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Protein
Submitted name:

Rho GTPase activating protein 4, isoform CRA_f

Gene

Arhgap4

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activationSAAS annotation

Enzyme and pathway databases

ReactomeiR-MMU-194840. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Submitted name:
Rho GTPase activating protein 4, isoform CRA_fImported
Submitted name:
Rho GTPase-activating protein 4Imported
Submitted name:
Rho GTPase-activating protein p115 splice form 1Imported
Gene namesi
Name:Arhgap4Imported
ORF Names:mCG_140218Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:2159577. Arhgap4.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSMUSG00000031389.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000067477.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 328F-BARInterPro annotationAdd BLAST310
Domaini518 – 706Rho-GAPInterPro annotationAdd BLAST189
Domaini757 – 816SH3InterPro annotationAdd BLAST60

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili144 – 171Sequence analysisAdd BLAST28
Coiled coili465 – 492Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coilPROSITE-ProRule annotationSAAS annotation, SH3 domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410KCV1. Eukaryota.
ENOG410YF76. LUCA.
GeneTreeiENSGT00760000118863.
HOGENOMiHOG000039980.
HOVERGENiHBG051637.
TreeFamiTF315892.

Family and domain databases

InterProiView protein in InterPro
IPR027267. AH/BAR-dom.
IPR031160. F_BAR.
IPR001060. FCH_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR001452. SH3_domain.
PfamiView protein in Pfam
PF00611. FCH. 1 hit.
PF00620. RhoGAP. 1 hit.
PF00018. SH3_1. 1 hit.
SMARTiView protein in SMART
SM00055. FCH. 1 hit.
SM00324. RhoGAP. 1 hit.
SM00326. SH3. 1 hit.
SUPFAMiSSF103657. SSF103657. 2 hits.
SSF48350. SSF48350. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiView protein in PROSITE
PS51741. F_BAR. 1 hit.
PS50238. RHOGAP. 1 hit.
PS50002. SH3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q80Z68-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAHGKLRRE RGLQPEYDAQ VKEMRWQLSE QLHCLELQGE LRRDLLQELA
60 70 80 90 100
EFMRRRAEVE LEYSRGLDKL AERFTSRSGR LGGSSQEQQS FRKEPTLLSP
110 120 130 140 150
LHCWAVLLEH TRQQSRESAA LSEVLAGPLA QRLSHISEDV GRIVKKSKDL
160 170 180 190 200
VQQLQAELLE VVSELQTTKK MYHVYHSESM NAETKLREAE RQEEKRSGRS
210 220 230 240 250
ALSTTTTTSA TTTTTTTTVE TGPHRKSSLK KGGRLVEKRQ AKYLEHKLKC
260 270 280 290 300
TKARNEYLLS LASVNAAISN YYLHDILDLM DCCDTGFHLA LEQALRSYTA
310 320 330 340 350
AESRTQTSQM QGLGSLEEAL EALDPPGDKA KVLEVHAMAF CPPLRFEYQP
360 370 380 390 400
HEDDEVAEVL IEMELWDEIL PRAQNIQSRL DQKTIETEEV NKTLKATLKA
410 420 430 440 450
LLEAVASEDG DILDSLQASP STESLKSTSS DPGTRQTGRR RNQQQETETF
460 470 480 490 500
YITKLQEYLS GRSILSKLQA KHEKLQEAIQ QGNKEKQETS RTQCTERKFH
510 520 530 540 550
KSHPPHPRFQ YNQRLFGGDL EKFIQSSGQP VPLVVESCIR FINLNGLQHE
560 570 580 590 600
GIFRVSGAQA RISEIRDAFE RGEDPLEKGC TVHDLDSVAG VLKLYFRSLE
610 620 630 640 650
PPLFPLDMFN ELLASAELEV VGERVEPVSH LLFKLPRPVL VVLRYLFTFL
660 670 680 690 700
NHLAQYSDEN MMDSYNLAVC FGPTLLPVPA GQDPVALQGR VNQLVQTLIL
710 720 730 740 750
QPARIFPPPA MLPGPIYEKC MAPPSASCLG DGQLESLIGE PELELKTGTT
760 770 780 790 800
AQEDDQEGVL EAVACFAYTG RTAQELTFQR GDVLRLYARA SSDWWRGEHA
810 820 830 840 850
GVQGLIPHKY ITLCEGDEKQ MAGSGLQAMG ESVSHPEGFL TLEFANRLEL
860 870 880 890 900
GTPPEALGPS RHRRPCLVPT SPEGHVEMDK AVAQNMNSVF KELLGKTAVR
910 920 930 940 950
QGHGLASTAS PSLGTLTPLA CSSISKNKVF SRGPGAPISP STSHPQGPDS

TRKPV
Length:955
Mass (Da):106,451
Last modified:June 1, 2003 - v1
Checksum:i3443807926C15D60
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL672002 Genomic DNA. No translation available.
AY183124 mRNA. Translation: AAO66338.1.
AK157294 mRNA. Translation: BAE34037.1.
CH466650 Genomic DNA. Translation: EDL29866.1.
RefSeqiNP_619536.2. NM_138630.2.
UniGeneiMm.482337.

Genome annotation databases

EnsembliENSMUST00000064376; ENSMUSP00000067477; ENSMUSG00000031389.
GeneIDi171207.
UCSCiuc009tna.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiQ80Z68_MOUSE
AccessioniPrimary (citable) accession number: Q80Z68
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: August 30, 2017
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported