone stimulus Source: RGD
  • cellular response to glucose stimulus Source: RGD
  • cellular response to retinoic acid Source: RGD
  • kidney development Source: RGD
  • negative regulation of angiogenesis Source: RGD
  • negative regulation of endothelial cell migration Source: RGD
  • negative regulation of epithelial cell proliferation involved in prostate gland development Source: Ensembl
  • negative regulation of gene expression Source: RGD
  • negative regulation of inflammatory response Source: RGD
  • negative regulation of neuron death Source: RGD
  • ovulation cycle Source: RGD
  • positive regulation of neuron projection development Source: RGD
  • response to acidic pH Source: RGD
  • response to arsenic-containing substance Source: RGD
  • retina development in camera-type eye Source: RGD
  • short-term memory Source: RGD

Protein family/group databases

MEROPSiI04.979

Names & Taxonomyi

Protein namesi
Submitted name:
Alpha-2 antiplasminImported
Submitted name:
Serine (Or cysteine) peptidase inhibitor, clade F, member 1, isoform CRA_cImported
Submitted name:
Serpin family F member 1Imported
Gene namesi
Name:Serpinf1Imported
Synonyms:Dmrs91Imported
ORF Names:rCG_34442Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi631369 Serpinf1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_501431194220 – 418Sequence analysisAdd BLAST399

Proteomic databases

PRIDEiQ80ZA3

Expressioni

Gene expression databases

BgeeiENSRNOG00000003172

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004313

Structurei

3D structure databases

SMRiQ80ZA3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini63 – 415SERPINInterPro annotationAdd BLAST353

Sequence similaritiesi

Belongs to the serpin family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00920000149046
HOGENOMiHOG000115489
HOVERGENiHBG106911
KOiK19614
OMAiLNCKIAQ
OrthoDBiEOG091G09UU
TreeFamiTF317350

Family and domain databases

CDDicd02052 PEDF, 1 hit
InterProiView protein in InterPro
IPR033832 PEDF
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q80ZA3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQTLVLLLWT GALLGHGSSQ NVPDSSQDSP APDSTGEPVV EEDDPFFKAP
60 70 80 90 100
VNKLAAAVSN FGYDLYRLRS GAVSTGNILL SPLSVATALS ALSLGAEQRT
110 120 130 140 150
ESVIHRALYY DLINNPDIHS TYKELLASVT APEKNFKSAS RIVFERKLRV
160 170 180 190 200
KSSFVAPLEK SYGTRPRILT GNPRIDLQEI NNWVQAQMKG KIARSTREMP
210 220 230 240 250
SALSILLLGV AYFKGQWATK FDSRKTTLQD FHLDEDRTVR VPMMSDPKAI
260 270 280 290 300
LRYGLDSDLN CKIAQLPLTG SMSIIFFLPL TVTQNLTMIE ESLTSEFVHD
310 320 330 340 350
IDRELKTIQA VLTVPKLKLS YEGDVTNSLQ DMKLQSLFES PDFSKITGKP
360 370 380 390 400
VKLTQVEHRA AFEWNEEGAG TSSNPDLQPV RLTFPLDYHL NRPFIFVLRD
410
TDTGALLFIG RILDPSST
Length:418
Mass (Da):46,465
Last modified:June 1, 2003 - v1
Checksum:i5C7CAFBD5199880F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC120096 Genomic DNA No translation available.
BC078686 mRNA Translation: AAH78686.1
AY216659 mRNA Translation: AAO60104.1
CH473948 Genomic DNA Translation: EDM05209.1
RefSeqiNP_808788.1, NM_177927.2
UniGeneiRn.16993

Genome annotation databases

EnsembliENSRNOT00000004313; ENSRNOP00000004313; ENSRNOG00000003172
GeneIDi287526
KEGGirno:287526

Similar proteinsi

Entry informationi

Entry nameiQ80ZA3_RAT
AccessioniPrimary (citable) accession number: Q80ZA3
Secondary accession number(s): F1LSW0
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: June 20, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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