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Q80Z64

- NANOG_MOUSE

UniProt

Q80Z64 - NANOG_MOUSE

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Protein
Homeobox protein NANOG
Gene
Nanog, Ecat4, Enk
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation.9 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi96 – 15560Homeobox3 Publications
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. chromatin binding Source: MGI
  3. enhancer sequence-specific DNA binding Source: BHF-UCL
  4. protein binding Source: UniProtKB
  5. sequence-specific DNA binding Source: BHF-UCL
  6. sequence-specific DNA binding transcription factor activity Source: UniProtKB
  7. transcription corepressor activity Source: UniProtKB
  8. transcription regulatory region DNA binding Source: MGI

GO - Biological processi

  1. cell proliferation Source: Ensembl
  2. embryo development Source: HGNC
  3. embryonic pattern specification Source: HGNC
  4. endodermal cell fate specification Source: MGI
  5. gonad development Source: HGNC
  6. mesodermal cell fate commitment Source: MGI
  7. negative regulation of BMP signaling pathway Source: MGI
  8. negative regulation of cell differentiation Source: MGI
  9. negative regulation of cell fate commitment Source: MGI
  10. negative regulation of endodermal cell fate specification Source: HGNC
  11. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  12. positive regulation of cell proliferation Source: MGI
  13. positive regulation of mitotic cell cycle Source: MGI
  14. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  15. positive regulation of transcription, DNA-templated Source: BHF-UCL
  16. response to organic substance Source: MGI
  17. response to retinoic acid Source: MGI
  18. somatic stem cell maintenance Source: Ensembl
  19. stem cell differentiation Source: MGI
  20. stem cell division Source: MGI
  21. stem cell maintenance Source: MGI
  22. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_216222. Transcriptional regulation of pluripotent stem cells.
REACT_220962. POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation.

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein NANOG
Alternative name(s):
ES cell-associated protein 4
Early embryo specific expression NK-type homeobox protein
Homeobox transcription factor Nanog
Gene namesi
Name:Nanog
Synonyms:Ecat4, Enk
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:1919200. Nanog.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleolus Source: Ensembl
  2. nucleoplasm Source: BHF-UCL
  3. nucleus Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Loss of pluripotency in both ICM and ES cells and differentiated into extraembryonic (parietal and visceral) endoderm lineage.1 Publication

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi112 – 1121K → E: Increases affinity for DNA and protein stability; when associated with R-147. 1 Publication
Mutagenesisi126 – 1261M → R: Increases affinity for DNA; when associated with E-137. 1 Publication
Mutagenesisi137 – 1371Y → E: Increases affinity for DNA; when associated with R-126. 1 Publication
Mutagenesisi138 – 1381K → E: Reduced affinity for DNA. 1 Publication
Mutagenesisi142 – 1421T → I: Slightly reduced affinity for DNA. 1 Publication
Mutagenesisi146 – 1461N → E: Strongly reduced affinity for DNA. 1 Publication
Mutagenesisi147 – 1471Q → R: Increases affinity for DNA and protein stability; when associated with E-112. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 305305Homeobox protein NANOG
PRO_0000261419Add
BLAST

Proteomic databases

PRIDEiQ80Z64.

Expressioni

Tissue specificityi

Not expressed in oocytes and spermatogonia (at protein level). Not expressed in many somatic organs, ovary, testis, fibroblast and hematopoietic cell lines.4 Publications

Developmental stagei

Expressed in the central portion of the morula, the inner cell mass (ICM) of the blastocyst, in embryonic stem (ES) and embryonic germ (EG) cells, in the epiblast between 6.5 and 7.5 dpc, in primordial germ cells (PGCs) between 7.75 and 12.5 dpc (at protein level). The expression in PGCs decreases in female germ cells that entered meiosis at 13.5 dpc and in male germ cells that entered mitotic arrest at 14.5 dpc (at protein level). Not expressed in unfertilized eggs or 2- or 8-cell-stage embryos (at protein level). Expressed in the central portion of the morula, the inner cell mass (ICM) of the blastocyst, in ES and EG cells, in the epiblast at 6 dpc and in PGCs of genital ridges between 11.5 and 12.5 dpc. Expression decreases with ES differentiation.6 Publications

Inductioni

By the transcription factor POU5F1 in ES cells that acts as a direct biphasic regulator: a steady-state concentration of POU5F1 up-regulated its expression, while an elevated concentration of POU5F1 down-regulated its expression. Up-regulated by the transcription factor FOXD3. Up-regulated in ES cells by transcription factors T (Brachyury) and STAT3. Down-regulated by p53 in response to DNA damage induced by ultraviolet light (UV) or doxorubicin. Down-regulated upon ES differentiation by mediating autorepression through interaction with ZNF281/ZFP281.5 Publications

Gene expression databases

BgeeiQ80Z64.
GenevestigatoriQ80Z64.

