Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Myomegalin

Gene

Pde4dip

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May function as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes.By similarity

GO - Molecular functioni

  • enzyme binding Source: UniProtKB

GO - Biological processi

  • cellular protein complex assembly Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Myomegalin
Alternative name(s):
Phosphodiesterase 4D-interacting protein
Gene namesi
Name:Pde4dip
Synonyms:Kiaa0454
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1891434. Pde4dip.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: UniProtKB
  • cytoplasm Source: UniProtKB
  • Golgi apparatus Source: UniProtKB
  • myofibril Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Golgi apparatus, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003076911 – 2224MyomegalinAdd BLAST2224

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei705PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ80YT7.
PaxDbiQ80YT7.
PRIDEiQ80YT7.

PTM databases

iPTMnetiQ80YT7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000038170.
ExpressionAtlasiQ80YT7. baseline and differential.
GenevisibleiQ80YT7. MM.

Interactioni

Subunit structurei

Interacts with PDE4D.By similarity

GO - Molecular functioni

  • enzyme binding Source: UniProtKB

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040905.

Structurei

3D structure databases

ProteinModelPortaliQ80YT7.
SMRiQ80YT7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1497 – 1588NBPFPROSITE-ProRule annotationAdd BLAST92

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili41 – 97Sequence analysisAdd BLAST57
Coiled coili162 – 205Sequence analysisAdd BLAST44
Coiled coili236 – 318Sequence analysisAdd BLAST83
Coiled coili350 – 682Sequence analysisAdd BLAST333
Coiled coili745 – 822Sequence analysisAdd BLAST78
Coiled coili856 – 886Sequence analysisAdd BLAST31
Coiled coili949 – 986Sequence analysisAdd BLAST38
Coiled coili1159 – 1187Sequence analysisAdd BLAST29
Coiled coili1295 – 1331Sequence analysisAdd BLAST37
Coiled coili1377 – 1401Sequence analysisAdd BLAST25
Coiled coili1769 – 1958Sequence analysisAdd BLAST190
Coiled coili2148 – 2191Sequence analysisAdd BLAST44

Sequence similaritiesi

Contains 1 NBPF domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IKC5. Eukaryota.
ENOG410ZJGS. LUCA.
GeneTreeiENSGT00530000063845.
HOGENOMiHOG000113709.
HOVERGENiHBG108166.
InParanoidiQ80YT7.
KOiK16549.
PhylomeDBiQ80YT7.
TreeFamiTF329233.

Family and domain databases

InterProiIPR012943. Cnn_1N.
IPR010630. NBPF_dom.
[Graphical view]
PfamiPF07989. Cnn_1N. 1 hit.
PF06758. DUF1220. 1 hit.
[Graphical view]
SMARTiSM01148. DUF1220. 1 hit.
[Graphical view]
PROSITEiPS51316. NBPF. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q80YT7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSNGYRTLSQ HLNDLKKENF SLKLRIYFLE ERMQQKYEVS REDVYKRNIE
60 70 80 90 100
LKVEVESLKR ELQDRKQHLD KTWADAEDLN SQNEAELRRQ VEERQQETEH
110 120 130 140 150
VYELLGNKIQ LLQEEPRLAK NEATEMETLV EAEKRCNLEL SERWTNAAKN
160 170 180 190 200
REDAAGDQEK PDQYSEALAQ RDRRIEELRQ SLAAQEGLVE QLSQEKRQLL
210 220 230 240 250
HLLEEPASME VQPVPKGLPT QQKPDLHETP TTQPPVSESH LAELQDKIQQ
260 270 280 290 300
TEATNKILQE KLNDLSCELK SAQESSQKQD TTIQSLKEML KSRESETEEL
310 320 330 340 350
YQVIEGQNDT MAKLREMLHQ SQLGQLHSSE GIAPAQQQVA LLDLQSALFC
360 370 380 390 400
SQLEIQRLQR LVRQKERQLA DGKRCVQLVE AAAQEREHQK EAAWKHNQEL
410 420 430 440 450
RKALQHLQGE LHSKSQQLHV LEAEKYNEIR TQGQNIQHLS HSLSHKEQLI
460 470 480 490 500
QELQELLQYR DNADKTLDTN EVFLEKLRQR IQDRAVALER VIDEKFSALE
510 520 530 540 550
EKDKELRQLR LAVRDRDHDL ERLRCVLSAN EATMQSMESL LRARGLEVEQ
560 570 580 590 600
LTATCQNLQW LKEELETKFG HWQKEQESII QQLQTSLHDR NKEVEDLSAT
610 620 630 640 650
LLCKLGPGQS EVAEELCQRL QRKERMLQDL LSDRNKQAVE HEMEIQGLLQ
660 670 680 690 700
SMGTREQERQ AAAEKMVQAF MERNSELQAL RQYLGGKELM TSSQTFISNQ
710 720 730 740 750
PAGVTSIGPH HGEQTDQGSM QMPSRDDSTS LTAREEASIP RSTLGDSDTV
760 770 780 790 800
AGLEKELSNA KEELELMAKK ERESQMELSA LQSMMAMQEE ELQVQAADLE
810 820 830 840 850
SLTRNVQIKE DLIKDLQMQL VDPEDIPAME RLTQEVLLLR EKVASVEPQG
860 870 880 890 900
QEVSGNKRQQ LLLMLEGLVD ERSRLNEALQ AERQLYSSLV KFHAQPENSE
910 920 930 940 950
RDGTLQVELE GAQVLRTRLE EVLGRSLERL SRLESLAAIG GGELESVQAQ
960 970 980 990 1000
EMLHLRAEIH QHLEEKRKAE VELKELKAQI EEAGFSSVSH ISRNTMLSLC
1010 1020 1030 1040 1050
LENAELKEQM GEAMSDGWEV EEDKEKGEVM LETVVAKGCL NENSLQAEFR
1060 1070 1080 1090 1100
KVQGKLKSAY NIINLLKEQL LLRSSEGNSK EMPELLVRLA REVDRMNTGL
1110 1120 1130 1140 1150
PSLGKHQHQE QENTTTARPG SRPQSLPLGA ALSVDGYQLE NKSQAQDSGH
1160 1170 1180 1190 1200
QPEFSLPGST KHLRSQLAQC RQRYQDLQEK LLISEATVFA QANQLEKYRA
1210 1220 1230 1240 1250
VFSESLVKQD SKQIQVDLQD LGYETCGRSE NEAEREETTS PECEEHNNLR
1260 1270 1280 1290 1300
PVVLMEGLCS EQGYLDPVLV SPPAKKPLEN KPGKQEEFRA HGTPDDSSLL
1310 1320 1330 1340 1350
RKDIRDLKAQ LQNANKVIQN LRSRVRSLSA TSDYSSSLER PRKLRAVATL
1360 1370 1380 1390 1400
EGASPHSVTD EDEGWLSDGT GAFYPPGLQA KKDLESLIQR VSQLEAQLPK
1410 1420 1430 1440 1450
TGLEGKLAEE LRCASWPGKY DSLIQDQARE LSYLRQKIRE GRGICYLLTQ
1460 1470 1480 1490 1500
HAKDTVKSFE DLLRSNDIDY YLGQSFREQL AQGGQLTERL TSKLSTKDHK
1510 1520 1530 1540 1550
SEKEEAGLEP LALRLSRELQ EKEKVIEVLQ AKLDTRSLSP PSSHAVSDSH
1560 1570 1580 1590 1600
RSASTTSFLS DDIEACSDMD VASEYTHYDE KKPSPSHSAA SASQGLKGES
1610 1620 1630 1640 1650
SSSPISLPTP QNPPKEASQA HPGFHFHSIP KPASLSQTPM HSALPSFVPF
1660 1670 1680 1690 1700
SPSGPPLLGC CETPMVSLAE AQQELQMLQK QLGESVSIAP PASTSTLLSN
1710 1720 1730 1740 1750
QTEASSPHYI NPAQPHTPTR STIELGRILE PGYLGSSGQW DMMRPQKGSV
1760 1770 1780 1790 1800
SGELSSGSSM YQLNSKPTGA DLLEEHLGEI RNLRQRLEES ICVNDRLREQ
1810 1820 1830 1840 1850
LQHRLSSTAR ENGSTSHFYS QGLESMPQLY NENRALREEN QSLQTRLSHA
1860 1870 1880 1890 1900
SRGHSQEVDH LREALLSSRS QLQELEKELE QQKAERQQLS LQSELQIYES
1910 1920 1930 1940 1950
LCENPKKALK AFSLDSCHQV PGELSCLVAE IRALRGQLEQ SIEVNNRLRL
1960 1970 1980 1990 2000
QLEQQMDRGA GKASLGPIAV GQSFPDKAEP ANLHQGSAAS PPVRDVGLNS
2010 2020 2030 2040 2050
PAMVLPNSSC SAPGSDHAIV TRTNNELSSD DSAAMKNPPK LEVDATDGPF
2060 2070 2080 2090 2100
ANKHGRHVIG HVDDYDALQQ QIGEGKLLIQ KILSLMRSAR SIPGQEAQDT
2110 2120 2130 2140 2150
EAPGNISAHE LRSSAKALNH ALEESTSLLN MFWRAALPNT HGPVLVGKEG
2160 2170 2180 2190 2200
QLMEKELLDL RAQVSQQEQI LQNTAARLKR ANQRKKSMEQ FIVSHLTRTH
2210 2220
DVLKKARTNL EMKSFRALTC TPAL
Length:2,224
Mass (Da):250,631
Last modified:October 23, 2007 - v2
Checksum:iD3EA6F593ACD2445
GO
Isoform 2 (identifier: Q80YT7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-211: MSNGYRTLSQ...LLEEPASMEV → MKEICRICAR...LCDEYLPIGF
     950-955: QEMLHL → RHKHAF
     956-2224: Missing.

