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Protein

B box and SPRY domain-containing protein

Gene

Bspry

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May regulate epithelial calcium transport by inhibiting TRPV5 activity.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri65 – 113B box-typeAdd BLAST49

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium, Metal-binding, Vitamin D, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
B box and SPRY domain-containing protein
Gene namesi
Name:Bspry
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2177191. Bspry.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002442581 – 473B box and SPRY domain-containing proteinAdd BLAST473

Proteomic databases

PaxDbiQ80YW5.
PRIDEiQ80YW5.

PTM databases

PhosphoSitePlusiQ80YW5.

Expressioni

Tissue specificityi

According to PubMed:10978534, testis-specific. According to PubMed:16371431, broadly expressed.2 Publications

Developmental stagei

Expression starts at E19 in brain.1 Publication

Inductioni

Down-regulated by vitamin D.1 Publication

Gene expression databases

BgeeiENSMUSG00000028392.
CleanExiMM_BSPRY.
ExpressionAtlasiQ80YW5. baseline and differential.
GenevisibleiQ80YW5. MM.

Interactioni

Subunit structurei

Interacts with YWHAZ/14-3-3 protein zeta (By similarity). Interacts with TRPV5 and TRPV6.By similarity1 Publication

Protein-protein interaction databases

BioGridi228643. 1 interactor.
IntActiQ80YW5. 1 interactor.
MINTiMINT-152245.
STRINGi10090.ENSMUSP00000030088.

Structurei

3D structure databases

ProteinModelPortaliQ80YW5.
SMRiQ80YW5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini259 – 455B30.2/SPRYPROSITE-ProRule annotationAdd BLAST197

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi16 – 52Pro-richAdd BLAST37

Sequence similaritiesi

Contains 1 B box-type zinc finger.Curated
Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri65 – 113B box-typeAdd BLAST49

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410ITF8. Eukaryota.
ENOG4111EI7. LUCA.
GeneTreeiENSGT00840000129835.
HOGENOMiHOG000057290.
HOVERGENiHBG080574.
InParanoidiQ80YW5.
OMAiRLGHNAF.
TreeFamiTF351014.

Family and domain databases

Gene3Di4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR000315. Znf_B-box.
[Graphical view]
PfamiPF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00589. PRY. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q80YW5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSADVSGTES GSESGPEPEP GPEPGPESRP ESRPKPGPGP EPRPESGPEP
60 70 80 90 100
GPRSGLRRGP KQGSERSQLC PEHFEPLSWF CLSERRPVCA TCAGFGGRCH
110 120 130 140 150
RHRIRRAEEH AEELRNKIVD QCERLQLQSA GISKYMAEVL QGKNQKAVVM
160 170 180 190 200
ASAARDLIIQ RLSLVRSLCE SEEQRLLEQV HGEEERAHQS ILTQRAHWVD
210 220 230 240 250
AVQKLDTLRT NMVDMITHLD DLQLIQREQE IFERAEEAEG ILDPQDSEKL
260 270 280 290 300
SFNEKCAWSP LLTQLWAASV LGSLSGVEEV LIDERTVSPL LHLSEDRRTL
310 320 330 340 350
TFIAKKSKVC SDEPERFDHW PNALAATAFQ TGLHAWIVNV KHSCAYKVGV
360 370 380 390 400
ASDQLPRKGS GNDCRLGHNA FSWVFSRYDQ EFCFSHNGYH EPLPLLRCPA
410 420 430 440 450
QLGMLLDLQA GELVFYEPAS GTVLHIHRAS FPQVLFPVFA VADQLISIVR
460 470
GPLATVRLDS PPHHPCRSGH ASR
Length:473
Mass (Da):52,751
Last modified:June 1, 2003 - v1
Checksum:i60FBC4A61A8F4A8E
GO
Isoform 2 (identifier: Q80YW5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     467-473: RSGHASR → SIRRTTCQDTVGQNVVVGVW

Show »
Length:486
Mass (Da):54,199
Checksum:iF9682B73348E417F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti17E → F in BAC29115 (PubMed:16141072).Curated1
Sequence conflicti137A → D in BAE36097 (PubMed:16141072).Curated1
Sequence conflicti169C → S in BAE36097 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_019529467 – 473RSGHASR → SIRRTTCQDTVGQNVVVGVW in isoform 2. 1 Publication7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ276690 mRNA. Translation: CAC09325.1.
AK035588 mRNA. Translation: BAC29115.1.
AK160930 mRNA. Translation: BAE36097.1.
AL732594 Genomic DNA. Translation: CAD83059.1.
AL732594 Genomic DNA. Translation: CAD83060.1.
BC003992 mRNA. Translation: AAH03992.2.
CCDSiCCDS18241.1. [Q80YW5-2]
RefSeqiNP_619594.1. NM_138653.1. [Q80YW5-2]
UniGeneiMm.29808.

Genome annotation databases

EnsembliENSMUST00000030088; ENSMUSP00000030088; ENSMUSG00000028392. [Q80YW5-2]
ENSMUST00000107449; ENSMUSP00000103073; ENSMUSG00000028392. [Q80YW5-1]
GeneIDi192120.
KEGGimmu:192120.
UCSCiuc008tex.1. mouse. [Q80YW5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ276690 mRNA. Translation: CAC09325.1.
AK035588 mRNA. Translation: BAC29115.1.
AK160930 mRNA. Translation: BAE36097.1.
AL732594 Genomic DNA. Translation: CAD83059.1.
AL732594 Genomic DNA. Translation: CAD83060.1.
BC003992 mRNA. Translation: AAH03992.2.
CCDSiCCDS18241.1. [Q80YW5-2]
RefSeqiNP_619594.1. NM_138653.1. [Q80YW5-2]
UniGeneiMm.29808.

3D structure databases

ProteinModelPortaliQ80YW5.
SMRiQ80YW5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi228643. 1 interactor.
IntActiQ80YW5. 1 interactor.
MINTiMINT-152245.
STRINGi10090.ENSMUSP00000030088.

PTM databases

PhosphoSitePlusiQ80YW5.

Proteomic databases

PaxDbiQ80YW5.
PRIDEiQ80YW5.

Protocols and materials databases

DNASUi192120.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030088; ENSMUSP00000030088; ENSMUSG00000028392. [Q80YW5-2]
ENSMUST00000107449; ENSMUSP00000103073; ENSMUSG00000028392. [Q80YW5-1]
GeneIDi192120.
KEGGimmu:192120.
UCSCiuc008tex.1. mouse. [Q80YW5-1]

Organism-specific databases

CTDi54836.
MGIiMGI:2177191. Bspry.

Phylogenomic databases

eggNOGiENOG410ITF8. Eukaryota.
ENOG4111EI7. LUCA.
GeneTreeiENSGT00840000129835.
HOGENOMiHOG000057290.
HOVERGENiHBG080574.
InParanoidiQ80YW5.
OMAiRLGHNAF.
TreeFamiTF351014.

Miscellaneous databases

ChiTaRSiBspry. mouse.
PROiQ80YW5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028392.
CleanExiMM_BSPRY.
ExpressionAtlasiQ80YW5. baseline and differential.
GenevisibleiQ80YW5. MM.

Family and domain databases

Gene3Di4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR000315. Znf_B-box.
[Graphical view]
PfamiPF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00589. PRY. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBSPRY_MOUSE
AccessioniPrimary (citable) accession number: Q80YW5
Secondary accession number(s): Q3TU74
, Q8BZF0, Q99KV7, Q9ER70
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.