Q80Z38 (SHAN2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
SH3 and multiple ankyrin repeat domains protein 2
Short name=Shank2

Alternative name(s):
Cortactin-binding protein 1
Short name=CortBP1

Gene names

Name:	Shank2
Synonyms:	Cortbp1, Kiaa1022

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1476 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction By similarity.
Subunit structure	Interacts with CTTN/cortactin SH3 domain, DLGAP1/GKAP and alpha-latrotoxin receptor 1. Is part of a complex with DLG4/PSD-95 and DLGAP1/GKAP. Interacts with DNM2 and BAIAP2. Interacts with SLC9A3, PLCB3 and CFTR. Interacts with DBNL By similarity. Interacts with GRID2. Ref.1
Subcellular location	Cytoplasm. Cell junction › synapse. Cell junction › synapse › postsynaptic cell membrane › postsynaptic density. Cell projection › growth cone By similarity. Note: Cytoplasm, postsynaptic density of neuronal cells. Colocalizes with cortactin in growth cones in differentiating hippocampal neurons By similarity. Present in the dendritic spines of cerebellar Purkinje cells. Ref.1
Tissue specificity	Highly expressed in brain. Ref.6
Domain	The PDZ domain is required for interaction with GRID2, PLCB3, SLC9A3 and CFTR.
Sequence similarities	Belongs to the SHANK family. Contains 1 PDZ (DHR) domain. Contains 1 SAM (sterile alpha motif) domain. Contains 1 SH3 domain.

Ontologies

Keywords
Cellular component	Cell junction Cell membrane Cell projection Cytoplasm Membrane Postsynaptic cell membrane Synapse
Coding sequence diversity	Alternative splicing
Domain	SH3 domain SH3-binding
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell dendritic spine Inferred from direct assay Ref.1. Source: BHF-UCL growth cone Inferred from electronic annotation. Source: UniProtKB-SubCell photoreceptor inner segment Inferred from direct assay PubMed 19299912. Source: BHF-UCL photoreceptor outer segment Inferred from direct assay PubMed 19299912. Source: BHF-UCL plasma membrane Inferred from direct assay Ref.1. Source: BHF-UCL postsynaptic density Inferred from electronic annotation. Source: UniProtKB-SubCell postsynaptic membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q80Z38-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q80Z38-2)

The sequence of this isoform differs from the canonical sequence as follows:
     380-383: Missing.

