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Q80YT7 (MYOME_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Myomegalin
Alternative name(s):
Phosphodiesterase 4D-interacting protein
Gene names
Name:Pde4dip
Synonyms:Kiaa0454
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length2224 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May function as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes By similarity.

Subunit structure

Interacts with PDE4D By similarity.

Subcellular location

Golgi apparatus By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity. Cytoplasm By similarity. Nucleus By similarity.

Sequence similarities

Contains 1 NBPF domain.

Sequence caution

The sequence AAH25653.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

The sequence BAC65568.1 differs from that shown. Reason: Erroneous initiation.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q80YT7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q80YT7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-211: MSNGYRTLSQ...LLEEPASMEV → MKEICRICAR...LCDEYLPIGF
     950-955: QEMLHL → RHKHAF
     956-2224: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 22242224Myomegalin
PRO_0000307691

Regions

Domain1497 – 158892NBPF
Coiled coil41 – 9757 Potential
Coiled coil162 – 20544 Potential
Coiled coil236 – 31883 Potential
Coiled coil350 – 682333 Potential
Coiled coil745 – 82278 Potential
Coiled coil856 – 88631 Potential
Coiled coil949 – 98638 Potential
Coiled coil1159 – 118729 Potential
Coiled coil1295 – 133137 Potential
Coiled coil1377 – 140125 Potential
Coiled coil1769 – 1958190 Potential
Coiled coil2148 – 219144 Potential

Amino acid modifications

Modified residue7051Phosphothreonine By similarity

Natural variations

Alternative sequence1 – 211211MSNGY…ASMEV → MKEICRICARELCGNQRRWI FHTASKLNLQVLLSHVLGKD VSRDGKAEFACSKCAFMLDR IYRFDTVIARIEALSLERLQ KLLLEKDRLKFCIASMYRKN NDDSGEENKAGSGTVDISGL PDMRYAALLQEDFAYSGFEC WVENEDQINDSHSCHASEGP GNRPRRCRGCAALRVADSDY EAICKVPRKVARSISYAPSS RWSTSICTEEPALSEVGPPD LASTKVPPDGESMEEGTPGS SVESLDASVQASPPQQKDEE TERSAKELVKCDYCSDEQAP QHLCNHKLELALSMIKGLDY KPIQSPRGSKLPIPVKSILP GAKPGHILTNGVSSSFLNRP LKPLYRTPVSYPWEISDGQE LWDDLCDEYLPIGF in isoform 2.
VSP_028784
Alternative sequence950 – 9556QEMLHL → RHKHAF in isoform 2.
VSP_028785
Alternative sequence956 – 22241269Missing in isoform 2.
VSP_028786

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 23, 2007. Version 2.
Checksum: D3EA6F593ACD2445

FASTA2,224250,631
        10         20         30         40         50         60 
MSNGYRTLSQ HLNDLKKENF SLKLRIYFLE ERMQQKYEVS REDVYKRNIE LKVEVESLKR 

        70         80         90        100        110        120 
ELQDRKQHLD KTWADAEDLN SQNEAELRRQ VEERQQETEH VYELLGNKIQ LLQEEPRLAK 

       130        140        150        160        170        180 
NEATEMETLV EAEKRCNLEL SERWTNAAKN REDAAGDQEK PDQYSEALAQ RDRRIEELRQ 

       190        200        210        220        230        240 
SLAAQEGLVE QLSQEKRQLL HLLEEPASME VQPVPKGLPT QQKPDLHETP TTQPPVSESH 

       250        260        270        280        290        300 
LAELQDKIQQ TEATNKILQE KLNDLSCELK SAQESSQKQD TTIQSLKEML KSRESETEEL 

       310        320        330        340        350        360 
YQVIEGQNDT MAKLREMLHQ SQLGQLHSSE GIAPAQQQVA LLDLQSALFC SQLEIQRLQR 

       370        380        390        400        410        420 
LVRQKERQLA DGKRCVQLVE AAAQEREHQK EAAWKHNQEL RKALQHLQGE LHSKSQQLHV 

       430        440        450        460        470        480 
LEAEKYNEIR TQGQNIQHLS HSLSHKEQLI QELQELLQYR DNADKTLDTN EVFLEKLRQR 

       490        500        510        520        530        540 
IQDRAVALER VIDEKFSALE EKDKELRQLR LAVRDRDHDL ERLRCVLSAN EATMQSMESL 

       550        560        570        580        590        600 
LRARGLEVEQ LTATCQNLQW LKEELETKFG HWQKEQESII QQLQTSLHDR NKEVEDLSAT 

       610        620        630        640        650        660 
LLCKLGPGQS EVAEELCQRL QRKERMLQDL LSDRNKQAVE HEMEIQGLLQ SMGTREQERQ 

       670        680        690        700        710        720 
AAAEKMVQAF MERNSELQAL RQYLGGKELM TSSQTFISNQ PAGVTSIGPH HGEQTDQGSM 

       730        740        750        760        770        780 
QMPSRDDSTS LTAREEASIP RSTLGDSDTV AGLEKELSNA KEELELMAKK ERESQMELSA 

       790        800        810        820        830        840 
LQSMMAMQEE ELQVQAADLE SLTRNVQIKE DLIKDLQMQL VDPEDIPAME RLTQEVLLLR 

       850        860        870        880        890        900 
EKVASVEPQG QEVSGNKRQQ LLLMLEGLVD ERSRLNEALQ AERQLYSSLV KFHAQPENSE 

       910        920        930        940        950        960 
RDGTLQVELE GAQVLRTRLE EVLGRSLERL SRLESLAAIG GGELESVQAQ EMLHLRAEIH 

       970        980        990       1000       1010       1020 
QHLEEKRKAE VELKELKAQI EEAGFSSVSH ISRNTMLSLC LENAELKEQM GEAMSDGWEV 

      1030       1040       1050       1060       1070       1080 
EEDKEKGEVM LETVVAKGCL NENSLQAEFR KVQGKLKSAY NIINLLKEQL LLRSSEGNSK 

      1090       1100       1110       1120       1130       1140 
EMPELLVRLA REVDRMNTGL PSLGKHQHQE QENTTTARPG SRPQSLPLGA ALSVDGYQLE 

      1150       1160       1170       1180       1190       1200 
NKSQAQDSGH QPEFSLPGST KHLRSQLAQC RQRYQDLQEK LLISEATVFA QANQLEKYRA 

      1210       1220       1230       1240       1250       1260 
VFSESLVKQD SKQIQVDLQD LGYETCGRSE NEAEREETTS PECEEHNNLR PVVLMEGLCS 

      1270       1280       1290       1300       1310       1320 
EQGYLDPVLV SPPAKKPLEN KPGKQEEFRA HGTPDDSSLL RKDIRDLKAQ LQNANKVIQN 

      1330       1340       1350       1360       1370       1380 
LRSRVRSLSA TSDYSSSLER PRKLRAVATL EGASPHSVTD EDEGWLSDGT GAFYPPGLQA 

      1390       1400       1410       1420       1430       1440 
KKDLESLIQR VSQLEAQLPK TGLEGKLAEE LRCASWPGKY DSLIQDQARE LSYLRQKIRE 

      1450       1460       1470       1480       1490       1500 
GRGICYLLTQ HAKDTVKSFE DLLRSNDIDY YLGQSFREQL AQGGQLTERL TSKLSTKDHK 

      1510       1520       1530       1540       1550       1560 
SEKEEAGLEP LALRLSRELQ EKEKVIEVLQ AKLDTRSLSP PSSHAVSDSH RSASTTSFLS 

      1570       1580       1590       1600       1610       1620 
DDIEACSDMD VASEYTHYDE KKPSPSHSAA SASQGLKGES SSSPISLPTP QNPPKEASQA 

      1630       1640       1650       1660       1670       1680 
HPGFHFHSIP KPASLSQTPM HSALPSFVPF SPSGPPLLGC CETPMVSLAE AQQELQMLQK 

      1690       1700       1710       1720       1730       1740 
QLGESVSIAP PASTSTLLSN QTEASSPHYI NPAQPHTPTR STIELGRILE PGYLGSSGQW 

      1750       1760       1770       1780       1790       1800 
DMMRPQKGSV SGELSSGSSM YQLNSKPTGA DLLEEHLGEI RNLRQRLEES ICVNDRLREQ 

      1810       1820       1830       1840       1850       1860 
LQHRLSSTAR ENGSTSHFYS QGLESMPQLY NENRALREEN QSLQTRLSHA SRGHSQEVDH 

      1870       1880       1890       1900       1910       1920 
LREALLSSRS QLQELEKELE QQKAERQQLS LQSELQIYES LCENPKKALK AFSLDSCHQV 

      1930       1940       1950       1960       1970       1980 
PGELSCLVAE IRALRGQLEQ SIEVNNRLRL QLEQQMDRGA GKASLGPIAV GQSFPDKAEP 

      1990       2000       2010       2020       2030       2040 
ANLHQGSAAS PPVRDVGLNS PAMVLPNSSC SAPGSDHAIV TRTNNELSSD DSAAMKNPPK 

      2050       2060       2070       2080       2090       2100 
LEVDATDGPF ANKHGRHVIG HVDDYDALQQ QIGEGKLLIQ KILSLMRSAR SIPGQEAQDT 

      2110       2120       2130       2140       2150       2160 
EAPGNISAHE LRSSAKALNH ALEESTSLLN MFWRAALPNT HGPVLVGKEG QLMEKELLDL 

      2170       2180       2190       2200       2210       2220 
RAQVSQQEQI LQNTAARLKR ANQRKKSMEQ FIVSHLTRTH DVLKKARTNL EMKSFRALTC 


TPAL 

« Hide

Isoform 2 [UniParc].

Checksum: DC39815A9629AD96
Show »

FASTA1,118126,615

References

[1]"Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Brain.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Strain: FVB/N.
Tissue: Brain and Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK122286 mRNA. Translation: BAC65568.1. Different initiation.
AC130541 Genomic DNA. No translation available.
AC153661 Genomic DNA. No translation available.
BC025653 mRNA. Translation: AAH25653.1. Sequence problems.
BC034266 mRNA. Translation: AAH34266.1.
BC050783 mRNA. Translation: AAH50783.1.
RefSeqNP_001034465.2. NM_001039376.2.
NP_835181.2. NM_178080.4.
UniGeneMm.129840.

3D structure databases

ProteinModelPortalQ80YT7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000088254.

Proteomic databases

PaxDbQ80YT7.
PRIDEQ80YT7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000045243; ENSMUSP00000040905; ENSMUSG00000038170. [Q80YT7-2]
GeneID83679.
KEGGmmu:83679.
UCSCuc008qpg.1. mouse. [Q80YT7-2]

Organism-specific databases

CTD9659.
MGIMGI:1891434. Pde4dip.
RougeSearch...

Phylogenomic databases

eggNOGNOG46262.
GeneTreeENSGT00530000063845.
HOGENOMHOG000113709.
HOVERGENHBG108166.
InParanoidQ80YT7.
KOK16549.
PhylomeDBQ80YT7.
TreeFamTF329233.

Gene expression databases

ArrayExpressQ80YT7.
BgeeQ80YT7.
GenevestigatorQ80YT7.

Family and domain databases

InterProIPR010630. NBPF_dom.
IPR012943. Spindle_assoc.
[Graphical view]
PfamPF06758. DUF1220. 1 hit.
PF07989. Microtub_assoc. 1 hit.
[Graphical view]
PROSITEPS51316. NBPF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSPDE4DIP. mouse.
NextBio350723.
PROQ80YT7.
SOURCESearch...

Entry information

Entry nameMYOME_MOUSE
AccessionPrimary (citable) accession number: Q80YT7
Secondary accession number(s): Q05CH5, Q80U00, Q8K240
Entry history
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: April 16, 2014
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot