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Protein

Tenascin-N

Gene

Tnn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Isoform 2 inhibits neurite outgrowth and cell migration in hippocampal explants while isoform 1 does not have this affect.1 Publication

GO - Molecular functioni

  • identical protein binding Source: MGI
  • integrin binding Source: MGI

GO - Biological processi

  • axonogenesis Source: MGI
  • cell growth Source: UniProtKB
  • cell-matrix adhesion Source: MGI
  • cell migration Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Tenascin-N
Short name:
TN-N
Gene namesi
Name:Tnn
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2665790. Tnn.

Subcellular locationi

GO - Cellular componenti

  • cell surface Source: MGI
  • proteinaceous extracellular matrix Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence analysisAdd
BLAST
Chaini27 – 15601534Tenascin-NPRO_0000007746Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi171 ↔ 181PROSITE-ProRule annotation
Disulfide bondi175 ↔ 186PROSITE-ProRule annotation
Disulfide bondi188 ↔ 197PROSITE-ProRule annotation
Disulfide bondi202 ↔ 212PROSITE-ProRule annotation
Disulfide bondi206 ↔ 217PROSITE-ProRule annotation
Disulfide bondi219 ↔ 228PROSITE-ProRule annotation
Disulfide bondi233 ↔ 243PROSITE-ProRule annotation
Disulfide bondi237 ↔ 248PROSITE-ProRule annotation
Disulfide bondi250 ↔ 259PROSITE-ProRule annotation
Glycosylationi1411 – 14111N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ80Z71.
PaxDbiQ80Z71.
PRIDEiQ80Z71.

PTM databases

iPTMnetiQ80Z71.
PhosphoSiteiQ80Z71.

Expressioni

Tissue specificityi

Highest expression in kidney followed by spleen and brain. In brain, highest expression is found in hippocampus, cerebellum and olfactory bulb.1 Publication

Developmental stagei

Hardly detectable at embryonic day 14, then increases until postnatal day 17 and remains detectable in the adult.1 Publication

Gene expression databases

BgeeiENSMUSG00000026725.
CleanExiMM_TNN.
ExpressionAtlasiQ80Z71. baseline and differential.
GenevisibleiQ80Z71. MM.

Interactioni

GO - Molecular functioni

  • identical protein binding Source: MGI
  • integrin binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039452.

Structurei

3D structure databases

ProteinModelPortaliQ80Z71.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini167 – 19832EGF-like 1Add
BLAST
Domaini199 – 22931EGF-like 2Add
BLAST
Domaini230 – 26031EGF-like 3Add
BLAST
Domaini264 – 35390Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini354 – 44491Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini445 – 53288Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST
Domaini533 – 62290Fibronectin type-III 4PROSITE-ProRule annotationAdd
BLAST
Domaini623 – 70684Fibronectin type-III 5PROSITE-ProRule annotationAdd
BLAST
Domaini709 – 79890Fibronectin type-III 6PROSITE-ProRule annotationAdd
BLAST
Domaini799 – 88284Fibronectin type-III 7PROSITE-ProRule annotationAdd
BLAST
Domaini885 – 97086Fibronectin type-III 8PROSITE-ProRule annotationAdd
BLAST
Domaini973 – 106290Fibronectin type-III 9PROSITE-ProRule annotationAdd
BLAST
Domaini1063 – 114482Fibronectin type-III 10PROSITE-ProRule annotationAdd
BLAST
Domaini1149 – 123890Fibronectin type-III 11PROSITE-ProRule annotationAdd
BLAST
Domaini1239 – 132587Fibronectin type-III 12PROSITE-ProRule annotationAdd
BLAST
Domaini1323 – 1540218Fibrinogen C-terminalPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the tenascin family.Curated
Contains 3 EGF-like domains.Curated
Contains 1 fibrinogen C-terminal domain.PROSITE-ProRule annotationCurated
Contains 12 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG1225. Eukaryota.
KOG2579. Eukaryota.
KOG3544. Eukaryota.
ENOG410ZYS4. LUCA.
GeneTreeiENSGT00830000128240.
HOGENOMiHOG000234355.
HOVERGENiHBG106611.
InParanoidiQ80Z71.
KOiK06252.
OMAiAPIDRYM.
OrthoDBiEOG091G03M1.
TreeFamiTF329915.

Family and domain databases

Gene3Di2.60.40.10. 12 hits.
3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR033080. TNW.
[Graphical view]
PANTHERiPTHR19143:SF252. PTHR19143:SF252. 3 hits.
PfamiPF00147. Fibrinogen_C. 1 hit.
PF00041. fn3. 12 hits.
[Graphical view]
SMARTiSM00181. EGF. 3 hits.
SM00186. FBG. 1 hit.
SM00060. FN3. 12 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 7 hits.
SSF56496. SSF56496. 1 hit.
PROSITEiPS00022. EGF_1. 3 hits.
PS01186. EGF_2. 3 hits.
PS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
PS50853. FN3. 12 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced.1 Publication
Isoform 1 (identifier: Q80Z71-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGLWGMLAFP LGFLLASVLL VASAPATPES PGCSNKEQQV TVSHTYKIDV
60 70 80 90 100
PKSALVQVET DPQSLSDDGT SLLAPGEDGE EQNIIFRHNI RLQTPQKNCD
110 120 130 140 150
LADSVQDLLA RMKKLEEEMA ELKEQCNTNR CCQGAADLSR HCSGHGTFLP
160 170 180 190 200
ETCSCHCDQG WEGADCDQPT CPGACNGHGR CVDGQCVCDA PYVGVDCAYA
210 220 230 240 250
ACPQDCSGHG VCVQGVCQCH EDFTAEDCSE QRCPGDCSGN GFCDTGECYC
260 270 280 290 300
EMGFTGPDCS QVVAPQGLQL LKSTENSLLV SWEPSSEVDY YLLSYYPLGK
310 320 330 340 350
EQATKQVRVP KEQHTYDITG LLPGTKYIVT LRNVKKDISS SPQHLLATTD
360 370 380 390 400
LAVVGTAWVN EETETSLDVE WENPLTEVDY YKLRYGPLTG QEVTEVTVPK
410 420 430 440 450
SRDPKSRYDI TGLQPGTEYK ITVVPIRGDL EGKPILLNGR TEIDGPTNVV
460 470 480 490 500
TNQVTEDTAS VSWDPVRADI DKYVVRYIAP DGETKEKAVP KDQSSTVLTG
510 520 530 540 550
LKPGEAYKVF VWAERGNQGS KKADTKALTE IDSPENLVTD RVTENSLSVS
560 570 580 590 600
WDPVEADIDR YVVSYTSVDG ETKQVPVKKD QRSTVLTGLS PGVEYKVYVW
610 620 630 640 650
AEKGDRESKK ANTKAPTDID SPKNLVTDQV TENTLSVSWD PVQANIDRYM
660 670 680 690 700
VSYTSADGET REVPVPKEKS STVLTGLRPG VEYKVHVWAQ KGTQESRKAN
710 720 730 740 750
TKAPTDIDGP KNLVTDQVTE TTLSVSWDPV EADIDRYMVR YTSPDGETKE
760 770 780 790 800
VPVSKDKSST VLRGLRPGVE YKVDVWAQKG AQDSRKANTK APTDIDSPKN
810 820 830 840 850
LVTEQVTEST ATVSWDPVEA DIDRYVVRYT SVDGETREFL VGKDQTSTVL
860 870 880 890 900
TGMRPGVEYQ VDVWAQKGTQ ESRKTSTKAP TDIDGPKNLV TDQVTETTLS
910 920 930 940 950
VSWDPVEADI DRYMVRYTSP DGETKEVPVS KDKSSTVLRG LRPGVEYKVD
960 970 980 990 1000
VWAQKGAQDS RKANTKAPTD IDSPKNLAID QVTETTLSVS WDPVQADIDR
1010 1020 1030 1040 1050
YVVRYTSADG ESKEFLIGKE QRSTVLTGLR PGVEYKVEVW AQKGARESKK
1060 1070 1080 1090 1100
ANTEGHTDID SPKNLVTNQV TENTATISWD PVQADIDRYM VRYTSADGET
1110 1120 1130 1140 1150
REIPVRKEKS STVLTGLRPG VEYTVQVWAQ KGARESKKAK TKAPTEIDSP
1160 1170 1180 1190 1200
KNLVTNRVTE NTATISWDPV RANIDRYMVR YTSADGETKE IPVSKDQSST
1210 1220 1230 1240 1250
ILTGLKPGME YTIHVWAQKG ARESKKADTK ALTEIDPPRN LRPFGVTHSG
1260 1270 1280 1290 1300
GVLTWLPPSA QIDGYILTYQ FPNGTVKEVE LPRGQQRFEL QDLEQGVTYP
1310 1320 1330 1340 1350
VSLVAFKGNQ RSRTVSTTLS TVDARFPHPS DCSQVQQNTN AASGLYTIYL
1360 1370 1380 1390 1400
NGDASRPMQV YCDMDTDGGG WIVFQRRNTG QLDFFKRWRS YVEGFGDPMK
1410 1420 1430 1440 1450
EFWLGLDKLH NLTTGTTTRY EVRADLQTFN ESAYAVYDFF QVASSKERYK
1460 1470 1480 1490 1500
LSVGKYRGTA GDALTYHNGW KFTTFDRDND IALSNCALTH HGGWWYKNCH
1510 1520 1530 1540 1550
LANPNGKYGE TKHSEGVNWE PWKGHEFSIP YVELKIRPFG YSRDRFSGRK
1560
KRSIGKARMF
Length:1,560
Mass (Da):173,090
Last modified:July 27, 2011 - v2
Checksum:i672FBADBC2DAFCB2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1221 – 12211A → P in AAO63807 (PubMed:12812753).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF455756 mRNA. Translation: AAO63807.1.
BC138335 mRNA. Translation: AAI38336.1.
BC138336 mRNA. Translation: AAI38337.1.
CCDSiCCDS15404.1. [Q80Z71-1]
RefSeqiNP_808507.2. NM_177839.3. [Q80Z71-1]
UniGeneiMm.90140.

Genome annotation databases

EnsembliENSMUST00000039178; ENSMUSP00000039452; ENSMUSG00000026725. [Q80Z71-1]
GeneIDi329278.
KEGGimmu:329278.
UCSCiuc007dee.2. mouse. [Q80Z71-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF455756 mRNA. Translation: AAO63807.1.
BC138335 mRNA. Translation: AAI38336.1.
BC138336 mRNA. Translation: AAI38337.1.
CCDSiCCDS15404.1. [Q80Z71-1]
RefSeqiNP_808507.2. NM_177839.3. [Q80Z71-1]
UniGeneiMm.90140.

3D structure databases

ProteinModelPortaliQ80Z71.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039452.

PTM databases

iPTMnetiQ80Z71.
PhosphoSiteiQ80Z71.

Proteomic databases

MaxQBiQ80Z71.
PaxDbiQ80Z71.
PRIDEiQ80Z71.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000039178; ENSMUSP00000039452; ENSMUSG00000026725. [Q80Z71-1]
GeneIDi329278.
KEGGimmu:329278.
UCSCiuc007dee.2. mouse. [Q80Z71-1]

Organism-specific databases

CTDi63923.
MGIiMGI:2665790. Tnn.

Phylogenomic databases

eggNOGiKOG1225. Eukaryota.
KOG2579. Eukaryota.
KOG3544. Eukaryota.
ENOG410ZYS4. LUCA.
GeneTreeiENSGT00830000128240.
HOGENOMiHOG000234355.
HOVERGENiHBG106611.
InParanoidiQ80Z71.
KOiK06252.
OMAiAPIDRYM.
OrthoDBiEOG091G03M1.
TreeFamiTF329915.

Miscellaneous databases

PROiQ80Z71.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026725.
CleanExiMM_TNN.
ExpressionAtlasiQ80Z71. baseline and differential.
GenevisibleiQ80Z71. MM.

Family and domain databases

Gene3Di2.60.40.10. 12 hits.
3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR033080. TNW.
[Graphical view]
PANTHERiPTHR19143:SF252. PTHR19143:SF252. 3 hits.
PfamiPF00147. Fibrinogen_C. 1 hit.
PF00041. fn3. 12 hits.
[Graphical view]
SMARTiSM00181. EGF. 3 hits.
SM00186. FBG. 1 hit.
SM00060. FN3. 12 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 7 hits.
SSF56496. SSF56496. 1 hit.
PROSITEiPS00022. EGF_1. 3 hits.
PS01186. EGF_2. 3 hits.
PS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
PS50853. FN3. 12 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTENN_MOUSE
AccessioniPrimary (citable) accession number: Q80Z71
Secondary accession number(s): B9EHR3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: July 27, 2011
Last modified: September 7, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.