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Protein

Protein sel-1 homolog 1

Gene

Sel1l

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a role in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Enhances SYVN1 stability. Plays a role in LPL maturation and secretion. Required for normal differentiation of the pancreas epithelium, and for normal exocrine function and survival of pancreatic cells (By similarity). May play a role in Notch signaling (PubMed:11401526).By similarity1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Notch signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Protein sel-1 homolog 1
Alternative name(s):
Suppressor of lin-12-like protein 1
Short name:
Sel-1L
Gene namesi
Name:Sel1l
Synonyms:Sel1h
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620147. Sel1l.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 738LumenalSequence analysisAdd BLAST717
Transmembranei739 – 759HelicalSequence analysisAdd BLAST21
Topological domaini760 – 794CytoplasmicSequence analysisAdd BLAST35

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000002229722 – 794Protein sel-1 homolog 1Add BLAST773

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi127 ↔ 153PROSITE-ProRule annotation
Disulfide bondi141 ↔ 168PROSITE-ProRule annotation
Glycosylationi195N-linked (GlcNAc...)Sequence analysis1
Glycosylationi217N-linked (GlcNAc...)Sequence analysis1
Glycosylationi272N-linked (GlcNAc...)Sequence analysis1
Glycosylationi431N-linked (GlcNAc...)Sequence analysis1
Glycosylationi608N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ80Z70.
PRIDEiQ80Z70.

PTM databases

iPTMnetiQ80Z70.
PhosphoSitePlusiQ80Z70.
UniCarbKBiQ80Z70.

Expressioni

Gene expression databases

BgeeiENSRNOG00000004464.

Interactioni

Subunit structurei

Homodimer and homooligomer. Interacts with SYVN1; the interaction is direct (By similarity). Part of a complex containing SEL1L, SYVN1 and DERL2. May form a complex with ERLEC1, HSPA5, OS9, and SYVN1. Interacts with FOXRED2 and EDEM1 (By similarity). Interacts with LPL and LMF1; may stabilize the complex formed by LPL and LMF1 and thereby promote the export of LPL dimers (By similarity).By similarity

Protein-protein interaction databases

BioGridi260692. 1 interactor.
MINTiMINT-4571298.
STRINGi10116.ENSRNOP00000043232.

Structurei

3D structure databases

ProteinModelPortaliQ80Z70.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini122 – 170Fibronectin type-IIPROSITE-ProRule annotationAdd BLAST49
Repeati183 – 218Sel1-like 1Add BLAST36
Repeati219 – 254Sel1-like 2Add BLAST36
Repeati255 – 290Sel1-like 3Add BLAST36
Repeati291 – 326Sel1-like 4Add BLAST36
Repeati373 – 409Sel1-like 5Add BLAST37
Repeati410 – 446Sel1-like 6Add BLAST37
Repeati447 – 482Sel1-like 7Add BLAST36
Repeati483 – 518Sel1-like 8Add BLAST36
Repeati519 – 554Sel1-like 9Add BLAST36
Repeati627 – 662Sel1-like 10Add BLAST36
Repeati664 – 699Sel1-like 11Add BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni22 – 737Interaction with ERLEC1, OS9 and SYVN1By similarityAdd BLAST716
Regioni352 – 537Important for homodimerization and oligomerizationBy similarityAdd BLAST186
Regioni643 – 723Interaction with SYVN1By similarityAdd BLAST81
Regioni738 – 794Mediates retention in the endoplasmic reticulumBy similarityAdd BLAST57

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi770 – 793Pro-richAdd BLAST24

Sequence similaritiesi

Belongs to the sel-1 family.Curated
Contains 1 fibronectin type-II domain.PROSITE-ProRule annotation
Contains 11 Sel1-like repeats.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1550. Eukaryota.
COG0790. LUCA.
HOGENOMiHOG000239927.
HOVERGENiHBG057766.
InParanoidiQ80Z70.
KOiK14026.
PhylomeDBiQ80Z70.

Family and domain databases

CDDicd00062. FN2. 1 hit.
Gene3Di1.25.40.10. 3 hits.
2.10.10.10. 1 hit.
InterProiIPR000562. FN_type2_col-bd.
IPR013806. Kringle-like.
IPR006597. Sel1-like.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF00040. fn2. 1 hit.
PF08238. Sel1. 12 hits.
[Graphical view]
SMARTiSM00059. FN2. 1 hit.
SM00671. SEL1. 11 hits.
[Graphical view]
SUPFAMiSSF57440. SSF57440. 1 hit.
PROSITEiPS00023. FN2_1. 1 hit.
PS51092. FN2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q80Z70-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQVRVRLLLL LCAVLLGSAA ASSDEETNQD ESLDSKGALP TDGSVKDHTT
60 70 80 90 100
GKVVLLARDL LILKDSEVES LLQDEEESSK SQEEVSVTED ISFLDSPNPS
110 120 130 140 150
SKTYEELKRV RKPVLTAIEG TAHGEPCHFP FLFLDKEYDE CTSDGREDGR
160 170 180 190 200
LWCATTYDYK TDEKWGFCET EEDAAKRRQM QEAEAIYQSG MKILNGSTRK
210 220 230 240 250
NQKREAYRYL QKAAGMNHTK ALERVSYALL FGDYLTQNIQ AAKEMFEKLT
260 270 280 290 300
EEGSPKGQTG LGFLYASGLG VNSSQAKALV YYTFGALGGN LIAHMVLGYR
310 320 330 340 350
YWAGIGVLQS CESALTHYRL VANHVASDIS LTGGSVVQRI RLPDEVENPG
360 370 380 390 400
MNSGMLEEDL IQYYQFLAEK GDVQAQVGLG QLHLHGGRGV EQNHQRAFDY
410 420 430 440 450
FNLAANAGNS HAMAFLGKMY SEGSDIVPQS NETALHYFKK AADMGNPVGQ
460 470 480 490 500
SGLGMAYLYG RGVQVNYDLA LKYFQKAAEQ GWVDGQLQLG SMYYNGIGVK
510 520 530 540 550
RDYKQALKYF NLASQGGHIL AFYNLAQMHA SGTGVMRSCH TAVELFKNVC
560 570 580 590 600
ERGRWSERLM TAYNSYKDDD YNAAVVQYLL LAEQGYEVAQ SNAAFILDQR
610 620 630 640 650
EATIVGENET YPRALLHWNR AASQGYTVAR IKLGDYHFYG FGTDVDYETA
660 670 680 690 700
FIHYRLASEQ QHSAQAMFNL GYMHEKGLGI KQDIHLAKRF YDMAAEASPD
710 720 730 740 750
AQVPVFLALC KLGVVYFLQY IREANIRDLF TQLDMDQLLG PEWDLYLMTI
760 770 780 790
IALLLGTVIA YRQRQHQDIP VPRPPGPRPA PPQQEGPPEQ QPPQ
Length:794
Mass (Da):88,683
Last modified:April 12, 2005 - v2
Checksum:iF0049AC1F8A9035E
GO

Sequence cautioni

The sequence AAO65770 differs from that shown. Reason: Frameshift at position 55.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF304853 mRNA. Translation: AAO65770.1. Frameshift.
RefSeqiNP_808794.2. NM_177933.2.
UniGeneiRn.162892.

Genome annotation databases

GeneIDi314352.
KEGGirno:314352.
UCSCiRGD:620147. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF304853 mRNA. Translation: AAO65770.1. Frameshift.
RefSeqiNP_808794.2. NM_177933.2.
UniGeneiRn.162892.

3D structure databases

ProteinModelPortaliQ80Z70.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi260692. 1 interactor.
MINTiMINT-4571298.
STRINGi10116.ENSRNOP00000043232.

PTM databases

iPTMnetiQ80Z70.
PhosphoSitePlusiQ80Z70.
UniCarbKBiQ80Z70.

Proteomic databases

PaxDbiQ80Z70.
PRIDEiQ80Z70.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi314352.
KEGGirno:314352.
UCSCiRGD:620147. rat.

Organism-specific databases

CTDi6400.
RGDi620147. Sel1l.

Phylogenomic databases

eggNOGiKOG1550. Eukaryota.
COG0790. LUCA.
HOGENOMiHOG000239927.
HOVERGENiHBG057766.
InParanoidiQ80Z70.
KOiK14026.
PhylomeDBiQ80Z70.

Miscellaneous databases

PROiQ80Z70.

Gene expression databases

BgeeiENSRNOG00000004464.

Family and domain databases

CDDicd00062. FN2. 1 hit.
Gene3Di1.25.40.10. 3 hits.
2.10.10.10. 1 hit.
InterProiIPR000562. FN_type2_col-bd.
IPR013806. Kringle-like.
IPR006597. Sel1-like.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF00040. fn2. 1 hit.
PF08238. Sel1. 12 hits.
[Graphical view]
SMARTiSM00059. FN2. 1 hit.
SM00671. SEL1. 11 hits.
[Graphical view]
SUPFAMiSSF57440. SSF57440. 1 hit.
PROSITEiPS00023. FN2_1. 1 hit.
PS51092. FN2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSE1L1_RAT
AccessioniPrimary (citable) accession number: Q80Z70
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: April 12, 2005
Last modified: November 2, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.