Interactioni

Subunit structurei

Interacts with SMAD1 and SALL4. Interacts with ZNF281/ZFP281.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Nr0b1Q610667EBI-2312517,EBI-2312665
Pou5f1P202634EBI-2312517,EBI-1606219
Rif1Q6PR545EBI-2312517,EBI-2312621
Slc8a1P704149EBI-2312517,EBI-2312694
Sox2P4843210EBI-2312517,EBI-2313612
Znf281Q99LI55EBI-2312517,EBI-2312719

Protein-protein interaction databases

BioGridi215050. 270 interactions.
DIPiDIP-29932N.
IntActiQ80Z64. 150 interactions.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi105 – 11713
Helixi123 – 13311
Helixi137 – 14913
Helixi152 – 1543

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2VI6X-ray2.60A/B/C/D/E/F/G/H96-155[»]
ProteinModelPortaliQ80Z64.
SMRiQ80Z64. Positions 101-155.

Miscellaneous databases

EvolutionaryTraceiQ80Z64.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati198 – 20251
Repeati203 – 20752
Repeati208 – 21253
Repeati213 – 21754
Repeati218 – 22255
Repeati223 – 22756
Repeati228 – 23257
Repeati233 – 23758
Repeati238 – 24259
Repeati243 – 247510

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni96 – 15560Sufficient for interaction with SALL4
Add
BLAST
Regioni198 – 2475010 X repeats starting with a Trp in each unit
Add
BLAST
Regioni198 – 24750Sufficient for transactivation activity
Add
BLAST
Regioni248 – 30558Sufficient for strong transactivation activity
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi198 – 24346Trp-rich
Add
BLAST

Sequence similaritiesi

Belongs to the Nanog homeobox family.

Keywords - Domaini

Homeobox, Repeat

Phylogenomic databases

eggNOGiNOG297592.
GeneTreeiENSGT00670000098076.
HOGENOMiHOG000236291.
HOVERGENiHBG058783.
InParanoidiQ80Z64.
KOiK10164.
OMAiTWTNPTW.
OrthoDBiEOG7D2FFV.
PhylomeDBiQ80Z64.
TreeFamiTF337402.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q80Z64-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSVGLPGPHS LPSSEEASNS GNASSMPAVF HPENYSCLQG SATEMLCTEA    50
ASPRPSSEDL PLQGSPDSST SPKQKLSSPE ADKGPEEEEN KVLARKQKMR 100
TVFSQAQLCA LKDRFQKQKY LSLQQMQELS SILNLSYKQV KTWFQNQRMK 150
CKRWQKNQWL KTSNGLIQKG SAPVEYPSIH CSYPQGYLVN ASGSLSMWGS 200
QTWTNPTWSS QTWTNPTWNN QTWTNPTWSS QAWTAQSWNG QPWNAAPLHN 250
FGEDFLQPYV QLQQNFSASD LEVNLEATRE SHAHFSTPQA LELFLNYSVT 300
PPGEI 305
Length:305
Mass (Da):34,240
Last modified:June 1, 2003 - v1
Checksum:i4EF96408B767C79F
GO
Isoform 2 (identifier: Q80Z64-2) [UniParc]FASTAAdd to Basket

Also known as: Nanog1a, Nanog1b

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: Missing.

