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Q80YX1

- TENA_MOUSE

UniProt

Q80YX1 - TENA_MOUSE

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Protein
Tenascin
Gene
Tnc, Hxb
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth when provided to neurons in culture. May play a role in supporting the growth of epithelial tumors. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6.By similarity1 Publication

GO - Molecular functioni

  1. syndecan binding Source: MGI

GO - Biological processi

  1. bud outgrowth involved in lung branching Source: Ensembl
  2. cell adhesion Source: UniProtKB-KW
  3. cellular response to prostaglandin D stimulus Source: Ensembl
  4. cellular response to retinoic acid Source: Ensembl
  5. cellular response to vitamin D Source: Ensembl
  6. mesenchymal-epithelial cell signaling involved in prostate gland development Source: MGI
  7. negative regulation of cell adhesion Source: Ensembl
  8. neuromuscular junction development Source: MGI
  9. odontogenesis of dentin-containing tooth Source: Ensembl
  10. peripheral nervous system axon regeneration Source: MGI
  11. positive regulation of cell proliferation Source: MGI
  12. positive regulation of gene expression Source: MGI
  13. prostate gland epithelium morphogenesis Source: MGI
  14. response to ethanol Source: Ensembl
  15. response to fibroblast growth factor Source: Ensembl
  16. response to mechanical stimulus Source: Ensembl
  17. wound healing Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiREACT_196606. ECM proteoglycans.
REACT_196644. Syndecan interactions.
REACT_216309. Integrin cell surface interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Tenascin
Short name:
TN
Alternative name(s):
Hexabrachion
Tenascin-C
Short name:
TN-C
Gene namesi
Name:Tnc
Synonyms:Hxb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:101922. Tnc.

Subcellular locationi

GO - Cellular componenti

  1. basement membrane Source: MGI
  2. extracellular region Source: MGI
  3. extracellular space Source: Ensembl
  4. interstitial matrix Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Disruption phenotypei

Mice show enhanced novelty-induced activity, reduced anxiety, delayed resynchronization to daylight reversal and weaker muscle strength.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 By similarityBy similarity
Add
BLAST
Chaini23 – 21102088Tenascin By similarityBy similarity
PRO_0000248607Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi38 – 381N-linked (GlcNAc...) Reviewed prediction
Glycosylationi166 – 1661N-linked (GlcNAc...) Reviewed prediction
Glycosylationi184 – 1841N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi190 ↔ 200 By similarity
Disulfide bondi194 ↔ 205 By similarity
Disulfide bondi207 ↔ 216 By similarity
Disulfide bondi221 ↔ 231 By similarity
Disulfide bondi225 ↔ 236 By similarity
Disulfide bondi238 ↔ 247 By similarity
Disulfide bondi252 ↔ 263 By similarity
Disulfide bondi256 ↔ 268 By similarity
Disulfide bondi270 ↔ 279 By similarity
Disulfide bondi284 ↔ 294 By similarity
Disulfide bondi288 ↔ 299 By similarity
Disulfide bondi301 ↔ 310 By similarity
Disulfide bondi315 ↔ 325 By similarity
Disulfide bondi319 ↔ 330 By similarity
Glycosylationi327 – 3271N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi332 ↔ 341 By similarity
Disulfide bondi346 ↔ 356 By similarity
Disulfide bondi350 ↔ 361 By similarity
Disulfide bondi363 ↔ 372 By similarity
Disulfide bondi377 ↔ 387 By similarity
Disulfide bondi381 ↔ 392 By similarity
Disulfide bondi394 ↔ 403 By similarity
Disulfide bondi408 ↔ 418 By similarity
Disulfide bondi412 ↔ 423 By similarity
Disulfide bondi425 ↔ 434 By similarity
Disulfide bondi439 ↔ 449 By similarity
Disulfide bondi443 ↔ 454 By similarity
Disulfide bondi456 ↔ 465 By similarity
Disulfide bondi470 ↔ 480 By similarity
Disulfide bondi474 ↔ 485 By similarity
Disulfide bondi487 ↔ 496 By similarity
Disulfide bondi501 ↔ 511 By similarity
Disulfide bondi505 ↔ 516 By similarity
Disulfide bondi518 ↔ 527 By similarity
Disulfide bondi532 ↔ 542 By similarity
Disulfide bondi536 ↔ 547 By similarity
Disulfide bondi549 ↔ 558 By similarity
Disulfide bondi563 ↔ 573 By similarity
Disulfide bondi567 ↔ 578 By similarity
Disulfide bondi580 ↔ 589 By similarity
Disulfide bondi594 ↔ 604 By similarity
Disulfide bondi598 ↔ 609 By similarity
Disulfide bondi611 ↔ 620 By similarity
Glycosylationi788 – 7881N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1018 – 10181N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1079 – 10791N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1093 – 10931N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1119 – 11191N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1184 – 11841N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1210 – 12101N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1275 – 12751N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1301 – 13011N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1354 – 13541N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1364 – 13641N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1394 – 13941N-linked (GlcNAc...)1 Publication
Glycosylationi1443 – 14431N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1718 – 17181N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1969 – 19691N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2071 – 20711N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ80YX1.
PaxDbiQ80YX1.
PRIDEiQ80YX1.

PTM databases

PhosphoSiteiQ80YX1.

Expressioni

Tissue specificityi

High levels of isoform 2 in lung and brain of newborn mice. High levels of isoform 5 in thymus, moderate levels in brain of newborn and adult mice. Low level of isoform 2 in adult brain.1 Publication

Developmental stagei

In kidney, isoform 2 is expressed at birth and isoform 5 at 2 weeks of age. In intestine, isoform 5 is expressed in day 13 embryos and isoform 2 at birth. In cerebellum, high levels of isoform 2 in day 17 embryos are down-regulated to moderate levels in newborn mice and undetectable levels in adult mice. Similarly, moderate levels of isoform 2 expressed in cerebrum of day 17 embryos are gradually down-regulated to undetectable levels in adult mice.2 Publications

Gene expression databases

ArrayExpressiQ80YX1.
BgeeiQ80YX1.
CleanExiMM_TNC.
GenevestigatoriQ80YX1.

Interactioni

Subunit structurei

Homohexamer; disulfide-linked. A homotrimer may be formed in the triple coiled-coil region and may be stabilized by disulfide rings at both ends. Two of such half-hexabrachions may be disulfide linked within the central globule. Interacts with CSPG4 By similarity.By similarity

Protein-protein interaction databases

IntActiQ80YX1. 1 interaction.
MINTiMINT-4110071.

Structurei

3D structure databases

ProteinModelPortaliQ80YX1.
SMRiQ80YX1. Positions 158-2098.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini174 – 18512EGF-like 1; incomplete
Add
BLAST
Domaini186 – 21631EGF-like 2
Add
BLAST
Domaini217 – 24731EGF-like 3
Add
BLAST
Domaini248 – 27932EGF-like 4
Add
BLAST
Domaini280 – 31031EGF-like 5
Add
BLAST
Domaini311 – 34131EGF-like 6
Add
BLAST
Domaini342 – 37231EGF-like 7
Add
BLAST
Domaini373 – 40331EGF-like 8
Add
BLAST
Domaini404 – 43431EGF-like 9
Add
BLAST
Domaini435 – 46531EGF-like 10
Add
BLAST
Domaini466 – 49631EGF-like 11
Add
BLAST
Domaini497 – 52731EGF-like 12
Add
BLAST
Domaini528 – 55831EGF-like 13
Add
BLAST
Domaini559 – 58931EGF-like 14
Add
BLAST
Domaini590 – 62132EGF-like 15
Add
BLAST
Domaini625 – 71591Fibronectin type-III 1
Add
BLAST
Domaini716 – 80489Fibronectin type-III 2
Add
BLAST
Domaini805 – 89490Fibronectin type-III 3
Add
BLAST
Domaini895 – 98894Fibronectin type-III 4
Add
BLAST
Domaini989 – 107789Fibronectin type-III 5
Add
BLAST
Domaini1078 – 116588Fibronectin type-III 6
Add
BLAST
Domaini1167 – 125993Fibronectin type-III 7
Add
BLAST
Domaini1260 – 134889Fibronectin type-III 8
Add
BLAST
Domaini1349 – 144092Fibronectin type-III 9
Add
BLAST
Domaini1442 – 153089Fibronectin type-III 10
Add
BLAST
Domaini1531 – 162090Fibronectin type-III 11
Add
BLAST
Domaini1621 – 171090Fibronectin type-III 12
Add
BLAST
Domaini1711 – 179787Fibronectin type-III 13
Add
BLAST
Domaini1798 – 188689Fibronectin type-III 14
Add
BLAST
Domaini1884 – 2099216Fibrinogen C-terminal
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili118 – 14225 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Belongs to the tenascin family.
Contains 15 EGF-like domains.

Keywords - Domaini

Coiled coil, EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00750000117522.
HOGENOMiHOG000234355.
HOVERGENiHBG008949.
InParanoidiQ80YX1.
KOiK06252.
OMAiGCCLQPA.
OrthoDBiEOG7X9G60.
PhylomeDBiQ80YX1.
TreeFamiTF329915.

Family and domain databases

Gene3Di2.60.40.10. 14 hits.
3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR013111. EGF_extracell.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF07974. EGF_2. 7 hits.
PF00147. Fibrinogen_C. 1 hit.
PF00041. fn3. 14 hits.
PF12661. hEGF. 2 hits.
[Graphical view]
SMARTiSM00181. EGF. 12 hits.
SM00186. FBG. 1 hit.
SM00060. FN3. 14 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 11 hits.
SSF56496. SSF56496. 1 hit.
PROSITEiPS00022. EGF_1. 15 hits.
PS01186. EGF_2. 14 hits.
PS50026. EGF_3. 5 hits.
PS51406. FIBRINOGEN_C_2. 1 hit.
PS50853. FN3. 14 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 11 Publication (identifier: Q80YX1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGAVTWLLPG IFLALFALTP EGGVLKKIIR HKRESGLNMT LPEENQPVVF     50
NHIYNIKLPM GSQCSVDLES ASGEKDLTPT PESSGSFQEH TVDGENQIVF 100
THRINIPRRA CGCAAAPDVK ELLSRLEELE LLVSSLREQC TMGTGCCLQP 150
AEGRLDTRPF CSGRGNFSAE GCGCVCEPGW KGPNCSEPDC PGNCNLRGQC 200
LDGQCICDEG FTGEDCSQLA CPNDCNDQGR CVNGVCVCFE GYAGPDCGLE 250
VCPVPCSEEH GMCVDGRCVC KDGFAGEDCN EPLCLNNCYN RGRCVENECV 300
CDEGFTGEDC SELICPNDCF DRGRCINGTC YCEEGFTGED CGELTCPNDC 350
QGRGQCEEGQ CVCNEGFAGA DCSEKRCPAD CHHRGRCLNG QCECDDGFTG 400
ADCGDLQCPN GCSGHGRCVN GQCVCDEGYT GEDCSQRRCP NDCHNRGLCV 450
QGKCICEQGF KGFDCSEMSC PNDCHQHGRC VNGMCICDDD YTGEDCRDRR 500
CPRDCSQRGR CVDGQCICED GFTGPDCAEL SCPSDCHGHG RCVNGQCICH 550
EGFTGKDCKE QRCPSDCHGQ GRCEDGQCIC HEGFTGLDCG QRSCPNDCSN 600
QGQCVSGRCI CNEGYTGIDC SEVSPPKDLI VTEVTEETVN LAWDNEMRVT 650
EYLIMYTPTH ADGLEMQFRV PGDQTSTTIR ELEPGVEYFI RVFAILENKR 700
SIPVSARVAT YLPAPEGLKF KSIKETSVEV EWDPLDIAFE TWEIIFRNMN 750
KEDEGEITKS LRRPETSYRQ TGLAPGQEYE ISLHIVKNNT RGPGLKKVTT 800
TRLDAPSHIE VKDVTDTTAL ITWFKPLAEI DSIELSYGIK DVPGDRTTID 850
LTHEDNQYSI GNLRPDTEYE VSLISRRVDM ASNPAKETFI TGLDAPRNLR 900
RVSQTDNSIT LEWRNVKADI DSYRIKYAPI SGGDHAEIDV PKSQQATTKT 950
TLTGLRPGTE YGIGVSAVKG DKESDPATIN AATEIDAPKD LRVSETTQDS 1000
LTFFWTTPLA KFDRYRLNYS LPTGQSMEVQ LPKDATSHVL TDLEPGQEYT 1050
VLLIAEKGRH KSKPARVKAS TEEVPSLENL TVTEAGWDGL RLNWTADDLA 1100
YEYFVIQVQE ANNVETAHNF TVPGNLRAAD IPGLKVATSY RVSIYGVARG 1150
YRTPVLSAET STGTTPNLGE VTVAEVGWDA LTLNWTAPEG AYKNFFIQVL 1200
EADTTQTVQN LTVPGGLRSV DLPGLKAATR YYITLRGVTQ DFGTAPLSVE 1250
VLTEDLPQLG GLSVTEVSWD GLTLNWTTDD LAYKHFVVQV QEANNVEAAQ 1300
NLTVPGSLRA VDIPGLKADT PYRVSIYGVI QGYRTPMLST DVSTAREPEI 1350
GNLNVSDVTP KSFNLSWTAT DGIFDMFTIE IIDSNRLLQT AEHNISGAER 1400
TAHISGLPPS TDFIVYLSGI APSIRTKTIS TTATTEALPL LENLTISDTN 1450
PYGFTVSWTA SENAFDSFLV TVVDSGKLLD PQEFTLSGTQ RKLELRGLIT 1500
GIGYEVLVSG FTQGHQTKPL RAETITEAEP EVDNLLVSDA TPDGFRLSWT 1550
ADEGIFDSFV IRIRDTKKQS EPQEISLPSP ERTRDITGLR EATEYEIELY 1600
GISRGRRSQP VSAIATTAMG SPKEIMFSDI TENAATVSWR APTAQVESFR 1650
ITYVPMTGGA PSMVTVDGTD TETRLVKLTP GVEYRVSVIA MKGFEESDPV 1700
SGTLITALDG PSGLLIANIT DSEALAMWQP AIATVDSYVI SYTGERVPEV 1750
TRTVSGNTVE YELHDLEPAT EYILSIFAEK GQQKSSTIAT KFTTDLDSPR 1800
EFTATEVQSE TALLTWRPPR ASVTGYLLVY ESVDGTVKEV IVGPDTTSYS 1850
LADLSPSTHY SARIQALSGS LRSKLIQTIF TTIGLLYPFP RDCSQAMLNG 1900
DTTSGLYTIY INGDKTQALE VYCDMTSDGG GWIVFLRRKN GREDFYRNWK 1950
AYAAGFGDRR EEFWLGLDNL SKITAQGQYE LRVDLQDHGE SAYAVYDRFS 2000
VGDAKSRYKL KVEGYSGTAG DSMNYHNGRS FSTYDKDTDS AITNCALSYK 2050
GAFWYKNCHR VNLMGRYGDN NHSQGVNWFH WKGHEYSIQF AEMKLRPSNF 2100
RNLEGRRKRA 2110
Length:2,110
Mass (Da):231,807
Last modified:June 1, 2003 - v1
Checksum:iA1FEA96F8BC2FE51
GO
Isoform 21 Publication (identifier: Q80YX1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1436-1526: Missing.

Show »
Length:2,019
Mass (Da):221,879
Checksum:i27C4BFFA2024304C
GO
Isoform 31 Publication (identifier: Q80YX1-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1254-1616: Missing.

Show »
Length:1,747
Mass (Da):192,063
Checksum:i18733FA4332BC36B
GO
Isoform 41 Publication (identifier: Q80YX1-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1163-1616: Missing.

Show »
Length:1,656
Mass (Da):182,340
Checksum:i1DC087F9641641AE
GO
Isoform 51 Publication (identifier: Q80YX1-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1072-1616: Missing.

Show »
Length:1,565
Mass (Da):172,354
Checksum:iA8BA58FE720C4BBD
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1072 – 1616545Missing in isoform 5. 1 Publication
VSP_052144Add
BLAST
Alternative sequencei1163 – 1616454Missing in isoform 4. 1 Publication
VSP_052145Add
BLAST
Alternative sequencei1254 – 1616363Missing in isoform 3. 1 Publication
VSP_052146Add
BLAST
Alternative sequencei1436 – 152691Missing in isoform 2. 1 Publication
VSP_052147Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti202 – 2021D → E in CAA39751. 1 Publication
Sequence conflicti318 – 3181D → S in CAA39751. 1 Publication
Sequence conflicti1019 – 10191Y → S in CAA39751. 1 Publication
Sequence conflicti1025 – 10251Q → H in CAA39751. 1 Publication
Sequence conflicti1306 – 13061G → S in CAA39751. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D90343 mRNA. Translation: BAA14355.1.
X56304 mRNA. Translation: CAA39751.1.
AL732556 Genomic DNA. Translation: CAD83047.1.
AL732556 Genomic DNA. Translation: CAD83048.1.
CCDSiCCDS18265.1. [Q80YX1-2]
PIRiJQ1322.
RefSeqiNP_035737.2. NM_011607.3. [Q80YX1-2]
XP_006537837.1. XM_006537774.1. [Q80YX1-1]
UniGeneiMm.454219.
Mm.980.

Genome annotation databases

EnsembliENSMUST00000030056; ENSMUSP00000030056; ENSMUSG00000028364. [Q80YX1-2]
ENSMUST00000107372; ENSMUSP00000102995; ENSMUSG00000028364. [Q80YX1-1]
ENSMUST00000107377; ENSMUSP00000103000; ENSMUSG00000028364. [Q80YX1-2]
GeneIDi21923.
KEGGimmu:21923.
UCSCiuc008thg.2. mouse. [Q80YX1-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D90343 mRNA. Translation: BAA14355.1 .
X56304 mRNA. Translation: CAA39751.1 .
AL732556 Genomic DNA. Translation: CAD83047.1 .
AL732556 Genomic DNA. Translation: CAD83048.1 .
CCDSi CCDS18265.1. [Q80YX1-2 ]
PIRi JQ1322.
RefSeqi NP_035737.2. NM_011607.3. [Q80YX1-2 ]
XP_006537837.1. XM_006537774.1. [Q80YX1-1 ]
UniGenei Mm.454219.
Mm.980.

3D structure databases

ProteinModelPortali Q80YX1.
SMRi Q80YX1. Positions 158-2098.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q80YX1. 1 interaction.
MINTi MINT-4110071.

PTM databases

PhosphoSitei Q80YX1.

Proteomic databases

MaxQBi Q80YX1.
PaxDbi Q80YX1.
PRIDEi Q80YX1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000030056 ; ENSMUSP00000030056 ; ENSMUSG00000028364 . [Q80YX1-2 ]
ENSMUST00000107372 ; ENSMUSP00000102995 ; ENSMUSG00000028364 . [Q80YX1-1 ]
ENSMUST00000107377 ; ENSMUSP00000103000 ; ENSMUSG00000028364 . [Q80YX1-2 ]
GeneIDi 21923.
KEGGi mmu:21923.
UCSCi uc008thg.2. mouse. [Q80YX1-2 ]

Organism-specific databases

CTDi 3371.
MGIi MGI:101922. Tnc.

Phylogenomic databases

eggNOGi NOG12793.
GeneTreei ENSGT00750000117522.
HOGENOMi HOG000234355.
HOVERGENi HBG008949.
InParanoidi Q80YX1.
KOi K06252.
OMAi GCCLQPA.
OrthoDBi EOG7X9G60.
PhylomeDBi Q80YX1.
TreeFami TF329915.

Enzyme and pathway databases

Reactomei REACT_196606. ECM proteoglycans.
REACT_196644. Syndecan interactions.
REACT_216309. Integrin cell surface interactions.

Miscellaneous databases

NextBioi 301496.
PROi Q80YX1.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q80YX1.
Bgeei Q80YX1.
CleanExi MM_TNC.
Genevestigatori Q80YX1.

Family and domain databases

Gene3Di 2.60.40.10. 14 hits.
3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProi IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR013111. EGF_extracell.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
[Graphical view ]
Pfami PF07974. EGF_2. 7 hits.
PF00147. Fibrinogen_C. 1 hit.
PF00041. fn3. 14 hits.
PF12661. hEGF. 2 hits.
[Graphical view ]
SMARTi SM00181. EGF. 12 hits.
SM00186. FBG. 1 hit.
SM00060. FN3. 14 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 11 hits.
SSF56496. SSF56496. 1 hit.
PROSITEi PS00022. EGF_1. 15 hits.
PS01186. EGF_2. 14 hits.
PS50026. EGF_3. 5 hits.
PS51406. FIBRINOGEN_C_2. 1 hit.
PS50853. FN3. 14 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Murine tenascin: cDNA cloning, structure and temporal expression of isoforms."
    Saga Y., Tsukamoto T., Jing N., Kusakabe M., Sakakura T.
    Gene 104:177-185(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3; 4 AND 5), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: GRS.
    Tissue: Mammary tumor.
  2. "Amino acid sequence of mouse tenascin and differential expression of two tenascin isoforms during embryogenesis."
    Weller A., Beck S., Ekblom P.
    J. Cell Biol. 112:355-362(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 5), DEVELOPMENTAL STAGE, GLYCOSYLATION.
    Strain: NMRI X 129.
    Tissue: Embryo.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "Enhanced novelty-induced activity, reduced anxiety, delayed resynchronization to daylight reversal and weaker muscle strength in tenascin-C-deficient mice."
    Morellini F., Schachner M.
    Eur. J. Neurosci. 23:1255-1268(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  5. "Proteome-wide characterization of N-glycosylation events by diagonal chromatography."
    Ghesquiere B., Van Damme J., Martens L., Vandekerckhove J., Gevaert K.
    J. Proteome Res. 5:2438-2447(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1394.
    Strain: C57BL/6.
    Tissue: Plasma.

Entry informationi

Entry nameiTENA_MOUSE
AccessioniPrimary (citable) accession number: Q80YX1
Secondary accession number(s): Q64706, Q80YX2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: June 1, 2003
Last modified: September 3, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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