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Q80YX1

- TENA_MOUSE

UniProt

Q80YX1 - TENA_MOUSE

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Protein

Tenascin

Gene

Tnc

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth when provided to neurons in culture. May play a role in supporting the growth of epithelial tumors. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6.By similarity1 Publication

GO - Molecular functioni

  1. syndecan binding Source: MGI

GO - Biological processi

  1. bud outgrowth involved in lung branching Source: Ensembl
  2. cell adhesion Source: UniProtKB-KW
  3. cellular response to prostaglandin D stimulus Source: Ensembl
  4. cellular response to retinoic acid Source: Ensembl
  5. cellular response to vitamin D Source: Ensembl
  6. mesenchymal-epithelial cell signaling involved in prostate gland development Source: MGI
  7. negative regulation of cell adhesion Source: Ensembl
  8. neuromuscular junction development Source: MGI
  9. odontogenesis of dentin-containing tooth Source: Ensembl
  10. osteoblast differentiation Source: Ensembl
  11. peripheral nervous system axon regeneration Source: MGI
  12. positive regulation of cell proliferation Source: MGI
  13. positive regulation of gene expression Source: MGI
  14. prostate gland epithelium morphogenesis Source: MGI
  15. response to ethanol Source: Ensembl
  16. response to fibroblast growth factor Source: Ensembl
  17. response to mechanical stimulus Source: Ensembl
  18. wound healing Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiREACT_196606. ECM proteoglycans.
REACT_196644. Syndecan interactions.
REACT_216309. Integrin cell surface interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Tenascin
Short name:
TN
Alternative name(s):
Hexabrachion
Tenascin-C
Short name:
TN-C
Gene namesi
Name:TncImported
Synonyms:HxbImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:101922. Tnc.

Subcellular locationi

GO - Cellular componenti

  1. basement membrane Source: MGI
  2. extracellular matrix Source: UniProtKB
  3. extracellular region Source: MGI
  4. extracellular space Source: Ensembl
  5. interstitial matrix Source: MGI
  6. membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Disruption phenotypei

Mice show enhanced novelty-induced activity, reduced anxiety, delayed resynchronization to daylight reversal and weaker muscle strength.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222By similarityAdd
BLAST
Chaini23 – 21102088TenascinBy similarityPRO_0000248607Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi38 – 381N-linked (GlcNAc...)Sequence Analysis
Glycosylationi166 – 1661N-linked (GlcNAc...)Sequence Analysis
Glycosylationi184 – 1841N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi190 ↔ 200Sequence Analysis
Disulfide bondi194 ↔ 205Sequence Analysis
Disulfide bondi207 ↔ 216Sequence Analysis
Disulfide bondi221 ↔ 231Sequence Analysis
Disulfide bondi225 ↔ 236Sequence Analysis
Disulfide bondi238 ↔ 247Sequence Analysis
Disulfide bondi252 ↔ 263Sequence Analysis
Disulfide bondi256 ↔ 268Sequence Analysis
Disulfide bondi270 ↔ 279Sequence Analysis
Disulfide bondi284 ↔ 294Sequence Analysis
Disulfide bondi288 ↔ 299Sequence Analysis
Disulfide bondi301 ↔ 310Sequence Analysis
Disulfide bondi315 ↔ 325Sequence Analysis
Disulfide bondi319 ↔ 330Sequence Analysis
Glycosylationi327 – 3271N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi332 ↔ 341Sequence Analysis
Disulfide bondi346 ↔ 356Sequence Analysis
Disulfide bondi350 ↔ 361Sequence Analysis
Disulfide bondi363 ↔ 372Sequence Analysis
Disulfide bondi377 ↔ 387Sequence Analysis
Disulfide bondi381 ↔ 392Sequence Analysis
Disulfide bondi394 ↔ 403Sequence Analysis
Disulfide bondi408 ↔ 418Sequence Analysis
Disulfide bondi412 ↔ 423Sequence Analysis
Disulfide bondi425 ↔ 434Sequence Analysis
Disulfide bondi439 ↔ 449Sequence Analysis
Disulfide bondi443 ↔ 454Sequence Analysis
Disulfide bondi456 ↔ 465Sequence Analysis
Disulfide bondi470 ↔ 480Sequence Analysis
Disulfide bondi474 ↔ 485Sequence Analysis
Disulfide bondi487 ↔ 496Sequence Analysis
Disulfide bondi501 ↔ 511Sequence Analysis
Disulfide bondi505 ↔ 516Sequence Analysis
Disulfide bondi518 ↔ 527Sequence Analysis
Disulfide bondi532 ↔ 542Sequence Analysis
Disulfide bondi536 ↔ 547Sequence Analysis
Disulfide bondi549 ↔ 558Sequence Analysis
Disulfide bondi563 ↔ 573Sequence Analysis
Disulfide bondi567 ↔ 578Sequence Analysis
Disulfide bondi580 ↔ 589Sequence Analysis
Disulfide bondi594 ↔ 604Sequence Analysis
Disulfide bondi598 ↔ 609Sequence Analysis
Disulfide bondi611 ↔ 620Sequence Analysis
Glycosylationi788 – 7881N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1018 – 10181N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1079 – 10791N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1093 – 10931N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1119 – 11191N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1184 – 11841N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1210 – 12101N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1275 – 12751N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1301 – 13011N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1354 – 13541N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1364 – 13641N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1394 – 13941N-linked (GlcNAc...)1 Publication
Glycosylationi1443 – 14431N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1718 – 17181N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1969 – 19691N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2071 – 20711N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

N-glycosylated.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ80YX1.
PaxDbiQ80YX1.
PRIDEiQ80YX1.

PTM databases

PhosphoSiteiQ80YX1.

Expressioni

Tissue specificityi

High levels of isoform 2 in lung and brain of newborn mice. High levels of isoform 5 in thymus, moderate levels in brain of newborn and adult mice. Low level of isoform 2 in adult brain.1 Publication

Developmental stagei

In kidney, isoform 2 is expressed at birth and isoform 5 at 2 weeks of age. In intestine, isoform 5 is expressed in day 13 embryos and isoform 2 at birth. In cerebellum, high levels of isoform 2 in day 17 embryos are down-regulated to moderate levels in newborn mice and undetectable levels in adult mice. Similarly, moderate levels of isoform 2 expressed in cerebrum of day 17 embryos are gradually down-regulated to undetectable levels in adult mice.2 Publications

Gene expression databases

BgeeiQ80YX1.
CleanExiMM_TNC.
ExpressionAtlasiQ80YX1. baseline and differential.
GenevestigatoriQ80YX1.

Interactioni

Subunit structurei

Homohexamer; disulfide-linked. A homotrimer may be formed in the triple coiled-coil region and may be stabilized by disulfide rings at both ends. Two of such half-hexabrachions may be disulfide linked within the central globule. Interacts with CSPG4 (By similarity).By similarity

Protein-protein interaction databases

IntActiQ80YX1. 1 interaction.
MINTiMINT-4110071.

Structurei

3D structure databases

ProteinModelPortaliQ80YX1.
SMRiQ80YX1. Positions 158-1343, 1348-2098.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini174 – 18512EGF-like 1; incompletePROSITE-ProRule annotationAdd
BLAST
Domaini186 – 21631EGF-like 2PROSITE-ProRule annotationAdd
BLAST
Domaini217 – 24731EGF-like 3PROSITE-ProRule annotationAdd
BLAST
Domaini248 – 27932EGF-like 4PROSITE-ProRule annotationAdd
BLAST
Domaini280 – 31031EGF-like 5PROSITE-ProRule annotationAdd
BLAST
Domaini311 – 34131EGF-like 6PROSITE-ProRule annotationAdd
BLAST
Domaini342 – 37231EGF-like 7PROSITE-ProRule annotationAdd
BLAST
Domaini373 – 40331EGF-like 8PROSITE-ProRule annotationAdd
BLAST
Domaini404 – 43431EGF-like 9PROSITE-ProRule annotationAdd
BLAST
Domaini435 – 46531EGF-like 10PROSITE-ProRule annotationAdd
BLAST
Domaini466 – 49631EGF-like 11PROSITE-ProRule annotationAdd
BLAST
Domaini497 – 52731EGF-like 12PROSITE-ProRule annotationAdd
BLAST
Domaini528 – 55831EGF-like 13PROSITE-ProRule annotationAdd
BLAST
Domaini559 – 58931EGF-like 14PROSITE-ProRule annotationAdd
BLAST
Domaini590 – 62132EGF-like 15PROSITE-ProRule annotationAdd
BLAST
Domaini625 – 71591Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini716 – 80489Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini805 – 89490Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST
Domaini895 – 98894Fibronectin type-III 4PROSITE-ProRule annotationAdd
BLAST
Domaini989 – 107789Fibronectin type-III 5PROSITE-ProRule annotationAdd
BLAST
Domaini1078 – 116588Fibronectin type-III 6PROSITE-ProRule annotationAdd
BLAST
Domaini1167 – 125993Fibronectin type-III 7PROSITE-ProRule annotationAdd
BLAST
Domaini1260 – 134889Fibronectin type-III 8PROSITE-ProRule annotationAdd
BLAST
Domaini1349 – 144092Fibronectin type-III 9PROSITE-ProRule annotationAdd
BLAST
Domaini1442 – 153089Fibronectin type-III 10PROSITE-ProRule annotationAdd
BLAST
Domaini1531 – 162090Fibronectin type-III 11PROSITE-ProRule annotationAdd
BLAST
Domaini1621 – 171090Fibronectin type-III 12PROSITE-ProRule annotationAdd
BLAST
Domaini1711 – 179787Fibronectin type-III 13PROSITE-ProRule annotationAdd
BLAST
Domaini1798 – 188689Fibronectin type-III 14PROSITE-ProRule annotationAdd
BLAST
Domaini1884 – 2099216Fibrinogen C-terminalPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili118 – 14225Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the tenascin family.Sequence Analysis
Contains 15 EGF-like domains.PROSITE-ProRule annotation
Contains 1 fibrinogen C-terminal domain.PROSITE-ProRule annotation
Contains 14 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00770000120463.
HOGENOMiHOG000234355.
HOVERGENiHBG008949.
InParanoidiQ80YX1.
KOiK06252.
OMAiGCCLQPA.
OrthoDBiEOG7X9G60.
PhylomeDBiQ80YX1.
TreeFamiTF329915.

Family and domain databases

Gene3Di2.60.40.10. 14 hits.
3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR013111. EGF_extracell.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF07974. EGF_2. 7 hits.
PF00147. Fibrinogen_C. 1 hit.
PF00041. fn3. 14 hits.
PF12661. hEGF. 2 hits.
[Graphical view]
SMARTiSM00181. EGF. 12 hits.
SM00186. FBG. 1 hit.
SM00060. FN3. 14 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 11 hits.
SSF56496. SSF56496. 1 hit.
PROSITEiPS00022. EGF_1. 15 hits.
PS01186. EGF_2. 14 hits.
PS50026. EGF_3. 5 hits.
PS51406. FIBRINOGEN_C_2. 1 hit.
PS50853. FN3. 14 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q80YX1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGAVTWLLPG IFLALFALTP EGGVLKKIIR HKRESGLNMT LPEENQPVVF
60 70 80 90 100
NHIYNIKLPM GSQCSVDLES ASGEKDLTPT PESSGSFQEH TVDGENQIVF
110 120 130 140 150
THRINIPRRA CGCAAAPDVK ELLSRLEELE LLVSSLREQC TMGTGCCLQP
160 170 180 190 200
AEGRLDTRPF CSGRGNFSAE GCGCVCEPGW KGPNCSEPDC PGNCNLRGQC
210 220 230 240 250
LDGQCICDEG FTGEDCSQLA CPNDCNDQGR CVNGVCVCFE GYAGPDCGLE
260 270 280 290 300
VCPVPCSEEH GMCVDGRCVC KDGFAGEDCN EPLCLNNCYN RGRCVENECV
310 320 330 340 350
CDEGFTGEDC SELICPNDCF DRGRCINGTC YCEEGFTGED CGELTCPNDC
360 370 380 390 400
QGRGQCEEGQ CVCNEGFAGA DCSEKRCPAD CHHRGRCLNG QCECDDGFTG
410 420 430 440 450
ADCGDLQCPN GCSGHGRCVN GQCVCDEGYT GEDCSQRRCP NDCHNRGLCV
460 470 480 490 500
QGKCICEQGF KGFDCSEMSC PNDCHQHGRC VNGMCICDDD YTGEDCRDRR
510 520 530 540 550
CPRDCSQRGR CVDGQCICED GFTGPDCAEL SCPSDCHGHG RCVNGQCICH
560 570 580 590 600
EGFTGKDCKE QRCPSDCHGQ GRCEDGQCIC HEGFTGLDCG QRSCPNDCSN
610 620 630 640 650
QGQCVSGRCI CNEGYTGIDC SEVSPPKDLI VTEVTEETVN LAWDNEMRVT
660 670 680 690 700
EYLIMYTPTH ADGLEMQFRV PGDQTSTTIR ELEPGVEYFI RVFAILENKR
710 720 730 740 750
SIPVSARVAT YLPAPEGLKF KSIKETSVEV EWDPLDIAFE TWEIIFRNMN
760 770 780 790 800
KEDEGEITKS LRRPETSYRQ TGLAPGQEYE ISLHIVKNNT RGPGLKKVTT
810 820 830 840 850
TRLDAPSHIE VKDVTDTTAL ITWFKPLAEI DSIELSYGIK DVPGDRTTID
860 870 880 890 900
LTHEDNQYSI GNLRPDTEYE VSLISRRVDM ASNPAKETFI TGLDAPRNLR
910 920 930 940 950
RVSQTDNSIT LEWRNVKADI DSYRIKYAPI SGGDHAEIDV PKSQQATTKT
960 970 980 990 1000
TLTGLRPGTE YGIGVSAVKG DKESDPATIN AATEIDAPKD LRVSETTQDS
1010 1020 1030 1040 1050
LTFFWTTPLA KFDRYRLNYS LPTGQSMEVQ LPKDATSHVL TDLEPGQEYT
1060 1070 1080 1090 1100
VLLIAEKGRH KSKPARVKAS TEEVPSLENL TVTEAGWDGL RLNWTADDLA
1110 1120 1130 1140 1150
YEYFVIQVQE ANNVETAHNF TVPGNLRAAD IPGLKVATSY RVSIYGVARG
1160 1170 1180 1190 1200
YRTPVLSAET STGTTPNLGE VTVAEVGWDA LTLNWTAPEG AYKNFFIQVL
1210 1220 1230 1240 1250
EADTTQTVQN LTVPGGLRSV DLPGLKAATR YYITLRGVTQ DFGTAPLSVE
1260 1270 1280 1290 1300
VLTEDLPQLG GLSVTEVSWD GLTLNWTTDD LAYKHFVVQV QEANNVEAAQ
1310 1320 1330 1340 1350
NLTVPGSLRA VDIPGLKADT PYRVSIYGVI QGYRTPMLST DVSTAREPEI
1360 1370 1380 1390 1400
GNLNVSDVTP KSFNLSWTAT DGIFDMFTIE IIDSNRLLQT AEHNISGAER
1410 1420 1430 1440 1450
TAHISGLPPS TDFIVYLSGI APSIRTKTIS TTATTEALPL LENLTISDTN
1460 1470 1480 1490 1500
PYGFTVSWTA SENAFDSFLV TVVDSGKLLD PQEFTLSGTQ RKLELRGLIT
1510 1520 1530 1540 1550
GIGYEVLVSG FTQGHQTKPL RAETITEAEP EVDNLLVSDA TPDGFRLSWT
1560 1570 1580 1590 1600
ADEGIFDSFV IRIRDTKKQS EPQEISLPSP ERTRDITGLR EATEYEIELY
1610 1620 1630 1640 1650
GISRGRRSQP VSAIATTAMG SPKEIMFSDI TENAATVSWR APTAQVESFR
1660 1670 1680 1690 1700
ITYVPMTGGA PSMVTVDGTD TETRLVKLTP GVEYRVSVIA MKGFEESDPV
1710 1720 1730 1740 1750
SGTLITALDG PSGLLIANIT DSEALAMWQP AIATVDSYVI SYTGERVPEV
1760 1770 1780 1790 1800
TRTVSGNTVE YELHDLEPAT EYILSIFAEK GQQKSSTIAT KFTTDLDSPR
1810 1820 1830 1840 1850
EFTATEVQSE TALLTWRPPR ASVTGYLLVY ESVDGTVKEV IVGPDTTSYS
1860 1870 1880 1890 1900
LADLSPSTHY SARIQALSGS LRSKLIQTIF TTIGLLYPFP RDCSQAMLNG
1910 1920 1930 1940 1950
DTTSGLYTIY INGDKTQALE VYCDMTSDGG GWIVFLRRKN GREDFYRNWK
1960 1970 1980 1990 2000
AYAAGFGDRR EEFWLGLDNL SKITAQGQYE LRVDLQDHGE SAYAVYDRFS
2010 2020 2030 2040 2050
VGDAKSRYKL KVEGYSGTAG DSMNYHNGRS FSTYDKDTDS AITNCALSYK
2060 2070 2080 2090 2100
GAFWYKNCHR VNLMGRYGDN NHSQGVNWFH WKGHEYSIQF AEMKLRPSNF
2110
RNLEGRRKRA
Length:2,110
Mass (Da):231,807
Last modified:June 1, 2003 - v1
Checksum:iA1FEA96F8BC2FE51
GO
Isoform 21 Publication (identifier: Q80YX1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1436-1526: Missing.

Show »
Length:2,019
Mass (Da):221,879
Checksum:i27C4BFFA2024304C
GO
Isoform 31 Publication (identifier: Q80YX1-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1254-1616: Missing.

Show »
Length:1,747
Mass (Da):192,063
Checksum:i18733FA4332BC36B
GO
Isoform 41 Publication (identifier: Q80YX1-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1163-1616: Missing.

Show »
Length:1,656
Mass (Da):182,340
Checksum:i1DC087F9641641AE
GO
Isoform 51 Publication (identifier: Q80YX1-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1072-1616: Missing.

Show »
Length:1,565
Mass (Da):172,354
Checksum:iA8BA58FE720C4BBD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti202 – 2021D → E in CAA39751. (PubMed:1703162)Curated
Sequence conflicti318 – 3181D → S in CAA39751. (PubMed:1703162)Curated
Sequence conflicti1019 – 10191Y → S in CAA39751. (PubMed:1703162)Curated
Sequence conflicti1025 – 10251Q → H in CAA39751. (PubMed:1703162)Curated
Sequence conflicti1306 – 13061G → S in CAA39751. (PubMed:1703162)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1072 – 1616545Missing in isoform 5. 2 PublicationsVSP_052144Add
BLAST
Alternative sequencei1163 – 1616454Missing in isoform 4. 1 PublicationVSP_052145Add
BLAST
Alternative sequencei1254 – 1616363Missing in isoform 3. 1 PublicationVSP_052146Add
BLAST
Alternative sequencei1436 – 152691Missing in isoform 2. 2 PublicationsVSP_052147Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D90343 mRNA. Translation: BAA14355.1.
X56304 mRNA. Translation: CAA39751.1.
AL732556 Genomic DNA. Translation: CAD83047.1.
AL732556 Genomic DNA. Translation: CAD83048.1.
CCDSiCCDS18265.1. [Q80YX1-2]
PIRiJQ1322.
RefSeqiNP_035737.2. NM_011607.3. [Q80YX1-2]
XP_006537837.1. XM_006537774.1. [Q80YX1-1]
UniGeneiMm.454219.
Mm.980.

Genome annotation databases

EnsembliENSMUST00000030056; ENSMUSP00000030056; ENSMUSG00000028364. [Q80YX1-2]
ENSMUST00000107372; ENSMUSP00000102995; ENSMUSG00000028364. [Q80YX1-1]
ENSMUST00000107377; ENSMUSP00000103000; ENSMUSG00000028364. [Q80YX1-2]
GeneIDi21923.
KEGGimmu:21923.
UCSCiuc008thg.2. mouse. [Q80YX1-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D90343 mRNA. Translation: BAA14355.1 .
X56304 mRNA. Translation: CAA39751.1 .
AL732556 Genomic DNA. Translation: CAD83047.1 .
AL732556 Genomic DNA. Translation: CAD83048.1 .
CCDSi CCDS18265.1. [Q80YX1-2 ]
PIRi JQ1322.
RefSeqi NP_035737.2. NM_011607.3. [Q80YX1-2 ]
XP_006537837.1. XM_006537774.1. [Q80YX1-1 ]
UniGenei Mm.454219.
Mm.980.

3D structure databases

ProteinModelPortali Q80YX1.
SMRi Q80YX1. Positions 158-1343, 1348-2098.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q80YX1. 1 interaction.
MINTi MINT-4110071.

PTM databases

PhosphoSitei Q80YX1.

Proteomic databases

MaxQBi Q80YX1.
PaxDbi Q80YX1.
PRIDEi Q80YX1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000030056 ; ENSMUSP00000030056 ; ENSMUSG00000028364 . [Q80YX1-2 ]
ENSMUST00000107372 ; ENSMUSP00000102995 ; ENSMUSG00000028364 . [Q80YX1-1 ]
ENSMUST00000107377 ; ENSMUSP00000103000 ; ENSMUSG00000028364 . [Q80YX1-2 ]
GeneIDi 21923.
KEGGi mmu:21923.
UCSCi uc008thg.2. mouse. [Q80YX1-2 ]

Organism-specific databases

CTDi 3371.
MGIi MGI:101922. Tnc.

Phylogenomic databases

eggNOGi NOG12793.
GeneTreei ENSGT00770000120463.
HOGENOMi HOG000234355.
HOVERGENi HBG008949.
InParanoidi Q80YX1.
KOi K06252.
OMAi GCCLQPA.
OrthoDBi EOG7X9G60.
PhylomeDBi Q80YX1.
TreeFami TF329915.

Enzyme and pathway databases

Reactomei REACT_196606. ECM proteoglycans.
REACT_196644. Syndecan interactions.
REACT_216309. Integrin cell surface interactions.

Miscellaneous databases

NextBioi 301496.
PROi Q80YX1.
SOURCEi Search...

Gene expression databases

Bgeei Q80YX1.
CleanExi MM_TNC.
ExpressionAtlasi Q80YX1. baseline and differential.
Genevestigatori Q80YX1.

Family and domain databases

Gene3Di 2.60.40.10. 14 hits.
3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProi IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR013111. EGF_extracell.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
[Graphical view ]
Pfami PF07974. EGF_2. 7 hits.
PF00147. Fibrinogen_C. 1 hit.
PF00041. fn3. 14 hits.
PF12661. hEGF. 2 hits.
[Graphical view ]
SMARTi SM00181. EGF. 12 hits.
SM00186. FBG. 1 hit.
SM00060. FN3. 14 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 11 hits.
SSF56496. SSF56496. 1 hit.
PROSITEi PS00022. EGF_1. 15 hits.
PS01186. EGF_2. 14 hits.
PS50026. EGF_3. 5 hits.
PS51406. FIBRINOGEN_C_2. 1 hit.
PS50853. FN3. 14 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Murine tenascin: cDNA cloning, structure and temporal expression of isoforms."
    Saga Y., Tsukamoto T., Jing N., Kusakabe M., Sakakura T.
    Gene 104:177-185(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3; 4 AND 5), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: GRSImported.
    Tissue: Mammary tumor1 Publication.
  2. "Amino acid sequence of mouse tenascin and differential expression of two tenascin isoforms during embryogenesis."
    Weller A., Beck S., Ekblom P.
    J. Cell Biol. 112:355-362(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 5), DEVELOPMENTAL STAGE, GLYCOSYLATION.
    Strain: NMRI X 129Imported.
    Tissue: EmbryoImported.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "Enhanced novelty-induced activity, reduced anxiety, delayed resynchronization to daylight reversal and weaker muscle strength in tenascin-C-deficient mice."
    Morellini F., Schachner M.
    Eur. J. Neurosci. 23:1255-1268(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  5. "Proteome-wide characterization of N-glycosylation events by diagonal chromatography."
    Ghesquiere B., Van Damme J., Martens L., Vandekerckhove J., Gevaert K.
    J. Proteome Res. 5:2438-2447(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1394.
    Strain: C57BL/6.
    Tissue: Plasma.

Entry informationi

Entry nameiTENA_MOUSE
AccessioniPrimary (citable) accession number: Q80YX1
Secondary accession number(s): Q64706, Q80YX2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: June 1, 2003
Last modified: November 26, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3