##gff-version 3 Q80Z64 UniProtKB Chain 1 305 . . . ID=PRO_0000261419;Note=Homeobox protein NANOG Q80Z64 UniProtKB Repeat 198 202 . . . Note=1 Q80Z64 UniProtKB Repeat 203 207 . . . Note=2 Q80Z64 UniProtKB Repeat 208 212 . . . Note=3 Q80Z64 UniProtKB Repeat 213 217 . . . Note=4 Q80Z64 UniProtKB Repeat 218 222 . . . Note=5 Q80Z64 UniProtKB Repeat 223 227 . . . Note=6 Q80Z64 UniProtKB Repeat 228 232 . . . Note=7 Q80Z64 UniProtKB Repeat 233 237 . . . Note=8 Q80Z64 UniProtKB Repeat 238 242 . . . Note=9 Q80Z64 UniProtKB Repeat 243 247 . . . Note=10 Q80Z64 UniProtKB DNA binding 96 155 . . . Note=Homeobox;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00108 Q80Z64 UniProtKB Region 1 30 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q80Z64 UniProtKB Region 46 95 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q80Z64 UniProtKB Region 96 155 . . . Note=Sufficient for interaction with SALL4;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16840789;Dbxref=PMID:16840789 Q80Z64 UniProtKB Region 123 152 . . . Note=Required for DNA-binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9H9S0 Q80Z64 UniProtKB Region 198 247 . . . Note=10 X repeats starting with a Trp in each unit Q80Z64 UniProtKB Region 198 247 . . . Note=Sufficient for transactivation activity Q80Z64 UniProtKB Region 248 305 . . . Note=Sufficient for strong transactivation activity Q80Z64 UniProtKB Compositional bias 12 29 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q80Z64 UniProtKB Compositional bias 58 77 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q80Z64 UniProtKB Compositional bias 79 95 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q80Z64 UniProtKB Alternative sequence 1 25 . . . ID=VSP_021689;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15108323;Dbxref=PMID:15108323 Q80Z64 UniProtKB Mutagenesis 101 101 . . . Note=Decreased protein expression. Decreased embryonic stem cell self-renewal. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25825768;Dbxref=PMID:25825768 Q80Z64 UniProtKB Mutagenesis 103 103 . . . Note=Decreased protein expression and stability. Decreased embryonic stem cell self-renewal. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25825768;Dbxref=PMID:25825768 Q80Z64 UniProtKB Mutagenesis 112 112 . . . Note=Increases affinity for DNA and protein stability%3B when associated with R-147. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18177668;Dbxref=PMID:18177668 Q80Z64 UniProtKB Mutagenesis 120 120 . . . Note=Decreased protein expression and stability. Decreased embryonic stem cell self-renewal. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25825768;Dbxref=PMID:25825768 Q80Z64 UniProtKB Mutagenesis 123 123 . . . Note=Increased protein expression and stability. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25825768;Dbxref=PMID:25825768 Q80Z64 UniProtKB Mutagenesis 125 125 . . . Note=Decreased protein expression. No effect on protein stability. Q->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25825768;Dbxref=PMID:25825768 Q80Z64 UniProtKB Mutagenesis 126 126 . . . Note=No effect on protein stability. M->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25825768;Dbxref=PMID:25825768 Q80Z64 UniProtKB Mutagenesis 126 126 . . . Note=Increases affinity for DNA%3B when associated with E-137. M->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18177668;Dbxref=PMID:18177668 Q80Z64 UniProtKB Mutagenesis 137 137 . . . Note=Increased protein expression. Decreased protein stability. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25825768;Dbxref=PMID:25825768 Q80Z64 UniProtKB Mutagenesis 137 137 . . . Note=Increases affinity for DNA%3B when associated with R-126. Y->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18177668;Dbxref=PMID:18177668 Q80Z64 UniProtKB Mutagenesis 138 138 . . . Note=Decreased protein expression and stability. Decreased embryonic stem cell self-renewal. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25825768;Dbxref=PMID:25825768 Q80Z64 UniProtKB Mutagenesis 138 138 . . . Note=Reduced affinity for DNA. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18177668;Dbxref=PMID:18177668 Q80Z64 UniProtKB Mutagenesis 141 141 . . . Note=Decreased protein stability. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25825768;Dbxref=PMID:25825768 Q80Z64 UniProtKB Mutagenesis 142 142 . . . Note=Decreased protein expression and stability. Decreased embryonic stem cell self-renewal. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25825768;Dbxref=PMID:25825768 Q80Z64 UniProtKB Mutagenesis 142 142 . . . Note=Slightly reduced affinity for DNA. T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18177668;Dbxref=PMID:18177668 Q80Z64 UniProtKB Mutagenesis 145 145 . . . Note=Increased protein expression. No effect on protein stability. Q->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25825768;Dbxref=PMID:25825768 Q80Z64 UniProtKB Mutagenesis 146 146 . . . Note=No effect on protein stability. Decreased embryonic stem cell self-renewal. N->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25825768;Dbxref=PMID:25825768 Q80Z64 UniProtKB Mutagenesis 146 146 . . . Note=Strongly reduced affinity for DNA. N->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18177668;Dbxref=PMID:18177668 Q80Z64 UniProtKB Mutagenesis 147 147 . . . Note=Increases affinity for DNA and protein stability%3B when associated with E-112. Q->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18177668;Dbxref=PMID:18177668 Q80Z64 UniProtKB Mutagenesis 148 148 . . . Note=Decreased protein stability. Decreased embryonic stem cell self-renewal. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25825768;Dbxref=PMID:25825768 Q80Z64 UniProtKB Mutagenesis 149 149 . . . Note=Increased protein expression. No effect on protein stability. M->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25825768;Dbxref=PMID:25825768 Q80Z64 UniProtKB Mutagenesis 152 152 . . . Note=Decreased protein expression and stability. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25825768;Dbxref=PMID:25825768 Q80Z64 UniProtKB Sequence conflict 149 149 . . . Note=M->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q80Z64 UniProtKB Helix 105 117 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2VI6 Q80Z64 UniProtKB Helix 123 133 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2VI6 Q80Z64 UniProtKB Helix 137 149 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2VI6 Q80Z64 UniProtKB Helix 152 154 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2VI6