Isoform 3 (identifier: Q80Z38-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-210: Missing.
     211-238: SQAETRADRSKKLFRHYTVGSYDSFDAA → MMSVPGGGAATVMMTGYNNGRYPRNSLY
     380-383: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1476	1476	SH3 and multiple ankyrin repeat domains protein 2		PRO_0000247760
Regions
	Domain	147 – 206	60	SH3
	Domain	247 – 341	95	PDZ
	Domain	1413 – 1476	64	SAM
	Motif	1169 – 1175	7	SH3-binding Potential
	Compositional bias	24 – 27	4	Poly-Arg
	Compositional bias	355 – 358	4	Poly-Pro
	Compositional bias	513 – 560	48	Pro-rich
	Compositional bias	1017 – 1020	4	Poly-Pro
	Compositional bias	1169 – 1211	43	Pro-rich
	Compositional bias	1348 – 1353	6	Poly-Pro
Amino acid modifications
	Modified residue	586	1	Phosphoserine Ref.7
	Modified residue	730	1	Phosphothreonine Ref.7
	Modified residue	903	1	Phosphothreonine Ref.7
	Modified residue	1334	1	Phosphoserine Ref.10
	Modified residue	1338	1	Phosphoserine Ref.7 Ref.10
	Modified residue	1340	1	Phosphothreonine Ref.9
	Glycosylation	1292	1	O-linked (GlcNAc...) Ref.8
Natural variations
	Alternative sequence	1 – 210	210	Missing in isoform 3.		VSP_041614
	Alternative sequence	211 – 238	28	SQAET…SFDAA → MMSVPGGGAATVMMTGYNNG RYPRNSLY in isoform 3.		VSP_041615
	Alternative sequence	380 – 383	4	Missing in isoform 2 and isoform 3.		VSP_020040
Experimental info
	Sequence conflict	1071	1	S → P in BAC58120. Ref.1
	Sequence conflict	1071	1	S → P in BAD90424. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 27, 2011. Version 2. Checksum: 0B5B0EBDFD6BAAA7	FASTA	1,476	158,969
	10 20 30 40 50 60 MKSLLNAFTK KEVPFREAPA YSNRRRRPPN TLAAPRVLLR SNSDNNLNAG APEWAVCSAA 70 80 90 100 110 120 TSHRSLSPQL LQQTPSKPDG ATKSLGSYTP GPRSRSPSLN RLGGTAEDGK RTQPHWHVGS 130 140 150 160 170 180 PFTPGANKDS LSTFEYPGPR RKLYSAVPGR LFVAVKPYQP QVDGEIPLHR GDRVKVLSIG 190 200 210 220 230 240 EGGFWEGSAR GHIGWFPAEC VEEVQCKPRD SQAETRADRS KKLFRHYTVG SYDSFDAASD 250 260 270 280 290 300 CIIEDKTVVL QKKDNEGFGF VLRGAKADTP IEEFTPTPAF PALQYLESVD EGGVAWQAGL 310 320 330 340 350 360 RTGDFLIEVN NENVVKVGHR QVVNMIRQGG NHLILKVVTV TRNLDPDDTA RKKAPPPPKR 370 380 390 400 410 420 APTTALTLRS KSMTAELEEL GLSLVDKASV RKKKDKPEEI VPASKPSRTA ENVAIESRVA 430 440 450 460 470 480 TIKQRPTSRC FPAASDVNSV YERQGIAVMT PTVPGSPKGP FLGLPRGTMR RQKSIDSRIF 490 500 510 520 530 540 LSGITEEERQ FLAPPMLKFT RSLSMPDTSE DIPPPPQSVP PSPPPPSPTT YNCPRSPTPR 550 560 570 580 590 600 VYGTIKPAFN QNPVVAKVPP ATRSDTVATM MREKGMFYRR ELDRFSLDSE DVYSRSPAPQ 610 620 630 640 650 660 AAFRTKRGQM PENPYSEVGK IASKAVYVPA KPARRKGVLV KQSNVEDSPE KTCSIPIPTI 670 680 690 700 710 720 IVKEPSTSSS GKSSQGSSME IDPQATEPGQ LRPDDSLTVS SPFAAAIAGA VRDREKRLEA 730 740 750 760 770 780 RRNSPAFLST DLGDEDVGLG PPAPRMQASK FPEEGGFGDE DETEQPLLPT PGAAPRELEN 790 800 810 820 830 840 HFLGGGEAGA QGEAGGPLSS TSKAKGPESG PAAPLKSSSP AGPENYVHPL TGRLLDPSSP 850 860 870 880 890 900 LALALSARDR AMQESQQGHK GEAPKADLNK PLYIDTKMRP SVESGFPPVT RQNTRGPLRR 910 920 930 940 950 960 QETENKYETD LGKDRRADDK KNMLINIVDT AQQKSAGLLM VHTVDVPMAG PPLEEEEDRE 970 980 990 1000 1010 1020 DGDTKPDHSP STVPEGVPKT EGALQISAAP EPAVAPGRTI VAAGSVEEAV ILPFRIPPPP 1030 