Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Vang-like protein 1

Gene

Vangl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • multicellular organism development Source: InterPro
  • pigmentation Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Vang-like protein 1
Alternative name(s):
Loop-tail protein 2
Van Gogh-like protein 1
Gene namesi
Name:Vangl1
Synonyms:Lpp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:2159344 Vangl1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 114CytoplasmicSequence analysisAdd BLAST114
Transmembranei115 – 135Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini136 – 153ExtracellularSequence analysisAdd BLAST18
Transmembranei154 – 174Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini175 – 184CytoplasmicSequence analysis10
Transmembranei185 – 205Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini206 – 224ExtracellularSequence analysisAdd BLAST19
Transmembranei225 – 245Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini246 – 526CytoplasmicSequence analysisAdd BLAST281

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001861941 – 526Vang-like protein 1Add BLAST526

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei88PhosphoserineCombined sources1
Modified residuei90PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ80Z96
PaxDbiQ80Z96
PRIDEiQ80Z96

PTM databases

iPTMnetiQ80Z96
PhosphoSitePlusiQ80Z96

Expressioni

Gene expression databases

BgeeiENSMUSG00000027860
CleanExiMM_VANGL1
ExpressionAtlasiQ80Z96 baseline and differential
GenevisibleiQ80Z96 MM

Interactioni

Subunit structurei

Heterodimer with Vangl2. Interacts through its C-terminal region with the N-terminal half of DVL1, DVL2 and DVL3. The PDZ domain of DVL1, DVL2 and DVL3 is required for the interaction.2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi230877, 12 interactors
CORUMiQ80Z96
IntActiQ80Z96, 15 interactors
MINTiQ80Z96
STRINGi10090.ENSMUSP00000125043

Structurei

3D structure databases

ProteinModelPortaliQ80Z96
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Vang family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3814 Eukaryota
ENOG410XPVT LUCA
GeneTreeiENSGT00390000012496
HOGENOMiHOG000230590
HOVERGENiHBG058215
InParanoidiQ80Z96
KOiK04510
OMAiIVFVLKC
OrthoDBiEOG091G056W
PhylomeDBiQ80Z96
TreeFamiTF313467

Family and domain databases

InterProiView protein in InterPro
IPR009539 VANGL
PANTHERiPTHR20886 PTHR20886, 1 hit
PfamiView protein in Pfam
PF06638 Strabismus, 1 hit
PIRSFiPIRSF007991 Strabismus, 1 hit

Sequencei

Sequence statusi: Complete.

Q80Z96-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTESTYSGY SYYSSHSKKS HRQGERTRER HKSPRNKDGR GSEKSVTIQA
60 70 80 90 100
PAGEPLLAND SARTGAEEVQ DDNWGETTTA ITGTSEHSIS QEDIARISKD
110 120 130 140 150
MEDSVGLDCK RYLGLTVASF LGLLVFLTPI AFILLPQILW REELKPCGAI
160 170 180 190 200
CEGLLISVSF KLLILLIGTW ALFFRKQRAD VPRVFVFRAL LLVLIFLFVV
210 220 230 240 250
SYWLFYGVRI LDSRDQNYKD IVQYAVSLVD ALLFIHYLAI VLLELRQLQP
260 270 280 290 300
MFTLQVVRST DGESRFYSLG HLSIQRAALV VLENYYKDFT IYNPNLLTAS
310 320 330 340 350
KFRAAKHMAG LKVYNVDGPS NNATGQSRAM IAAAARRRDS SHNELYYEEA
360 370 380 390 400
EHERRVKKRR ARLVVAVEEA FIHIQRLQAE EQQKSPGEVM DPREAAQAIF
410 420 430 440 450
PSMARALQKY LRTTRQQHYH SMESILQHLA FCITNSMTPK AFLERYLSAG
460 470 480 490 500
PTLQYDKDRW LSTQWRLISE EAVTNGLRDG IVFVLKCLDF SLVVNVKKIP
510 520
FIVLSEEFID PKSHKFVLRL QSETSV
Length:526
Mass (Da):60,064
Last modified:July 27, 2011 - v2
Checksum:iDCA3CD50A4C0E69A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti279L → V in AAO61752 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF481860 mRNA Translation: AAO61752.1
CH466608 Genomic DNA Translation: EDL07618.1
BC138519 mRNA Translation: AAI38520.1
BC138520 mRNA Translation: AAI38521.1
BC024687 mRNA Translation: AAH24687.1
CCDSiCCDS17686.1
RefSeqiNP_808213.2, NM_177545.5
UniGeneiMm.118004

Genome annotation databases

EnsembliENSMUST00000029453; ENSMUSP00000029453; ENSMUSG00000027860
GeneIDi229658
KEGGimmu:229658
UCSCiuc008qrs.3 mouse

Similar proteinsi

Entry informationi

Entry nameiVANG1_MOUSE
AccessioniPrimary (citable) accession number: Q80Z96
Secondary accession number(s): B2RRP5, Q8QZT3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: July 27, 2011
Last modified: May 23, 2018
This is version 106 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health