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Protein

Origin recognition complex subunit 1

Gene

Orc1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei93Histone H4K20me2By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi521 – 528ATPSequence analysis8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • chromatin binding Source: RGD
  • DNA binding Source: UniProtKB-KW

GO - Biological processi

  • DNA replication Source: UniProtKB-KW
  • positive regulation of G0 to G1 transition Source: RGD
  • positive regulation of smooth muscle cell proliferation Source: RGD
Complete GO annotation...

Keywords - Biological processi

DNA replication

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Origin recognition complex subunit 1
Gene namesi
Name:Orc1
Synonyms:Orc1l
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi631435. Orc1.

Subcellular locationi

GO - Cellular componenti

  • nuclear origin of replication recognition complex Source: UniProtKB
  • nucleus Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003303571 – 848Origin recognition complex subunit 1Add BLAST848

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei193PhosphoserineBy similarity1
Modified residuei252PhosphoserineBy similarity1
Modified residuei270PhosphoserineBy similarity1
Modified residuei284PhosphoserineBy similarity1
Modified residuei314N6-acetyllysineBy similarity1
Modified residuei325PhosphoserineBy similarity1
Modified residuei404PhosphoserineBy similarity1
Modified residuei407PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated during mitosis.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ80Z32.
PRIDEiQ80Z32.

PTM databases

iPTMnetiQ80Z32.
PhosphoSitePlusiQ80Z32.

Interactioni

Subunit structurei

Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase (By similarity). Interacts with CDC6 and KAT7/HBO1 (By similarity). Interacts with LRWD1 predominantly during the G1 phase and with less affinity during mitosis, when phosphorylated (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012492.

Structurei

3D structure databases

ProteinModelPortaliQ80Z32.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 170BAHPROSITE-ProRule annotationAdd BLAST127

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni488 – 848Necessary and sufficient for ORC complex assemblyBy similarityAdd BLAST361

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi393 – 396Poly-Glu4

Domaini

The BAH domain mediates binding to dimethylated histone H4 'Lys-20' (H4K20me2), which is enriched at replication origins.By similarity

Sequence similaritiesi

Belongs to the ORC1 family.Curated
Contains 1 BAH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1514. Eukaryota.
COG1474. LUCA.
HOGENOMiHOG000231132.
HOVERGENiHBG007873.
InParanoidiQ80Z32.
KOiK02603.
PhylomeDBiQ80Z32.

Family and domain databases

CDDicd08768. Cdc6_C. 1 hit.
Gene3Di1.10.10.10. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR001025. BAH_dom.
IPR015163. Cdc6_C.
IPR027417. P-loop_NTPase.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF01426. BAH. 1 hit.
PF09079. Cdc6_C. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00439. BAH. 1 hit.
SM01074. Cdc6_C. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51038. BAH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80Z32-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSYVTRQKT RQTFSWVGRP LPNRKQFYQM YKEICMKING CSEIHIKVGQ
60 70 80 90 100
FVLIQGEDNQ KPYVAKLIEL FENGSEVPPK KYARVQWFVR FCEIPIPKRH
110 120 130 140 150
LLGRRPSAQE IFWYDCSDCD NDIHVETIIG PVQVVALAPE DEIPVNQKSE
160 170 180 190 200
ETLFVKLSWN KKNFAPLPPE ELAALRRLEC QKPLEAKTKS VKSPSWSTAE
210 220 230 240 250
QEVKRIESSH STSRSYQDPA HTVTPNAMKS LECGGFTRKP NMRLSRKILC
260 270 280 290 300
DSLDSQKTCK RRAAFSETTS PPKKPQPGEI KTSSALETLG KNGHTQPFFA
310 320 330 340 350
KSSMVLRTRG TAVKTTKLTV ESALSPVRSR SRYSVAPSVG LTPQYIGRKA
360 370 380 390 400
KEQETHKEPI HTSLRARRRS SLLTLKRIKQ QLWLLDDDKS DQEEEESISS
410 420 430 440 450
VEVSDSSSEE EDESVPSPPT GKPVGQSRTR RTASKPSSQT PSKSPKKTFR
460 470 480 490 500
PRPPLHATPQ IRDRNLAVQE PASVLEEARL RLHVSAVPDS LPCREQEFQD
510 520 530 540 550
IYSFVESKLL DGTGGCMYIS GVPGTGKTAT VHEVIRCLQQ AAQTNDVPPF
560 570 580 590 600
EYVEVNGMKL TEPHQVYVQI LQKLTGQKAT ANHAAELLAK QFCSRGSQKE
610 620 630 640 650
TTVLLVDELD LLWTHKQDVL YNLFDWPTHK GARLVVLTIA NTMDLPERIM
660 670 680 690 700
MNRVASRLGL TRMSFQPYSH SQLKQILVSR LKHLKAFEDD AVQLVARKVA
710 720 730 740 750
ALSGDARRCL DICRRATEIC EVSHQRGDSQ CLVTVAHLME AIDEMFSSSY
760 770 780 790 800
ITAIKNSSVL EQSFLRAIIA EFRRSGLEEA TFQQIYSQHV ALCRMEGLPY
810 820 830 840
PTMSETMAVC SRLGSCRILL VEPSRNDLLL RVRLNVSQND VLYALKEE
Length:848
Mass (Da):95,760
Last modified:June 1, 2003 - v1
Checksum:i957F3C3FE4A99F48
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB105378 mRNA. Translation: BAC65338.1.
RefSeqiNP_808792.1. NM_177931.2.
UniGeneiRn.92486.

Genome annotation databases

GeneIDi313479.
KEGGirno:313479.
UCSCiRGD:631435. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB105378 mRNA. Translation: BAC65338.1.
RefSeqiNP_808792.1. NM_177931.2.
UniGeneiRn.92486.

3D structure databases

ProteinModelPortaliQ80Z32.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012492.

PTM databases

iPTMnetiQ80Z32.
PhosphoSitePlusiQ80Z32.

Proteomic databases

PaxDbiQ80Z32.
PRIDEiQ80Z32.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi313479.
KEGGirno:313479.
UCSCiRGD:631435. rat.

Organism-specific databases

CTDi4998.
RGDi631435. Orc1.

Phylogenomic databases

eggNOGiKOG1514. Eukaryota.
COG1474. LUCA.
HOGENOMiHOG000231132.
HOVERGENiHBG007873.
InParanoidiQ80Z32.
KOiK02603.
PhylomeDBiQ80Z32.

Miscellaneous databases

PROiQ80Z32.

Family and domain databases

CDDicd08768. Cdc6_C. 1 hit.
Gene3Di1.10.10.10. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR001025. BAH_dom.
IPR015163. Cdc6_C.
IPR027417. P-loop_NTPase.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF01426. BAH. 1 hit.
PF09079. Cdc6_C. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00439. BAH. 1 hit.
SM01074. Cdc6_C. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51038. BAH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiORC1_RAT
AccessioniPrimary (citable) accession number: Q80Z32
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.