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Q80YT7

- MYOME_MOUSE

UniProt

Q80YT7 - MYOME_MOUSE

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Protein

Myomegalin

Gene

Pde4dip

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May function as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes.By similarity

GO - Molecular functioni

  1. enzyme binding Source: UniProtKB

GO - Biological processi

  1. cellular protein complex assembly Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Myomegalin
Alternative name(s):
Phosphodiesterase 4D-interacting protein
Gene namesi
Name:Pde4dip
Synonyms:Kiaa0454
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:1891434. Pde4dip.

Subcellular locationi

Golgi apparatus By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity. Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. centrosome Source: UniProtKB
  2. cytoplasm Source: UniProtKB
  3. Golgi apparatus Source: UniProtKB
  4. myofibril Source: UniProtKB
  5. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Golgi apparatus, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 22242224MyomegalinPRO_0000307691Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei705 – 7051PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ80YT7.
PaxDbiQ80YT7.
PRIDEiQ80YT7.

Expressioni

Gene expression databases

BgeeiQ80YT7.
ExpressionAtlasiQ80YT7. baseline and differential.
GenevestigatoriQ80YT7.

Interactioni

Subunit structurei

Interacts with PDE4D.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000088254.

Structurei

3D structure databases

ProteinModelPortaliQ80YT7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1497 – 158892NBPFPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili41 – 9757Sequence AnalysisAdd
BLAST
Coiled coili162 – 20544Sequence AnalysisAdd
BLAST
Coiled coili236 – 31883Sequence AnalysisAdd
BLAST
Coiled coili350 – 682333Sequence AnalysisAdd
BLAST
Coiled coili745 – 82278Sequence AnalysisAdd
BLAST
Coiled coili856 – 88631Sequence AnalysisAdd
BLAST
Coiled coili949 – 98638Sequence AnalysisAdd
BLAST
Coiled coili1159 – 118729Sequence AnalysisAdd
BLAST
Coiled coili1295 – 133137Sequence AnalysisAdd
BLAST
Coiled coili1377 – 140125Sequence AnalysisAdd
BLAST
Coiled coili1769 – 1958190Sequence AnalysisAdd
BLAST
Coiled coili2148 – 219144Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 1 NBPF domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG46262.
GeneTreeiENSGT00530000063845.
HOGENOMiHOG000113709.
HOVERGENiHBG108166.
InParanoidiQ80YT7.
KOiK16549.
OMAiINDSHSC.
PhylomeDBiQ80YT7.
TreeFamiTF329233.

Family and domain databases

InterProiIPR010630. NBPF_dom.
IPR012943. Spindle_assoc.
[Graphical view]
PfamiPF06758. DUF1220. 1 hit.
PF07989. Microtub_assoc. 1 hit.
[Graphical view]
PROSITEiPS51316. NBPF. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q80YT7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSNGYRTLSQ HLNDLKKENF SLKLRIYFLE ERMQQKYEVS REDVYKRNIE
60 70 80 90 100
LKVEVESLKR ELQDRKQHLD KTWADAEDLN SQNEAELRRQ VEERQQETEH
110 120 130 140 150
VYELLGNKIQ LLQEEPRLAK NEATEMETLV EAEKRCNLEL SERWTNAAKN
160 170 180 190 200
REDAAGDQEK PDQYSEALAQ RDRRIEELRQ SLAAQEGLVE QLSQEKRQLL
210 220 230 240 250
HLLEEPASME VQPVPKGLPT QQKPDLHETP TTQPPVSESH LAELQDKIQQ
260 270 280 290 300
TEATNKILQE KLNDLSCELK SAQESSQKQD TTIQSLKEML KSRESETEEL
310 320 330 340 350
YQVIEGQNDT MAKLREMLHQ SQLGQLHSSE GIAPAQQQVA LLDLQSALFC
360 370 380 390 400
SQLEIQRLQR LVRQKERQLA DGKRCVQLVE AAAQEREHQK EAAWKHNQEL
410 420 430 440 450
RKALQHLQGE LHSKSQQLHV LEAEKYNEIR TQGQNIQHLS HSLSHKEQLI
460 470 480 490 500
QELQELLQYR DNADKTLDTN EVFLEKLRQR IQDRAVALER VIDEKFSALE
510 520 530 540 550
EKDKELRQLR LAVRDRDHDL ERLRCVLSAN EATMQSMESL LRARGLEVEQ
560 570 580 590 600
LTATCQNLQW LKEELETKFG HWQKEQESII QQLQTSLHDR NKEVEDLSAT
610 620 630 640 650
LLCKLGPGQS EVAEELCQRL QRKERMLQDL LSDRNKQAVE HEMEIQGLLQ
660 670 680 690 700
SMGTREQERQ AAAEKMVQAF MERNSELQAL RQYLGGKELM TSSQTFISNQ
710 720 730 740 750
PAGVTSIGPH HGEQTDQGSM QMPSRDDSTS LTAREEASIP RSTLGDSDTV
760 770 780 790 800
AGLEKELSNA KEELELMAKK ERESQMELSA LQSMMAMQEE ELQVQAADLE
810 820 830 840 850
SLTRNVQIKE DLIKDLQMQL VDPEDIPAME RLTQEVLLLR EKVASVEPQG
860 870 880 890 900
QEVSGNKRQQ LLLMLEGLVD ERSRLNEALQ AERQLYSSLV KFHAQPENSE
910 920 930 940 950
RDGTLQVELE GAQVLRTRLE EVLGRSLERL SRLESLAAIG GGELESVQAQ
960 970 980 990 1000
EMLHLRAEIH QHLEEKRKAE VELKELKAQI EEAGFSSVSH ISRNTMLSLC
1010 1020 1030 1040 1050
LENAELKEQM GEAMSDGWEV EEDKEKGEVM LETVVAKGCL NENSLQAEFR
1060 1070 1080 1090 1100
KVQGKLKSAY NIINLLKEQL LLRSSEGNSK EMPELLVRLA REVDRMNTGL
1110 1120 1130 1140 1150
PSLGKHQHQE QENTTTARPG SRPQSLPLGA ALSVDGYQLE NKSQAQDSGH
1160 1170 1180 1190 1200
QPEFSLPGST KHLRSQLAQC RQRYQDLQEK LLISEATVFA QANQLEKYRA
1210 1220 1230 1240 1250
VFSESLVKQD SKQIQVDLQD LGYETCGRSE NEAEREETTS PECEEHNNLR
1260 1270 1280 1290 1300
PVVLMEGLCS EQGYLDPVLV SPPAKKPLEN KPGKQEEFRA HGTPDDSSLL
1310 1320 1330 1340 1350
RKDIRDLKAQ LQNANKVIQN LRSRVRSLSA TSDYSSSLER PRKLRAVATL
1360 1370 1380 1390 1400
EGASPHSVTD EDEGWLSDGT GAFYPPGLQA KKDLESLIQR VSQLEAQLPK
1410 1420 1430 1440 1450
TGLEGKLAEE LRCASWPGKY DSLIQDQARE LSYLRQKIRE GRGICYLLTQ
1460 1470 1480 1490 1500
HAKDTVKSFE DLLRSNDIDY YLGQSFREQL AQGGQLTERL TSKLSTKDHK
1510 1520 1530 1540 1550
SEKEEAGLEP LALRLSRELQ EKEKVIEVLQ AKLDTRSLSP PSSHAVSDSH
1560 1570 1580 1590 1600
RSASTTSFLS DDIEACSDMD VASEYTHYDE KKPSPSHSAA SASQGLKGES
1610 1620 1630 1640 1650
SSSPISLPTP QNPPKEASQA HPGFHFHSIP KPASLSQTPM HSALPSFVPF
1660 1670 1680 1690 1700
SPSGPPLLGC CETPMVSLAE AQQELQMLQK QLGESVSIAP PASTSTLLSN
1710 1720 1730 1740 1750
QTEASSPHYI NPAQPHTPTR STIELGRILE PGYLGSSGQW DMMRPQKGSV
1760 1770 1780 1790 1800
SGELSSGSSM YQLNSKPTGA DLLEEHLGEI RNLRQRLEES ICVNDRLREQ
1810 1820 1830 1840 1850
LQHRLSSTAR ENGSTSHFYS QGLESMPQLY NENRALREEN QSLQTRLSHA
1860 1870 1880 1890 1900
SRGHSQEVDH LREALLSSRS QLQELEKELE QQKAERQQLS LQSELQIYES
1910 1920 1930 1940 1950
LCENPKKALK AFSLDSCHQV PGELSCLVAE IRALRGQLEQ SIEVNNRLRL
1960 1970 1980 1990 2000
QLEQQMDRGA GKASLGPIAV GQSFPDKAEP ANLHQGSAAS PPVRDVGLNS
2010 2020 2030 2040 2050
PAMVLPNSSC SAPGSDHAIV TRTNNELSSD DSAAMKNPPK LEVDATDGPF
2060 2070 2080 2090 2100
ANKHGRHVIG HVDDYDALQQ QIGEGKLLIQ KILSLMRSAR SIPGQEAQDT
2110 2120 2130 2140 2150
EAPGNISAHE LRSSAKALNH ALEESTSLLN MFWRAALPNT HGPVLVGKEG
2160 2170 2180 2190 2200
QLMEKELLDL RAQVSQQEQI LQNTAARLKR ANQRKKSMEQ FIVSHLTRTH
2210 2220
DVLKKARTNL EMKSFRALTC TPAL
Length:2,224
Mass (Da):250,631
Last modified:October 23, 2007 - v2
Checksum:iD3EA6F593ACD2445
GO
Isoform 2 (identifier: Q80YT7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-211: MSNGYRTLSQ...LLEEPASMEV → MKEICRICAR...LCDEYLPIGF
     950-955: QEMLHL → RHKHAF
     956-2224: Missing.

