Q80YX1 (TENA_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tenascin
Short name=TN

Alternative name(s):
Hexabrachion
Tenascin-C
Short name=TN-C

Gene names

Name:	Tnc
Synonyms:	Hxb

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	2110 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth when provided to neurons in culture. May play a role in supporting the growth of epithelial tumors. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. Ref.4 UniProtKB P24821
Subunit structure	Homohexamer; disulfide-linked. A homotrimer may be formed in the triple coiled-coil region and may be stabilized by disulfide rings at both ends. Two of such half-hexabrachions may be disulfide linked within the central globule. Interacts with CSPG4 By similarity. UniProtKB P24821
Subcellular location	Secreted › extracellular space › extracellular matrix By similarity.
Tissue specificity	High levels of isoform 2 in lung and brain of newborn mice. High levels of isoform 5 in thymus, moderate levels in brain of newborn and adult mice. Low level of isoform 2 in adult brain. Ref.1
Developmental stage	In kidney, isoform 2 is expressed at birth and isoform 5 at 2 weeks of age. In intestine, isoform 5 is expressed in day 13 embryos and isoform 2 at birth. In cerebellum, high levels of isoform 2 in day 17 embryos are down-regulated to moderate levels in newborn mice and undetectable levels in adult mice. Similarly, moderate levels of isoform 2 expressed in cerebrum of day 17 embryos are gradually down-regulated to undetectable levels in adult mice. Ref.1 Ref.2
Post-translational modification	N-glycosylated. Ref.2
Disruption phenotype	Mice show enhanced novelty-induced activity, reduced anxiety, delayed resynchronization to daylight reversal and weaker muscle strength. Ref.4
Sequence similarities	Belongs to the tenascin family. Contains 15 EGF-like domains. Contains 1 fibrinogen C-terminal domain. Contains 14 fibronectin type-III domains.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Extracellular matrix Secreted
Coding sequence diversity	Alternative splicing
Domain	Coiled coil EGF-like domain Repeat Signal
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell adhesion Inferred from electronic annotation. Source: UniProtKB-KW mesenchymal-epithelial cell signaling involved in prostate gland development Inferred from mutant phenotype PubMed 18950615. Source: MGI neuromuscular junction development Inferred from mutant phenotype PubMed 9593587. Source: MGI peripheral nervous system axon regeneration Inferred from mutant phenotype PubMed 16262655. Source: MGI positive regulation of cell proliferation Inferred from direct assay PubMed 19690384. Source: MGI positive regulation of gene expression Inferred from direct assay PubMed 19690384. Source: MGI prostate gland epithelium morphogenesis Inferred from mutant phenotype PubMed 18950615. Source: MGI
Cellular_component	basement membrane Inferred from direct assay PubMed 18950615PubMed 7687262PubMed 9013311. Source: MGI extracellular space Inferred from electronic annotation. Source: Compara interstitial matrix Inferred from direct assay PubMed 11767049. Source: MGI
Molecular_function	syndecan binding Inferred from sequence orthology PubMed 8769660. Source: MGI
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 Ref.3 (identifier: Q80YX1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 Ref.1 (identifier: Q80YX1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1436-1526: Missing.

Isoform 3 Ref.1 (identifier: Q80YX1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1254-1616: Missing.

Isoform 4 Ref.1 (identifier: Q80YX1-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1163-1616: Missing.

Isoform 5 Ref.1 (identifier: Q80YX1-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1072-1616: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	By similarity UniProtKB P24821
	Chain	23 – 2110	2088	Tenascin By similarity UniProtKB P24821		PRO_0000248607
Regions
	Domain	174 – 185	12	EGF-like 1; incomplete
	Domain	186 – 216	31	EGF-like 2
	Domain	217 – 247	31	EGF-like 3
	Domain	248 – 279	32	EGF-like 4
	Domain	280 – 310	31	EGF-like 5
	Domain	311 – 341	31	EGF-like 6
	Domain	342 – 372	31	EGF-like 7
	Domain	373 – 403	31	EGF-like 8
	Domain	404 – 434	31	EGF-like 9
	Domain	435 – 465	31	EGF-like 10
	Domain	466 – 496	31	EGF-like 11
	Domain	497 – 527	31	EGF-like 12
	Domain	528 – 558	31	EGF-like 13
	Domain	559 – 589	31	EGF-like 14
	Domain	590 – 621	32	EGF-like 15
	Domain	622 – 710	89	Fibronectin type-III 1
	Domain	713 – 801	89	Fibronectin type-III 2
	Domain	802 – 891	90	Fibronectin type-III 3
	Domain	892 – 983	92	Fibronectin type-III 4
	Domain	984 – 1071	88	Fibronectin type-III 5
	Domain	1073 – 1164	92	Fibronectin type-III 6
	Domain	1166 – 1253	88	Fibronectin type-III 7
	Domain	1257 – 1344	88	Fibronectin type-III 8
	Domain	1348 – 1435	88	Fibronectin type-III 9
	Domain	1437 – 1526	90	Fibronectin type-III 10
	Domain	1528 – 1617	90	Fibronectin type-III 11
	Domain	1618 – 1706	89	Fibronectin type-III 12
	Domain	1707 – 1794	88	Fibronectin type-III 13
	Domain	1795 – 1882	88	Fibronectin type-III 14
	Domain	1884 – 2099	216	Fibrinogen C-terminal
	Coiled coil	118 – 142	25	Potential
Amino acid modifications
	Modified residue	70	1	Phosphoserine Ref.7
	Modified residue	72	1	Phosphoserine Ref.6 Ref.7
	Glycosylation	38	1	N-linked (GlcNAc...) Potential
	Glycosylation	166	1	N-linked (GlcNAc...) Potential
	Glycosylation	184	1	N-linked (GlcNAc...) Potential
	Glycosylation	327	1	N-linked (GlcNAc...) Potential
	Glycosylation	788	1	N-linked (GlcNAc...) Potential
	Glycosylation	1018	1	N-linked (GlcNAc...) Potential
	Glycosylation	1079	1	N-linked (GlcNAc...) Potential
	Glycosylation	1093	1	N-linked (GlcNAc...) Potential
	Glycosylation	1119	1	N-linked (GlcNAc...) Potential
	Glycosylation	1184	1	N-linked (GlcNAc...) Potential
	Glycosylation	1210	1	N-linked (GlcNAc...) Potential
	Glycosylation	1275	1	N-linked (GlcNAc...) Potential
	Glycosylation	1301	1	N-linked (GlcNAc...) Potential
	Glycosylation	1354	1	N-linked (GlcNAc...) Potential
	Glycosylation	1364	1	N-linked (GlcNAc...) Potential
	Glycosylation	1394	1	N-linked (GlcNAc...) Ref.5
	Glycosylation	1443	1	N-linked (GlcNAc...) Potential
	Glycosylation	1718	1	N-linked (GlcNAc...) Potential
	Glycosylation	1969	1	N-linked (GlcNAc...) Potential
	Glycosylation	2071	1	N-linked (GlcNAc...) Potential
	Disulfide bond	190 ↔ 200		By similarity
	Disulfide bond	194 ↔ 205		By similarity
	Disulfide bond	207 ↔ 216		By similarity
	Disulfide bond	221 ↔ 231		By similarity
	Disulfide bond	225 ↔ 236		By similarity
	Disulfide bond	238 ↔ 247		By similarity
	Disulfide bond	252 ↔ 263		By similarity
	Disulfide bond	256 ↔ 268		By similarity
	Disulfide bond	270 ↔ 279		By similarity
	Disulfide bond	284 ↔ 294		By similarity
	Disulfide bond	288 ↔ 299		By similarity
	Disulfide bond	301 ↔ 310		By similarity
	Disulfide bond	315 ↔ 325		By similarity
	Disulfide bond	319 ↔ 330		By similarity
	Disulfide bond	332 ↔ 341		By similarity
	Disulfide bond	346 ↔ 356		By similarity
	Disulfide bond	350 ↔ 361		By similarity
	Disulfide bond	363 ↔ 372		By similarity
	Disulfide bond	377 ↔ 387		By similarity
	Disulfide bond	381 ↔ 392		By similarity
	Disulfide bond	394 ↔ 403		By similarity
	Disulfide bond	408 ↔ 418		By similarity
	Disulfide bond	412 ↔ 423		By similarity
	Disulfide bond	425 ↔ 434		By similarity
	Disulfide bond	439 ↔ 449		By similarity
	Disulfide bond	443 ↔ 454		By similarity
	Disulfide bond	456 ↔ 465		By similarity
	Disulfide bond	470 ↔ 480		By similarity
	Disulfide bond	474 ↔ 485		By similarity
	Disulfide bond	487 ↔ 496		By similarity
	Disulfide bond	501 ↔ 511		By similarity
	Disulfide bond	505 ↔ 516		By similarity
	Disulfide bond	518 ↔ 527		By similarity
	Disulfide bond	532 ↔ 542		By similarity
	Disulfide bond	536 ↔ 547		By similarity
	Disulfide bond	549 ↔ 558		By similarity
	Disulfide bond	563 ↔ 573		By similarity
	Disulfide bond	567 ↔ 578		By similarity
	Disulfide bond	580 ↔ 589		By similarity
	Disulfide bond	594 ↔ 604		By similarity
	Disulfide bond	598 ↔ 609		By similarity
	Disulfide bond	611 ↔ 620		By similarity
Natural variations
	Alternative sequence	1072 – 1616	545	Missing in isoform 5. Ref.1		VSP_052144
	Alternative sequence	1163 – 1616	454	Missing in isoform 4. Ref.1		VSP_052145
	Alternative sequence	1254 – 1616	363	Missing in isoform 3. Ref.1		VSP_052146
	Alternative sequence	1436 – 1526	91	Missing in isoform 2. Ref.1		VSP_052147
Experimental info
	Sequence conflict	202	1	D → E in CAA39751. Ref.2
	Sequence conflict	318	1	D → S in CAA39751. Ref.2
	Sequence conflict	1019	1	Y → S in CAA39751. Ref.2
	Sequence conflict	1025	1	Q → H in CAA39751. Ref.2
	Sequence conflict	1306	1	G → S in CAA39751. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: A1FEA96F8BC2FE51	FASTA	2,110	231,807
	10 20 30 40 50 60 MGAVTWLLPG IFLALFALTP EGGVLKKIIR HKRESGLNMT LPEENQPVVF NHIYNIKLPM 70 80 90 100 110 120 GSQCSVDLES ASGEKDLTPT PESSGSFQEH TVDGENQIVF THRINIPRRA CGCAAAPDVK 130 140 150 160 170 180 ELLSRLEELE LLVSSLREQC TMGTGCCLQP AEGRLDTRPF CSGRGNFSAE GCGCVCEPGW 190 200 210 220 230 240 KGPNCSEPDC PGNCNLRGQC LDGQCICDEG FTGEDCSQLA CPNDCNDQGR CVNGVCVCFE 250 260 270 280 290 300 GYAGPDCGLE VCPVPCSEEH GMCVDGRCVC KDGFAGEDCN EPLCLNNCYN RGRCVENECV 310 320 330 340 350 360 CDEGFTGEDC SELICPNDCF DRGRCINGTC YCEEGFTGED CGELTCPNDC QGRGQCEEGQ 370 380 390 400 410 420 CVCNEGFAGA DCSEKRCPAD CHHRGRCLNG QCECDDGFTG ADCGDLQCPN GCSGHGRCVN 430 440 450 460 470 480 GQCVCDEGYT GEDCSQRRCP NDCHNRGLCV QGKCICEQGF KGFDCSEMSC PNDCHQHGRC 490 500 510 520 530 540 VNGMCICDDD YTGEDCRDRR CPRDCSQRGR CVDGQCICED GFTGPDCAEL SCPSDCHGHG 550 560 570 580 590 600 RCVNGQCICH EGFTGKDCKE QRCPSDCHGQ GRCEDGQCIC HEGFTGLDCG QRSCPNDCSN 610 620 630 640 650 660 QGQCVSGRCI CNEGYTGIDC SEVSPPKDLI VTEVTEETVN LAWDNEMRVT EYLIMYTPTH 670 680 690 700 710 720 ADGLEMQFRV PGDQTSTTIR ELEPGVEYFI RVFAILENKR SIPVSARVAT YLPAPEGLKF 730 740 750 760 770 780 KSIKETSVEV EWDPLDIAFE TWEIIFRNMN KEDEGEITKS LRRPETSYRQ TGLAPGQEYE 790 800 810 820 830 840 ISLHIVKNNT RGPGLKKVTT TRLDAPSHIE VKDVTDTTAL ITWFKPLAEI DSIELSYGIK 850 860 870 880 890 900 DVPGDRTTID LTHEDNQYSI GNLRPDTEYE VSLISRRVDM ASNPAKETFI TGLDAPRNLR 910 920 930 940 950 960 RVSQTDNSIT LEWRNVKADI DSYRIKYAPI SGGDHAEIDV PKSQQATTKT TLTGLRPGTE 970 980 990 1000 1010 1020 YGIGVSAVKG DKESDPATIN AATEIDAPKD LRVSETTQDS LTFFWTTPLA KFDRYRLNYS 1030 1040 1050 1060 1070 1080 LPTGQSMEVQ LPKDATSHVL TDLEPGQEYT VLLIAEKGRH KSKPARVKAS TEEVPSLENL 1090 1100 1110 1120 1130 1140 TVTEAGWDGL RLNWTADDLA YEYFVIQVQE ANNVETAHNF TVPGNLRAAD IPGLKVATSY 1150 1160 1170 1180 1190 1200 RVSIYGVARG YRTPVLSAET STGTTPNLGE VTVAEVGWDA LTLNWTAPEG AYKNFFIQVL 1210 1220 1230 1240 1250 1260 EADTTQTVQN LTVPGGLRSV DLPGLKAATR YYITLRGVTQ DFGTAPLSVE VLTEDLPQLG 1270 1280 1290 1300 1310 1320 GLSVTEVSWD GLTLNWTTDD LAYKHFVVQV QEANNVEAAQ NLTVPGSLRA VDIPGLKADT 1330 1340 1350 1360 1370 1380 PYRVSIYGVI QGYRTPMLST DVSTAREPEI GNLNVSDVTP KSFNLSWTAT DGIFDMFTIE 1390 1400 1410 1420 1430 1440 IIDSNRLLQT AEHNISGAER TAHISGLPPS TDFIVYLSGI APSIRTKTIS TTATTEALPL 1450 1460 1470 1480 1490 1500 LENLTISDTN PYGFTVSWTA SENAFDSFLV TVVDSGKLLD PQEFTLSGTQ RKLELRGLIT 1510 1520 1530 1540 1550 1560 GIGYEVLVSG FTQGHQTKPL RAETITEAEP EVDNLLVSDA TPDGFRLSWT ADEGIFDSFV 1570 1580 1590 1600 1610 1620 IRIRDTKKQS EPQEISLPSP ERTRDITGLR EATEYEIELY GISRGRRSQP VSAIATTAMG 1630 1640 1650 1660 1670 1680 SPKEIMFSDI TENAATVSWR APTAQVESFR ITYVPMTGGA PSMVTVDGTD TETRLVKLTP 1690 1700 1710 1720 1730 1740 GVEYRVSVIA MKGFEESDPV SGTLITALDG PSGLLIANIT DSEALAMWQP AIATVDSYVI 1750 1760 1770 1780 1790 1800 SYTGERVPEV TRTVSGNTVE YELHDLEPAT EYILSIFAEK GQQKSSTIAT KFTTDLDSPR 1810 1820 1830 1840 1850 1860 EFTATEVQSE TALLTWRPPR ASVTGYLLVY ESVDGTVKEV IVGPDTTSYS LADLSPSTHY 1870 1880 1890 1900 1910 1920 SARIQALSGS LRSKLIQTIF TTIGLLYPFP RDCSQAMLNG DTTSGLYTIY INGDKTQALE 1930 1940 1950 1960 1970 1980 VYCDMTSDGG GWIVFLRRKN GREDFYRNWK AYAAGFGDRR EEFWLGLDNL SKITAQGQYE 1990 2000 2010 2020 2030 2040 LRVDLQDHGE SAYAVYDRFS VGDAKSRYKL KVEGYSGTAG DSMNYHNGRS FSTYDKDTDS 2050 2060 2070 2080 2090 2100 AITNCALSYK GAFWYKNCHR VNLMGRYGDN NHSQGVNWFH WKGHEYSIQF AEMKLRPSNF 2110 RNLEGRRKRA
	Isoform 2 [UniParc]. Checksum: 27C4BFFA2024304C	FASTA	2,019	221,879
	10 20 30 40 50 60 MGAVTWLLPG IFLALFALTP EGGVLKKIIR HKRESGLNMT LPEENQPVVF NHIYNIKLPM 70 80 90 100 110 120 GSQCSVDLES ASGEKDLTPT PESSGSFQEH TVDGENQIVF THRINIPRRA CGCAAAPDVK 130 140 150 160 170 180 ELLSRLEELE LLVSSLREQC TMGTGCCLQP AEGRLDTRPF CSGRGNFSAE GCGCVCEPGW 190 200 210 220 230 240 KGPNCSEPDC PGNCNLRGQC LDGQCICDEG FTGEDCSQLA CPNDCNDQGR CVNGVCVCFE 250 260 270 280 290 300 GYAGPDCGLE VCPVPCSEEH GMCVDGRCVC KDGFAGEDCN EPLCLNNCYN RGRCVENECV 310 320 330 340 350 360 CDEGFTGEDC SELICPNDCF DRGRCINGTC YCEEGFTGED CGELTCPNDC QGRGQCEEGQ 370 380 390 400 410 420 CVCNEGFAGA DCSEKRCPAD CHHRGRCLNG QCECDDGFTG ADCGDLQCPN GCSGHGRCVN 430 440 450 460 470 480 GQCVCDEGYT GEDCSQRRCP NDCHNRGLCV QGKCICEQGF KGFDCSEMSC PNDCHQHGRC 490 500 510 520 530 540 VNGMCICDDD YTGEDCRDRR CPRDCSQRGR CVDGQCICED GFTGPDCAEL SCPSDCHGHG 550 560 570 580 590 600 RCVNGQCICH EGFTGKDCKE QRCPSDCHGQ GRCEDGQCIC HEGFTGLDCG QRSCPNDCSN 610 620 630 640 650 660 QGQCVSGRCI CNEGYTGIDC SEVSPPKDLI VTEVTEETVN LAWDNEMRVT EYLIMYTPTH 670 680 690 700 710 720 ADGLEMQFRV PGDQTSTTIR ELEPGVEYFI RVFAILENKR SIPVSARVAT YLPAPEGLKF 730 740 750 760 770 780 KSIKETSVEV EWDPLDIAFE TWEIIFRNMN KEDEGEITKS LRRPETSYRQ TGLAPGQEYE 790 800 810 820 830 840 ISLHIVKNNT RGPGLKKVTT TRLDAPSHIE VKDVTDTTAL ITWFKPLAEI DSIELSYGIK 850 860 870 880 890 900 DVPGDRTTID LTHEDNQYSI GNLRPDTEYE VSLISRRVDM ASNPAKETFI TGLDAPRNLR 910 920 930 940 950 960 RVSQTDNSIT LEWRNVKADI DSYRIKYAPI SGGDHAEIDV PKSQQATTKT TLTGLRPGTE 970 980 990 1000 1010 1020 YGIGVSAVKG DKESDPATIN AATEIDAPKD LRVSETTQDS LTFFWTTPLA KFDRYRLNYS 1030 1040 1050 1060 1070 1080 LPTGQSMEVQ LPKDATSHVL TDLEPGQEYT VLLIAEKGRH KSKPARVKAS TEEVPSLENL 1090 1100 1110 1120 1130 1140 TVTEAGWDGL RLNWTADDLA YEYFVIQVQE ANNVETAHNF TVPGNLRAAD IPGLKVATSY 1150 1160 1170 1180 1190 1200 RVSIYGVARG YRTPVLSAET STGTTPNLGE VTVAEVGWDA LTLNWTAPEG AYKNFFIQVL 1210 1220 1230 1240 1250 1260 EADTTQTVQN LTVPGGLRSV DLPGLKAATR YYITLRGVTQ DFGTAPLSVE VLTEDLPQLG 1270 1280 1290 1300 1310 1320 GLSVTEVSWD GLTLNWTTDD LAYKHFVVQV QEANNVEAAQ NLTVPGSLRA VDIPGLKADT 1330 1340 1350 1360 1370 1380 PYRVSIYGVI QGYRTPMLST DVSTAREPEI GNLNVSDVTP KSFNLSWTAT DGIFDMFTIE 1390 1400 1410 1420 1430 1440 IIDSNRLLQT AEHNISGAER TAHISGLPPS TDFIVYLSGI APSIRTKTIS TTATTEAEPE 1450 1460 1470 1480 1490 1500 VDNLLVSDAT PDGFRLSWTA DEGIFDSFVI RIRDTKKQSE PQEISLPSPE RTRDITGLRE 1510 1520 1530 1540 1550 1560 ATEYEIELYG ISRGRRSQPV SAIATTAMGS PKEIMFSDIT ENAATVSWRA PTAQVESFRI 1570 1580 1590 1600 1610 1620 TYVPMTGGAP SMVTVDGTDT ETRLVKLTPG VEYRVSVIAM KGFEESDPVS GTLITALDGP 1630 1640 1650 1660 1670 1680 SGLLIANITD SEALAMWQPA IATVDSYVIS YTGERVPEVT RTVSGNTVEY ELHDLEPATE 1690 1700 1710 1720 1730 1740 YILSIFAEKG QQKSSTIATK FTTDLDSPRE FTATEVQSET ALLTWRPPRA SVTGYLLVYE 1750 1760 1770 1780 1790 1800 SVDGTVKEVI VGPDTTSYSL ADLSPSTHYS ARIQALSGSL RSKLIQTIFT TIGLLYPFPR 1810 1820 1830 1840 1850 1860 DCSQAMLNGD TTSGLYTIYI NGDKTQALEV YCDMTSDGGG WIVFLRRKNG REDFYRNWKA 1870 1880 1890 1900 1910 1920 YAAGFGDRRE EFWLGLDNLS KITAQGQYEL RVDLQDHGES AYAVYDRFSV GDAKSRYKLK 1930 1940 1950 1960 1970 1980 VEGYSGTAGD SMNYHNGRSF STYDKDTDSA ITNCALSYKG AFWYKNCHRV NLMGRYGDNN 1990 2000 2010 HSQGVNWFHW KGHEYSIQFA EMKLRPSNFR NLEGRRKRA
	Isoform 3 [UniParc]. Checksum: 18733FA4332BC36B	FASTA	1,747	192,063
	10 20 30 40 50 60 MGAVTWLLPG IFLALFALTP EGGVLKKIIR HKRESGLNMT LPEENQPVVF NHIYNIKLPM 70 80 90 100 110 120 GSQCSVDLES ASGEKDLTPT PESSGSFQEH TVDGENQIVF THRINIPRRA CGCAAAPDVK 130 140 150 160 170 180 ELLSRLEELE LLVSSLREQC TMGTGCCLQP AEGRLDTRPF CSGRGNFSAE GCGCVCEPGW 190 200 210 220 230 240 KGPNCSEPDC PGNCNLRGQC LDGQCICDEG FTGEDCSQLA CPNDCNDQGR CVNGVCVCFE 250 260 270 280 290 300 GYAGPDCGLE VCPVPCSEEH GMCVDGRCVC KDGFAGEDCN EPLCLNNCYN RGRCVENECV 310 320 330 340 350 360 CDEGFTGEDC SELICPNDCF DRGRCINGTC YCEEGFTGED CGELTCPNDC QGRGQCEEGQ 370 380 390 400 410 420 CVCNEGFAGA DCSEKRCPAD CHHRGRCLNG QCECDDGFTG ADCGDLQCPN GCSGHGRCVN 430 440 450 460 470 480 GQCVCDEGYT GEDCSQRRCP NDCHNRGLCV QGKCICEQGF KGFDCSEMSC PNDCHQHGRC 490 500 510 520 530 540 VNGMCICDDD YTGEDCRDRR CPRDCSQRGR CVDGQCICED GFTGPDCAEL SCPSDCHGHG 550 560 570 580 590 600 RCVNGQCICH EGFTGKDCKE QRCPSDCHGQ GRCEDGQCIC HEGFTGLDCG QRSCPNDCSN 610 620 630 640 650 660 QGQCVSGRCI CNEGYTGIDC SEVSPPKDLI VTEVTEETVN LAWDNEMRVT EYLIMYTPTH 670 680 690 700 710 720 ADGLEMQFRV PGDQTSTTIR ELEPGVEYFI RVFAILENKR SIPVSARVAT YLPAPEGLKF 730 740 750 760 770 780 KSIKETSVEV EWDPLDIAFE TWEIIFRNMN KEDEGEITKS LRRPETSYRQ TGLAPGQEYE 790 800 810 820 830 840 ISLHIVKNNT RGPGLKKVTT TRLDAPSHIE VKDVTDTTAL ITWFKPLAEI DSIELSYGIK 850 860 870 880 890 900 DVPGDRTTID LTHEDNQYSI GNLRPDTEYE VSLISRRVDM ASNPAKETFI TGLDAPRNLR 910 920 930 940 950 960 RVSQTDNSIT LEWRNVKADI DSYRIKYAPI SGGDHAEIDV PKSQQATTKT TLTGLRPGTE 970 980 990 1000 1010 1020 YGIGVSAVKG DKESDPATIN AATEIDAPKD LRVSETTQDS LTFFWTTPLA KFDRYRLNYS 1030 1040 1050 1060 1070 1080 LPTGQSMEVQ LPKDATSHVL TDLEPGQEYT VLLIAEKGRH KSKPARVKAS TEEVPSLENL 1090 1100 1110 1120 1130 1140 TVTEAGWDGL RLNWTADDLA YEYFVIQVQE ANNVETAHNF TVPGNLRAAD IPGLKVATSY 1150 1160 1170 1180 1190 1200 RVSIYGVARG YRTPVLSAET STGTTPNLGE VTVAEVGWDA LTLNWTAPEG AYKNFFIQVL 1210 1220 1230 1240 1250 1260 EADTTQTVQN LTVPGGLRSV DLPGLKAATR YYITLRGVTQ DFGTAPLSVE VLTTAMGSPK 1270 1280 1290 1300 1310 1320 EIMFSDITEN AATVSWRAPT AQVESFRITY VPMTGGAPSM VTVDGTDTET RLVKLTPGVE 1330 1340 1350 1360 1370 1380 YRVSVIAMKG FEESDPVSGT LITALDGPSG LLIANITDSE ALAMWQPAIA TVDSYVISYT 1390 1400 1410 1420 1430 1440 GERVPEVTRT VSGNTVEYEL HDLEPATEYI LSIFAEKGQQ KSSTIATKFT TDLDSPREFT 1450 1460 1470 1480 1490 1500 ATEVQSETAL LTWRPPRASV TGYLLVYESV DGTVKEVIVG PDTTSYSLAD LSPSTHYSAR 1510 1520 1530 1540 1550 1560 IQALSGSLRS KLIQTIFTTI GLLYPFPRDC SQAMLNGDTT SGLYTIYING DKTQALEVYC 1570 1580 1590 1600 1610 1620 DMTSDGGGWI VFLRRKNGRE DFYRNWKAYA AGFGDRREEF WLGLDNLSKI TAQGQYELRV 1630 1640 1650 1660 1670 1680 DLQDHGESAY AVYDRFSVGD AKSRYKLKVE GYSGTAGDSM NYHNGRSFST YDKDTDSAIT 1690 1700 1710 1720 1730 1740 NCALSYKGAF WYKNCHRVNL MGRYGDNNHS QGVNWFHWKG HEYSIQFAEM KLRPSNFRNL EGRRKRA
	Isoform 4 [UniParc]. Checksum: 1DC087F9641641AE	FASTA	1,656	182,340
	10 20 30 40 50 60 MGAVTWLLPG IFLALFALTP EGGVLKKIIR HKRESGLNMT LPEENQPVVF NHIYNIKLPM 70 80 90 100 110 120 GSQCSVDLES ASGEKDLTPT PESSGSFQEH TVDGENQIVF THRINIPRRA CGCAAAPDVK 130 140 150 160 170 180 ELLSRLEELE LLVSSLREQC TMGTGCCLQP AEGRLDTRPF CSGRGNFSAE GCGCVCEPGW 190 200 210 220 230 240 KGPNCSEPDC PGNCNLRGQC LDGQCICDEG FTGEDCSQLA CPNDCNDQGR CVNGVCVCFE 250 260 270 280 290 300 GYAGPDCGLE VCPVPCSEEH GMCVDGRCVC KDGFAGEDCN EPLCLNNCYN RGRCVENECV 310 320 330 340 350 360 CDEGFTGEDC SELICPNDCF DRGRCINGTC YCEEGFTGED CGELTCPNDC QGRGQCEEGQ 370 380 390 400 410 420 CVCNEGFAGA DCSEKRCPAD CHHRGRCLNG QCECDDGFTG ADCGDLQCPN GCSGHGRCVN 430 440 450 460 470 480 GQCVCDEGYT GEDCSQRRCP NDCHNRGLCV QGKCICEQGF KGFDCSEMSC PNDCHQHGRC 490 500 510 520 530 540 VNGMCICDDD YTGEDCRDRR CPRDCSQRGR CVDGQCICED GFTGPDCAEL SCPSDCHGHG 550 560 570 580 590 600 RCVNGQCICH EGFTGKDCKE QRCPSDCHGQ GRCEDGQCIC HEGFTGLDCG QRSCPNDCSN 610 620 630 640 650 660 QGQCVSGRCI CNEGYTGIDC SEVSPPKDLI VTEVTEETVN LAWDNEMRVT EYLIMYTPTH 670 680 690 700 710 720 ADGLEMQFRV PGDQTSTTIR ELEPGVEYFI RVFAILENKR SIPVSARVAT YLPAPEGLKF 730 740 750 760 770 780 KSIKETSVEV EWDPLDIAFE TWEIIFRNMN KEDEGEITKS LRRPETSYRQ TGLAPGQEYE 790 800 810 820 830 840 ISLHIVKNNT RGPGLKKVTT TRLDAPSHIE VKDVTDTTAL ITWFKPLAEI DSIELSYGIK 850 860 870 880 890 900 DVPGDRTTID LTHEDNQYSI GNLRPDTEYE VSLISRRVDM ASNPAKETFI TGLDAPRNLR 910 920 930 940 950 960 RVSQTDNSIT LEWRNVKADI DSYRIKYAPI SGGDHAEIDV PKSQQATTKT TLTGLRPGTE 970 980 990 1000 1010 1020 YGIGVSAVKG DKESDPATIN AATEIDAPKD LRVSETTQDS LTFFWTTPLA KFDRYRLNYS 1030 1040 1050 1060 1070 1080 LPTGQSMEVQ LPKDATSHVL TDLEPGQEYT VLLIAEKGRH KSKPARVKAS TEEVPSLENL 1090 1100 1110 1120 1130 1140 TVTEAGWDGL RLNWTADDLA YEYFVIQVQE ANNVETAHNF TVPGNLRAAD IPGLKVATSY 1150 1160 1170 1180 1190 1200 RVSIYGVARG YRTPVLSAET STTAMGSPKE IMFSDITENA ATVSWRAPTA QVESFRITYV 1210 1220 1230 1240 1250 1260 PMTGGAPSMV TVDGTDTETR LVKLTPGVEY RVSVIAMKGF EESDPVSGTL ITALDGPSGL 1270 1280 1290 1300 1310 1320 LIANITDSEA LAMWQPAIAT VDSYVISYTG ERVPEVTRTV SGNTVEYELH DLEPATEYIL 1330 1340 1350 1360 1370 1380 SIFAEKGQQK SSTIATKFTT DLDSPREFTA TEVQSETALL TWRPPRASVT GYLLVYESVD 1390 1400 1410 1420 1430 1440 GTVKEVIVGP DTTSYSLADL SPSTHYSARI QALSGSLRSK LIQTIFTTIG LLYPFPRDCS 1450 1460 1470 1480 1490 1500 QAMLNGDTTS GLYTIYINGD KTQALEVYCD MTSDGGGWIV FLRRKNGRED FYRNWKAYAA 1510 1520 1530 1540 1550 1560 GFGDRREEFW LGLDNLSKIT AQGQYELRVD LQDHGESAYA VYDRFSVGDA KSRYKLKVEG 1570 1580 1590 1600 1610 1620 YSGTAGDSMN YHNGRSFSTY DKDTDSAITN CALSYKGAFW YKNCHRVNLM GRYGDNNHSQ 1630 1640 1650 GVNWFHWKGH EYSIQFAEMK LRPSNFRNLE GRRKRA
	Isoform 5 [UniParc]. Checksum: A8BA58FE720C4BBD	FASTA	1,565	172,354
	10 20 30 40 50 60 MGAVTWLLPG IFLALFALTP EGGVLKKIIR HKRESGLNMT LPEENQPVVF NHIYNIKLPM 70 80 90 100 110 120 GSQCSVDLES ASGEKDLTPT PESSGSFQEH TVDGENQIVF THRINIPRRA CGCAAAPDVK 130 140 150 160 170 180 ELLSRLEELE LLVSSLREQC TMGTGCCLQP AEGRLDTRPF CSGRGNFSAE GCGCVCEPGW 190 200 210 220 230 240 KGPNCSEPDC PGNCNLRGQC LDGQCICDEG FTGEDCSQLA CPNDCNDQGR CVNGVCVCFE 250 260 270 280 290 300 GYAGPDCGLE VCPVPCSEEH GMCVDGRCVC KDGFAGEDCN EPLCLNNCYN RGRCVENECV 310 320 330 340 350 360 CDEGFTGEDC SELICPNDCF DRGRCINGTC YCEEGFTGED CGELTCPNDC QGRGQCEEGQ 370 380 390 400 410 420 CVCNEGFAGA DCSEKRCPAD CHHRGRCLNG QCECDDGFTG ADCGDLQCPN GCSGHGRCVN 430 440 450 460 470 480 GQCVCDEGYT GEDCSQRRCP NDCHNRGLCV QGKCICEQGF KGFDCSEMSC PNDCHQHGRC 490 500 510 520 530 540 VNGMCICDDD YTGEDCRDRR CPRDCSQRGR CVDGQCICED GFTGPDCAEL SCPSDCHGHG 550 560 570 580 590 600 RCVNGQCICH EGFTGKDCKE QRCPSDCHGQ GRCEDGQCIC HEGFTGLDCG QRSCPNDCSN 610 620 630 640 650 660 QGQCVSGRCI CNEGYTGIDC SEVSPPKDLI VTEVTEETVN LAWDNEMRVT EYLIMYTPTH 670 680 690 700 710 720 ADGLEMQFRV PGDQTSTTIR ELEPGVEYFI RVFAILENKR SIPVSARVAT YLPAPEGLKF 730 740 750 760 770 780 KSIKETSVEV EWDPLDIAFE TWEIIFRNMN KEDEGEITKS LRRPETSYRQ TGLAPGQEYE 790 800 810 820 830 840 ISLHIVKNNT RGPGLKKVTT TRLDAPSHIE VKDVTDTTAL ITWFKPLAEI DSIELSYGIK 850 860 870 880 890 900 DVPGDRTTID LTHEDNQYSI GNLRPDTEYE VSLISRRVDM ASNPAKETFI TGLDAPRNLR 910 920 930 940 950 960 RVSQTDNSIT LEWRNVKADI DSYRIKYAPI SGGDHAEIDV PKSQQATTKT TLTGLRPGTE 970 980 990 1000 1010 1020 YGIGVSAVKG DKESDPATIN AATEIDAPKD LRVSETTQDS LTFFWTTPLA KFDRYRLNYS 1030 1040 1050 1060 1070 1080 LPTGQSMEVQ LPKDATSHVL TDLEPGQEYT VLLIAEKGRH KSKPARVKAS TTAMGSPKEI 1090 1100 1110 1120 1130 1140 MFSDITENAA TVSWRAPTAQ VESFRITYVP MTGGAPSMVT VDGTDTETRL VKLTPGVEYR 1150 1160 1170 1180 1190 1200 VSVIAMKGFE ESDPVSGTLI TALDGPSGLL IANITDSEAL AMWQPAIATV DSYVISYTGE 1210 1220 1230 1240 1250 1260 RVPEVTRTVS GNTVEYELHD LEPATEYILS IFAEKGQQKS STIATKFTTD LDSPREFTAT 1270 1280 1290 1300 1310 1320 EVQSETALLT WRPPRASVTG YLLVYESVDG TVKEVIVGPD TTSYSLADLS PSTHYSARIQ 1330 1340 1350 1360 1370 1380 ALSGSLRSKL IQTIFTTIGL LYPFPRDCSQ AMLNGDTTSG LYTIYINGDK TQALEVYCDM 1390 1400 1410 1420 1430 1440 TSDGGGWIVF LRRKNGREDF YRNWKAYAAG FGDRREEFWL GLDNLSKITA QGQYELRVDL 1450 1460 1470 1480 1490 1500 QDHGESAYAV YDRFSVGDAK SRYKLKVEGY SGTAGDSMNY HNGRSFSTYD KDTDSAITNC 1510 1520 1530 1540 1550 1560 ALSYKGAFWY KNCHRVNLMG RYGDNNHSQG VNWFHWKGHE YSIQFAEMKL RPSNFRNLEG RRKRA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Murine tenascin: cDNA cloning, structure and temporal expression of isoforms." Saga Y., Tsukamoto T., Jing N., Kusakabe M., Sakakura T. Gene 104:177-185(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3; 4 AND 5), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE. Strain: GRS. Tissue: Mammary tumor.
[2]	"Amino acid sequence of mouse tenascin and differential expression of two tenascin isoforms during embryogenesis." Weller A., Beck S., Ekblom P. J. Cell Biol. 112:355-362(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 5), DEVELOPMENTAL STAGE, GLYCOSYLATION. Strain: NMRI X 129. Tissue: Embryo.
[3]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[4]	"Enhanced novelty-induced activity, reduced anxiety, delayed resynchronization to daylight reversal and weaker muscle strength in tenascin-C-deficient mice." Morellini F., Schachner M. Eur. J. Neurosci. 23:1255-1268(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, DISRUPTION PHENOTYPE.
[5]	"Proteome-wide characterization of N-glycosylation events by diagonal chromatography." Ghesquiere B., Van Damme J., Martens L., Vandekerckhove J., Gevaert K. J. Proteome Res. 5:2438-2447(2006) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1394, MASS SPECTROMETRY. Strain: C57BL/6. Tissue: Plasma.
[6]	"Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations." Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M. Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-72, MASS SPECTROMETRY. Tissue: Brain cortex.
[7]	"Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry." Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., Faessler R., Mann M. J. Proteome Res. 7:5314-5326(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-70 AND SER-72, MASS SPECTROMETRY. Tissue: Melanoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D90343 mRNA. Translation: BAA14355.1. X56304 mRNA. Translation: CAA39751.1. AL732556 Genomic DNA. Translation: CAD83047.1. AL732556 Genomic DNA. Translation: CAD83048.1.
IPI	IPI00403938. IPI00420656. IPI00785310. IPI00785346. IPI00785360.
PIR	JQ1322.
RefSeq	NP_035737.2. NM_011607.3.
UniGene	Mm.454219. Mm.980.
3D structure databases
HSSP	HSSP built from PDB template 1TEN based on UniProtKB P24821.
ProteinModelPortal	Q80YX1.
SMR	Q80YX1. Positions 116-143, 158-2098.
ModBase	Search...
PTM databases
PhosphoSite	Q80YX1.
Proteomic databases
PaxDb	Q80YX1.
PRIDE	Q80YX1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000030056; ENSMUSP00000030056; ENSMUSG00000028364. ENSMUST00000107372; ENSMUSP00000102995; ENSMUSG00000028364. ENSMUST00000107377; ENSMUSP00000103000; ENSMUSG00000028364.
GeneID	21923.
KEGG	mmu:21923.
UCSC	uc008thg.2. mouse.
Organism-specific databases
CTD	3371.
MGI	MGI:101922. Tnc.
Phylogenomic databases
eggNOG	NOG12793.
GeneTree	ENSGT00690000102056.
HOGENOM	HOG000234355.
HOVERGEN	HBG008949.
InParanoid	Q80YX1.
KO	K06252.
OMA	GQRSCPN.
OrthoDB	EOG4MSCX9.
Gene expression databases
ArrayExpress	Q80YX1.
Bgee	Q80YX1.
CleanEx	MM_TNC.
Genevestigator	Q80YX1.
GermOnline	ENSMUSG00000028364. Mus musculus.
Family and domain databases
Gene3D	2.60.40.10. 14 hits. 3.90.215.10. 1 hit. 4.10.530.10. 1 hit.
InterPro	IPR000742. EG-like_dom. IPR013032. EGF-like_CS. IPR013111. EGF_extracell. IPR014716. Fibrinogen_a/b/g_C_1. IPR014715. Fibrinogen_a/b/g_C_2. IPR002181. Fibrinogen_a/b/g_C_dom. IPR003961. Fibronectin_type3. IPR013783. Ig-like_fold. [Graphical view]
Pfam	PF07974. EGF_2. 7 hits. PF00147. Fibrinogen_C. 1 hit. PF00041. fn3. 14 hits. PF12661. hEGF. 2 hits. [Graphical view]
SMART	SM00181. EGF. 12 hits. SM00186. FBG. 1 hit. SM00060. FN3. 14 hits. [Graphical view]
SUPFAM	SSF56496. Fibrinogen_a/b/g_C. 1 hit. SSF49265. FN_III-like. 14 hits.
PROSITE	PS00022. EGF_1. 15 hits. PS01186. EGF_2. 14 hits. PS50026. EGF_3. 5 hits. PS00514. FIBRINOGEN_C_1. False negative. PS51406. FIBRINOGEN_C_2. 1 hit. PS50853. FN3. 14 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	301496.
SOURCE	Search...

Entry information

Entry name

TENA_MOUSE

Accession

Primary (citable) accession number: Q80YX1
Secondary accession number(s): Q64706, Q80YX2

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 5, 2006
Last sequence update:	June 1, 2003
Last modified:	May 1, 2013
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program