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Q80Z68

- Q80Z68_MOUSE

UniProt

Q80Z68 - Q80Z68_MOUSE

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Protein
Submitted name: Protein Arhgap4
Gene
Arhgap4, mCG_140218
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. Rho GTPase activator activity Source: Ensembl
Complete GO annotation...

GO - Biological processi

  1. negative regulation of axon extension Source: Ensembl
  2. negative regulation of fibroblast migration Source: Ensembl
  3. signal transduction Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_204733. G alpha (12/13) signalling events.
REACT_209641. NRAGE signals death through JNK.
REACT_210090. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein Arhgap4Imported
Submitted name:
Rho GTPase activating protein 4, isoform CRA_fImported
Submitted name:
Rho GTPase-activating protein p115 splice form 1Imported
Gene namesi
Name:Arhgap4Imported
ORF Names:mCG_140218Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:2159577. Arhgap4.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. focal adhesion Source: Ensembl
  3. growth cone Source: Ensembl
  4. nucleus Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ80Z68.

Family & Domainsi

Sequence similaritiesi

Contains FCH domain.SAAS annotations

Keywords - Domaini

SH3 domainSAAS annotations

Phylogenomic databases

GeneTreeiENSGT00710000106292.
HOGENOMiHOG000039980.
HOVERGENiHBG051637.
TreeFamiTF315892.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
InterProiIPR001060. FCH_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00611. FCH. 1 hit.
PF00620. RhoGAP. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
SMARTiSM00055. FCH. 1 hit.
SM00324. RhoGAP. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS50133. FCH. 1 hit.
PS50238. RHOGAP. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80Z68-1 [UniParc]FASTAAdd to Basket

« Hide

MAAHGKLRRE RGLQPEYDAQ VKEMRWQLSE QLHCLELQGE LRRDLLQELA    50
EFMRRRAEVE LEYSRGLDKL AERFTSRSGR LGGSSQEQQS FRKEPTLLSP 100
LHCWAVLLEH TRQQSRESAA LSEVLAGPLA QRLSHISEDV GRIVKKSKDL 150
VQQLQAELLE VVSELQTTKK MYHVYHSESM NAETKLREAE RQEEKRSGRS 200
ALSTTTTTSA TTTTTTTTVE TGPHRKSSLK KGGRLVEKRQ AKYLEHKLKC 250
TKARNEYLLS LASVNAAISN YYLHDILDLM DCCDTGFHLA LEQALRSYTA 300
AESRTQTSQM QGLGSLEEAL EALDPPGDKA KVLEVHAMAF CPPLRFEYQP 350
HEDDEVAEVL IEMELWDEIL PRAQNIQSRL DQKTIETEEV NKTLKATLKA 400
LLEAVASEDG DILDSLQASP STESLKSTSS DPGTRQTGRR RNQQQETETF 450
YITKLQEYLS GRSILSKLQA KHEKLQEAIQ QGNKEKQETS RTQCTERKFH 500
KSHPPHPRFQ YNQRLFGGDL EKFIQSSGQP VPLVVESCIR FINLNGLQHE 550
GIFRVSGAQA RISEIRDAFE RGEDPLEKGC TVHDLDSVAG VLKLYFRSLE 600
PPLFPLDMFN ELLASAELEV VGERVEPVSH LLFKLPRPVL VVLRYLFTFL 650
NHLAQYSDEN MMDSYNLAVC FGPTLLPVPA GQDPVALQGR VNQLVQTLIL 700
QPARIFPPPA MLPGPIYEKC MAPPSASCLG DGQLESLIGE PELELKTGTT 750
AQEDDQEGVL EAVACFAYTG RTAQELTFQR GDVLRLYARA SSDWWRGEHA 800
GVQGLIPHKY ITLCEGDEKQ MAGSGLQAMG ESVSHPEGFL TLEFANRLEL 850
GTPPEALGPS RHRRPCLVPT SPEGHVEMDK AVAQNMNSVF KELLGKTAVR 900
QGHGLASTAS PSLGTLTPLA CSSISKNKVF SRGPGAPISP STSHPQGPDS 950
TRKPV 955
Length:955
Mass (Da):106,451
Last modified:June 1, 2003 - v1
Checksum:i3443807926C15D60
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL672002 Genomic DNA. No translation available.
AY183124 mRNA. Translation: AAO66338.1.
AK157294 mRNA. Translation: BAE34037.1.
CH466650 Genomic DNA. Translation: EDL29866.1.
RefSeqiNP_619536.2. NM_138630.2.
UniGeneiMm.482337.

Genome annotation databases

EnsembliENSMUST00000064376; ENSMUSP00000067477; ENSMUSG00000031389.
GeneIDi171207.
KEGGimmu:171207.
UCSCiuc009tna.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL672002 Genomic DNA. No translation available.
AY183124 mRNA. Translation: AAO66338.1 .
AK157294 mRNA. Translation: BAE34037.1 .
CH466650 Genomic DNA. Translation: EDL29866.1 .
RefSeqi NP_619536.2. NM_138630.2.
UniGenei Mm.482337.

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000064376 ; ENSMUSP00000067477 ; ENSMUSG00000031389 .
GeneIDi 171207.
KEGGi mmu:171207.
UCSCi uc009tna.2. mouse.

Organism-specific databases

CTDi 393.
MGIi MGI:2159577. Arhgap4.

Phylogenomic databases

GeneTreei ENSGT00710000106292.
HOGENOMi HOG000039980.
HOVERGENi HBG051637.
TreeFami TF315892.

Enzyme and pathway databases

Reactomei REACT_204733. G alpha (12/13) signalling events.
REACT_209641. NRAGE signals death through JNK.
REACT_210090. Rho GTPase cycle.

Miscellaneous databases

ChiTaRSi ARHGAP4. mouse.
NextBioi 370690.
SOURCEi Search...

Gene expression databases

Genevestigatori Q80Z68.

Family and domain databases

Gene3Di 1.10.555.10. 1 hit.
InterProi IPR001060. FCH_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view ]
Pfami PF00611. FCH. 1 hit.
PF00620. RhoGAP. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view ]
SMARTi SM00055. FCH. 1 hit.
SM00324. RhoGAP. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF48350. SSF48350. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEi PS50133. FCH. 1 hit.
PS50238. RHOGAP. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
    Tissue: Activated spleenImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
    Tissue: Activated spleenImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
    Tissue: Activated spleenImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
    Tissue: Activated spleenImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
    Tissue: Activated spleenImported.
  6. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  7. "ARHGAP4/Arhgap4 transcripts in human and mouse."
    Reichwald K., Petz U., Rosenthal A., Platzer M.
    Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BALB/cImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
    Tissue: Activated spleenImported.
  9. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
    Tissue: Activated spleenImported.
  10. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
    Tissue: Activated spleenImported.
  11. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  12. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  13. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ80Z68_MOUSE
AccessioniPrimary (citable) accession number: Q80Z68
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: September 3, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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