1040 1050 1060 1070 1080 LASVDLDEDF LFTEPLPPPL EFANSFDIPD DRAASVPALA DLVKQKKNDT SQPPTLNSSQ 1090 1100 1110 1120 1130 1140 PANSTDSKKP AGISNCLPSS FLPPPESFDA VTDSGIEEVD SRSSSDHHLE TTSTISTVSS 1150 1160 1170 1180 1190 1200 ISTLSSEGGE SMDTCTVYAD GQAFVVDKPP VPPKPKMKPI VHKSNALYQD TLPEEDTDGF 1210 1220 1230 1240 1250 1260 VIPPPAPPPP PGSAQAGVAK VIQPRTSKLW GDVPEVKSPI LSGPKANVIS ELNSILQQMN 1270 1280 1290 1300 1310 1320 RGKSVKPGEG LELPVGAKSA NLAPRSPEVM STVSGTRSTT VTFTVRPGTS QPITLQSRPP 1330 1340 1350 1360 1370 1380 DYESRTSGPR RAPSPVVSPT ELSKEILPTP PPPSATAASP SPTLSDVFSL PSQSPAGDLF 1390 1400 1410 1420 1430 1440 GLNPAGRSRS PSPSILQQPI SNKPFTTKPV HLWTKPDVAD WLESLNLGEH KETFMDNEID 1450 1460 1470 GSHLPNLQKE DLIDLGVTRV GHRMNIERAL KQLLDR
	Isoform 2 [UniParc]. Checksum: 0BBCF1E8E351834C	FASTA	1,472	158,599
	10 20 30 40 50 60 MKSLLNAFTK KEVPFREAPA YSNRRRRPPN TLAAPRVLLR SNSDNNLNAG APEWAVCSAA 70 80 90 100 110 120 TSHRSLSPQL LQQTPSKPDG ATKSLGSYTP GPRSRSPSLN RLGGTAEDGK RTQPHWHVGS 130 140 150 160 170 180 PFTPGANKDS LSTFEYPGPR RKLYSAVPGR LFVAVKPYQP QVDGEIPLHR GDRVKVLSIG 190 200 210 220 230 240 EGGFWEGSAR GHIGWFPAEC VEEVQCKPRD SQAETRADRS KKLFRHYTVG SYDSFDAASD 250 260 270 280 290 300 CIIEDKTVVL QKKDNEGFGF VLRGAKADTP IEEFTPTPAF PALQYLESVD EGGVAWQAGL 310 320 330 340 350 360 RTGDFLIEVN NENVVKVGHR QVVNMIRQGG NHLILKVVTV TRNLDPDDTA RKKAPPPPKR 370 380 390 400 410 420 APTTALTLRS KSMTAELEEL VDKASVRKKK DKPEEIVPAS KPSRTAENVA IESRVATIKQ 430 440 450 460 470 480 RPTSRCFPAA SDVNSVYERQ GIAVMTPTVP GSPKGPFLGL PRGTMRRQKS IDSRIFLSGI 490 500 510 520 530 540 TEEERQFLAP PMLKFTRSLS MPDTSEDIPP PPQSVPPSPP PPSPTTYNCP RSPTPRVYGT 550 560 570 580 590 600 IKPAFNQNPV VAKVPPATRS DTVATMMREK GMFYRRELDR FSLDSEDVYS RSPAPQAAFR 610 620 630 640 650 660 TKRGQMPENP YSEVGKIASK AVYVPAKPAR RKGVLVKQSN VEDSPEKTCS IPIPTIIVKE 670 680 690 700 710 720 PSTSSSGKSS QGSSMEIDPQ ATEPGQLRPD DSLTVSSPFA AAIAGAVRDR EKRLEARRNS 730 740 750 760 770 780 PAFLSTDLGD EDVGLGPPAP RMQASKFPEE GGFGDEDETE QPLLPTPGAA PRELENHFLG 790 800 810 820 830 840 GGEAGAQGEA GGPLSSTSKA KGPESGPAAP LKSSSPAGPE NYVHPLTGRL LDPSSPLALA 850 860 870 880 890 900 LSARDRAMQE SQQGHKGEAP KADLNKPLYI DTKMRPSVES GFPPVTRQNT RGPLRRQETE 910 920 930 940 950 960 NKYETDLGKD RRADDKKNML INIVDTAQQK SAGLLMVHTV DVPMAGPPLE EEEDREDGDT 970 980 990 1000 1010 1020 KPDHSPSTVP EGVPKTEGAL QISAAPEPAV APGRTIVAAG SVEEAVILPF RIPPPPLASV 1030 1040 1050 1060 1070 1080 DLDEDFLFTE PLPPPLEFAN SFDIPDDRAA SVPALADLVK QKKNDTSQPP TLNSSQPANS 1090 1100 1110 1120 1130 1140 TDSKKPAGIS NCLPSSFLPP PESFDAVTDS GIEEVDSRSS SDHHLETTST ISTVSSISTL 1150 1160 1170 1180 1190 1200 SSEGGESMDT CTVYADGQAF VVDKPPVPPK PKMKPIVHKS NALYQDTLPE EDTDGFVIPP 1210 1220 1230 1240 1250 1260 PAPPPPPGSA QAGVAKVIQP RTSKLWGDVP EVKSPILSGP KANVISELNS ILQQMNRGKS 1270 1280 1290 1300 1310 1320 VKPGEGLELP VGAKSANLAP RSPEVMSTVS GTRSTTVTFT VRPGTSQPIT LQSRPPDYES 1330 1340 1350 1360 1370 1380 RTSGPRRAPS PVVSPTELSK EILPTPPPPS ATAASPSPTL SDVFSLPSQS PAGDLFGLNP 1390 1400 1410 1420 1430 1440 AGRSRSPSPS ILQQPISNKP FTTKPVHLWT KPDVADWLES LNLGEHKETF MDNEIDGSHL 1450 1460 1470 PNLQKEDLID LGVTRVGHRM NIERALKQLL DR
	Isoform 3 [UniParc]. Checksum: BF3B96EFA165D7B9	FASTA	1,262	135,412
	10 20 30 40 50 60 MMSVPGGGAA TVMMTGYNNG RYPRNSLYSD CIIEDKTVVL QKKDNEGFGF VLRGAKADTP 70 80 90 100 110 120 IEEFTPTPAF PALQYLESVD EGGVAWQAGL RTGDFLIEVN NENVVKVGHR QVVNMIRQGG 130 140 150 160 170 180 NHLILKVVTV TRNLDPDDTA RKKAPPPPKR APTTALTLRS KSMTAELEEL VDKASVRKKK 190 200 210 220 230 240 DKPEEIVPAS KPSRTAENVA IESRVATIKQ RPTSRCFPAA SDVNSVYERQ GIAVMTPTVP 250 260 270 280 290 300 GSPKGPFLGL PRGTMRRQKS IDSRIFLSGI TEEERQFLAP PMLKFTRSLS MPDTSEDIPP 310 320 330 340 350 360 PPQSVPPSPP PPSPTTYNCP RSPTPRVYGT IKPAFNQNPV VAKVPPATRS DTVATMMREK 370 380 390 400 410 420 GMFYRRELDR FSLDSEDVYS RSPAPQAAFR TKRGQMPENP YSEVGKIASK AVYVPAKPAR 430 440 450 460 470 480 RKGVLVKQSN VEDSPEKTCS IPIPTIIVKE PSTSSSGKSS QGSSMEIDPQ ATEPGQLRPD 490 500 510 520 530 540 DSLTVSSPFA AAIAGAVRDR EKRLEARRNS PAFLSTDLGD EDVGLGPPAP RMQASKFPEE 550 560 570 580 590 600 GGFGDEDETE QPLLPTPGAA PRELENHFLG GGEAGAQGEA GGPLSSTSKA KGPESGPAAP 610 620 630 640 650 660 LKSSSPAGPE NYVHPLTGRL LDPSSPLALA LSARDRAMQE SQQGHKGEAP KADLNKPLYI 670 680 690 700 710 720 DTKMRPSVES GFPPVTRQNT RGPLRRQETE NKYETDLGKD RRADDKKNML INIVDTAQQK 730 740 750 760 770 780 SAGLLMVHTV DVPMAGPPLE EEEDREDGDT KPDHSPSTVP EGVPKTEGAL QISAAPEPAV 790 800 810 820 830 840 APGRTIVAAG SVEEAVILPF RIPPPPLASV DLDEDFLFTE PLPPPLEFAN SFDIPDDRAA 850 860 870 880 890 900 SVPALADLVK QKKNDTSQPP TLNSSQPANS TDSKKPAGIS NCLPSSFLPP PESFDAVTDS 910 920 930 940 950 960 GIEEVDSRSS SDHHLETTST ISTVSSISTL SSEGGESMDT CTVYADGQAF VVDKPPVPPK 970 980 990 1000 1010 1020 PKMKPIVHKS NALYQDTLPE EDTDGFVIPP PAPPPPPGSA QAGVAKVIQP RTSKLWGDVP 1030 1040 1050 1060 1070 1080 EVKSPILSGP KANVISELNS ILQQMNRGKS VKPGEGLELP VGAKSANLAP RSPEVMSTVS 1090 1100 1110 1120 1130 1140 GTRSTTVTFT VRPGTSQPIT LQSRPPDYES RTSGPRRAPS PVVSPTELSK EILPTPPPPS 1150 1160 1170 1180 1190 1200 ATAASPSPTL SDVFSLPSQS PAGDLFGLNP AGRSRSPSPS ILQQPISNKP FTTKPVHLWT 1210 1220 1230 1240 1250 1260 KPDVADWLES LNLGEHKETF MDNEIDGSHL PNLQKEDLID LGVTRVGHRM NIERALKQLL DR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Direct interaction of GluRdelta2 with Shank scaffold proteins in cerebellar Purkinje cells." Uemura T., Mori H., Mishina M. Mol. Cell. Neurosci. 26:330-341(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, INTERACTION WITH GRID2.
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
[4]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-350 (ISOFORMS 1/2). Strain: C57BL/6J. Tissue: Brain cortex.
[5]	"Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H. Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 345-1476 (ISOFORM 2). Tissue: Fetal brain.
[6]	"Identification of a novel cortactin SH3 domain-binding protein and its localization to growth cones of cultured neurons." Du Y., Weed S.A., Xiong W.-C., Marshall T.D., Parsons J.T. Mol. Cell. Biol. 18:5838-5851(1998) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[7]	"Comprehensive identification of phosphorylation sites in postsynaptic density preparations." Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L. Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-586; THR-730; THR-903 AND SER-1338, MASS SPECTROMETRY. Tissue: Brain.
[8]	"O-linked N-acetylglucosamine proteomics of postsynaptic density preparations using lectin weak affinity chromatography and mass spectrometry." Vosseller K., Trinidad J.C., Chalkley R.J., Specht C.G., Thalhammer A., Lynn A.J., Snedecor J.O., Guan S., Medzihradszky K.F., Maltby D.A., Schoepfer R., Burlingame A.L. Mol. Cell. Proteomics 5:923-934(2006) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT THR-1292, MASS SPECTROMETRY. Tissue: Brain.
[9]	"Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations." Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M. Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1340, MASS SPECTROMETRY. Tissue: Brain cortex.
[10]	"Large-scale phosphorylation analysis of mouse liver." Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1334 AND SER-1338, MASS SPECTROMETRY. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB099695 mRNA. Translation: BAC58120.1. AC124520 Genomic DNA. No translation available. AC127546 Genomic DNA. No translation available. AC140268 Genomic DNA. No translation available. AC152166 Genomic DNA. No translation available. BC167171 mRNA. Translation: AAI67171.1. AK139360 mRNA. Translation: BAE23976.1. AK220363 mRNA. Translation: BAD90424.1.
IPI	IPI00349908. IPI00757097. IPI00889283.
RefSeq	NP_001074839.2. NM_001081370.2. NP_001106844.2. NM_001113373.2.
UniGene	Mm.483624.
3D structure databases
ProteinModelPortal	Q80Z38.
SMR	Q80Z38. Positions 148-205, 240-343, 1410-1473.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q80Z38. 3 interactions.
PTM databases
PhosphoSite	Q80Z38.
Proteomic databases
PaxDb	Q80Z38.
PRIDE	Q80Z38.
Protocols and materials databases
DNASU	210274.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000097929; ENSMUSP00000095542; ENSMUSG00000037541.
GeneID	210274.
KEGG	mmu:210274.
UCSC	uc009kqe.2. mouse.
Organism-specific databases
CTD	22941.
MGI	MGI:2671987. Shank2.
Rouge	Search...
Phylogenomic databases
eggNOG	COG0666.
GeneTree	ENSGT00510000046474.
HOGENOM	HOG000293276.
HOVERGEN	HBG054027.
KO	K15009.
Gene expression databases
ArrayExpress	Q80Z38.
Bgee	Q80Z38.
CleanEx	MM_SHANK2.
Genevestigator	Q80Z38.
Family and domain databases
Gene3D	1.10.150.50. 1 hit.
InterPro	IPR001478. PDZ. IPR001660. SAM. IPR013761. SAM/pointed. IPR021129. SAM_type1. IPR011511. SH3_2. IPR001452. SH3_domain. [Graphical view]
Pfam	PF00595. PDZ. 1 hit. PF00536. SAM_1. 1 hit. PF07653. SH3_2. 1 hit. [Graphical view]
SMART	SM00228. PDZ. 1 hit. SM00454. SAM. 1 hit. SM00326. SH3. 1 hit. [Graphical view]
SUPFAM	SSF50156. PDZ. 1 hit. SSF47769. SAM_homology. 1 hit. SSF50044. SH3. 1 hit.
PROSITE	PS50106. PDZ. 1 hit. PS50105. SAM_DOMAIN. 1 hit. PS50002. SH3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	372912.
SOURCE	Search...

Entry information

Entry name

SHAN2_MOUSE

Accession

Primary (citable) accession number: Q80Z38
Secondary accession number(s): E9QPH7, Q3UTK4, Q5DU07

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 25, 2006
Last sequence update:	July 27, 2011
Last modified:	May 1, 2013
This is version 74 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program