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Protein

Neuronal regeneration-related protein

Gene

Nrep

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

May have roles in neural function. Ectopic expression promotes axonal regeneration. Augments also motility of gliomas (By similarity). May also have roles in cellular differentiation (By similarity). Induces differentiation of fibroblast into myofibroblast and myofibroblast ameboid migration (By similarity). Increases retinoic-acid regulation of lipid-droplet biogenesis (By similarity). Down-regulates the expression of TGFB1 and TGFB2 but not of TGFB3 (By similarity). May play a role in the regulation of alveolar generation (By similarity).By similarity1 Publication

GO - Biological processi

  • axon regeneration Source: RGD
  • regulation of neuron differentiation Source: RGD
  • regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal regeneration-related protein
Alternative name(s):
Neuronal protein 3.1
Protein p311
Gene namesi
Name:Nrep
Synonyms:P311
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi

Organism-specific databases

RGDi631411 Nrep

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002535971 – 68Neuronal regeneration-related proteinAdd BLAST68

Post-translational modificationi

Phosphorylated on Ser-59. Phosphorylation decreases stability and activity.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ80Z34
PRIDEiQ80Z34

Expressioni

Gene expression databases

BgeeiENSRNOG00000020467

Interactioni

Subunit structurei

Interacts with FLNA. Interacts with the latency-associated peptides (LAP) of TGFB1 and TGFB2; the interaction results in a decrease in TGFB autoinduction.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027739

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410J38C Eukaryota
ENOG4111AXH LUCA
GeneTreeiENSGT00390000016521
HOGENOMiHOG000237339
HOVERGENiHBG052654
InParanoidiQ80Z34
OMAiYPELLVW
OrthoDBiEOG091G14OY
PhylomeDBiQ80Z34
TreeFamiTF336368

Family and domain databases

InterProiView protein in InterPro
IPR024417 Neuronal_3.1
PANTHERiPTHR17102 PTHR17102, 1 hit
PfamiView protein in Pfam
PF11092 Alveol-reg_P311, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD019364 PD019364, 1 hit

Sequencei

Sequence statusi: Complete.

Q80Z34-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVYYPELLVW VSQEPFPYKE MEGGLTKGRL PVPKEVNRKK MDEPIAASLI
60
PPGNHEPGSP AIGYLHPF
Length:68
Mass (Da):7,648
Last modified:June 1, 2003 - v1
Checksum:iFE6F4D1E8C7B6C0C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB072344 mRNA Translation: BAC65245.1
RefSeqiNP_835197.1, NM_178096.3
XP_006254657.1, XM_006254595.2
UniGeneiRn.8180

Genome annotation databases

EnsembliENSRNOT00000027739; ENSRNOP00000027739; ENSRNOG00000020467
GeneIDi338475
KEGGirno:338475
UCSCiRGD:631411 rat

Similar proteinsi

Entry informationi

Entry nameiNREP_RAT
AccessioniPrimary (citable) accession number: Q80Z34
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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