Show »
Length:1,118
Mass (Da):126,615
Checksum:iDC39815A9629AD96
GO

Sequence cautioni

The sequence AAH25653 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAC65568 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0287841 – 211MSNGY…ASMEV → MKEICRICARELCGNQRRWI FHTASKLNLQVLLSHVLGKD VSRDGKAEFACSKCAFMLDR IYRFDTVIARIEALSLERLQ KLLLEKDRLKFCIASMYRKN NDDSGEENKAGSGTVDISGL PDMRYAALLQEDFAYSGFEC WVENEDQINDSHSCHASEGP GNRPRRCRGCAALRVADSDY EAICKVPRKVARSISYAPSS RWSTSICTEEPALSEVGPPD LASTKVPPDGESMEEGTPGS SVESLDASVQASPPQQKDEE TERSAKELVKCDYCSDEQAP QHLCNHKLELALSMIKGLDY KPIQSPRGSKLPIPVKSILP GAKPGHILTNGVSSSFLNRP LKPLYRTPVSYPWEISDGQE LWDDLCDEYLPIGF in isoform 2. 2 PublicationsAdd BLAST211
Alternative sequenceiVSP_028785950 – 955QEMLHL → RHKHAF in isoform 2. 2 Publications6
Alternative sequenceiVSP_028786956 – 2224Missing in isoform 2. 2 PublicationsAdd BLAST1269

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122286 mRNA. Translation: BAC65568.1. Different initiation.
AC130541 Genomic DNA. No translation available.
AC153661 Genomic DNA. No translation available.
BC025653 mRNA. Translation: AAH25653.1. Sequence problems.
BC034266 mRNA. Translation: AAH34266.1.
BC050783 mRNA. Translation: AAH50783.1.
CCDSiCCDS38562.1. [Q80YT7-2]
RefSeqiNP_001034465.2. NM_001039376.2.
NP_835181.2. NM_178080.4. [Q80YT7-2]
UniGeneiMm.129840.

Genome annotation databases

EnsembliENSMUST00000045243; ENSMUSP00000040905; ENSMUSG00000038170. [Q80YT7-2]
GeneIDi83679.
KEGGimmu:83679.
UCSCiuc008qpg.1. mouse. [Q80YT7-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122286 mRNA. Translation: BAC65568.1. Different initiation.
AC130541 Genomic DNA. No translation available.
AC153661 Genomic DNA. No translation available.
BC025653 mRNA. Translation: AAH25653.1. Sequence problems.
BC034266 mRNA. Translation: AAH34266.1.
BC050783 mRNA. Translation: AAH50783.1.
CCDSiCCDS38562.1. [Q80YT7-2]
RefSeqiNP_001034465.2. NM_001039376.2.
NP_835181.2. NM_178080.4. [Q80YT7-2]
UniGeneiMm.129840.

3D structure databases

ProteinModelPortaliQ80YT7.
SMRiQ80YT7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040905.

PTM databases

iPTMnetiQ80YT7.

Proteomic databases

EPDiQ80YT7.
PaxDbiQ80YT7.
PRIDEiQ80YT7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000045243; ENSMUSP00000040905; ENSMUSG00000038170. [Q80YT7-2]
GeneIDi83679.
KEGGimmu:83679.
UCSCiuc008qpg.1. mouse. [Q80YT7-2]

Organism-specific databases

CTDi9659.
MGIiMGI:1891434. Pde4dip.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IKC5. Eukaryota.
ENOG410ZJGS. LUCA.
GeneTreeiENSGT00530000063845.
HOGENOMiHOG000113709.
HOVERGENiHBG108166.
InParanoidiQ80YT7.
KOiK16549.
PhylomeDBiQ80YT7.
TreeFamiTF329233.

Miscellaneous databases

ChiTaRSiPde4dip. mouse.
PROiQ80YT7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038170.
ExpressionAtlasiQ80YT7. baseline and differential.
GenevisibleiQ80YT7. MM.

Family and domain databases

InterProiIPR012943. Cnn_1N.
IPR010630. NBPF_dom.
[Graphical view]
PfamiPF07989. Cnn_1N. 1 hit.
PF06758. DUF1220. 1 hit.
[Graphical view]
SMARTiSM01148. DUF1220. 1 hit.
[Graphical view]
PROSITEiPS51316. NBPF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYOME_MOUSE
AccessioniPrimary (citable) accession number: Q80YT7
Secondary accession number(s): Q05CH5, Q80U00, Q8K240
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: November 2, 2016
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.