Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Neuronal regeneration-related protein

Gene

Nrep

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May have roles in neural function. Ectopic expression promotes axonal regeneration. Augments also motility of gliomas (By similarity). May also have roles in cellular differentiation (By similarity). Induces differentiation of fibroblast into myofibroblast and myofibroblast ameboid migration (By similarity). Increases retinoic-acid regulation of lipid-droplet biogenesis (By similarity). Down-regulates the expression of TGFB1 and TGFB2 but not of TGFB3 (By similarity). May play a role in the regulation of alveolar generation (By similarity).By similarity1 Publication

GO - Biological processi

  • axon regeneration Source: RGD
  • regulation of neuron differentiation Source: RGD
  • regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal regeneration-related protein
Alternative name(s):
Neuronal protein 3.1
Protein p311
Gene namesi
Name:Nrep
Synonyms:P311
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 18

Organism-specific databases

RGDi631411. Nrep.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: RGD
  • nucleus Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6868Neuronal regeneration-related proteinPRO_0000253597Add
BLAST

Post-translational modificationi

Phosphorylated on Ser-59. Phosphorylation decreases stability and activity.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ80Z34.
PRIDEiQ80Z34.

Expressioni

Gene expression databases

BgeeiENSRNOG00000020467.

Interactioni

Subunit structurei

Interacts with FLNA. Interacts with the latency-associated peptides (LAP) of TGFB1 and TGFB2; the interaction results in a decrease in TGFB autoinduction.By similarity

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410J38C. Eukaryota.
ENOG4111AXH. LUCA.
GeneTreeiENSGT00390000016521.
HOGENOMiHOG000237339.
HOVERGENiHBG052654.
InParanoidiQ80Z34.
OMAiYPELLVW.
OrthoDBiEOG091G14OY.
PhylomeDBiQ80Z34.
TreeFamiTF336368.

Family and domain databases

InterProiIPR024417. Neuronal_3.1.
[Graphical view]
PANTHERiPTHR17102. PTHR17102. 1 hit.
PfamiPF11092. Alveol-reg_P311. 1 hit.
[Graphical view]
ProDomiPD019364. PD019364. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Q80Z34-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVYYPELLVW VSQEPFPYKE MEGGLTKGRL PVPKEVNRKK MDEPIAASLI
60
PPGNHEPGSP AIGYLHPF
Length:68
Mass (Da):7,648
Last modified:June 1, 2003 - v1
Checksum:iFE6F4D1E8C7B6C0C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB072344 mRNA. Translation: BAC65245.1.
RefSeqiNP_835197.1. NM_178096.3.
XP_006254657.1. XM_006254595.1.
UniGeneiRn.8180.

Genome annotation databases

EnsembliENSRNOT00000027739; ENSRNOP00000027739; ENSRNOG00000020467.
GeneIDi338475.
KEGGirno:338475.
UCSCiRGD:631411. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB072344 mRNA. Translation: BAC65245.1.
RefSeqiNP_835197.1. NM_178096.3.
XP_006254657.1. XM_006254595.1.
UniGeneiRn.8180.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiQ80Z34.
PRIDEiQ80Z34.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000027739; ENSRNOP00000027739; ENSRNOG00000020467.
GeneIDi338475.
KEGGirno:338475.
UCSCiRGD:631411. rat.

Organism-specific databases

CTDi9315.
RGDi631411. Nrep.

Phylogenomic databases

eggNOGiENOG410J38C. Eukaryota.
ENOG4111AXH. LUCA.
GeneTreeiENSGT00390000016521.
HOGENOMiHOG000237339.
HOVERGENiHBG052654.
InParanoidiQ80Z34.
OMAiYPELLVW.
OrthoDBiEOG091G14OY.
PhylomeDBiQ80Z34.
TreeFamiTF336368.

Miscellaneous databases

PROiQ80Z34.

Gene expression databases

BgeeiENSRNOG00000020467.

Family and domain databases

InterProiIPR024417. Neuronal_3.1.
[Graphical view]
PANTHERiPTHR17102. PTHR17102. 1 hit.
PfamiPF11092. Alveol-reg_P311. 1 hit.
[Graphical view]
ProDomiPD019364. PD019364. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Entry informationi

Entry nameiNREP_RAT
AccessioniPrimary (citable) accession number: Q80Z34
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: June 1, 2003
Last modified: September 7, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.