Show »
Length:280
Mass (Da):31,859
Checksum:i090B8AC6C26A37C6
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2525Missing in isoform 2.
VSP_021689Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti149 – 1491M → V in BAC76998. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB093574 mRNA. Translation: BAC76998.1.
AY278951 mRNA. Translation: AAP92157.1.
AF507043 mRNA. Translation: AAO67362.1.
AY455282 mRNA. Translation: AAS57554.1.
AY455285 mRNA. Translation: AAS57556.1.
AK010332 mRNA. Translation: BAE43219.1.
CCDSiCCDS39623.1. [Q80Z64-1]
RefSeqiNP_001276757.1. NM_001289828.1.
NP_001276759.1. NM_001289830.1. [Q80Z64-2]
NP_001276760.1. NM_001289831.1. [Q80Z64-2]
NP_082292.1. NM_028016.3. [Q80Z64-1]
XP_006506714.1. XM_006506651.1. [Q80Z64-1]
UniGeneiMm.485537.
Mm.491626.
Mm.6047.

Genome annotation databases

EnsembliENSMUST00000012540; ENSMUSP00000012540; ENSMUSG00000012396. [Q80Z64-1]
ENSMUST00000112580; ENSMUSP00000108199; ENSMUSG00000012396. [Q80Z64-2]
ENSMUST00000112581; ENSMUSP00000108200; ENSMUSG00000012396. [Q80Z64-2]
GeneIDi71950.
KEGGimmu:71950.
UCSCiuc009dpo.1. mouse. [Q80Z64-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB093574 mRNA. Translation: BAC76998.1 .
AY278951 mRNA. Translation: AAP92157.1 .
AF507043 mRNA. Translation: AAO67362.1 .
AY455282 mRNA. Translation: AAS57554.1 .
AY455285 mRNA. Translation: AAS57556.1 .
AK010332 mRNA. Translation: BAE43219.1 .
CCDSi CCDS39623.1. [Q80Z64-1 ]
RefSeqi NP_001276757.1. NM_001289828.1.
NP_001276759.1. NM_001289830.1. [Q80Z64-2 ]
NP_001276760.1. NM_001289831.1. [Q80Z64-2 ]
NP_082292.1. NM_028016.3. [Q80Z64-1 ]
XP_006506714.1. XM_006506651.1. [Q80Z64-1 ]
UniGenei Mm.485537.
Mm.491626.
Mm.6047.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2VI6 X-ray 2.60 A/B/C/D/E/F/G/H 96-155 [» ]
ProteinModelPortali Q80Z64.
SMRi Q80Z64. Positions 101-155.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 215050. 270 interactions.
DIPi DIP-29932N.
IntActi Q80Z64. 150 interactions.

Proteomic databases

PRIDEi Q80Z64.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000012540 ; ENSMUSP00000012540 ; ENSMUSG00000012396 . [Q80Z64-1 ]
ENSMUST00000112580 ; ENSMUSP00000108199 ; ENSMUSG00000012396 . [Q80Z64-2 ]
ENSMUST00000112581 ; ENSMUSP00000108200 ; ENSMUSG00000012396 . [Q80Z64-2 ]
GeneIDi 71950.
KEGGi mmu:71950.
UCSCi uc009dpo.1. mouse. [Q80Z64-1 ]

Organism-specific databases

CTDi 79923.
MGIi MGI:1919200. Nanog.

Phylogenomic databases

eggNOGi NOG297592.
GeneTreei ENSGT00670000098076.
HOGENOMi HOG000236291.
HOVERGENi HBG058783.
InParanoidi Q80Z64.
KOi K10164.
OMAi TWTNPTW.
OrthoDBi EOG7D2FFV.
PhylomeDBi Q80Z64.
TreeFami TF337402.

Enzyme and pathway databases

Reactomei REACT_216222. Transcriptional regulation of pluripotent stem cells.
REACT_220962. POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation.

Miscellaneous databases

EvolutionaryTracei Q80Z64.
NextBioi 335028.
PROi Q80Z64.
SOURCEi Search...

