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Q80Z38

- SHAN2_MOUSE

UniProt

Q80Z38 - SHAN2_MOUSE

Protein

SH3 and multiple ankyrin repeat domains protein 2

Gene

Shank2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction By similarity.By similarity

    GO - Molecular functioni

    1. ionotropic glutamate receptor binding Source: BHF-UCL

    GO - Biological processi

    1. adult behavior Source: BHF-UCL
    2. exploration behavior Source: BHF-UCL
    3. learning Source: BHF-UCL
    4. long term synaptic depression Source: BHF-UCL
    5. long-term synaptic potentiation Source: BHF-UCL
    6. memory Source: BHF-UCL
    7. social behavior Source: BHF-UCL
    8. synapse assembly Source: BHF-UCL
    9. vocalization behavior Source: BHF-UCL

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    SH3 and multiple ankyrin repeat domains protein 2
    Short name:
    Shank2
    Alternative name(s):
    Cortactin-binding protein 1
    Short name:
    CortBP1
    Gene namesi
    Name:Shank2
    Synonyms:Cortbp1, Kiaa1022
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:2671987. Shank2.

    Subcellular locationi

    Apical cell membrane By similarity. Cytoplasm 1 Publication. Cell junctionsynapse 1 Publication. Cell junctionsynapsepostsynaptic cell membranepostsynaptic density 1 Publication. Cell projectiondendritic spine 1 Publication. Cell projectiongrowth cone By similarity
    Note: Colocalizes with cortactin in growth cones in differentiating hippocampal neurons. Colocalized with PDE4D to the apical membrane of colonic crypt cells By similarity. Present in the dendritic spines of cerebellar Purkinje cells.By similarity

    GO - Cellular componenti

    1. apical plasma membrane Source: BHF-UCL
    2. brush border membrane Source: BHF-UCL
    3. cell junction Source: UniProtKB-KW
    4. ciliary membrane Source: BHF-UCL
    5. cytoplasm Source: UniProtKB-SubCell
    6. dendritic spine Source: BHF-UCL
    7. growth cone Source: BHF-UCL
    8. neuronal cell body Source: BHF-UCL
    9. neuron projection Source: BHF-UCL
    10. photoreceptor inner segment Source: BHF-UCL
    11. photoreceptor outer segment Source: BHF-UCL
    12. plasma membrane Source: BHF-UCL
    13. postsynaptic density Source: BHF-UCL
    14. postsynaptic membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Cell projection, Cytoplasm, Membrane, Postsynaptic cell membrane, Synapse

    Pathology & Biotechi

    Disruption phenotypei

    Mutants are viable, but with reduced body weight and a lower survival rate compared to their wild-type littermates. They are extremely hiperactive and display profound autistic-like behavioral alterations including repetitive grooming as well as abnormalities in vocal and social behaviors. Mutants exhibit fewer dendritic spines and show reduced basal synaptic transmission, a reduced frequency of miniature excitatory postsynaptic currents and enhanced NMDA receptor-mediated excitatory currents at the physiological level. They also show a brain-region-specific up-regulation of ionotropic glutamate receptors and increased levels of SHANK3.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 14761476SH3 and multiple ankyrin repeat domains protein 2PRO_0000247760Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei586 – 5861Phosphoserine1 Publication
    Modified residuei903 – 9031Phosphothreonine1 Publication
    Glycosylationi1292 – 12921O-linked (GlcNAc)1 Publication

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ80Z38.
    PaxDbiQ80Z38.
    PRIDEiQ80Z38.

    PTM databases

    PhosphoSiteiQ80Z38.

    Expressioni

    Tissue specificityi

    Detected in brain (at protein level), where it is highly expressed in Purkinje cells.3 Publications

    Gene expression databases

    BgeeiQ80Z38.
    CleanExiMM_SHANK2.
    GenevestigatoriQ80Z38.

    Interactioni

    Subunit structurei

    Is part of a complex with DLG4/PSD-95 and DLGAP1/GKAP. Interacts with CTTN/cortactin SH3 domain, DLGAP1/GKAP and alpha-latrotoxin receptor 1. Interacts with DNM2, DBNL, GRID2, BAIAP2, SLC9A3, PLCB3 and CFTR. Interacts (via proline-rich region) with PDE4D. Interacts with ABI1 (via SH3 domain).2 Publications

    Protein-protein interaction databases

    BioGridi229144. 2 interactions.
    IntActiQ80Z38. 4 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ80Z38.
    SMRiQ80Z38. Positions 148-205, 240-343, 1410-1473.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini147 – 20660SH3PROSITE-ProRule annotationAdd
    BLAST
    Domaini247 – 34195PDZPROSITE-ProRule annotationAdd
    BLAST
    Domaini1413 – 147664SAMPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi1169 – 11757SH3-bindingSequence Analysis

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi24 – 274Poly-Arg
    Compositional biasi355 – 3584Poly-Pro
    Compositional biasi513 – 56048Pro-richAdd
    BLAST
    Compositional biasi1017 – 10204Poly-Pro
    Compositional biasi1169 – 121143Pro-richAdd
    BLAST
    Compositional biasi1348 – 13536Poly-Pro

    Domaini

    The PDZ domain is required for interaction with GRID2, PLCB3, SLC9A3 and CFTR.

    Sequence similaritiesi

    Belongs to the SHANK family.Curated
    Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
    Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH3 domain, SH3-binding

    Phylogenomic databases

    eggNOGiCOG0666.
    GeneTreeiENSGT00510000046474.
    HOGENOMiHOG000293276.
    HOVERGENiHBG054027.
    KOiK15009.

    Family and domain databases

    Gene3Di1.10.150.50. 1 hit.
    2.30.42.10. 1 hit.
    InterProiIPR001478. PDZ.
    IPR001660. SAM.
    IPR013761. SAM/pointed.
    IPR021129. SAM_type1.
    IPR011511. SH3_2.
    IPR001452. SH3_domain.
    [Graphical view]
    PfamiPF00595. PDZ. 1 hit.
    PF00536. SAM_1. 1 hit.
    PF07653. SH3_2. 1 hit.
    [Graphical view]
    SMARTiSM00228. PDZ. 1 hit.
    SM00454. SAM. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF47769. SSF47769. 1 hit.
    SSF50044. SSF50044. 1 hit.
    SSF50156. SSF50156. 1 hit.
    PROSITEiPS50106. PDZ. 1 hit.
    PS50105. SAM_DOMAIN. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q80Z38-1) [UniParc]FASTAAdd to Basket

    Also known as: E

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKSLLNAFTK KEVPFREAPA YSNRRRRPPN TLAAPRVLLR SNSDNNLNAG     50
    APEWAVCSAA TSHRSLSPQL LQQTPSKPDG ATKSLGSYTP GPRSRSPSLN 100
    RLGGTAEDGK RTQPHWHVGS PFTPGANKDS LSTFEYPGPR RKLYSAVPGR 150
    LFVAVKPYQP QVDGEIPLHR GDRVKVLSIG EGGFWEGSAR GHIGWFPAEC 200
    VEEVQCKPRD SQAETRADRS KKLFRHYTVG SYDSFDAASD CIIEDKTVVL 250
    QKKDNEGFGF VLRGAKADTP IEEFTPTPAF PALQYLESVD EGGVAWQAGL 300
    RTGDFLIEVN NENVVKVGHR QVVNMIRQGG NHLILKVVTV TRNLDPDDTA 350
    RKKAPPPPKR APTTALTLRS KSMTAELEEL GLSLVDKASV RKKKDKPEEI 400
    VPASKPSRTA ENVAIESRVA TIKQRPTSRC FPAASDVNSV YERQGIAVMT 450
    PTVPGSPKGP FLGLPRGTMR RQKSIDSRIF LSGITEEERQ FLAPPMLKFT 500
    RSLSMPDTSE DIPPPPQSVP PSPPPPSPTT YNCPRSPTPR VYGTIKPAFN 550
    QNPVVAKVPP ATRSDTVATM MREKGMFYRR ELDRFSLDSE DVYSRSPAPQ 600
    AAFRTKRGQM PENPYSEVGK IASKAVYVPA KPARRKGVLV KQSNVEDSPE 650
    KTCSIPIPTI IVKEPSTSSS GKSSQGSSME IDPQATEPGQ LRPDDSLTVS 700
    SPFAAAIAGA VRDREKRLEA RRNSPAFLST DLGDEDVGLG PPAPRMQASK 750
    FPEEGGFGDE DETEQPLLPT PGAAPRELEN HFLGGGEAGA QGEAGGPLSS 800
    TSKAKGPESG PAAPLKSSSP AGPENYVHPL TGRLLDPSSP LALALSARDR 850
    AMQESQQGHK GEAPKADLNK PLYIDTKMRP SVESGFPPVT RQNTRGPLRR 900
    QETENKYETD LGKDRRADDK KNMLINIVDT AQQKSAGLLM VHTVDVPMAG 950
    PPLEEEEDRE DGDTKPDHSP STVPEGVPKT EGALQISAAP EPAVAPGRTI 1000
    VAAGSVEEAV ILPFRIPPPP LASVDLDEDF LFTEPLPPPL EFANSFDIPD 1050
    DRAASVPALA DLVKQKKNDT SQPPTLNSSQ PANSTDSKKP AGISNCLPSS 1100
    FLPPPESFDA VTDSGIEEVD SRSSSDHHLE TTSTISTVSS ISTLSSEGGE 1150
    SMDTCTVYAD GQAFVVDKPP VPPKPKMKPI VHKSNALYQD TLPEEDTDGF 1200
    VIPPPAPPPP PGSAQAGVAK VIQPRTSKLW GDVPEVKSPI LSGPKANVIS 1250
    ELNSILQQMN RGKSVKPGEG LELPVGAKSA NLAPRSPEVM STVSGTRSTT 1300
    VTFTVRPGTS QPITLQSRPP DYESRTSGPR RAPSPVVSPT ELSKEILPTP 1350
    PPPSATAASP SPTLSDVFSL PSQSPAGDLF GLNPAGRSRS PSPSILQQPI 1400
    SNKPFTTKPV HLWTKPDVAD WLESLNLGEH KETFMDNEID GSHLPNLQKE 1450
    DLIDLGVTRV GHRMNIERAL KQLLDR 1476
    Length:1,476
    Mass (Da):158,969
    Last modified:July 27, 2011 - v2
    Checksum:i0B5B0EBDFD6BAAA7
    GO
    Isoform 2 (identifier: Q80Z38-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         380-383: Missing.

    Show »
    Length:1,472
    Mass (Da):158,599
    Checksum:i0BBCF1E8E351834C
    GO
    Isoform 3 (identifier: Q80Z38-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-210: Missing.
         211-238: SQAETRADRSKKLFRHYTVGSYDSFDAA → MMSVPGGGAATVMMTGYNNGRYPRNSLY
         380-383: Missing.

    Show »
    Length:1,262
    Mass (Da):135,412
    Checksum:iBF3B96EFA165D7B9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1071 – 10711S → P in BAC58120. (PubMed:15207857)Curated
    Sequence conflicti1071 – 10711S → P in BAD90424. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 210210Missing in isoform 3. 1 PublicationVSP_041614Add
    BLAST
    Alternative sequencei211 – 23828SQAET…SFDAA → MMSVPGGGAATVMMTGYNNG RYPRNSLY in isoform 3. 1 PublicationVSP_041615Add
    BLAST
    Alternative sequencei380 – 3834Missing in isoform 2 and isoform 3. 2 PublicationsVSP_020040

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB099695 mRNA. Translation: BAC58120.1.
    AC124520 Genomic DNA. No translation available.
    AC127546 Genomic DNA. No translation available.
    AC140268 Genomic DNA. No translation available.
    AC152166 Genomic DNA. No translation available.
    BC167171 mRNA. Translation: AAI67171.1.
    AK139360 mRNA. Translation: BAE23976.1.
    AK220363 mRNA. Translation: BAD90424.1.
    CCDSiCCDS40201.1. [Q80Z38-3]
    RefSeqiNP_001074839.2. NM_001081370.2.
    NP_001106844.2. NM_001113373.2.
    XP_006508596.1. XM_006508533.1. [Q80Z38-1]
    UniGeneiMm.483624.

    Genome annotation databases

    EnsembliENSMUST00000097929; ENSMUSP00000095542; ENSMUSG00000037541. [Q80Z38-3]
    GeneIDi210274.
    KEGGimmu:210274.
    UCSCiuc009kqe.2. mouse. [Q80Z38-2]
    uc009kqf.1. mouse. [Q80Z38-3]
    uc009kqg.1. mouse. [Q80Z38-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB099695 mRNA. Translation: BAC58120.1 .
    AC124520 Genomic DNA. No translation available.
    AC127546 Genomic DNA. No translation available.
    AC140268 Genomic DNA. No translation available.
    AC152166 Genomic DNA. No translation available.
    BC167171 mRNA. Translation: AAI67171.1 .
    AK139360 mRNA. Translation: BAE23976.1 .
    AK220363 mRNA. Translation: BAD90424.1 .
    CCDSi CCDS40201.1. [Q80Z38-3 ]
    RefSeqi NP_001074839.2. NM_001081370.2.
    NP_001106844.2. NM_001113373.2.
    XP_006508596.1. XM_006508533.1. [Q80Z38-1 ]
    UniGenei Mm.483624.

    3D structure databases

    ProteinModelPortali Q80Z38.
    SMRi Q80Z38. Positions 148-205, 240-343, 1410-1473.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 229144. 2 interactions.
    IntActi Q80Z38. 4 interactions.

    PTM databases

    PhosphoSitei Q80Z38.

    Proteomic databases

    MaxQBi Q80Z38.
    PaxDbi Q80Z38.
    PRIDEi Q80Z38.

    Protocols and materials databases

    DNASUi 210274.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000097929 ; ENSMUSP00000095542 ; ENSMUSG00000037541 . [Q80Z38-3 ]
    GeneIDi 210274.
    KEGGi mmu:210274.
    UCSCi uc009kqe.2. mouse. [Q80Z38-2 ]
    uc009kqf.1. mouse. [Q80Z38-3 ]
    uc009kqg.1. mouse. [Q80Z38-1 ]

    Organism-specific databases

    CTDi 22941.
    MGIi MGI:2671987. Shank2.
    Rougei Search...

    Phylogenomic databases

    eggNOGi COG0666.
    GeneTreei ENSGT00510000046474.
    HOGENOMi HOG000293276.
    HOVERGENi HBG054027.
    KOi K15009.

    Miscellaneous databases

    NextBioi 372912.
    PROi Q80Z38.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q80Z38.
    CleanExi MM_SHANK2.
    Genevestigatori Q80Z38.

    Family and domain databases

    Gene3Di 1.10.150.50. 1 hit.
    2.30.42.10. 1 hit.
    InterProi IPR001478. PDZ.
    IPR001660. SAM.
    IPR013761. SAM/pointed.
    IPR021129. SAM_type1.
    IPR011511. SH3_2.
    IPR001452. SH3_domain.
    [Graphical view ]
    Pfami PF00595. PDZ. 1 hit.
    PF00536. SAM_1. 1 hit.
    PF07653. SH3_2. 1 hit.
    [Graphical view ]
    SMARTi SM00228. PDZ. 1 hit.
    SM00454. SAM. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47769. SSF47769. 1 hit.
    SSF50044. SSF50044. 1 hit.
    SSF50156. SSF50156. 1 hit.
    PROSITEi PS50106. PDZ. 1 hit.
    PS50105. SAM_DOMAIN. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Direct interaction of GluRdelta2 with Shank scaffold proteins in cerebellar Purkinje cells."
      Uemura T., Mori H., Mishina M.
      Mol. Cell. Neurosci. 26:330-341(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, INTERACTION WITH GRID2.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-350 (ISOFORMS 1/2).
      Strain: C57BL/6J.
      Tissue: Brain cortex.
    5. "Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H.
      Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 345-1476 (ISOFORM 2).
      Tissue: Fetal brain.
    6. "Identification of a novel cortactin SH3 domain-binding protein and its localization to growth cones of cultured neurons."
      Du Y., Weed S.A., Xiong W.-C., Marshall T.D., Parsons J.T.
      Mol. Cell. Biol. 18:5838-5851(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    7. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
      Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
      Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-586 AND THR-903, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain.
    8. "O-linked N-acetylglucosamine proteomics of postsynaptic density preparations using lectin weak affinity chromatography and mass spectrometry."
      Vosseller K., Trinidad J.C., Chalkley R.J., Specht C.G., Thalhammer A., Lynn A.J., Snedecor J.O., Guan S., Medzihradszky K.F., Maltby D.A., Schoepfer R., Burlingame A.L.
      Mol. Cell. Proteomics 5:923-934(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT THR-1292.
      Tissue: Brain.
    9. "Dynamic regulation of cystic fibrosis transmembrane conductance regulator by competitive interactions of molecular adaptors."
      Lee J.H., Richter W., Namkung W., Kim K.H., Kim E., Conti M., Lee M.G.
      J. Biol. Chem. 282:10414-10422(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PDE4D, TISSUE SPECIFICITY.
    10. "Shank3 mutant mice display autistic-like behaviours and striatal dysfunction."
      Peca J., Feliciano C., Ting J.T., Wang W., Wells M.F., Venkatraman T.N., Lascola C.D., Fu Z., Feng G.
      Nature 472:437-442(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    11. Cited for: DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiSHAN2_MOUSE
    AccessioniPrimary (citable) accession number: Q80Z38
    Secondary accession number(s): E9QPH7, Q3UTK4, Q5DU07
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2006
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 88 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3