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Q80Z39

- HCAR2_RAT

UniProt

Q80Z39 - HCAR2_RAT

Protein

Hydroxycarboxylic acid receptor 2

Gene

Hcar2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.3 Publications

    GO - Molecular functioni

    1. GTP binding Source: Ensembl
    2. nicotinic acid receptor activity Source: UniProtKB
    3. purinergic nucleotide receptor activity Source: Ensembl

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. negative regulation of lipid catabolic process Source: UniProtKB
    3. positive regulation of adiponectin secretion Source: UniProtKB
    4. positive regulation of neutrophil apoptotic process Source: UniProtKB

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Apoptosis

    Enzyme and pathway databases

    ReactomeiREACT_196371. Hydroxycarboxylic acid-binding receptors.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hydroxycarboxylic acid receptor 2
    Alternative name(s):
    G-protein coupled receptor 109
    G-protein coupled receptor 109A
    G-protein coupled receptor HM74
    Niacin receptor 1
    Nicotinic acid receptor
    Protein PUMA-G
    Gene namesi
    Name:Hcar2
    Synonyms:Gpr109, Gpr109a, Gpr109b, Niacr1, Pumag
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 12

    Organism-specific databases

    RGDi727952. Hcar2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 360360Hydroxycarboxylic acid receptor 2PRO_0000069606Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi97 ↔ 174PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiQ80Z39.

    PTM databases

    PhosphoSiteiQ80Z39.

    Expressioni

    Tissue specificityi

    Expressed in adipose tissue, lung and spleen.2 Publications

    Gene expression databases

    GenevestigatoriQ80Z39.

    Interactioni

    Structurei

    3D structure databases

    ProteinModelPortaliQ80Z39.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3030ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini52 – 609CytoplasmicSequence Analysis
    Topological domaini82 – 9817ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini120 – 14021CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini162 – 18928ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini211 – 22616CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini248 – 27023ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini292 – 36069CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei31 – 5121Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei61 – 8121Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei99 – 11921Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei141 – 16121Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei190 – 21021Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei227 – 24721Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei271 – 29121Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG148880.
    GeneTreeiENSGT00510000046798.
    InParanoidiQ80Z39.
    KOiK08402.
    OMAiRAINFIM.
    OrthoDBiEOG7R56SR.
    PhylomeDBiQ80Z39.
    TreeFamiTF330775.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR028017. HCAR2/3_rcpt.
    [Graphical view]
    PANTHERiPTHR24231:SF0. PTHR24231:SF0. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q80Z39-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKQNHFLVI NGKNCCVFRD ENIAKVLPPV LGLEFVFGLL GNGLALWIFC    50
    FHLKSWKSSR IFLFNLAVAD FLLIICLPFL TDNYVQNWDW RFGSIPCRVM 100
    LFMLAMNRQG SIIFLTVVAV DRYFRVVHPH HFLNKISNRT AAIISCFLWG 150
    ITIGLTVHLL YTDMMTRNGD ANLCSSFSIC YTFRWHDAMF LLEFFLPLGI 200
    ILFCSGRIIW SLRQRQMDRH VKIKRAINFI MVVAIVFVIC FLPSVAVRIR 250
    IFWLLYKHNV RNCDIYSSVD LAFFTTLSFT YMNSMLDPVV YYFSSPSFPN 300
    FFSTCINRCL RRKTLGEPDN NRSTSVELTG DPSTIRSIPG ALMTDPSEPG 350
    SPPYLASTSR 360
    Length:360
    Mass (Da):41,459
    Last modified:June 1, 2003 - v1
    Checksum:i975BDEBCA448A6C5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB103062 mRNA. Translation: BAC58009.1.
    RefSeqiNP_852141.1. NM_181476.1.
    UniGeneiRn.214478.

    Genome annotation databases

    EnsembliENSRNOT00000032249; ENSRNOP00000036057; ENSRNOG00000026653.
    GeneIDi353250.
    KEGGirno:353250.
    UCSCiRGD:727952. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB103062 mRNA. Translation: BAC58009.1 .
    RefSeqi NP_852141.1. NM_181476.1.
    UniGenei Rn.214478.

    3D structure databases

    ProteinModelPortali Q80Z39.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi Q80Z39.
    ChEMBLi CHEMBL4731.
    GuidetoPHARMACOLOGYi 312.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q80Z39.

    Proteomic databases

    PRIDEi Q80Z39.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000032249 ; ENSRNOP00000036057 ; ENSRNOG00000026653 .
    GeneIDi 353250.
    KEGGi rno:353250.
    UCSCi RGD:727952. rat.

    Organism-specific databases

    CTDi 353250.
    RGDi 727952. Hcar2.

    Phylogenomic databases

    eggNOGi NOG148880.
    GeneTreei ENSGT00510000046798.
    InParanoidi Q80Z39.
    KOi K08402.
    OMAi RAINFIM.
    OrthoDBi EOG7R56SR.
    PhylomeDBi Q80Z39.
    TreeFami TF330775.

    Enzyme and pathway databases

    Reactomei REACT_196371. Hydroxycarboxylic acid-binding receptors.

    Miscellaneous databases

    NextBioi 672627.
    PROi Q80Z39.

    Gene expression databases

    Genevestigatori Q80Z39.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR028017. HCAR2/3_rcpt.
    [Graphical view ]
    PANTHERi PTHR24231:SF0. PTHR24231:SF0. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    2. Cited for: FUNCTION, TISSUE SPECIFICITY, CHARACTERIZATION.
    3. "Niacin stimulates adiponectin secretion through the GPR109A receptor."
      Plaisance E.P., Lukasova M., Offermanns S., Zhang Y., Cao G., Judd R.L.
      Am. J. Physiol. 296:E549-E558(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiHCAR2_RAT
    AccessioniPrimary (citable) accession number: Q80Z39
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3