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Protein

Hydroxycarboxylic acid receptor 2

Gene

Hcar2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.3 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processApoptosis

Enzyme and pathway databases

ReactomeiR-RNO-3296197 Hydroxycarboxylic acid-binding receptors
R-RNO-373076 Class A/1 (Rhodopsin-like receptors)
R-RNO-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxycarboxylic acid receptor 2
Alternative name(s):
G-protein coupled receptor 109
G-protein coupled receptor 109A
G-protein coupled receptor HM74
Niacin receptor 1
Nicotinic acid receptor
Protein PUMA-G
Gene namesi
Name:Hcar2
Synonyms:Gpr109, Gpr109a, Gpr109b, Niacr1, Pumag
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi727952 Hcar2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 30ExtracellularSequence analysisAdd BLAST30
Transmembranei31 – 51Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini52 – 60CytoplasmicSequence analysis9
Transmembranei61 – 81Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini82 – 98ExtracellularSequence analysisAdd BLAST17
Transmembranei99 – 119Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini120 – 140CytoplasmicSequence analysisAdd BLAST21
Transmembranei141 – 161Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini162 – 189ExtracellularSequence analysisAdd BLAST28
Transmembranei190 – 210Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini211 – 226CytoplasmicSequence analysisAdd BLAST16
Transmembranei227 – 247Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini248 – 270ExtracellularSequence analysisAdd BLAST23
Transmembranei271 – 291Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini292 – 360CytoplasmicSequence analysisAdd BLAST69

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4731
GuidetoPHARMACOLOGYi312

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000696061 – 360Hydroxycarboxylic acid receptor 2Add BLAST360

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi97 ↔ 174PROSITE-ProRule annotation
Modified residuei325PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiQ80Z39
PRIDEiQ80Z39

PTM databases

iPTMnetiQ80Z39
PhosphoSitePlusiQ80Z39

Expressioni

Tissue specificityi

Expressed in adipose tissue, lung and spleen.2 Publications

Gene expression databases

BgeeiENSRNOG00000026653
GenevisibleiQ80Z39 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000036057

Chemistry databases

BindingDBiQ80Z39

Structurei

3D structure databases

ProteinModelPortaliQ80Z39
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKI5 Eukaryota
ENOG4110VUM LUCA
GeneTreeiENSGT00510000046798
InParanoidiQ80Z39
KOiK08402
OMAiKWDWKFG
OrthoDBiEOG091G0AN6
PhylomeDBiQ80Z39
TreeFamiTF330775

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR028017 HCAR2/3_rcpt
PANTHERiPTHR24231:SF0 PTHR24231:SF0, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q80Z39-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKQNHFLVI NGKNCCVFRD ENIAKVLPPV LGLEFVFGLL GNGLALWIFC
60 70 80 90 100
FHLKSWKSSR IFLFNLAVAD FLLIICLPFL TDNYVQNWDW RFGSIPCRVM
110 120 130 140 150
LFMLAMNRQG SIIFLTVVAV DRYFRVVHPH HFLNKISNRT AAIISCFLWG
160 170 180 190 200
ITIGLTVHLL YTDMMTRNGD ANLCSSFSIC YTFRWHDAMF LLEFFLPLGI
210 220 230 240 250
ILFCSGRIIW SLRQRQMDRH VKIKRAINFI MVVAIVFVIC FLPSVAVRIR
260 270 280 290 300
IFWLLYKHNV RNCDIYSSVD LAFFTTLSFT YMNSMLDPVV YYFSSPSFPN
310 320 330 340 350
FFSTCINRCL RRKTLGEPDN NRSTSVELTG DPSTIRSIPG ALMTDPSEPG
360
SPPYLASTSR
Length:360
Mass (Da):41,459
Last modified:June 1, 2003 - v1
Checksum:i975BDEBCA448A6C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB103062 mRNA Translation: BAC58009.1
RefSeqiNP_852141.1, NM_181476.1
UniGeneiRn.214478

Genome annotation databases

EnsembliENSRNOT00000032249; ENSRNOP00000036057; ENSRNOG00000026653
GeneIDi353250
KEGGirno:353250
UCSCiRGD:727952 rat

Similar proteinsi

Entry informationi

Entry nameiHCAR2_RAT
AccessioniPrimary (citable) accession number: Q80Z39
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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