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Q80Z39

- HCAR2_RAT

UniProt

Q80Z39 - HCAR2_RAT

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Protein

Hydroxycarboxylic acid receptor 2

Gene
Hcar2, Gpr109, Gpr109a, Gpr109b, Niacr1, Pumag
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.3 Publications

GO - Molecular functioni

  1. GTP binding Source: Ensembl
  2. nicotinic acid receptor activity Source: UniProtKB
  3. purinergic nucleotide receptor activity Source: Ensembl

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. negative regulation of lipid catabolic process Source: UniProtKB
  3. positive regulation of adiponectin secretion Source: UniProtKB
  4. positive regulation of neutrophil apoptotic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

ReactomeiREACT_196371. Hydroxycarboxylic acid-binding receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxycarboxylic acid receptor 2
Alternative name(s):
G-protein coupled receptor 109
G-protein coupled receptor 109A
G-protein coupled receptor HM74
Niacin receptor 1
Nicotinic acid receptor
Protein PUMA-G
Gene namesi
Name:Hcar2
Synonyms:Gpr109, Gpr109a, Gpr109b, Niacr1, Pumag
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 12

Organism-specific databases

RGDi727952. Hcar2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3030Extracellular Reviewed predictionAdd
BLAST
Transmembranei31 – 5121Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini52 – 609Cytoplasmic Reviewed prediction
Transmembranei61 – 8121Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini82 – 9817Extracellular Reviewed predictionAdd
BLAST
Transmembranei99 – 11921Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini120 – 14021Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei141 – 16121Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini162 – 18928Extracellular Reviewed predictionAdd
BLAST
Transmembranei190 – 21021Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini211 – 22616Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei227 – 24721Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini248 – 27023Extracellular Reviewed predictionAdd
BLAST
Transmembranei271 – 29121Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini292 – 36069Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 360360Hydroxycarboxylic acid receptor 2PRO_0000069606Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi97 ↔ 174 By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ80Z39.

PTM databases

PhosphoSiteiQ80Z39.

Expressioni

Tissue specificityi

Expressed in adipose tissue, lung and spleen.2 Publications

Gene expression databases

GenevestigatoriQ80Z39.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliQ80Z39.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG148880.
GeneTreeiENSGT00510000046798.
InParanoidiQ80Z39.
KOiK08402.
OMAiRAINFIM.
OrthoDBiEOG7R56SR.
PhylomeDBiQ80Z39.
TreeFamiTF330775.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR028017. HCAR2/3_rcpt.
[Graphical view]
PANTHERiPTHR24231:SF0. PTHR24231:SF0. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80Z39-1 [UniParc]FASTAAdd to Basket

« Hide

MSKQNHFLVI NGKNCCVFRD ENIAKVLPPV LGLEFVFGLL GNGLALWIFC    50
FHLKSWKSSR IFLFNLAVAD FLLIICLPFL TDNYVQNWDW RFGSIPCRVM 100
LFMLAMNRQG SIIFLTVVAV DRYFRVVHPH HFLNKISNRT AAIISCFLWG 150
ITIGLTVHLL YTDMMTRNGD ANLCSSFSIC YTFRWHDAMF LLEFFLPLGI 200
ILFCSGRIIW SLRQRQMDRH VKIKRAINFI MVVAIVFVIC FLPSVAVRIR 250
IFWLLYKHNV RNCDIYSSVD LAFFTTLSFT YMNSMLDPVV YYFSSPSFPN 300
FFSTCINRCL RRKTLGEPDN NRSTSVELTG DPSTIRSIPG ALMTDPSEPG 350
SPPYLASTSR 360
Length:360
Mass (Da):41,459
Last modified:June 1, 2003 - v1
Checksum:i975BDEBCA448A6C5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB103062 mRNA. Translation: BAC58009.1.
RefSeqiNP_852141.1. NM_181476.1.
UniGeneiRn.214478.

Genome annotation databases

EnsembliENSRNOT00000032249; ENSRNOP00000036057; ENSRNOG00000026653.
GeneIDi353250.
KEGGirno:353250.
UCSCiRGD:727952. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB103062 mRNA. Translation: BAC58009.1 .
RefSeqi NP_852141.1. NM_181476.1.
UniGenei Rn.214478.

3D structure databases

ProteinModelPortali Q80Z39.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi Q80Z39.
ChEMBLi CHEMBL4731.
GuidetoPHARMACOLOGYi 312.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q80Z39.

Proteomic databases

PRIDEi Q80Z39.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000032249 ; ENSRNOP00000036057 ; ENSRNOG00000026653 .
GeneIDi 353250.
KEGGi rno:353250.
UCSCi RGD:727952. rat.

Organism-specific databases

CTDi 353250.
RGDi 727952. Hcar2.

Phylogenomic databases

eggNOGi NOG148880.
GeneTreei ENSGT00510000046798.
InParanoidi Q80Z39.
KOi K08402.
OMAi RAINFIM.
OrthoDBi EOG7R56SR.
PhylomeDBi Q80Z39.
TreeFami TF330775.

Enzyme and pathway databases

Reactomei REACT_196371. Hydroxycarboxylic acid-binding receptors.

Miscellaneous databases

NextBioi 672627.
PROi Q80Z39.

Gene expression databases

Genevestigatori Q80Z39.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR028017. HCAR2/3_rcpt.
[Graphical view ]
PANTHERi PTHR24231:SF0. PTHR24231:SF0. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
  2. Cited for: FUNCTION, TISSUE SPECIFICITY, CHARACTERIZATION.
  3. "Niacin stimulates adiponectin secretion through the GPR109A receptor."
    Plaisance E.P., Lukasova M., Offermanns S., Zhang Y., Cao G., Judd R.L.
    Am. J. Physiol. 296:E549-E558(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiHCAR2_RAT
AccessioniPrimary (citable) accession number: Q80Z39
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: June 1, 2003
Last modified: September 3, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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