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Protein

Cytohesin-4

Gene

Cyth4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF factors through replacement of GDP with GTP (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei279 – 2791Phosphatidylinositol 3,4,5-trisphosphateBy similarity
Binding sitei290 – 2901Phosphatidylinositol 3,4,5-trisphosphateBy similarity
Binding sitei300 – 3001Phosphatidylinositol 3,4,5-trisphosphateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytohesin-4
Alternative name(s):
PH, SEC7 and coiled-coil domain-containing protein 4
Gene namesi
Name:Cyth4
Synonyms:Pscd4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2441702. Cyth4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 393393Cytohesin-4PRO_0000120204Add
BLAST

Proteomic databases

EPDiQ80YW0.
MaxQBiQ80YW0.
PaxDbiQ80YW0.
PRIDEiQ80YW0.

PTM databases

iPTMnetiQ80YW0.
PhosphoSiteiQ80YW0.

Expressioni

Gene expression databases

BgeeiQ80YW0.
ExpressionAtlasiQ80YW0. baseline and differential.
GenevisibleiQ80YW0. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000042698.

Structurei

3D structure databases

ProteinModelPortaliQ80YW0.
SMRiQ80YW0. Positions 60-390.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini54 – 241188SEC7PROSITE-ProRule annotationAdd
BLAST
Domaini259 – 375117PHPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni268 – 2758Phosphatidylinositol 3,4,5-trisphosphate bindingBy similarity
Regioni386 – 3938C-terminal autoinhibitory regionBy similarity

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili13 – 5644Sequence analysisAdd
BLAST

Domaini

Binds via its PH domain to the inositol head group of phosphatidylinositol 3,4,5-trisphosphate.By similarity
Autoinhibited by its C-terminal basic region.By similarity

Sequence similaritiesi

Contains 1 PH domain.PROSITE-ProRule annotation
Contains 1 SEC7 domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0930. Eukaryota.
COG5307. LUCA.
GeneTreeiENSGT00760000119036.
HOVERGENiHBG002647.
InParanoidiQ80YW0.
KOiK18441.
OMAiGERDPIN.
OrthoDBiEOG7RBZ9C.
PhylomeDBiQ80YW0.
TreeFamiTF352091.

Family and domain databases

Gene3Di1.10.1000.11. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR023394. Sec7_alpha_orthog.
IPR000904. Sec7_dom.
[Graphical view]
PfamiPF00169. PH. 1 hit.
PF01369. Sec7. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00222. Sec7. 1 hit.
[Graphical view]
SUPFAMiSSF48425. SSF48425. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS50190. SEC7. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80YW0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVCHTDPAE LSSGEAKELQ QIKWHRKQLL EDIQKLKDEI ADVFAQIDCF
60 70 80 90 100
ESTEESRMAQ KEKEMCIGRK KFNMDPNKGI QYLIEHKLLT SDVQDIAQFL
110 120 130 140 150
YKGDGLNKTA IGTYLGEKDP INLQVLQAFV DCHEFANLNL VQALRQFLWS
160 170 180 190 200
FRLPGEAQKI DRMMEAFAAR YCLCNPGVFR STDTCYVLSF SVIMLNTGLH
210 220 230 240 250
NPNVRDRPPF ERFVTMNRGI NSGSDLPEEQ LRNLFDSIKS EPFSIPEDDG
260 270 280 290 300
GDLTHTFFNP DREGWLLKLG GRVKTWKRRW FILTDNCLYY FEFTTDKEPR
310 320 330 340 350
GIIPLENLSV QKVEDPKKPF CLELYNPSCR GQKIKACKTD GDGKVVEGKH
360 370 380 390
ESYRISAANA EERDQWIEAI RASITRVPFY DLLSARKKKI VGK
Length:393
Mass (Da):45,285
Last modified:June 1, 2003 - v1
Checksum:iA021643E86DC57A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF079972 mRNA. Translation: AAD46734.1.
CCDSiCCDS27620.1.
RefSeqiNP_082471.2. NM_028195.3.
UniGeneiMm.32911.

Genome annotation databases

EnsembliENSMUST00000043069; ENSMUSP00000042698; ENSMUSG00000018008.
GeneIDi72318.
KEGGimmu:72318.
UCSCiuc007wps.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF079972 mRNA. Translation: AAD46734.1.
CCDSiCCDS27620.1.
RefSeqiNP_082471.2. NM_028195.3.
UniGeneiMm.32911.

3D structure databases

ProteinModelPortaliQ80YW0.
SMRiQ80YW0. Positions 60-390.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000042698.

PTM databases

iPTMnetiQ80YW0.
PhosphoSiteiQ80YW0.

Proteomic databases

EPDiQ80YW0.
MaxQBiQ80YW0.
PaxDbiQ80YW0.
PRIDEiQ80YW0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043069; ENSMUSP00000042698; ENSMUSG00000018008.
GeneIDi72318.
KEGGimmu:72318.
UCSCiuc007wps.2. mouse.

Organism-specific databases

CTDi27128.
MGIiMGI:2441702. Cyth4.

Phylogenomic databases

eggNOGiKOG0930. Eukaryota.
COG5307. LUCA.
GeneTreeiENSGT00760000119036.
HOVERGENiHBG002647.
InParanoidiQ80YW0.
KOiK18441.
OMAiGERDPIN.
OrthoDBiEOG7RBZ9C.
PhylomeDBiQ80YW0.
TreeFamiTF352091.

Miscellaneous databases

NextBioi336004.
PROiQ80YW0.
SOURCEiSearch...

Gene expression databases

BgeeiQ80YW0.
ExpressionAtlasiQ80YW0. baseline and differential.
GenevisibleiQ80YW0. MM.

Family and domain databases

Gene3Di1.10.1000.11. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR023394. Sec7_alpha_orthog.
IPR000904. Sec7_dom.
[Graphical view]
PfamiPF00169. PH. 1 hit.
PF01369. Sec7. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00222. Sec7. 1 hit.
[Graphical view]
SUPFAMiSSF48425. SSF48425. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS50190. SEC7. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse cytohesin-4, a novel Sec7 and PH domain containing and integrin associated protein."
    Liu D., Zhang H., Lu J.
    Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Spleen.

Entry informationi

Entry nameiCYH4_MOUSE
AccessioniPrimary (citable) accession number: Q80YW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: June 1, 2003
Last modified: March 16, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.