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Protein

Neuronal growth regulator 1

Gene

Negr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in cell-adhesion. May function as a trans-neural growth-promoting factor in regenerative axon sprouting in the mammalian brain.1 Publication

GO - Biological processi

  • feeding behavior Source: MGI
  • locomotory behavior Source: MGI
  • positive regulation of neuron projection development Source: MGI
  • single organismal cell-cell adhesion Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal growth regulator 1
Alternative name(s):
Kindred of IgLON
Short name:
Kilon
Neurotractin
Gene namesi
Name:Negr1
Synonyms:Kiaa3001, Ntra
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:2444846. Negr1.

Subcellular locationi

GO - Cellular componenti

  • anchored component of membrane Source: UniProtKB-KW
  • extracellular exosome Source: MGI
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31By similarityAdd BLAST31
ChainiPRO_000001503932 – 318Neuronal growth regulator 1Add BLAST287
PropeptideiPRO_0000015040319 – 348Removed in mature formSequence analysisAdd BLAST30

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi54 ↔ 112PROSITE-ProRule annotation
Glycosylationi67N-linked (GlcNAc...)Sequence analysis1
Glycosylationi149N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi154 ↔ 197PROSITE-ProRule annotation
Modified residuei181PhosphotyrosineCombined sources1
Disulfide bondi239 ↔ 291PROSITE-ProRule annotation
Glycosylationi269N-linked (GlcNAc...)Sequence analysis1
Glycosylationi280N-linked (GlcNAc...)Sequence analysis1
Glycosylationi288N-linked (GlcNAc...)Sequence analysis1
Glycosylationi301N-linked (GlcNAc...)Sequence analysis1
Lipidationi318GPI-anchor amidated glycineCurated1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ80Z24.
PaxDbiQ80Z24.
PeptideAtlasiQ80Z24.
PRIDEiQ80Z24.

PTM databases

iPTMnetiQ80Z24.
PhosphoSitePlusiQ80Z24.

Expressioni

Tissue specificityi

Expressed in brain.1 Publication

Gene expression databases

BgeeiENSMUSG00000040037.
CleanExiMM_NEGR1.
ExpressionAtlasiQ80Z24. baseline and differential.
GenevisibleiQ80Z24. MM.

Interactioni

Protein-protein interaction databases

IntActiQ80Z24. 1 interactor.
STRINGi10090.ENSMUSP00000073664.

Structurei

3D structure databases

ProteinModelPortaliQ80Z24.
SMRiQ80Z24.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 128Ig-like C2-type 1Add BLAST97
Domaini133 – 215Ig-like C2-type 2Add BLAST83
Domaini219 – 307Ig-like C2-type 3Add BLAST89

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410KD5Q. Eukaryota.
ENOG4110TBP. LUCA.
GeneTreeiENSGT00860000133697.
HOGENOMiHOG000019085.
HOVERGENiHBG017341.
InParanoidiQ80Z24.
KOiK06775.
OMAiMTINETN.
OrthoDBiEOG091G0B5D.
PhylomeDBiQ80Z24.
TreeFamiTF351104.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF07679. I-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q80Z24-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLLAQGACC SNQWLAAVLL SLCSCLPAGQ SVDFPWAAVD NMLVRKGDTA
60 70 80 90 100
VLRCYLEDGA SKGAWLNRSS IIFAGGDKWS VDPRVSISTL NKRDYSLQIQ
110 120 130 140 150
NVDVTDDGPY TCSVQTQHTP RTMQVHLTVQ VPPKIYDISN DMTINEGTNV
160 170 180 190 200
TLTCLATGKP EPVISWRHIS PSAKPFENGQ YLDIYGITRD QAGEYECSAE
210 220 230 240 250
NDVSFPDVKK VRVIVNFAPT IQEIKSGTVT PGRSGLIRCE GAGVPPPAFE
260 270 280 290 300
WYKGEKRLFN GQQGIIIQNF STRSILTVTN VTQEHFGNYT CVAANKLGTT
310 320 330 340
NASLPLNPPS TAQYGITGSA CDLFSCWSLA LTLSSVISIF YLKNAILQ
Length:348
Mass (Da):37,900
Last modified:June 1, 2003 - v1
Checksum:i30520A146A9FA198
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ487032 mRNA. Translation: CAD31699.1.
AK142298 mRNA. Translation: BAE25018.1.
AK147253 mRNA. Translation: BAE27799.1.
AK122576 mRNA. Translation: BAC65858.2.
CCDSiCCDS17930.1.
RefSeqiNP_001034183.1. NM_001039094.3.
NP_796248.1. NM_177274.4.
UniGeneiMm.317293.

Genome annotation databases

EnsembliENSMUST00000074015; ENSMUSP00000073664; ENSMUSG00000040037.
GeneIDi320840.
KEGGimmu:320840.
UCSCiuc008rvc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ487032 mRNA. Translation: CAD31699.1.
AK142298 mRNA. Translation: BAE25018.1.
AK147253 mRNA. Translation: BAE27799.1.
AK122576 mRNA. Translation: BAC65858.2.
CCDSiCCDS17930.1.
RefSeqiNP_001034183.1. NM_001039094.3.
NP_796248.1. NM_177274.4.
UniGeneiMm.317293.

3D structure databases

ProteinModelPortaliQ80Z24.
SMRiQ80Z24.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ80Z24. 1 interactor.
STRINGi10090.ENSMUSP00000073664.

PTM databases

iPTMnetiQ80Z24.
PhosphoSitePlusiQ80Z24.

Proteomic databases

MaxQBiQ80Z24.
PaxDbiQ80Z24.
PeptideAtlasiQ80Z24.
PRIDEiQ80Z24.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000074015; ENSMUSP00000073664; ENSMUSG00000040037.
GeneIDi320840.
KEGGimmu:320840.
UCSCiuc008rvc.2. mouse.

Organism-specific databases

CTDi257194.
MGIiMGI:2444846. Negr1.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410KD5Q. Eukaryota.
ENOG4110TBP. LUCA.
GeneTreeiENSGT00860000133697.
HOGENOMiHOG000019085.
HOVERGENiHBG017341.
InParanoidiQ80Z24.
KOiK06775.
OMAiMTINETN.
OrthoDBiEOG091G0B5D.
PhylomeDBiQ80Z24.
TreeFamiTF351104.

Miscellaneous databases

ChiTaRSiNegr1. mouse.
PROiQ80Z24.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040037.
CleanExiMM_NEGR1.
ExpressionAtlasiQ80Z24. baseline and differential.
GenevisibleiQ80Z24. MM.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF07679. I-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNEGR1_MOUSE
AccessioniPrimary (citable) accession number: Q80Z24
Secondary accession number(s): Q3UHQ8, Q80T70
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: June 1, 2003
Last modified: November 30, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.