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Protein
Submitted name:

Protein Cxcl12

Gene

Cxcl12

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • chemoattractant activity Source: GO_Central
  • chemokine activity Source: RGD
  • CXCR chemokine receptor binding Source: GO_Central

GO - Biological processi

  • adult locomotory behavior Source: RGD
  • brain development Source: RGD
  • cell migration Source: RGD
  • chemokine-mediated signaling pathway Source: GO_Central
  • immune response Source: InterPro
  • induction of positive chemotaxis Source: GO_Central
  • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage Source: Ensembl
  • negative regulation of leukocyte apoptotic process Source: Ensembl
  • negative regulation of leukocyte tethering or rolling Source: Ensembl
  • neuron migration Source: RGD
  • organ regeneration Source: RGD
  • positive regulation of axon extension involved in axon guidance Source: RGD
  • positive regulation of cell adhesion Source: Ensembl
  • positive regulation of cell migration Source: RGD
  • positive regulation of cell proliferation Source: RGD
  • positive regulation of dopamine secretion Source: RGD
  • positive regulation of endothelial cell proliferation Source: RGD
  • positive regulation of monocyte chemotaxis Source: Ensembl
  • positive regulation of neuron differentiation Source: RGD
  • positive regulation of T cell migration Source: Ensembl
  • regulation of calcium ion transport Source: RGD
  • response to heat Source: RGD
  • response to hypoxia Source: RGD
  • response to mechanical stimulus Source: RGD
  • response to peptide hormone Source: RGD
  • response to radiation Source: RGD
  • telencephalon cell migration Source: RGD
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-1251985. Nuclear signaling by ERBB4.
R-RNO-380108. Chemokine receptors bind chemokines.
R-RNO-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein Cxcl12Imported
Submitted name:
Stromal cell-derived factor-1 gammaImported
Gene namesi
Name:Cxcl12Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi3651. Cxcl12.

Subcellular locationi

GO - Cellular componenti

  • external side of plasma membrane Source: GO_Central
  • extracellular exosome Source: Ensembl
  • extracellular space Source: RGD
  • plasma membrane Source: RGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 11998Sequence analysisPRO_5007927029Add
BLAST

PTM databases

PhosphoSiteiQ80YV8.

Expressioni

Gene expression databases

BgeeiENSRNOG00000013589.

Interactioni

GO - Molecular functioni

  • chemokine activity Source: RGD
  • CXCR chemokine receptor binding Source: GO_Central

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000059574.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 8660SCYInterPro annotationAdd
BLAST

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410J1S5. Eukaryota.
ENOG4112BS6. LUCA.
GeneTreeiENSGT00390000014056.
HOGENOMiHOG000220915.
HOVERGENiHBG107437.
OMAiSTPNCAL.
OrthoDBiEOG091G14JB.
TreeFamiTF353159.

Family and domain databases

InterProiIPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.

Sequencei

Sequence statusi: Complete.

Q80YV8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAKVVAVLA LVLAALCISD GKPVSLSYRC PCRFFESHVA RANVKHLKIL
60 70 80 90 100
NTPNCALQIV ARLKSNNRQV CIDPKLKWIQ EYLDKALNKG RREEKVGKKE
110
KIGKKKRQKK RKAAQKKKN
Length:119
Mass (Da):13,551
Last modified:June 1, 2003 - v1
Checksum:i5E1D99E44DC36FA8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07061847 Genomic DNA. No translation available.
AABR07061848 Genomic DNA. No translation available.
AF217564 mRNA. Translation: AAF63712.1.
RefSeqiNP_001029055.1. NM_001033883.1.
UniGeneiRn.54439.

Genome annotation databases

EnsembliENSRNOT00000066670; ENSRNOP00000059574; ENSRNOG00000013589.
GeneIDi24772.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07061847 Genomic DNA. No translation available.
AABR07061848 Genomic DNA. No translation available.
AF217564 mRNA. Translation: AAF63712.1.
RefSeqiNP_001029055.1. NM_001033883.1.
UniGeneiRn.54439.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000059574.

PTM databases

PhosphoSiteiQ80YV8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000066670; ENSRNOP00000059574; ENSRNOG00000013589.
GeneIDi24772.

Organism-specific databases

CTDi6387.
RGDi3651. Cxcl12.

Phylogenomic databases

eggNOGiENOG410J1S5. Eukaryota.
ENOG4112BS6. LUCA.
GeneTreeiENSGT00390000014056.
HOGENOMiHOG000220915.
HOVERGENiHBG107437.
OMAiSTPNCAL.
OrthoDBiEOG091G14JB.
TreeFamiTF353159.

Enzyme and pathway databases

ReactomeiR-RNO-1251985. Nuclear signaling by ERBB4.
R-RNO-380108. Chemokine receptors bind chemokines.
R-RNO-418594. G alpha (i) signalling events.

Gene expression databases

BgeeiENSRNOG00000013589.

Family and domain databases

InterProiIPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ80YV8_RAT
AccessioniPrimary (citable) accession number: Q80YV8
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: September 7, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.