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Q80YT7

- MYOME_MOUSE

UniProt

Q80YT7 - MYOME_MOUSE

Protein

Myomegalin

Gene

Pde4dip

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 2 (23 Oct 2007)
      Previous versions | rss
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    Functioni

    May function as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes.By similarity

    GO - Molecular functioni

    1. enzyme binding Source: UniProtKB
    2. protein binding Source: MGI

    GO - Biological processi

    1. cellular protein complex assembly Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Myomegalin
    Alternative name(s):
    Phosphodiesterase 4D-interacting protein
    Gene namesi
    Name:Pde4dip
    Synonyms:Kiaa0454
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:1891434. Pde4dip.

    Subcellular locationi

    Golgi apparatus By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity. Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. centrosome Source: UniProtKB
    2. cytoplasm Source: UniProtKB
    3. Golgi apparatus Source: UniProtKB
    4. myofibril Source: UniProtKB
    5. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Golgi apparatus, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 22242224MyomegalinPRO_0000307691Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei705 – 7051PhosphothreonineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ80YT7.
    PaxDbiQ80YT7.
    PRIDEiQ80YT7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ80YT7.
    BgeeiQ80YT7.
    GenevestigatoriQ80YT7.

    Interactioni

    Subunit structurei

    Interacts with PDE4D.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000088254.

    Structurei

    3D structure databases

    ProteinModelPortaliQ80YT7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1497 – 158892NBPFPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili41 – 9757Sequence AnalysisAdd
    BLAST
    Coiled coili162 – 20544Sequence AnalysisAdd
    BLAST
    Coiled coili236 – 31883Sequence AnalysisAdd
    BLAST
    Coiled coili350 – 682333Sequence AnalysisAdd
    BLAST
    Coiled coili745 – 82278Sequence AnalysisAdd
    BLAST
    Coiled coili856 – 88631Sequence AnalysisAdd
    BLAST
    Coiled coili949 – 98638Sequence AnalysisAdd
    BLAST
    Coiled coili1159 – 118729Sequence AnalysisAdd
    BLAST
    Coiled coili1295 – 133137Sequence AnalysisAdd
    BLAST
    Coiled coili1377 – 140125Sequence AnalysisAdd
    BLAST
    Coiled coili1769 – 1958190Sequence AnalysisAdd
    BLAST
    Coiled coili2148 – 219144Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 NBPF domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG46262.
    GeneTreeiENSGT00530000063845.
    HOGENOMiHOG000113709.
    HOVERGENiHBG108166.
    InParanoidiQ80YT7.
    KOiK16549.
    OMAiINDSHSC.
    PhylomeDBiQ80YT7.
    TreeFamiTF329233.

    Family and domain databases

    InterProiIPR010630. NBPF_dom.
    IPR012943. Spindle_assoc.
    [Graphical view]
    PfamiPF06758. DUF1220. 1 hit.
    PF07989. Microtub_assoc. 1 hit.
    [Graphical view]
    PROSITEiPS51316. NBPF. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q80YT7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSNGYRTLSQ HLNDLKKENF SLKLRIYFLE ERMQQKYEVS REDVYKRNIE     50
    LKVEVESLKR ELQDRKQHLD KTWADAEDLN SQNEAELRRQ VEERQQETEH 100
    VYELLGNKIQ LLQEEPRLAK NEATEMETLV EAEKRCNLEL SERWTNAAKN 150
    REDAAGDQEK PDQYSEALAQ RDRRIEELRQ SLAAQEGLVE QLSQEKRQLL 200
    HLLEEPASME VQPVPKGLPT QQKPDLHETP TTQPPVSESH LAELQDKIQQ 250
    TEATNKILQE KLNDLSCELK SAQESSQKQD TTIQSLKEML KSRESETEEL 300
    YQVIEGQNDT MAKLREMLHQ SQLGQLHSSE GIAPAQQQVA LLDLQSALFC 350
    SQLEIQRLQR LVRQKERQLA DGKRCVQLVE AAAQEREHQK EAAWKHNQEL 400
    RKALQHLQGE LHSKSQQLHV LEAEKYNEIR TQGQNIQHLS HSLSHKEQLI 450
    QELQELLQYR DNADKTLDTN EVFLEKLRQR IQDRAVALER VIDEKFSALE 500
    EKDKELRQLR LAVRDRDHDL ERLRCVLSAN EATMQSMESL LRARGLEVEQ 550
    LTATCQNLQW LKEELETKFG HWQKEQESII QQLQTSLHDR NKEVEDLSAT 600
    LLCKLGPGQS EVAEELCQRL QRKERMLQDL LSDRNKQAVE HEMEIQGLLQ 650
    SMGTREQERQ AAAEKMVQAF MERNSELQAL RQYLGGKELM TSSQTFISNQ 700
    PAGVTSIGPH HGEQTDQGSM QMPSRDDSTS LTAREEASIP RSTLGDSDTV 750
    AGLEKELSNA KEELELMAKK ERESQMELSA LQSMMAMQEE ELQVQAADLE 800
    SLTRNVQIKE DLIKDLQMQL VDPEDIPAME RLTQEVLLLR EKVASVEPQG 850
    QEVSGNKRQQ LLLMLEGLVD ERSRLNEALQ AERQLYSSLV KFHAQPENSE 900
    RDGTLQVELE GAQVLRTRLE EVLGRSLERL SRLESLAAIG GGELESVQAQ 950
    EMLHLRAEIH QHLEEKRKAE VELKELKAQI EEAGFSSVSH ISRNTMLSLC 1000
    LENAELKEQM GEAMSDGWEV EEDKEKGEVM LETVVAKGCL NENSLQAEFR 1050
    KVQGKLKSAY NIINLLKEQL LLRSSEGNSK EMPELLVRLA REVDRMNTGL 1100
    PSLGKHQHQE QENTTTARPG SRPQSLPLGA ALSVDGYQLE NKSQAQDSGH 1150
    QPEFSLPGST KHLRSQLAQC RQRYQDLQEK LLISEATVFA QANQLEKYRA 1200
    VFSESLVKQD SKQIQVDLQD LGYETCGRSE NEAEREETTS PECEEHNNLR 1250
    PVVLMEGLCS EQGYLDPVLV SPPAKKPLEN KPGKQEEFRA HGTPDDSSLL 1300
    RKDIRDLKAQ LQNANKVIQN LRSRVRSLSA TSDYSSSLER PRKLRAVATL 1350
    EGASPHSVTD EDEGWLSDGT GAFYPPGLQA KKDLESLIQR VSQLEAQLPK 1400
    TGLEGKLAEE LRCASWPGKY DSLIQDQARE LSYLRQKIRE GRGICYLLTQ 1450
    HAKDTVKSFE DLLRSNDIDY YLGQSFREQL AQGGQLTERL TSKLSTKDHK 1500
    SEKEEAGLEP LALRLSRELQ EKEKVIEVLQ AKLDTRSLSP PSSHAVSDSH 1550
    RSASTTSFLS DDIEACSDMD VASEYTHYDE KKPSPSHSAA SASQGLKGES 1600
    SSSPISLPTP QNPPKEASQA HPGFHFHSIP KPASLSQTPM HSALPSFVPF 1650
    SPSGPPLLGC CETPMVSLAE AQQELQMLQK QLGESVSIAP PASTSTLLSN 1700
    QTEASSPHYI NPAQPHTPTR STIELGRILE PGYLGSSGQW DMMRPQKGSV 1750
    SGELSSGSSM YQLNSKPTGA DLLEEHLGEI RNLRQRLEES ICVNDRLREQ 1800
    LQHRLSSTAR ENGSTSHFYS QGLESMPQLY NENRALREEN QSLQTRLSHA 1850
    SRGHSQEVDH LREALLSSRS QLQELEKELE QQKAERQQLS LQSELQIYES 1900
    LCENPKKALK AFSLDSCHQV PGELSCLVAE IRALRGQLEQ SIEVNNRLRL 1950
    QLEQQMDRGA GKASLGPIAV GQSFPDKAEP ANLHQGSAAS PPVRDVGLNS 2000
    PAMVLPNSSC SAPGSDHAIV TRTNNELSSD DSAAMKNPPK LEVDATDGPF 2050
    ANKHGRHVIG HVDDYDALQQ QIGEGKLLIQ KILSLMRSAR SIPGQEAQDT 2100
    EAPGNISAHE LRSSAKALNH ALEESTSLLN MFWRAALPNT HGPVLVGKEG 2150
    QLMEKELLDL RAQVSQQEQI LQNTAARLKR ANQRKKSMEQ FIVSHLTRTH 2200
    DVLKKARTNL EMKSFRALTC TPAL 2224
    Length:2,224
    Mass (Da):250,631
    Last modified:October 23, 2007 - v2
    Checksum:iD3EA6F593ACD2445
    GO
    Isoform 2 (identifier: Q80YT7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-211: MSNGYRTLSQ...LLEEPASMEV → MKEICRICAR...LCDEYLPIGF
         950-955: QEMLHL → RHKHAF
         956-2224: Missing.

    Show »
    Length:1,118
    Mass (Da):126,615
    Checksum:iDC39815A9629AD96
    GO

    Sequence cautioni

    The sequence AAH25653.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
    The sequence BAC65568.1 differs from that shown. Reason: Erroneous initiation.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 211211MSNGY…ASMEV → MKEICRICARELCGNQRRWI FHTASKLNLQVLLSHVLGKD VSRDGKAEFACSKCAFMLDR IYRFDTVIARIEALSLERLQ KLLLEKDRLKFCIASMYRKN NDDSGEENKAGSGTVDISGL PDMRYAALLQEDFAYSGFEC WVENEDQINDSHSCHASEGP GNRPRRCRGCAALRVADSDY EAICKVPRKVARSISYAPSS RWSTSICTEEPALSEVGPPD LASTKVPPDGESMEEGTPGS SVESLDASVQASPPQQKDEE TERSAKELVKCDYCSDEQAP QHLCNHKLELALSMIKGLDY KPIQSPRGSKLPIPVKSILP GAKPGHILTNGVSSSFLNRP LKPLYRTPVSYPWEISDGQE LWDDLCDEYLPIGF in isoform 2. 2 PublicationsVSP_028784Add
    BLAST
    Alternative sequencei950 – 9556QEMLHL → RHKHAF in isoform 2. 2 PublicationsVSP_028785
    Alternative sequencei956 – 22241269Missing in isoform 2. 2 PublicationsVSP_028786Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK122286 mRNA. Translation: BAC65568.1. Different initiation.
    AC130541 Genomic DNA. No translation available.
    AC153661 Genomic DNA. No translation available.
    BC025653 mRNA. Translation: AAH25653.1. Sequence problems.
    BC034266 mRNA. Translation: AAH34266.1.
    BC050783 mRNA. Translation: AAH50783.1.
    CCDSiCCDS38562.1. [Q80YT7-2]
    RefSeqiNP_001034465.2. NM_001039376.2.
    NP_835181.2. NM_178080.4. [Q80YT7-2]
    UniGeneiMm.129840.

    Genome annotation databases

    EnsembliENSMUST00000045243; ENSMUSP00000040905; ENSMUSG00000038170. [Q80YT7-2]
    GeneIDi83679.
    KEGGimmu:83679.
    UCSCiuc008qpg.1. mouse. [Q80YT7-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK122286 mRNA. Translation: BAC65568.1 . Different initiation.
    AC130541 Genomic DNA. No translation available.
    AC153661 Genomic DNA. No translation available.
    BC025653 mRNA. Translation: AAH25653.1 . Sequence problems.
    BC034266 mRNA. Translation: AAH34266.1 .
    BC050783 mRNA. Translation: AAH50783.1 .
    CCDSi CCDS38562.1. [Q80YT7-2 ]
    RefSeqi NP_001034465.2. NM_001039376.2.
    NP_835181.2. NM_178080.4. [Q80YT7-2 ]
    UniGenei Mm.129840.

    3D structure databases

    ProteinModelPortali Q80YT7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000088254.

    Proteomic databases

    MaxQBi Q80YT7.
    PaxDbi Q80YT7.
    PRIDEi Q80YT7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000045243 ; ENSMUSP00000040905 ; ENSMUSG00000038170 . [Q80YT7-2 ]
    GeneIDi 83679.
    KEGGi mmu:83679.
    UCSCi uc008qpg.1. mouse. [Q80YT7-2 ]

    Organism-specific databases

    CTDi 9659.
    MGIi MGI:1891434. Pde4dip.
    Rougei Search...

    Phylogenomic databases

    eggNOGi NOG46262.
    GeneTreei ENSGT00530000063845.
    HOGENOMi HOG000113709.
    HOVERGENi HBG108166.
    InParanoidi Q80YT7.
    KOi K16549.
    OMAi INDSHSC.
    PhylomeDBi Q80YT7.
    TreeFami TF329233.

    Miscellaneous databases

    ChiTaRSi PDE4DIP. mouse.
    NextBioi 350723.
    PROi Q80YT7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q80YT7.
    Bgeei Q80YT7.
    Genevestigatori Q80YT7.

    Family and domain databases

    InterProi IPR010630. NBPF_dom.
    IPR012943. Spindle_assoc.
    [Graphical view ]
    Pfami PF06758. DUF1220. 1 hit.
    PF07989. Microtub_assoc. 1 hit.
    [Graphical view ]
    PROSITEi PS51316. NBPF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
      DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: FVB/N.
      Tissue: Brain and Mammary tumor.

    Entry informationi

    Entry nameiMYOME_MOUSE
    AccessioniPrimary (citable) accession number: Q80YT7
    Secondary accession number(s): Q05CH5, Q80U00, Q8K240
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: October 23, 2007
    Last modified: October 1, 2014
    This is version 77 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3