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Protein
Submitted name:

C-X-C motif chemokine ligand 12

Gene

Cxcl12

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • adult locomotory behavior Source: RGD
  • ameboidal-type cell migration Source: RGD
  • animal organ regeneration Source: RGD
  • brain development Source: RGD
  • branching involved in blood vessel morphogenesis Source: RGD
  • cell-cell adhesion Source: RGD
  • cell chemotaxis Source: RGD
  • cell migration Source: RGD
  • chemokine-mediated signaling pathway Source: RGD
  • defense response Source: InterPro
  • detection of mechanical stimulus involved in sensory perception of pain Source: RGD
  • detection of temperature stimulus involved in sensory perception of pain Source: RGD
  • dopaminergic neuron differentiation Source: RGD
  • germ cell development Source: RGD
  • germ cell migration Source: RGD
  • immune response Source: InterPro
  • induction of positive chemotaxis Source: RGD
  • motor neuron axon guidance Source: RGD
  • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage Source: RGD
  • negative regulation of leukocyte apoptotic process Source: RGD
  • negative regulation of leukocyte tethering or rolling Source: RGD
  • neuron migration Source: RGD
  • positive regulation of axon extension involved in axon guidance Source: RGD
  • positive regulation of calcium ion import Source: RGD
  • positive regulation of cell adhesion Source: RGD
  • positive regulation of cell migration Source: RGD
  • positive regulation of cell proliferation Source: RGD
  • positive regulation of dopamine secretion Source: RGD
  • positive regulation of endothelial cell proliferation Source: RGD
  • positive regulation of monocyte chemotaxis Source: RGD
  • positive regulation of myoblast fusion Source: RGD
  • positive regulation of neuron differentiation Source: RGD
  • positive regulation of T cell migration Source: RGD
  • regulation of calcium ion transport Source: RGD
  • regulation of cell migration Source: RGD
  • response to heat Source: RGD
  • response to hypoxia Source: RGD
  • response to mechanical stimulus Source: RGD
  • response to peptide hormone Source: RGD
  • response to radiation Source: RGD
  • response to ultrasound Source: RGD
  • T cell proliferation Source: RGD
  • telencephalon cell migration Source: RGD

Enzyme and pathway databases

ReactomeiR-RNO-376176. Signaling by ROBO receptors.
R-RNO-380108. Chemokine receptors bind chemokines.
R-RNO-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Submitted name:
C-X-C motif chemokine ligand 12Imported
Submitted name:
Stromal cell-derived factor-1 gammaImported
Gene namesi
Name:Cxcl12Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi3651. Cxcl12.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_501121097522 – 119Sequence analysisAdd BLAST98

Expressioni

Gene expression databases

BgeeiENSRNOG00000013589.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000059574.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 86SCYInterPro annotationAdd BLAST60

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410J1S5. Eukaryota.
ENOG4112BS6. LUCA.
GeneTreeiENSGT00390000014056.
HOGENOMiHOG000220915.
HOVERGENiHBG107437.
OMAiSTPNCAL.
OrthoDBiEOG091G14JB.
TreeFamiTF353159.

Family and domain databases

CDDicd00273. Chemokine_CXC. 1 hit.
InterProiView protein in InterPro
IPR001811. Chemokine_IL8-like_dom.
IPR033899. CXC_Chemokine_domain.
IPR036048. Interleukin_8-like_sf.
PfamiView protein in Pfam
PF00048. IL8. 1 hit.
SMARTiView protein in SMART
SM00199. SCY. 1 hit.
SUPFAMiSSF54117. SSF54117. 1 hit.

Sequencei

Sequence statusi: Complete.

Q80YV8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAKVVAVLA LVLAALCISD GKPVSLSYRC PCRFFESHVA RANVKHLKIL
60 70 80 90 100
NTPNCALQIV ARLKSNNRQV CIDPKLKWIQ EYLDKALNKG RREEKVGKKE
110
KIGKKKRQKK RKAAQKKKN
Length:119
Mass (Da):13,551
Last modified:June 1, 2003 - v1
Checksum:i5E1D99E44DC36FA8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07061847 Genomic DNA. No translation available.
AABR07061848 Genomic DNA. No translation available.
AF217564 mRNA. Translation: AAF63712.1.
RefSeqiNP_001029055.1. NM_001033883.1.
UniGeneiRn.54439.

Genome annotation databases

EnsembliENSRNOT00000066670; ENSRNOP00000059574; ENSRNOG00000013589.
GeneIDi24772.

Similar proteinsi

Entry informationi

Entry nameiQ80YV8_RAT
AccessioniPrimary (citable) accession number: Q80YV8
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: November 22, 2017
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported