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Q80Z68

- Q80Z68_MOUSE

UniProt

Q80Z68 - Q80Z68_MOUSE

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Protein
Submitted name:

Protein Arhgap4

Gene

Arhgap4

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. Rho GTPase activator activity Source: Ensembl

GO - Biological processi

  1. negative regulation of axon extension Source: Ensembl
  2. negative regulation of fibroblast migration Source: Ensembl
  3. signal transduction Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_204733. G alpha (12/13) signalling events.
REACT_209641. NRAGE signals death through JNK.
REACT_210090. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein Arhgap4Imported
Submitted name:
Rho GTPase activating protein 4, isoform CRA_fImported
Submitted name:
Rho GTPase-activating protein p115 splice form 1Imported
Gene namesi
Name:Arhgap4Imported
ORF Names:mCG_140218Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:2159577. Arhgap4.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. growth cone Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ80Z68.

Family & Domainsi

Sequence similaritiesi

Contains FCH domain.SAAS annotation

Keywords - Domaini

SH3 domainSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118863.
HOGENOMiHOG000039980.
HOVERGENiHBG051637.
TreeFamiTF315892.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
InterProiIPR001060. FCH_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00611. FCH. 1 hit.
PF00620. RhoGAP. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
SMARTiSM00055. FCH. 1 hit.
SM00324. RhoGAP. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS50133. FCH. 1 hit.
PS50238. RHOGAP. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80Z68-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAHGKLRRE RGLQPEYDAQ VKEMRWQLSE QLHCLELQGE LRRDLLQELA
60 70 80 90 100
EFMRRRAEVE LEYSRGLDKL AERFTSRSGR LGGSSQEQQS FRKEPTLLSP
110 120 130 140 150
LHCWAVLLEH TRQQSRESAA LSEVLAGPLA QRLSHISEDV GRIVKKSKDL
160 170 180 190 200
VQQLQAELLE VVSELQTTKK MYHVYHSESM NAETKLREAE RQEEKRSGRS
210 220 230 240 250
ALSTTTTTSA TTTTTTTTVE TGPHRKSSLK KGGRLVEKRQ AKYLEHKLKC
260 270 280 290 300
TKARNEYLLS LASVNAAISN YYLHDILDLM DCCDTGFHLA LEQALRSYTA
310 320 330 340 350
AESRTQTSQM QGLGSLEEAL EALDPPGDKA KVLEVHAMAF CPPLRFEYQP
360 370 380 390 400
HEDDEVAEVL IEMELWDEIL PRAQNIQSRL DQKTIETEEV NKTLKATLKA
410 420 430 440 450
LLEAVASEDG DILDSLQASP STESLKSTSS DPGTRQTGRR RNQQQETETF
460 470 480 490 500
YITKLQEYLS GRSILSKLQA KHEKLQEAIQ QGNKEKQETS RTQCTERKFH
510 520 530 540 550
KSHPPHPRFQ YNQRLFGGDL EKFIQSSGQP VPLVVESCIR FINLNGLQHE
560 570 580 590 600
GIFRVSGAQA RISEIRDAFE RGEDPLEKGC TVHDLDSVAG VLKLYFRSLE
610 620 630 640 650
PPLFPLDMFN ELLASAELEV VGERVEPVSH LLFKLPRPVL VVLRYLFTFL
660 670 680 690 700
NHLAQYSDEN MMDSYNLAVC FGPTLLPVPA GQDPVALQGR VNQLVQTLIL
710 720 730 740 750
QPARIFPPPA MLPGPIYEKC MAPPSASCLG DGQLESLIGE PELELKTGTT
760 770 780 790 800
AQEDDQEGVL EAVACFAYTG RTAQELTFQR GDVLRLYARA SSDWWRGEHA
810 820 830 840 850
GVQGLIPHKY ITLCEGDEKQ MAGSGLQAMG ESVSHPEGFL TLEFANRLEL
860 870 880 890 900
GTPPEALGPS RHRRPCLVPT SPEGHVEMDK AVAQNMNSVF KELLGKTAVR
910 920 930 940 950
QGHGLASTAS PSLGTLTPLA CSSISKNKVF SRGPGAPISP STSHPQGPDS

TRKPV
Length:955
Mass (Da):106,451
Last modified:June 1, 2003 - v1
Checksum:i3443807926C15D60
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL672002 Genomic DNA. No translation available.
AY183124 mRNA. Translation: AAO66338.1.
AK157294 mRNA. Translation: BAE34037.1.
CH466650 Genomic DNA. Translation: EDL29866.1.
RefSeqiNP_619536.2. NM_138630.2.
UniGeneiMm.482337.

Genome annotation databases

EnsembliENSMUST00000064376; ENSMUSP00000067477; ENSMUSG00000031389.
GeneIDi171207.
KEGGimmu:171207.
UCSCiuc009tna.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL672002 Genomic DNA. No translation available.
AY183124 mRNA. Translation: AAO66338.1 .
AK157294 mRNA. Translation: BAE34037.1 .
CH466650 Genomic DNA. Translation: EDL29866.1 .
RefSeqi NP_619536.2. NM_138630.2.
UniGenei Mm.482337.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000064376 ; ENSMUSP00000067477 ; ENSMUSG00000031389 .
GeneIDi 171207.
KEGGi mmu:171207.
UCSCi uc009tna.2. mouse.

Organism-specific databases

CTDi 393.
MGIi MGI:2159577. Arhgap4.

Phylogenomic databases

GeneTreei ENSGT00760000118863.
HOGENOMi HOG000039980.
HOVERGENi HBG051637.
TreeFami TF315892.

Enzyme and pathway databases

Reactomei REACT_204733. G alpha (12/13) signalling events.
REACT_209641. NRAGE signals death through JNK.
REACT_210090. Rho GTPase cycle.

Miscellaneous databases

ChiTaRSi ARHGAP4. mouse.
NextBioi 370690.
SOURCEi Search...

Gene expression databases

Genevestigatori Q80Z68.

Family and domain databases

Gene3Di 1.10.555.10. 1 hit.
InterProi IPR001060. FCH_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view ]
Pfami PF00611. FCH. 1 hit.
PF00620. RhoGAP. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view ]
SMARTi SM00055. FCH. 1 hit.
SM00324. RhoGAP. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF48350. SSF48350. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEi PS50133. FCH. 1 hit.
PS50238. RHOGAP. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
    Tissue: Activated spleenImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
    Tissue: Activated spleenImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
    Tissue: Activated spleenImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
    Tissue: Activated spleenImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
    Tissue: Activated spleenImported.
  6. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  7. "ARHGAP4/Arhgap4 transcripts in human and mouse."
    Reichwald K., Petz U., Rosenthal A., Platzer M.
    Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BALB/cImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
    Tissue: Activated spleenImported.
  9. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
    Tissue: Activated spleenImported.
  10. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
    Tissue: Activated spleenImported.
  11. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  12. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  13. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ80Z68_MOUSE
AccessioniPrimary (citable) accession number: Q80Z68
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3