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Protein

Vang-like protein 1

Gene

Vangl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Vang-like protein 1
Alternative name(s):
Loop-tail protein 2
Van Gogh-like protein 1
Gene namesi
Name:Vangl1
Synonyms:Lpp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:2159344. Vangl1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 114114CytoplasmicSequence analysisAdd
BLAST
Transmembranei115 – 13521Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini136 – 15318ExtracellularSequence analysisAdd
BLAST
Transmembranei154 – 17421Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini175 – 18410CytoplasmicSequence analysis
Transmembranei185 – 20521Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini206 – 22419ExtracellularSequence analysisAdd
BLAST
Transmembranei225 – 24521Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini246 – 526281CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: MGI
  • lateral plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 526526Vang-like protein 1PRO_0000186194Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei88 – 881PhosphoserineCombined sources
Modified residuei90 – 901PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ80Z96.
PaxDbiQ80Z96.
PRIDEiQ80Z96.

PTM databases

iPTMnetiQ80Z96.
PhosphoSiteiQ80Z96.

Expressioni

Gene expression databases

BgeeiQ80Z96.
CleanExiMM_VANGL1.
ExpressionAtlasiQ80Z96. baseline and differential.
GenevisibleiQ80Z96. MM.

Interactioni

Subunit structurei

Heterodimer with Vangl2. Interacts through its C-terminal region with the N-terminal half of DVL1, DVL2 and DVL3. The PDZ domain of DVL1, DVL2 and DVL3 is required for the interaction.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Dlg4P310164EBI-1750708,EBI-375655From a different organism.
Dvl1P511412EBI-1750708,EBI-1538407
Dvl2Q608384EBI-1750708,EBI-641940
Dvl3Q610622EBI-1750708,EBI-1538450

Protein-protein interaction databases

BioGridi230877. 11 interactions.
IntActiQ80Z96. 15 interactions.
MINTiMINT-8416696.
STRINGi10090.ENSMUSP00000125043.

Structurei

3D structure databases

ProteinModelPortaliQ80Z96.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Vang family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3814. Eukaryota.
ENOG410XPVT. LUCA.
GeneTreeiENSGT00390000012496.
HOGENOMiHOG000230590.
HOVERGENiHBG058215.
InParanoidiQ80Z96.
KOiK04510.
OMAiSVGLDCR.
OrthoDBiEOG7MSMNR.
PhylomeDBiQ80Z96.
TreeFamiTF313467.

Family and domain databases

InterProiIPR009539. VANGL.
[Graphical view]
PANTHERiPTHR20886. PTHR20886. 1 hit.
PfamiPF06638. Strabismus. 1 hit.
[Graphical view]
PIRSFiPIRSF007991. Strabismus. 1 hit.

Sequencei

Sequence statusi: Complete.

Q80Z96-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTESTYSGY SYYSSHSKKS HRQGERTRER HKSPRNKDGR GSEKSVTIQA
60 70 80 90 100
PAGEPLLAND SARTGAEEVQ DDNWGETTTA ITGTSEHSIS QEDIARISKD
110 120 130 140 150
MEDSVGLDCK RYLGLTVASF LGLLVFLTPI AFILLPQILW REELKPCGAI
160 170 180 190 200
CEGLLISVSF KLLILLIGTW ALFFRKQRAD VPRVFVFRAL LLVLIFLFVV
210 220 230 240 250
SYWLFYGVRI LDSRDQNYKD IVQYAVSLVD ALLFIHYLAI VLLELRQLQP
260 270 280 290 300
MFTLQVVRST DGESRFYSLG HLSIQRAALV VLENYYKDFT IYNPNLLTAS
310 320 330 340 350
KFRAAKHMAG LKVYNVDGPS NNATGQSRAM IAAAARRRDS SHNELYYEEA
360 370 380 390 400
EHERRVKKRR ARLVVAVEEA FIHIQRLQAE EQQKSPGEVM DPREAAQAIF
410 420 430 440 450
PSMARALQKY LRTTRQQHYH SMESILQHLA FCITNSMTPK AFLERYLSAG
460 470 480 490 500
PTLQYDKDRW LSTQWRLISE EAVTNGLRDG IVFVLKCLDF SLVVNVKKIP
510 520
FIVLSEEFID PKSHKFVLRL QSETSV
Length:526
Mass (Da):60,064
Last modified:July 27, 2011 - v2
Checksum:iDCA3CD50A4C0E69A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti279 – 2791L → V in AAO61752 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF481860 mRNA. Translation: AAO61752.1.
CH466608 Genomic DNA. Translation: EDL07618.1.
BC138519 mRNA. Translation: AAI38520.1.
BC138520 mRNA. Translation: AAI38521.1.
BC024687 mRNA. Translation: AAH24687.1.
CCDSiCCDS17686.1.
RefSeqiNP_808213.2. NM_177545.5.
UniGeneiMm.118004.

Genome annotation databases

EnsembliENSMUST00000029453; ENSMUSP00000029453; ENSMUSG00000027860.
GeneIDi229658.
KEGGimmu:229658.
UCSCiuc008qrs.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF481860 mRNA. Translation: AAO61752.1.
CH466608 Genomic DNA. Translation: EDL07618.1.
BC138519 mRNA. Translation: AAI38520.1.
BC138520 mRNA. Translation: AAI38521.1.
BC024687 mRNA. Translation: AAH24687.1.
CCDSiCCDS17686.1.
RefSeqiNP_808213.2. NM_177545.5.
UniGeneiMm.118004.

3D structure databases

ProteinModelPortaliQ80Z96.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230877. 11 interactions.
IntActiQ80Z96. 15 interactions.
MINTiMINT-8416696.
STRINGi10090.ENSMUSP00000125043.

PTM databases

iPTMnetiQ80Z96.
PhosphoSiteiQ80Z96.

Proteomic databases

MaxQBiQ80Z96.
PaxDbiQ80Z96.
PRIDEiQ80Z96.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029453; ENSMUSP00000029453; ENSMUSG00000027860.
GeneIDi229658.
KEGGimmu:229658.
UCSCiuc008qrs.3. mouse.

Organism-specific databases

CTDi81839.
MGIiMGI:2159344. Vangl1.

Phylogenomic databases

eggNOGiKOG3814. Eukaryota.
ENOG410XPVT. LUCA.
GeneTreeiENSGT00390000012496.
HOGENOMiHOG000230590.
HOVERGENiHBG058215.
InParanoidiQ80Z96.
KOiK04510.
OMAiSVGLDCR.
OrthoDBiEOG7MSMNR.
PhylomeDBiQ80Z96.
TreeFamiTF313467.

Miscellaneous databases

ChiTaRSiVangl1. mouse.
PROiQ80Z96.
SOURCEiSearch...

Gene expression databases

BgeeiQ80Z96.
CleanExiMM_VANGL1.
ExpressionAtlasiQ80Z96. baseline and differential.
GenevisibleiQ80Z96. MM.

Family and domain databases

InterProiIPR009539. VANGL.
[Graphical view]
PANTHERiPTHR20886. PTHR20886. 1 hit.
PfamiPF06638. Strabismus. 1 hit.
[Graphical view]
PIRSFiPIRSF007991. Strabismus. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of LPP2, a second Vang-like protein."
    Doudney K., Paternotte C., Murdoch J.N., Copp A.J., Stanier P.
    Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary cancer.
  4. "Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family."
    Torban E., Wang H.-J., Groulx N., Gros P.
    J. Biol. Chem. 279:52703-52713(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DVL1; DVL2 AND DVL3.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-88 AND SER-90, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Kidney and Pancreas.
  6. "Molecular characterisation of endogenous Vangl2/Vangl1 heteromeric protein complexes."
    Belotti E., Puvirajesinghe T.M., Audebert S., Baudelet E., Camoin L., Pierres M., Lasvaux L., Ferracci G., Montcouquiol M., Borg J.P.
    PLoS ONE 7:E46213-E46213(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, SUBUNIT.

Entry informationi

Entry nameiVANG1_MOUSE
AccessioniPrimary (citable) accession number: Q80Z96
Secondary accession number(s): B2RRP5, Q8QZT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: July 27, 2011
Last modified: June 8, 2016
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.