Gene expression databases

Bgeei Q80Z64.
Genevestigatori Q80Z64.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells."
    Mitsui K., Tokuzawa Y., Itoh H., Segawa K., Murakami M., Takahashi K., Maruyama M., Maeda M., Yamanaka S.
    Cell 113:631-642(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, DNA-BINDING, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
  2. "Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells."
    Chambers I., Colby D., Robertson M., Nichols J., Lee S., Tweedie S., Smith A.
    Cell 113:643-655(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
    Strain: 129/Ola.
    Tissue: Embryonic stem cell.
  3. "A novel NK-type homeobox gene, ENK (early embryo specific NK), preferentially expressed in embryonic stem cells."
    Wang S.-H., Tsai M.-S., Chiang M.-F., Li H.
    Gene Expr. Patterns 3:99-103(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), DEVELOPMENTAL STAGE.
    Strain: FVB.
    Tissue: Embryonic stem cell.
  4. "Identification, cloning and expression analysis of the pluripotency promoting Nanog genes in mouse and human."
    Hart A.H., Hartley L., Ibrahim M., Robb L.
    Dev. Dyn. 230:187-198(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
    Strain: C57BL/6.
  5. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Embryonic stem cell.
  6. "Identification of two distinct transactivation domains in the pluripotency sustaining factor nanog."
    Pan G.J., Pei D.Q.
    Cell Res. 13:499-502(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. Cited for: DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
  8. "The stem cell pluripotency factor NANOG activates transcription with two unusually potent subdomains at its C terminus."
    Pan G., Pei D.
    J. Biol. Chem. 280:1401-1407(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DNA-BINDING.
  9. "Pluripotential competence of cells associated with Nanog activity."
    Hatano S.Y., Tada M., Kimura H., Yamaguchi S., Kono T., Nakano T., Suemori H., Nakatsuji N., Tada T.
    Mech. Dev. 122:67-79(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
  10. "p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression."
    Lin T., Chao C., Saito S., Mazur S.J., Murphy M.E., Appella E., Xu Y.
    Nat. Cell Biol. 7:165-171(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  11. "A negative feedback loop of transcription factors that controls stem cell pluripotency and self-renewal."
    Pan G., Li J., Zhou Y., Zheng H., Pei D.
    FASEB J. 20:1730-1732(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  12. "Sall4 interacts with Nanog and co-occupies Nanog genomic sites in embryonic stem cells."
    Wu Q., Chen X., Zhang J., Loh Y.-H., Low T.-Y., Zhang W., Zhang W., Sze S.-K., Lim B., Ng H.-H.
    J. Biol. Chem. 281:24090-24094(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SALL4, DNA-BINDING.
  13. "Nanog promotes transfer of pluripotency after cell fusion."
    Silva J., Chambers I., Pollard S., Smith A.
    Nature 441:997-1001(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  14. Cited for: FUNCTION, INDUCTION.
  15. "Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of embryonic stem cells."
    Suzuki A., Raya A., Kawakami Y., Morita M., Matsui T., Nakashima K., Gage F.H., Rodriguez-Esteban C., Izpisua Belmonte J.C.
    Proc. Natl. Acad. Sci. U.S.A. 103:10294-10299(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH SMAD1, INDUCTION.
  16. "Zfp281 functions as a transcriptional repressor for pluripotency of mouse embryonic stem cells."
    Fidalgo M., Shekar P.C., Ang Y.S., Fujiwara Y., Orkin S.H., Wang J.
    Stem Cells 29:1705-1716(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH ZNF281.
  17. "Zfp281 mediates Nanog autorepression through recruitment of the NuRD complex and inhibits somatic cell reprogramming."
    Fidalgo M., Faiola F., Pereira C.F., Ding J., Saunders A., Gingold J., Schaniel C., Lemischka I.R., Silva J.C., Wang J.
    Proc. Natl. Acad. Sci. U.S.A. 109:16202-16207(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH ZNF281, INDUCTION.
  18. "Crystal structure and DNA binding of the homeodomain of the stem cell transcription factor Nanog."
    Jauch R., Ng C.K.L., Saikatendu K.S., Stevens R.C., Kolatkar P.R.
    J. Mol. Biol. 376:758-770(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 96-155, INTERACTION WITH DNA, PARTIAL PROTEIN SEQUENCE, MUTAGENESIS OF LYS-112; MET-126; TYR-137; LYS-138; THR-142; ASN-146 AND GLN-147.

Entry informationi

Entry nameiNANOG_MOUSE
AccessioniPrimary (citable) accession number: Q80Z64
Secondary accession number(s): Q6SMR1, Q7TN85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: June 1, 2003
Last modified: September 3, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

'Nanog' is derived from 'Tir nan Og' the mythologic Celtic land of the ever young.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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