Q80Z37Q3U5B5Q3UPZ1Q3USN3Q3UZ55Q8BXP2Q8CFF5Q8CGC8Q920L3TOPRS_MOUSEE3 ubiquitin-protein ligase Topors2.3.2.27RING-type E3 ubiquitin transferase ToporsSUMO1-protein E3 ligase ToporsTopoisomerase I-binding RING finger proteinTopoisomerase I-binding arginine/serine-rich proteinTumor suppressor p53-binding protein 3p53-binding protein 3p53BP3ToporsMus musculusMouseEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMusDJ-1 restores p53 transcription activity inhibited by Topors/p53BP3.NUCLEOTIDE SEQUENCE [MRNA]FUNCTIONINTERACTION WITH PARK7 AND TP53SUBCELLULAR LOCATIONTopors, a p53 and topoisomerase I-binding RING finger protein, is a coactivator of p53 in growth suppression induced by DNA damage.NUCLEOTIDE SEQUENCE [MRNA]FUNCTIONINTERACTION WITH TP53SUBCELLULAR LOCATIONINDUCTIONThe status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]The transcriptional landscape of the mammalian genome.NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-824Large-scale phosphorylation analysis of mouse liver.PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1016IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]A tissue-specific atlas of mouse protein phosphorylation and expression.PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-99; SER-861; SER-863; SER-909; SER-911; SER-999; SER-1016 AND SER-1025IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]Functions as an E3 ubiquitin-protein ligase and as a E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA-damage-induced cell death through IKBKE sumoylation.S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.Interacts with TOP1. Interacts with the SUMO1 conjugating enzyme UBE2I. Interacts with SUMO1. Interacts with NKX3-1; polyubiquitinates NKX3-1 and induces its proteasomal degradation. Interacts with SIN3A; sumoylates SIN3A. Interacts with IKBKE; induced by DNA damage (By similarity). Interacts with p53/TP53. Interacts with PARK7/DJ-1.NucleusNucleusPML bodyLocalizes to discrete nuclear foci which partly overlap with PML nuclear bodies. Targeted to PML nuclear bodies upon DNA damage.By genotoxic agents such as cisplatin and camptothecin.Phosphorylation at Ser-99 regulates the E3 ubiquitin-protein ligase activity but not the SUMO1-protein ligase activity. Phosphorylation at Ser-718 increases the E3 ubiquitin-protein ligase activity versus the E3 SUMO1-protein ligase activity resulting in increased p53/TP53 ubiquitination and degradation.Sumoylated.Contaminating sequence. Potential poly-A sequence.DNA damageIsopeptide bondMetal-bindingNucleusPhosphoproteinReference proteomeTransferaseUbl conjugationUbl conjugation pathwayZincZinc-fingerSFLPSASAMGSQPPPPGSPLSREEGEAPPLVPAEEGRRRSRRVRLRGSCRHRPSLLSRRELASNGPAVPATASSEIMASAAKEFKMDNFSPKAGTSKLQQTVPADASPDSKCPICLDRFDNVSYLDRCLHKFCFRCVQEWSKNKAECPLCKQPFDSIFHSVRAEDDFKEYVLRPSYNGSFTNPEVRRFRYRTTMTRERSASLYSPSSTVSRRTTTPPDSGVLFEGLGISTRPRDVDIPQFMRQMALRGPTTTDERSLRKIQEQDIINFRRTLYRAGVRVRSIEDGGRYRDISAEFFRRNPACLHRLVPWLKRELTVLFGAHGSLVNIVQHIIMSNVTRYDLESQAFVSDLRPFLLNRTEHFIHEFISFARSPFNMAAFDQHANYDCPPSSEEGSRSDSSVITISPDEAETQELDMNASTVRQAPWDDETPGPSYSSSEQVHVGVSSLLNSSDSSDEELVSGGTTSQIQGVQTNDDVNNDSDSSSDNCVIVGFVKPLAERTPELVELSSDSEELGPYEKVETVKTQEQEQSYSSGDSDVSRASSPRSVLGKDEQMSKSHCDSDTRISSKKEEKRSTSLPAPRDSSSTRGDRVCSPYNHRHRKGGRSRSSDSRSQSRSGHDPRNHRKHGKKRLRNKRSRSRESSSRPRARKDKKRSRTRDSSWSRRSQTLSLSSGSTSRSRSRSSDHGKRRSRSRNRDRYYLRNNYGSKYKWEYTYYSRNKDRDGYESSYRRRTLSRAHYSRQSSSPEFRIQSFSERTNARKKNHSERKYYYYERRRSRSVSSNRSRTTSAGPDRVRNEKPGGKRKYKTRHLEGTSEEAQPAREFTSKGKDSHYQKSKLDGSYKNESDSFSDSRSSDRETKHKRRRRRTRSLSVEIVYEGKATDTSKHHKKKKKKHKKKHKKHHGDNTSRSPVVITIDSDSDGESEVKAGIECSNGSLPQPIQDGAFETKDVVTIEDELGVLDKDCDVTALADDLSTSQTVENCDSPAVPVEQTLDVREESTFASDLESQSSNVSIQAEPSRPVPSPRTSLSSVSPGRDCDVS
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