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Protein

Cytohesin-4

Gene

Cyth4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF factors through replacement of GDP with GTP (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei279Phosphatidylinositol 3,4,5-trisphosphateBy similarity1
Binding sitei290Phosphatidylinositol 3,4,5-trisphosphateBy similarity1
Binding sitei300Phosphatidylinositol 3,4,5-trisphosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGuanine-nucleotide releasing factor
LigandLipid-binding

Enzyme and pathway databases

ReactomeiR-MMU-6811438 Intra-Golgi traffic

Names & Taxonomyi

Protein namesi
Recommended name:
Cytohesin-4
Alternative name(s):
PH, SEC7 and coiled-coil domain-containing protein 4
Gene namesi
Name:Cyth4
Synonyms:Pscd4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2441702 Cyth4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001202041 – 393Cytohesin-4Add BLAST393

Proteomic databases

EPDiQ80YW0
MaxQBiQ80YW0
PaxDbiQ80YW0
PRIDEiQ80YW0

PTM databases

iPTMnetiQ80YW0
PhosphoSitePlusiQ80YW0

Expressioni

Gene expression databases

BgeeiENSMUSG00000018008
ExpressionAtlasiQ80YW0 baseline and differential
GenevisibleiQ80YW0 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000042698

Structurei

3D structure databases

ProteinModelPortaliQ80YW0
SMRiQ80YW0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini54 – 241SEC7PROSITE-ProRule annotationAdd BLAST188
Domaini259 – 375PHPROSITE-ProRule annotationAdd BLAST117

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni268 – 275Phosphatidylinositol 3,4,5-trisphosphate bindingBy similarity8
Regioni386 – 393C-terminal autoinhibitory regionBy similarity8

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili13 – 56Sequence analysisAdd BLAST44

Domaini

Binds via its PH domain to the inositol head group of phosphatidylinositol 3,4,5-trisphosphate.By similarity
Autoinhibited by its C-terminal basic region.By similarity

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0930 Eukaryota
COG5307 LUCA
GeneTreeiENSGT00760000119036
HOVERGENiHBG002647
InParanoidiQ80YW0
KOiK18441
OMAiNVRDRPP
OrthoDBiEOG091G0RZS
PhylomeDBiQ80YW0
TreeFamiTF352091

Family and domain databases

Gene3Di1.10.1000.11, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR023394 Sec7_C_sf
IPR000904 Sec7_dom
IPR035999 Sec7_dom_sf
PfamiView protein in Pfam
PF00169 PH, 1 hit
PF01369 Sec7, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00222 Sec7, 1 hit
SUPFAMiSSF48425 SSF48425, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS50190 SEC7, 1 hit

Sequencei

Sequence statusi: Complete.

Q80YW0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVCHTDPAE LSSGEAKELQ QIKWHRKQLL EDIQKLKDEI ADVFAQIDCF
60 70 80 90 100
ESTEESRMAQ KEKEMCIGRK KFNMDPNKGI QYLIEHKLLT SDVQDIAQFL
110 120 130 140 150
YKGDGLNKTA IGTYLGEKDP INLQVLQAFV DCHEFANLNL VQALRQFLWS
160 170 180 190 200
FRLPGEAQKI DRMMEAFAAR YCLCNPGVFR STDTCYVLSF SVIMLNTGLH
210 220 230 240 250
NPNVRDRPPF ERFVTMNRGI NSGSDLPEEQ LRNLFDSIKS EPFSIPEDDG
260 270 280 290 300
GDLTHTFFNP DREGWLLKLG GRVKTWKRRW FILTDNCLYY FEFTTDKEPR
310 320 330 340 350
GIIPLENLSV QKVEDPKKPF CLELYNPSCR GQKIKACKTD GDGKVVEGKH
360 370 380 390
ESYRISAANA EERDQWIEAI RASITRVPFY DLLSARKKKI VGK
Length:393
Mass (Da):45,285
Last modified:June 1, 2003 - v1
Checksum:iA021643E86DC57A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF079972 mRNA Translation: AAD46734.1
CCDSiCCDS27620.1
RefSeqiNP_082471.2, NM_028195.3
UniGeneiMm.32911

Genome annotation databases

EnsembliENSMUST00000043069; ENSMUSP00000042698; ENSMUSG00000018008
GeneIDi72318
KEGGimmu:72318
UCSCiuc007wps.2 mouse

Similar proteinsi

Entry informationi

Entry nameiCYH4_MOUSE
AccessioniPrimary (citable) accession number: Q80YW0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: June 1, 2003
Last modified: March 28, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health