Show »
Length:1,118
Mass (Da):126,615
Checksum:iDC39815A9629AD96
GO

Sequence cautioni

The sequence AAH25653.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAC65568.1 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 211211MSNGY…ASMEV → MKEICRICARELCGNQRRWI FHTASKLNLQVLLSHVLGKD VSRDGKAEFACSKCAFMLDR IYRFDTVIARIEALSLERLQ KLLLEKDRLKFCIASMYRKN NDDSGEENKAGSGTVDISGL PDMRYAALLQEDFAYSGFEC WVENEDQINDSHSCHASEGP GNRPRRCRGCAALRVADSDY EAICKVPRKVARSISYAPSS RWSTSICTEEPALSEVGPPD LASTKVPPDGESMEEGTPGS SVESLDASVQASPPQQKDEE TERSAKELVKCDYCSDEQAP QHLCNHKLELALSMIKGLDY KPIQSPRGSKLPIPVKSILP GAKPGHILTNGVSSSFLNRP LKPLYRTPVSYPWEISDGQE LWDDLCDEYLPIGF in isoform 2. 2 PublicationsVSP_028784Add
BLAST
Alternative sequencei950 – 9556QEMLHL → RHKHAF in isoform 2. 2 PublicationsVSP_028785
Alternative sequencei956 – 22241269Missing in isoform 2. 2 PublicationsVSP_028786Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122286 mRNA. Translation: BAC65568.1. Different initiation.
AC130541 Genomic DNA. No translation available.
AC153661 Genomic DNA. No translation available.
BC025653 mRNA. Translation: AAH25653.1. Sequence problems.
BC034266 mRNA. Translation: AAH34266.1.
BC050783 mRNA. Translation: AAH50783.1.
CCDSiCCDS38562.1. [Q80YT7-2]
RefSeqiNP_001034465.2. NM_001039376.2.
NP_835181.2. NM_178080.4. [Q80YT7-2]
UniGeneiMm.129840.

Genome annotation databases

EnsembliENSMUST00000045243; ENSMUSP00000040905; ENSMUSG00000038170. [Q80YT7-2]
GeneIDi83679.
KEGGimmu:83679.
UCSCiuc008qpg.1. mouse. [Q80YT7-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122286 mRNA. Translation: BAC65568.1 . Different initiation.
AC130541 Genomic DNA. No translation available.
AC153661 Genomic DNA. No translation available.
BC025653 mRNA. Translation: AAH25653.1 . Sequence problems.
BC034266 mRNA. Translation: AAH34266.1 .
BC050783 mRNA. Translation: AAH50783.1 .
CCDSi CCDS38562.1. [Q80YT7-2 ]
RefSeqi NP_001034465.2. NM_001039376.2.
NP_835181.2. NM_178080.4. [Q80YT7-2 ]
UniGenei Mm.129840.

3D structure databases

ProteinModelPortali Q80YT7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000088254.

Proteomic databases

MaxQBi Q80YT7.
PaxDbi Q80YT7.
PRIDEi Q80YT7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000045243 ; ENSMUSP00000040905 ; ENSMUSG00000038170 . [Q80YT7-2 ]
GeneIDi 83679.
KEGGi mmu:83679.
UCSCi uc008qpg.1. mouse. [Q80YT7-2 ]

Organism-specific databases

CTDi 9659.
MGIi MGI:1891434. Pde4dip.
Rougei Search...

Phylogenomic databases

eggNOGi NOG46262.
GeneTreei ENSGT00530000063845.
HOGENOMi HOG000113709.
HOVERGENi HBG108166.
InParanoidi Q80YT7.
KOi K16549.
OMAi INDSHSC.
PhylomeDBi Q80YT7.
TreeFami TF329233.

Miscellaneous databases

ChiTaRSi Pde4dip. mouse.
NextBioi 350723.
PROi Q80YT7.
SOURCEi Search...

Gene expression databases

Bgeei Q80YT7.
ExpressionAtlasi Q80YT7. baseline and differential.
Genevestigatori Q80YT7.

Family and domain databases

InterProi IPR010630. NBPF_dom.
IPR012943. Spindle_assoc.
[Graphical view ]
Pfami PF06758. DUF1220. 1 hit.
PF07989. Microtub_assoc. 1 hit.
[Graphical view ]
PROSITEi PS51316. NBPF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
    DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: FVB/N.
    Tissue: Brain and Mammary tumor.

Entry informationi

Entry nameiMYOME_MOUSE
AccessioniPrimary (citable) accession number: Q80YT7
Secondary accession number(s): Q05CH5, Q80U00, Q8K240
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: November 26, 2014
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3