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Q80Z64 (NANOG_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein NANOG
Alternative name(s):
ES cell-associated protein 4
Early embryo specific expression NK-type homeobox protein
Homeobox transcription factor Nanog
Gene names
Name:Nanog
Synonyms:Ecat4, Enk
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length305 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation. Ref.1 Ref.2 Ref.6 Ref.8 Ref.13 Ref.14 Ref.15 Ref.16 Ref.17

Subunit structure

Interacts with SMAD1 and SALL4. Interacts with ZNF281/ZFP281. Ref.12 Ref.15 Ref.16 Ref.17 Ref.18

Subcellular location

Nucleus Ref.9.

Tissue specificity

Not expressed in oocytes and spermatogonia (at protein level). Not expressed in many somatic organs, ovary, testis, fibroblast and hematopoietic cell lines. Ref.1 Ref.2 Ref.4 Ref.7

Developmental stage

Expressed in the central portion of the morula, the inner cell mass (ICM) of the blastocyst, in embryonic stem (ES) and embryonic germ (EG) cells, in the epiblast between 6.5 and 7.5 dpc, in primordial germ cells (PGCs) between 7.75 and 12.5 dpc (at protein level). The expression in PGCs decreases in female germ cells that entered meiosis at 13.5 dpc and in male germ cells that entered mitotic arrest at 14.5 dpc (at protein level). Not expressed in unfertilized eggs or 2- or 8-cell-stage embryos (at protein level). Expressed in the central portion of the morula, the inner cell mass (ICM) of the blastocyst, in ES and EG cells, in the epiblast at 6 dpc and in PGCs of genital ridges between 11.5 and 12.5 dpc. Expression decreases with ES differentiation. Ref.1 Ref.2 Ref.3 Ref.4 Ref.7 Ref.9

Induction

By the transcription factor POU5F1 in ES cells that acts as a direct biphasic regulator: a steady-state concentration of POU5F1 up-regulated its expression, while an elevated concentration of POU5F1 down-regulated its expression. Up-regulated by the transcription factor FOXD3. Up-regulated in ES cells by transcription factors T (Brachyury) and STAT3. Down-regulated by p53 in response to DNA damage induced by ultraviolet light (UV) or doxorubicin. Down-regulated upon ES differentiation by mediating autorepression through interaction with ZNF281/ZFP281. Ref.10 Ref.11 Ref.14 Ref.15 Ref.17

Disruption phenotype

Loss of pluripotency in both ICM and ES cells and differentiated into extraembryonic (parietal and visceral) endoderm lineage. Ref.1

Miscellaneous

'Nanog' is derived from 'Tir nan Og' the mythologic Celtic land of the ever young.

Sequence similarities

Belongs to the Nanog homeobox family.

Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
   DomainHomeobox
Repeat
   LigandDNA-binding
   Molecular functionActivator
Developmental protein
Repressor
   Technical term3D-structure
Complete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processcell proliferation

Inferred from electronic annotation. Source: Ensembl

embryo development

Inferred from expression pattern Ref.4. Source: HGNC

embryonic pattern specification

Inferred from expression pattern Ref.4. Source: HGNC

endodermal cell fate specification

Inferred from sequence orthology PubMed 21245162. Source: MGI

gonad development

Inferred from expression pattern Ref.4. Source: HGNC

mesodermal cell fate commitment

Inferred from genetic interaction Ref.15. Source: MGI

negative regulation of BMP signaling pathway

Inferred from direct assay Ref.15. Source: MGI

negative regulation of cell differentiation

Inferred from direct assay PubMed 17940068. Source: MGI

negative regulation of cell fate commitment

Inferred from direct assay Ref.15. Source: MGI

negative regulation of endodermal cell fate specification

Traceable author statement PubMed 16501172. Source: HGNC

negative regulation of transcription from RNA polymerase II promoter

Inferred from genetic interaction Ref.15. Source: MGI

positive regulation of cell proliferation

Inferred from direct assay PubMed 16259959. Source: MGI

positive regulation of mitotic cell cycle

Inferred from direct assay PubMed 16259959. Source: MGI

positive regulation of transcription from RNA polymerase II promoter

Inferred from mutant phenotype PubMed 20937355. Source: BHF-UCL

positive regulation of transcription, DNA-templated

Inferred from mutant phenotype PubMed 20937355. Source: BHF-UCL

response to organic substance

Inferred from direct assay PubMed 18400104. Source: MGI

response to retinoic acid

Inferred from direct assay PubMed 18400104. Source: MGI

somatic stem cell maintenance

Inferred from electronic annotation. Source: Ensembl

stem cell differentiation

Inferred from direct assay PubMed 20123909. Source: MGI

stem cell division

Inferred from direct assay Ref.2. Source: MGI

stem cell maintenance

Inferred from direct assay Ref.15. Source: MGI

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleolus

Inferred from electronic annotation. Source: Ensembl

nucleoplasm

Inferred from direct assay PubMed 21076177. Source: BHF-UCL

nucleus

Inferred from direct assay PubMed 20937355. Source: BHF-UCL

   Molecular_functionDNA binding

Inferred from direct assay Ref.1Ref.14. Source: MGI

chromatin binding

Inferred from direct assay PubMed 18467660. Source: MGI

enhancer sequence-specific DNA binding

Inferred from direct assay PubMed 21062744. Source: BHF-UCL

protein binding

Inferred from physical interaction Ref.16Ref.17. Source: UniProtKB

sequence-specific DNA binding

Inferred from direct assay PubMed 20937355. Source: BHF-UCL

sequence-specific DNA binding transcription factor activity

Inferred from mutant phenotype Ref.17. Source: UniProtKB

transcription corepressor activity

Inferred from mutant phenotype Ref.17. Source: UniProtKB

transcription regulatory region DNA binding

Inferred from direct assay PubMed 20123909. Source: MGI

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q80Z64-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q80Z64-2)

Also known as: Nanog1a; Nanog1b;

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 305305Homeobox protein NANOG
PRO_0000261419

Regions

Repeat198 – 20251
Repeat203 – 20752
Repeat208 – 21253
Repeat213 – 21754
Repeat218 – 22255
Repeat223 – 22756
Repeat228 – 23257
Repeat233 – 23758
Repeat238 – 24259
Repeat243 – 247510
DNA binding96 – 15560Homeobox Ref.1 Ref.8 Ref.12
Region96 – 15560Sufficient for interaction with SALL4
Region198 – 2475010 X repeats starting with a Trp in each unit
Region198 – 24750Sufficient for transactivation activity
Region248 – 30558Sufficient for strong transactivation activity
Compositional bias198 – 24346Trp-rich

Natural variations

Alternative sequence1 – 2525Missing in isoform 2.
VSP_021689

Experimental info

Mutagenesis1121K → E: Increases affinity for DNA and protein stability; when associated with R-147. Ref.18
Mutagenesis1261M → R: Increases affinity for DNA; when associated with E-137. Ref.18
Mutagenesis1371Y → E: Increases affinity for DNA; when associated with R-126. Ref.18
Mutagenesis1381K → E: Reduced affinity for DNA. Ref.18
Mutagenesis1421T → I: Slightly reduced affinity for DNA. Ref.18
Mutagenesis1461N → E: Strongly reduced affinity for DNA. Ref.18
Mutagenesis1471Q → R: Increases affinity for DNA and protein stability; when associated with E-112. Ref.18
Sequence conflict1491M → V in BAC76998. Ref.1

Secondary structure

......... 305
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 4EF96408B767C79F

FASTA30534,240
        10         20         30         40         50         60 
MSVGLPGPHS LPSSEEASNS GNASSMPAVF HPENYSCLQG SATEMLCTEA ASPRPSSEDL 

        70         80         90        100        110        120 
PLQGSPDSST SPKQKLSSPE ADKGPEEEEN KVLARKQKMR TVFSQAQLCA LKDRFQKQKY 

       130        140        150        160        170        180 
LSLQQMQELS SILNLSYKQV KTWFQNQRMK CKRWQKNQWL KTSNGLIQKG SAPVEYPSIH 

       190        200        210        220        230        240 
CSYPQGYLVN ASGSLSMWGS QTWTNPTWSS QTWTNPTWNN QTWTNPTWSS QAWTAQSWNG 

       250        260        270        280        290        300 
QPWNAAPLHN FGEDFLQPYV QLQQNFSASD LEVNLEATRE SHAHFSTPQA LELFLNYSVT 


PPGEI 

« Hide

Isoform 2 (Nanog1a) (Nanog1b) [UniParc].

Checksum: 090B8AC6C26A37C6
Show »

FASTA28031,859

References

« Hide 'large scale' references
[1]"The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells."
Mitsui K., Tokuzawa Y., Itoh H., Segawa K., Murakami M., Takahashi K., Maruyama M., Maeda M., Yamanaka S.
Cell 113:631-642(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, DNA-BINDING, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
[2]"Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells."
Chambers I., Colby D., Robertson M., Nichols J., Lee S., Tweedie S., Smith A.
Cell 113:643-655(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
Strain: 129/Ola.
Tissue: Embryonic stem cell.
[3]"A novel NK-type homeobox gene, ENK (early embryo specific NK), preferentially expressed in embryonic stem cells."
Wang S.-H., Tsai M.-S., Chiang M.-F., Li H.
Gene Expr. Patterns 3:99-103(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), DEVELOPMENTAL STAGE.
Strain: FVB.
Tissue: Embryonic stem cell.
[4]"Identification, cloning and expression analysis of the pluripotency promoting Nanog genes in mouse and human."
Hart A.H., Hartley L., Ibrahim M., Robb L.
Dev. Dyn. 230:187-198(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
Strain: C57BL/6.
[5]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: C57BL/6J.
Tissue: Embryonic stem cell.
[6]"Identification of two distinct transactivation domains in the pluripotency sustaining factor nanog."
Pan G.J., Pei D.Q.
Cell Res. 13:499-502(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[7]"Nanog expression in mouse germ cell development."
Yamaguchi S., Kimura H., Tada M., Nakatsuji N., Tada T.
Gene Expr. Patterns 5:639-646(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
[8]"The stem cell pluripotency factor NANOG activates transcription with two unusually potent subdomains at its C terminus."
Pan G., Pei D.
J. Biol. Chem. 280:1401-1407(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, DNA-BINDING.
[9]"Pluripotential competence of cells associated with Nanog activity."
Hatano S.Y., Tada M., Kimura H., Yamaguchi S., Kono T., Nakano T., Suemori H., Nakatsuji N., Tada T.
Mech. Dev. 122:67-79(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
[10]"p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression."
Lin T., Chao C., Saito S., Mazur S.J., Murphy M.E., Appella E., Xu Y.
Nat. Cell Biol. 7:165-171(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[11]"A negative feedback loop of transcription factors that controls stem cell pluripotency and self-renewal."
Pan G., Li J., Zhou Y., Zheng H., Pei D.
FASEB J. 20:1730-1732(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[12]"Sall4 interacts with Nanog and co-occupies Nanog genomic sites in embryonic stem cells."
Wu Q., Chen X., Zhang J., Loh Y.-H., Low T.-Y., Zhang W., Zhang W., Sze S.-K., Lim B., Ng H.-H.
J. Biol. Chem. 281:24090-24094(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH SALL4, DNA-BINDING.
[13]"Nanog promotes transfer of pluripotency after cell fusion."
Silva J., Chambers I., Pollard S., Smith A.
Nature 441:997-1001(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[14]"The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells."
Loh Y.-H., Wu Q., Chew J.-L., Vega V.B., Zhang W., Chen X., Bourque G., George J., Leong B., Liu J., Wong K.-Y., Sung K.W., Lee C.W., Zhao X.-D., Chiu K.-P., Lipovich L., Kuznetsov V.A., Robson P. expand/collapse author list , Stanton L.W., Wei C.-L., Ruan Y., Lim B., Ng H.-H.
Nat. Genet. 38:431-440(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INDUCTION.
[15]"Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of embryonic stem cells."
Suzuki A., Raya A., Kawakami Y., Morita M., Matsui T., Nakashima K., Gage F.H., Rodriguez-Esteban C., Izpisua Belmonte J.C.
Proc. Natl. Acad. Sci. U.S.A. 103:10294-10299(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH SMAD1, INDUCTION.
[16]"Zfp281 functions as a transcriptional repressor for pluripotency of mouse embryonic stem cells."
Fidalgo M., Shekar P.C., Ang Y.S., Fujiwara Y., Orkin S.H., Wang J.
Stem Cells 29:1705-1716(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH ZNF281.
[17]"Zfp281 mediates Nanog autorepression through recruitment of the NuRD complex and inhibits somatic cell reprogramming."
Fidalgo M., Faiola F., Pereira C.F., Ding J., Saunders A., Gingold J., Schaniel C., Lemischka I.R., Silva J.C., Wang J.
Proc. Natl. Acad. Sci. U.S.A. 109:16202-16207(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH ZNF281, INDUCTION.
[18]"Crystal structure and DNA binding of the homeodomain of the stem cell transcription factor Nanog."
Jauch R., Ng C.K.L., Saikatendu K.S., Stevens R.C., Kolatkar P.R.
J. Mol. Biol. 376:758-770(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 96-155, INTERACTION WITH DNA, PARTIAL PROTEIN SEQUENCE, MUTAGENESIS OF LYS-112; MET-126; TYR-137; LYS-138; THR-142; ASN-146 AND GLN-147.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB093574 mRNA. Translation: BAC76998.1.
AY278951 mRNA. Translation: AAP92157.1.
AF507043 mRNA. Translation: AAO67362.1.
AY455282 mRNA. Translation: AAS57554.1.
AY455285 mRNA. Translation: AAS57556.1.
AK010332 mRNA. Translation: BAE43219.1.
CCDSCCDS39623.1. [Q80Z64-1]
RefSeqNP_001276757.1. NM_001289828.1.
NP_001276759.1. NM_001289830.1. [Q80Z64-2]
NP_001276760.1. NM_001289831.1. [Q80Z64-2]
NP_082292.1. NM_028016.3. [Q80Z64-1]
XP_006506714.1. XM_006506651.1. [Q80Z64-1]
UniGeneMm.485537.
Mm.491626.
Mm.6047.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2VI6X-ray2.60A/B/C/D/E/F/G/H96-155[»]
ProteinModelPortalQ80Z64.
SMRQ80Z64. Positions 101-155.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid215050. 270 interactions.
DIPDIP-29932N.
IntActQ80Z64. 150 interactions.

Proteomic databases

PRIDEQ80Z64.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000012540; ENSMUSP00000012540; ENSMUSG00000012396. [Q80Z64-1]
ENSMUST00000112580; ENSMUSP00000108199; ENSMUSG00000012396. [Q80Z64-2]
ENSMUST00000112581; ENSMUSP00000108200; ENSMUSG00000012396. [Q80Z64-2]
GeneID71950.
KEGGmmu:71950.
UCSCuc009dpo.1. mouse. [Q80Z64-1]

Organism-specific databases

CTD79923.
MGIMGI:1919200. Nanog.

Phylogenomic databases

eggNOGNOG297592.
GeneTreeENSGT00670000098076.
HOGENOMHOG000236291.
HOVERGENHBG058783.
InParanoidQ80Z64.
KOK10164.
OMATWTNPTW.
OrthoDBEOG7D2FFV.
PhylomeDBQ80Z64.
TreeFamTF337402.

Gene expression databases

BgeeQ80Z64.
GenevestigatorQ80Z64.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ80Z64.
NextBio335028.
PROQ80Z64.
SOURCESearch...

Entry information

Entry nameNANOG_MOUSE
AccessionPrimary (citable) accession number: Q80Z64
Secondary accession number(s): Q6SMR1, Q7TN85
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: June 1, 2003
Last modified: July 9, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot