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Q80YX1

- TENA_MOUSE

UniProt

Q80YX1 - TENA_MOUSE

Protein

Tenascin

Gene

Tnc

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth when provided to neurons in culture. May play a role in supporting the growth of epithelial tumors. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6.By similarity1 Publication

    GO - Molecular functioni

    1. syndecan binding Source: MGI

    GO - Biological processi

    1. bud outgrowth involved in lung branching Source: Ensembl
    2. cell adhesion Source: UniProtKB-KW
    3. cellular response to prostaglandin D stimulus Source: Ensembl
    4. cellular response to retinoic acid Source: Ensembl
    5. cellular response to vitamin D Source: Ensembl
    6. mesenchymal-epithelial cell signaling involved in prostate gland development Source: MGI
    7. negative regulation of cell adhesion Source: Ensembl
    8. neuromuscular junction development Source: MGI
    9. odontogenesis of dentin-containing tooth Source: Ensembl
    10. peripheral nervous system axon regeneration Source: MGI
    11. positive regulation of cell proliferation Source: MGI
    12. positive regulation of gene expression Source: MGI
    13. prostate gland epithelium morphogenesis Source: MGI
    14. response to ethanol Source: Ensembl
    15. response to fibroblast growth factor Source: Ensembl
    16. response to mechanical stimulus Source: Ensembl
    17. wound healing Source: Ensembl

    Keywords - Biological processi

    Cell adhesion

    Enzyme and pathway databases

    ReactomeiREACT_196606. ECM proteoglycans.
    REACT_196644. Syndecan interactions.
    REACT_216309. Integrin cell surface interactions.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tenascin
    Short name:
    TN
    Alternative name(s):
    Hexabrachion
    Tenascin-C
    Short name:
    TN-C
    Gene namesi
    Name:TncImported
    Synonyms:HxbImported
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:101922. Tnc.

    Subcellular locationi

    GO - Cellular componenti

    1. basement membrane Source: MGI
    2. extracellular region Source: MGI
    3. extracellular space Source: Ensembl
    4. interstitial matrix Source: MGI

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    Pathology & Biotechi

    Disruption phenotypei

    Mice show enhanced novelty-induced activity, reduced anxiety, delayed resynchronization to daylight reversal and weaker muscle strength.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222By similarityAdd
    BLAST
    Chaini23 – 21102088TenascinBy similarityPRO_0000248607Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi38 – 381N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi166 – 1661N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi184 – 1841N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi190 ↔ 200Sequence Analysis
    Disulfide bondi194 ↔ 205Sequence Analysis
    Disulfide bondi207 ↔ 216Sequence Analysis
    Disulfide bondi221 ↔ 231Sequence Analysis
    Disulfide bondi225 ↔ 236Sequence Analysis
    Disulfide bondi238 ↔ 247Sequence Analysis
    Disulfide bondi252 ↔ 263Sequence Analysis
    Disulfide bondi256 ↔ 268Sequence Analysis
    Disulfide bondi270 ↔ 279Sequence Analysis
    Disulfide bondi284 ↔ 294Sequence Analysis
    Disulfide bondi288 ↔ 299Sequence Analysis
    Disulfide bondi301 ↔ 310Sequence Analysis
    Disulfide bondi315 ↔ 325Sequence Analysis
    Disulfide bondi319 ↔ 330Sequence Analysis
    Glycosylationi327 – 3271N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi332 ↔ 341Sequence Analysis
    Disulfide bondi346 ↔ 356Sequence Analysis
    Disulfide bondi350 ↔ 361Sequence Analysis
    Disulfide bondi363 ↔ 372Sequence Analysis
    Disulfide bondi377 ↔ 387Sequence Analysis
    Disulfide bondi381 ↔ 392Sequence Analysis
    Disulfide bondi394 ↔ 403Sequence Analysis
    Disulfide bondi408 ↔ 418Sequence Analysis
    Disulfide bondi412 ↔ 423Sequence Analysis
    Disulfide bondi425 ↔ 434Sequence Analysis
    Disulfide bondi439 ↔ 449Sequence Analysis
    Disulfide bondi443 ↔ 454Sequence Analysis
    Disulfide bondi456 ↔ 465Sequence Analysis
    Disulfide bondi470 ↔ 480Sequence Analysis
    Disulfide bondi474 ↔ 485Sequence Analysis
    Disulfide bondi487 ↔ 496Sequence Analysis
    Disulfide bondi501 ↔ 511Sequence Analysis
    Disulfide bondi505 ↔ 516Sequence Analysis
    Disulfide bondi518 ↔ 527Sequence Analysis
    Disulfide bondi532 ↔ 542Sequence Analysis
    Disulfide bondi536 ↔ 547Sequence Analysis
    Disulfide bondi549 ↔ 558Sequence Analysis
    Disulfide bondi563 ↔ 573Sequence Analysis
    Disulfide bondi567 ↔ 578Sequence Analysis
    Disulfide bondi580 ↔ 589Sequence Analysis
    Disulfide bondi594 ↔ 604Sequence Analysis
    Disulfide bondi598 ↔ 609Sequence Analysis
    Disulfide bondi611 ↔ 620Sequence Analysis
    Glycosylationi788 – 7881N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1018 – 10181N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1079 – 10791N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1093 – 10931N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1119 – 11191N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1184 – 11841N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1210 – 12101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1275 – 12751N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1301 – 13011N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1354 – 13541N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1364 – 13641N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1394 – 13941N-linked (GlcNAc...)2 Publications
    Glycosylationi1443 – 14431N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1718 – 17181N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1969 – 19691N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2071 – 20711N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    N-glycosylated.2 Publications

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ80YX1.
    PaxDbiQ80YX1.
    PRIDEiQ80YX1.

    PTM databases

    PhosphoSiteiQ80YX1.

    Expressioni

    Tissue specificityi

    High levels of isoform 2 in lung and brain of newborn mice. High levels of isoform 5 in thymus, moderate levels in brain of newborn and adult mice. Low level of isoform 2 in adult brain.1 Publication

    Developmental stagei

    In kidney, isoform 2 is expressed at birth and isoform 5 at 2 weeks of age. In intestine, isoform 5 is expressed in day 13 embryos and isoform 2 at birth. In cerebellum, high levels of isoform 2 in day 17 embryos are down-regulated to moderate levels in newborn mice and undetectable levels in adult mice. Similarly, moderate levels of isoform 2 expressed in cerebrum of day 17 embryos are gradually down-regulated to undetectable levels in adult mice.2 Publications

    Gene expression databases

    ArrayExpressiQ80YX1.
    BgeeiQ80YX1.
    CleanExiMM_TNC.
    GenevestigatoriQ80YX1.

    Interactioni

    Subunit structurei

    Homohexamer; disulfide-linked. A homotrimer may be formed in the triple coiled-coil region and may be stabilized by disulfide rings at both ends. Two of such half-hexabrachions may be disulfide linked within the central globule. Interacts with CSPG4 By similarity.By similarity

    Protein-protein interaction databases

    IntActiQ80YX1. 1 interaction.
    MINTiMINT-4110071.

    Structurei

    3D structure databases

    ProteinModelPortaliQ80YX1.
    SMRiQ80YX1. Positions 158-2098.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini174 – 18512EGF-like 1; incompletePROSITE-ProRule annotationAdd
    BLAST
    Domaini186 – 21631EGF-like 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini217 – 24731EGF-like 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini248 – 27932EGF-like 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini280 – 31031EGF-like 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini311 – 34131EGF-like 6PROSITE-ProRule annotationAdd
    BLAST
    Domaini342 – 37231EGF-like 7PROSITE-ProRule annotationAdd
    BLAST
    Domaini373 – 40331EGF-like 8PROSITE-ProRule annotationAdd
    BLAST
    Domaini404 – 43431EGF-like 9PROSITE-ProRule annotationAdd
    BLAST
    Domaini435 – 46531EGF-like 10PROSITE-ProRule annotationAdd
    BLAST
    Domaini466 – 49631EGF-like 11PROSITE-ProRule annotationAdd
    BLAST
    Domaini497 – 52731EGF-like 12PROSITE-ProRule annotationAdd
    BLAST
    Domaini528 – 55831EGF-like 13PROSITE-ProRule annotationAdd
    BLAST
    Domaini559 – 58931EGF-like 14PROSITE-ProRule annotationAdd
    BLAST
    Domaini590 – 62132EGF-like 15PROSITE-ProRule annotationAdd
    BLAST
    Domaini625 – 71591Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini716 – 80489Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini805 – 89490Fibronectin type-III 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini895 – 98894Fibronectin type-III 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini989 – 107789Fibronectin type-III 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini1078 – 116588Fibronectin type-III 6PROSITE-ProRule annotationAdd
    BLAST
    Domaini1167 – 125993Fibronectin type-III 7PROSITE-ProRule annotationAdd
    BLAST
    Domaini1260 – 134889Fibronectin type-III 8PROSITE-ProRule annotationAdd
    BLAST
    Domaini1349 – 144092Fibronectin type-III 9PROSITE-ProRule annotationAdd
    BLAST
    Domaini1442 – 153089Fibronectin type-III 10PROSITE-ProRule annotationAdd
    BLAST
    Domaini1531 – 162090Fibronectin type-III 11PROSITE-ProRule annotationAdd
    BLAST
    Domaini1621 – 171090Fibronectin type-III 12PROSITE-ProRule annotationAdd
    BLAST
    Domaini1711 – 179787Fibronectin type-III 13PROSITE-ProRule annotationAdd
    BLAST
    Domaini1798 – 188689Fibronectin type-III 14PROSITE-ProRule annotationAdd
    BLAST
    Domaini1884 – 2099216Fibrinogen C-terminalPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili118 – 14225Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the tenascin family.Sequence Analysis
    Contains 15 EGF-like domains.PROSITE-ProRule annotation
    Contains 1 fibrinogen C-terminal domain.PROSITE-ProRule annotation
    Contains 14 fibronectin type-III domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, EGF-like domain, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG12793.
    GeneTreeiENSGT00750000117522.
    HOGENOMiHOG000234355.
    HOVERGENiHBG008949.
    InParanoidiQ80YX1.
    KOiK06252.
    OMAiGCCLQPA.
    OrthoDBiEOG7X9G60.
    PhylomeDBiQ80YX1.
    TreeFamiTF329915.

    Family and domain databases

    Gene3Di2.60.40.10. 14 hits.
    3.90.215.10. 1 hit.
    4.10.530.10. 1 hit.
    InterProiIPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    IPR013111. EGF_extracell.
    IPR014716. Fibrinogen_a/b/g_C_1.
    IPR014715. Fibrinogen_a/b/g_C_2.
    IPR002181. Fibrinogen_a/b/g_C_dom.
    IPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    [Graphical view]
    PfamiPF07974. EGF_2. 7 hits.
    PF00147. Fibrinogen_C. 1 hit.
    PF00041. fn3. 14 hits.
    PF12661. hEGF. 2 hits.
    [Graphical view]
    SMARTiSM00181. EGF. 12 hits.
    SM00186. FBG. 1 hit.
    SM00060. FN3. 14 hits.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 11 hits.
    SSF56496. SSF56496. 1 hit.
    PROSITEiPS00022. EGF_1. 15 hits.
    PS01186. EGF_2. 14 hits.
    PS50026. EGF_3. 5 hits.
    PS51406. FIBRINOGEN_C_2. 1 hit.
    PS50853. FN3. 14 hits.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q80YX1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGAVTWLLPG IFLALFALTP EGGVLKKIIR HKRESGLNMT LPEENQPVVF     50
    NHIYNIKLPM GSQCSVDLES ASGEKDLTPT PESSGSFQEH TVDGENQIVF 100
    THRINIPRRA CGCAAAPDVK ELLSRLEELE LLVSSLREQC TMGTGCCLQP 150
    AEGRLDTRPF CSGRGNFSAE GCGCVCEPGW KGPNCSEPDC PGNCNLRGQC 200
    LDGQCICDEG FTGEDCSQLA CPNDCNDQGR CVNGVCVCFE GYAGPDCGLE 250
    VCPVPCSEEH GMCVDGRCVC KDGFAGEDCN EPLCLNNCYN RGRCVENECV 300
    CDEGFTGEDC SELICPNDCF DRGRCINGTC YCEEGFTGED CGELTCPNDC 350
    QGRGQCEEGQ CVCNEGFAGA DCSEKRCPAD CHHRGRCLNG QCECDDGFTG 400
    ADCGDLQCPN GCSGHGRCVN GQCVCDEGYT GEDCSQRRCP NDCHNRGLCV 450
    QGKCICEQGF KGFDCSEMSC PNDCHQHGRC VNGMCICDDD YTGEDCRDRR 500
    CPRDCSQRGR CVDGQCICED GFTGPDCAEL SCPSDCHGHG RCVNGQCICH 550
    EGFTGKDCKE QRCPSDCHGQ GRCEDGQCIC HEGFTGLDCG QRSCPNDCSN 600
    QGQCVSGRCI CNEGYTGIDC SEVSPPKDLI VTEVTEETVN LAWDNEMRVT 650
    EYLIMYTPTH ADGLEMQFRV PGDQTSTTIR ELEPGVEYFI RVFAILENKR 700
    SIPVSARVAT YLPAPEGLKF KSIKETSVEV EWDPLDIAFE TWEIIFRNMN 750
    KEDEGEITKS LRRPETSYRQ TGLAPGQEYE ISLHIVKNNT RGPGLKKVTT 800
    TRLDAPSHIE VKDVTDTTAL ITWFKPLAEI DSIELSYGIK DVPGDRTTID 850
    LTHEDNQYSI GNLRPDTEYE VSLISRRVDM ASNPAKETFI TGLDAPRNLR 900
    RVSQTDNSIT LEWRNVKADI DSYRIKYAPI SGGDHAEIDV PKSQQATTKT 950
    TLTGLRPGTE YGIGVSAVKG DKESDPATIN AATEIDAPKD LRVSETTQDS 1000
    LTFFWTTPLA KFDRYRLNYS LPTGQSMEVQ LPKDATSHVL TDLEPGQEYT 1050
    VLLIAEKGRH KSKPARVKAS TEEVPSLENL TVTEAGWDGL RLNWTADDLA 1100
    YEYFVIQVQE ANNVETAHNF TVPGNLRAAD IPGLKVATSY RVSIYGVARG 1150
    YRTPVLSAET STGTTPNLGE VTVAEVGWDA LTLNWTAPEG AYKNFFIQVL 1200
    EADTTQTVQN LTVPGGLRSV DLPGLKAATR YYITLRGVTQ DFGTAPLSVE 1250
    VLTEDLPQLG GLSVTEVSWD GLTLNWTTDD LAYKHFVVQV QEANNVEAAQ 1300
    NLTVPGSLRA VDIPGLKADT PYRVSIYGVI QGYRTPMLST DVSTAREPEI 1350
    GNLNVSDVTP KSFNLSWTAT DGIFDMFTIE IIDSNRLLQT AEHNISGAER 1400
    TAHISGLPPS TDFIVYLSGI APSIRTKTIS TTATTEALPL LENLTISDTN 1450
    PYGFTVSWTA SENAFDSFLV TVVDSGKLLD PQEFTLSGTQ RKLELRGLIT 1500
    GIGYEVLVSG FTQGHQTKPL RAETITEAEP EVDNLLVSDA TPDGFRLSWT 1550
    ADEGIFDSFV IRIRDTKKQS EPQEISLPSP ERTRDITGLR EATEYEIELY 1600
    GISRGRRSQP VSAIATTAMG SPKEIMFSDI TENAATVSWR APTAQVESFR 1650
    ITYVPMTGGA PSMVTVDGTD TETRLVKLTP GVEYRVSVIA MKGFEESDPV 1700
    SGTLITALDG PSGLLIANIT DSEALAMWQP AIATVDSYVI SYTGERVPEV 1750
    TRTVSGNTVE YELHDLEPAT EYILSIFAEK GQQKSSTIAT KFTTDLDSPR 1800
    EFTATEVQSE TALLTWRPPR ASVTGYLLVY ESVDGTVKEV IVGPDTTSYS 1850
    LADLSPSTHY SARIQALSGS LRSKLIQTIF TTIGLLYPFP RDCSQAMLNG 1900
    DTTSGLYTIY INGDKTQALE VYCDMTSDGG GWIVFLRRKN GREDFYRNWK 1950
    AYAAGFGDRR EEFWLGLDNL SKITAQGQYE LRVDLQDHGE SAYAVYDRFS 2000
    VGDAKSRYKL KVEGYSGTAG DSMNYHNGRS FSTYDKDTDS AITNCALSYK 2050
    GAFWYKNCHR VNLMGRYGDN NHSQGVNWFH WKGHEYSIQF AEMKLRPSNF 2100
    RNLEGRRKRA 2110
    Length:2,110
    Mass (Da):231,807
    Last modified:June 1, 2003 - v1
    Checksum:iA1FEA96F8BC2FE51
    GO
    Isoform 21 Publication (identifier: Q80YX1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1436-1526: Missing.

    Show »
    Length:2,019
    Mass (Da):221,879
    Checksum:i27C4BFFA2024304C
    GO
    Isoform 31 Publication (identifier: Q80YX1-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1254-1616: Missing.

    Show »
    Length:1,747
    Mass (Da):192,063
    Checksum:i18733FA4332BC36B
    GO
    Isoform 41 Publication (identifier: Q80YX1-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1163-1616: Missing.

    Show »
    Length:1,656
    Mass (Da):182,340
    Checksum:i1DC087F9641641AE
    GO
    Isoform 51 Publication (identifier: Q80YX1-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1072-1616: Missing.

    Show »
    Length:1,565
    Mass (Da):172,354
    Checksum:iA8BA58FE720C4BBD
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti202 – 2021D → E in CAA39751. (PubMed:1703162)Curated
    Sequence conflicti318 – 3181D → S in CAA39751. (PubMed:1703162)Curated
    Sequence conflicti1019 – 10191Y → S in CAA39751. (PubMed:1703162)Curated
    Sequence conflicti1025 – 10251Q → H in CAA39751. (PubMed:1703162)Curated
    Sequence conflicti1306 – 13061G → S in CAA39751. (PubMed:1703162)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1072 – 1616545Missing in isoform 5. 2 PublicationsVSP_052144Add
    BLAST
    Alternative sequencei1163 – 1616454Missing in isoform 4. 1 PublicationVSP_052145Add
    BLAST
    Alternative sequencei1254 – 1616363Missing in isoform 3. 1 PublicationVSP_052146Add
    BLAST
    Alternative sequencei1436 – 152691Missing in isoform 2. 2 PublicationsVSP_052147Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D90343 mRNA. Translation: BAA14355.1.
    X56304 mRNA. Translation: CAA39751.1.
    AL732556 Genomic DNA. Translation: CAD83047.1.
    AL732556 Genomic DNA. Translation: CAD83048.1.
    CCDSiCCDS18265.1. [Q80YX1-2]
    PIRiJQ1322.
    RefSeqiNP_035737.2. NM_011607.3. [Q80YX1-2]
    XP_006537837.1. XM_006537774.1. [Q80YX1-1]
    UniGeneiMm.454219.
    Mm.980.

    Genome annotation databases

    EnsembliENSMUST00000030056; ENSMUSP00000030056; ENSMUSG00000028364. [Q80YX1-2]
    ENSMUST00000107372; ENSMUSP00000102995; ENSMUSG00000028364. [Q80YX1-1]
    ENSMUST00000107377; ENSMUSP00000103000; ENSMUSG00000028364. [Q80YX1-2]
    GeneIDi21923.
    KEGGimmu:21923.
    UCSCiuc008thg.2. mouse. [Q80YX1-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D90343 mRNA. Translation: BAA14355.1 .
    X56304 mRNA. Translation: CAA39751.1 .
    AL732556 Genomic DNA. Translation: CAD83047.1 .
    AL732556 Genomic DNA. Translation: CAD83048.1 .
    CCDSi CCDS18265.1. [Q80YX1-2 ]
    PIRi JQ1322.
    RefSeqi NP_035737.2. NM_011607.3. [Q80YX1-2 ]
    XP_006537837.1. XM_006537774.1. [Q80YX1-1 ]
    UniGenei Mm.454219.
    Mm.980.

    3D structure databases

    ProteinModelPortali Q80YX1.
    SMRi Q80YX1. Positions 158-2098.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q80YX1. 1 interaction.
    MINTi MINT-4110071.

    PTM databases

    PhosphoSitei Q80YX1.

    Proteomic databases

    MaxQBi Q80YX1.
    PaxDbi Q80YX1.
    PRIDEi Q80YX1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000030056 ; ENSMUSP00000030056 ; ENSMUSG00000028364 . [Q80YX1-2 ]
    ENSMUST00000107372 ; ENSMUSP00000102995 ; ENSMUSG00000028364 . [Q80YX1-1 ]
    ENSMUST00000107377 ; ENSMUSP00000103000 ; ENSMUSG00000028364 . [Q80YX1-2 ]
    GeneIDi 21923.
    KEGGi mmu:21923.
    UCSCi uc008thg.2. mouse. [Q80YX1-2 ]

    Organism-specific databases

    CTDi 3371.
    MGIi MGI:101922. Tnc.

    Phylogenomic databases

    eggNOGi NOG12793.
    GeneTreei ENSGT00750000117522.
    HOGENOMi HOG000234355.
    HOVERGENi HBG008949.
    InParanoidi Q80YX1.
    KOi K06252.
    OMAi GCCLQPA.
    OrthoDBi EOG7X9G60.
    PhylomeDBi Q80YX1.
    TreeFami TF329915.

    Enzyme and pathway databases

    Reactomei REACT_196606. ECM proteoglycans.
    REACT_196644. Syndecan interactions.
    REACT_216309. Integrin cell surface interactions.

    Miscellaneous databases

    NextBioi 301496.
    PROi Q80YX1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q80YX1.
    Bgeei Q80YX1.
    CleanExi MM_TNC.
    Genevestigatori Q80YX1.

    Family and domain databases

    Gene3Di 2.60.40.10. 14 hits.
    3.90.215.10. 1 hit.
    4.10.530.10. 1 hit.
    InterProi IPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    IPR013111. EGF_extracell.
    IPR014716. Fibrinogen_a/b/g_C_1.
    IPR014715. Fibrinogen_a/b/g_C_2.
    IPR002181. Fibrinogen_a/b/g_C_dom.
    IPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    [Graphical view ]
    Pfami PF07974. EGF_2. 7 hits.
    PF00147. Fibrinogen_C. 1 hit.
    PF00041. fn3. 14 hits.
    PF12661. hEGF. 2 hits.
    [Graphical view ]
    SMARTi SM00181. EGF. 12 hits.
    SM00186. FBG. 1 hit.
    SM00060. FN3. 14 hits.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 11 hits.
    SSF56496. SSF56496. 1 hit.
    PROSITEi PS00022. EGF_1. 15 hits.
    PS01186. EGF_2. 14 hits.
    PS50026. EGF_3. 5 hits.
    PS51406. FIBRINOGEN_C_2. 1 hit.
    PS50853. FN3. 14 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Murine tenascin: cDNA cloning, structure and temporal expression of isoforms."
      Saga Y., Tsukamoto T., Jing N., Kusakabe M., Sakakura T.
      Gene 104:177-185(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3; 4 AND 5), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
      Strain: GRSImported.
      Tissue: Mammary tumor1 Publication.
    2. "Amino acid sequence of mouse tenascin and differential expression of two tenascin isoforms during embryogenesis."
      Weller A., Beck S., Ekblom P.
      J. Cell Biol. 112:355-362(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 5), DEVELOPMENTAL STAGE, GLYCOSYLATION.
      Strain: NMRI X 129Imported.
      Tissue: EmbryoImported.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. "Enhanced novelty-induced activity, reduced anxiety, delayed resynchronization to daylight reversal and weaker muscle strength in tenascin-C-deficient mice."
      Morellini F., Schachner M.
      Eur. J. Neurosci. 23:1255-1268(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE.
    5. "Proteome-wide characterization of N-glycosylation events by diagonal chromatography."
      Ghesquiere B., Van Damme J., Martens L., Vandekerckhove J., Gevaert K.
      J. Proteome Res. 5:2438-2447(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1394.
      Strain: C57BL/6.
      Tissue: Plasma.

    Entry informationi

    Entry nameiTENA_MOUSE
    AccessioniPrimary (citable) accession number: Q80YX1
    Secondary accession number(s): Q64706, Q80YX2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 5, 2006
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3