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Q80YV3

- TRRAP_MOUSE

UniProt

Q80YV3 - TRRAP_MOUSE

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Protein

Transformation/transcription domain-associated protein

Gene

Trrap

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4-mediated transcription activation. Probably acts by linking transcription factors such as E1A, MYC or E2F1 to HAT complexes such as STAGA thereby allowing transcription activation. Probably not required in the steps following histone acetylation in processes of transcription activation. May be required for the mitotic checkpoint and normal cell cycle progression. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome.1 Publication

GO - Molecular functioni

  1. phosphotransferase activity, alcohol group as acceptor Source: InterPro
  2. transcription coactivator activity Source: MGI

GO - Biological processi

  1. histone H2A acetylation Source: UniProtKB
  2. histone H4 acetylation Source: UniProtKB
  3. mitotic cell cycle checkpoint Source: MGI
  4. regulation of transcription, DNA-templated Source: MGI
  5. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Chromatin regulator

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transformation/transcription domain-associated protein
Alternative name(s):
Tra1 homolog
Gene namesi
Name:Trrap
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:2153272. Trrap.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. histone acetyltransferase complex Source: MGI
  2. NuA4 histone acetyltransferase complex Source: UniProtKB
  3. Swr1 complex Source: UniProtKB
  4. transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 25652565Transformation/transcription domain-associated proteinPRO_0000088852Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei749 – 7491PhosphoserineBy similarity
Modified residuei775 – 7751PhosphoserineBy similarity
Modified residuei1766 – 17661N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ80YV3.
PaxDbiQ80YV3.
PRIDEiQ80YV3.

PTM databases

PhosphoSiteiQ80YV3.

Expressioni

Gene expression databases

GenevestigatoriQ80YV3.

Interactioni

Subunit structurei

Interacts with MYC, E2F1 and E2F4 transcription factors. Interacts directly with p53/TP53. Interacts with GCN5L2. Component of various HAT complexes. Component of the PCAF complex, at least composed of TADA2L/ADA2, SUPT3H, TADA3L/ADA3, TAF5L/PAF65-beta, TAF6L/PAF65-alpha, TAF10/TAFII30, TAF12/TAFII20, TAF9/TAFII31 and TRRAP. Component of the TFTC-HAT complex, at least composed of TAF5L, TAF6L, TADA3L, SUPT3H/SPT3, TAF2/TAFII150, TAF4/TAFII135, TAF5/TAFII100, GCN5L2/GCN5, TAF10 and TRRAP. Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. Component of the STAGA complex, at least composed of SUPT3H, GCN5L2, SUPT7L, TAF5L, TAF6L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9. The STAGA core complex is associated with a subcomplex required for histone deubiquitination composed of ATXN7L3, ENY2 and USP22. Component of the BAF53 complex, at least composed of BAF53A, RUVBL1, SMARCA4/BRG1, and TRRAP, which preferentially acetylates histone H4 (and H2A) within nucleosomes. Interacts with NPAT (By similarity). Interaction with TELO2 AND TTI1. Component of a SWR1-like complex (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Kat2aQ9JHD23EBI-2942477,EBI-2943116

Protein-protein interaction databases

DIPiDIP-29177N.
IntActiQ80YV3. 23 interactions.
MINTiMINT-2568321.

Structurei

3D structure databases

ProteinModelPortaliQ80YV3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1403 – 1963561FATPROSITE-ProRule annotationAdd
BLAST
Domaini2234 – 2532299PI3K/PI4KPROSITE-ProRule annotationAdd
BLAST
Domaini2533 – 256533FATCPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni710 – 1087378Interaction with TP53By similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi745 – 76016Bipartite nuclear localization signalSequence AnalysisAdd
BLAST

Domaini

The PI3K/PI4K domain is required for the recruitment of HAT complexes, and the MYC-dependent transactivation. Although it is strongly related to the PI3/PI4-kinase family, it lacks the typical motifs that constitute the catalytic site of PI3/PI4-kinase proteins, and lacks such activity (By similarity).By similarity

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family. TRA1 subfamily.Curated
Contains 1 FAT domain.PROSITE-ProRule annotation
Contains 1 FATC domain.PROSITE-ProRule annotation
Contains 1 PI3K/PI4K domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5032.
HOVERGENiHBG079283.
InParanoidiQ80YV3.
PhylomeDBiQ80YV3.

Family and domain databases

Gene3Di1.10.1070.11. 1 hit.
1.25.40.10. 3 hits.
InterProiIPR016024. ARM-type_fold.
IPR003152. FATC.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR003151. PIK-rel_kinase_FAT.
IPR014009. PIK_FAT.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF02259. FAT. 1 hit.
PF00454. PI3_PI4_kinase. 1 hit.
[Graphical view]
SMARTiSM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 7 hits.
SSF56112. SSF56112. 2 hits.
PROSITEiPS51189. FAT. 1 hit.
PS51190. FATC. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80YV3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTRKFVKRSI FLHLLRHQPA NAQIGLMEGN TFCTTLQPRL FTMDLNVVEH
60 70 80 90 100
KVFYTELLNL CEAEDSALTK LPCYKSLPSL VPLRIAALNA LAACNYLPQS
110 120 130 140 150
REKIIAALFK ALNSTNSELQ EAGEACMRKF LEGATIEVDQ IHTHMRPLLM
160 170 180 190 200
MLGDYRSLTL NVVNRLTSVT RLFPNSFNDK FCDQMMQHLR KWMEVVVITH
210 220 230 240 250
KGGQRSDGNE MKICSAIINL FHLIPAAPQT LVKPPLEVVM ETERAMLIEA
260 270 280 290 300
GSPFREPLIK FLTRHPSQTV ELFMMGATLN DPQWSRMFMS FLKHKDARPL
310 320 330 340 350
RDVLAANPNR FITLLLPGGA QTAVRPGSSS TSNMRLDLQF QAIKIISIIV
360 370 380 390 400
KNDDAWLASQ HSLVSQLRRV WVSETFQERH RKENMAATNW KEPKLLAFCL
410 420 430 440 450
LNYCKRNYGD IELLFQLLRA FTGRFLCNMT FLKEYMEEEI PKNYSIAQKR
460 470 480 490 500
ALFFRFVEFN DPNFGDELKA KVLQHILNPA FLYSFEKGEG EQLLGPPNPE
510 520 530 540 550
GDNPESITSV FITKVLDPEK QADMLDSLRI YLLQYATLLV EHAPHHIHDN
560 570 580 590 600
NKNRNSKLRR LMTFAWPCLL SKACVDPACR YSGHLLLAHI IAKFAIHKKI
610 620 630 640 650
VLQVFHSLLK AHAMEARAIV RQAMAILTPA VPARMEDGHQ MLTHWTRKII
660 670 680 690 700
VEEGHTVPQL VHILHPIVQH FKVYYPVRHH LVQHMVSAMQ RLGFTPSVTI
710 720 730 740 750
EQRRLAVDLS EVVIKWELQR IKDQQPDSDM DPNSSGEGVN SVSIKRGLSV
760 770 780 790 800
DSAQEVKRFR AATGAISAVF GRSQSLPGAD SLLAKPIDKQ HTDTVVNFLI
810 820 830 840 850
RVACQVNDNT NTAGSPGEVL SRRCVNLLKT ALRPDMWCKS ELKLQWFDKL
860 870 880 890 900
LMTVEQPNQV NYGNICTGLE VLNFLLTVLQ SPAILSSFKP LQRGIAACMT
910 920 930 940 950
CGNTKVLRAV HSLLSRLMSI FPTEPSTSSV ASKYEELECL YAAVGKVIYE
960 970 980 990 1000
GLTNYEKATS ANPSQLFGTL MIHKSACCNN PSYIDRLISV FMRSLQKMVR
1010 1020 1030 1040 1050
EHLNPQTASG STEATAAGTS ELVMLSLDLV KTRLAVMSME MRKNFIQTIL
1060 1070 1080 1090 1100
TSLIEKSPDA KILRAVVKIV EEWVKNNSPM AANQTPTLRE KSILLVKMMT
1110 1120 1130 1140 1150
YIEKRFPEDL ELNAQFLDLV NYVYRDEALS GSELTAKLEP AFLSGLRCAQ
1160 1170 1180 1190 1200
PLIRAKFFEV FDNSMKRRVY ERLLYVTCSQ NWEAMGSHFW IKQCIELLLA
1210 1220 1230 1240 1250
VCEKSTAIGT SCQGAMLPSI TNVINLADSH DRAAFAMVTH VKQEPREREN
1260 1270 1280 1290 1300
SESKEEDVEI DIELAPGDQT STPKTKELSE KDIGNQLHML TNRHDKFLDT
1310 1320 1330 1340 1350
LREVKTGALL SAFVQLCHIS TTLAEKTWVQ LFPRLWKILS DRQQHALAGE
1360 1370 1380 1390 1400
ISPFLCSGSH QVQRDCQPSA LNCFVEAMSQ CVPPIPMRPC VLKYLGKTHN
1410 1420 1430 1440 1450
LWFRSTLMLE HQAFEKGLSL PIKPKQTTEF YEQESITPPQ QEILDSLAEL
1460 1470 1480 1490 1500
YSLLQEEDMW AGLWQKRCKF SETATAIAYE QHGFFEQAQE SYEKAMDKAK
1510 1520 1530 1540 1550
KEHERSNASP AIFPEYQLWE DHWIRCSKEL NQWEALTEFG QSKGHINPYL
1560 1570 1580 1590 1600
VLECAWRVSN WTAMKEALVQ VEVSCPKEMA WKVNMYRGYL AICHPEEQQL
1610 1620 1630 1640 1650
SFIERLVEMA SSLAIREWRR LPHVVSHVHT PLLQAAQQII ELQEAAQINA
1660 1670 1680 1690 1700
GLQPTNLGRN NSLHDMKTVV KTWRNRLPIV SDDLSHWSSV FMWRQHHYQA
1710 1720 1730 1740 1750
IVTAYENSSH HDPSSNNAML GVHASASAII QYGKIARKQG LVNVALDILS
1760 1770 1780 1790 1800
RIHTIPTVPI VDCFQKIRQQ VKCYLQLAGV MGKNECMQGL EVIESTNLKY
1810 1820 1830 1840 1850
FTKEMTAEFY ALKGMFLAQI NKSEEANKAF SAAVQMHDVL VKAWAMWGDY
1860 1870 1880 1890 1900
LESIFVKERQ LHLGVSAITC YLHACRHQNE SKSRKYLAKV LWLLSFDDDK
1910 1920 1930 1940 1950
NTLADAVDKY CIGVPPIQWL AWIPQLLTCL VGSEGKLLLN LISQVGRVYP
1960 1970 1980 1990 2000
QAVYFPIRTL YLTLKIEQRE RYKSDSGQQQ PSSAGNQSHS ASDPGPIRAT
2010 2020 2030 2040 2050
APMWRCSRIM HMQRELHPTL LSSLEGIVDQ MVWFRENWHE EVLRQLQQGL
2060 2070 2080 2090 2100
AKCYSVAFEK SGAVSDAKIT PHTLNFVKKL VSTFGVGLEN VSNVSTMFSS
2110 2120 2130 2140 2150
AASESLARRA QATAQDPVFQ KLKGQFTTDF DFSVPGSMKL HNLISKLKKW
2160 2170 2180 2190 2200
IKILEAKTKQ LPKFFLIEEK CRFLSNFSAQ TAEVEIPGEF LMPKPTHYYI
2210 2220 2230 2240 2250
KIARFMPRVE IVQKHNTAAR RLHIRGHNGK IYPYLVMNDA CLTESRREER
2260 2270 2280 2290 2300
VLQLLRLLNP CLEKRKETTK RHLFFTVPRV VAVSPQMRLV EDNPSSLSLV
2310 2320 2330 2340 2350
EIYKQRCAKK GIEHDNPISR YYDRLATVQA RGTQASHQVL RDILKEVQSN
2360 2370 2380 2390 2400
MVPRSMLKEW ALHTFPNATD YWTFRKMFTI QLALIGFAEF VLHLNRLNPE
2410 2420 2430 2440 2450
MLQIAQDTGK LNVAYFRFDI NDATGDLDAN RPVPFRLTPN ISEFLTTIGV
2460 2470 2480 2490 2500
SGPLTASMIA VARCFAQPNF KVDGVLKTVL RDEIIAWHKK TQEDTSSPLS
2510 2520 2530 2540 2550
AAGQPENMDS QQLVSLVQKA VTAIMTRLHN LAQFDGGESK VNTLVAAANS
2560
LDNLCRMDPA WHPWL
Length:2,565
Mass (Da):291,557
Last modified:November 28, 2003 - v2
Checksum:i702138B3F2642B21
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC029023 mRNA. Translation: AAH29023.1.
BC050105 mRNA. Translation: AAH50105.1.
AK029388 mRNA. Translation: BAC26431.1.
UniGeneiMm.273570.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC029023 mRNA. Translation: AAH29023.1 .
BC050105 mRNA. Translation: AAH50105.1 .
AK029388 mRNA. Translation: BAC26431.1 .
UniGenei Mm.273570.

3D structure databases

ProteinModelPortali Q80YV3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-29177N.
IntActi Q80YV3. 23 interactions.
MINTi MINT-2568321.

PTM databases

PhosphoSitei Q80YV3.

Proteomic databases

MaxQBi Q80YV3.
PaxDbi Q80YV3.
PRIDEi Q80YV3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:2153272. Trrap.

Phylogenomic databases

eggNOGi COG5032.
HOVERGENi HBG079283.
InParanoidi Q80YV3.
PhylomeDBi Q80YV3.

Miscellaneous databases

PROi Q80YV3.
SOURCEi Search...

Gene expression databases

Genevestigatori Q80YV3.

Family and domain databases

Gene3Di 1.10.1070.11. 1 hit.
1.25.40.10. 3 hits.
InterProi IPR016024. ARM-type_fold.
IPR003152. FATC.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR003151. PIK-rel_kinase_FAT.
IPR014009. PIK_FAT.
IPR011990. TPR-like_helical_dom.
[Graphical view ]
Pfami PF02259. FAT. 1 hit.
PF00454. PI3_PI4_kinase. 1 hit.
[Graphical view ]
SMARTi SM00146. PI3Kc. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 7 hits.
SSF56112. SSF56112. 2 hits.
PROSITEi PS51189. FAT. 1 hit.
PS51190. FATC. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo and Kidney.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2211-2565.
    Strain: C57BL/6J.
    Tissue: Head.
  3. "Disruption of Trrap causes early embryonic lethality and defects in cell cycle progression."
    Herceg Z., Hulla W., Gell D., Cuenin C., Lleonart M., Jackson S., Wang Z.-Q.
    Nat. Genet. 29:206-211(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiTRRAP_MOUSE
AccessioniPrimary (citable) accession number: Q80YV3
Secondary accession number(s): Q8C0Z5, Q8K104
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: November 28, 2003
Last modified: October 29, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3