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Q80YT7

- MYOME_MOUSE

UniProt

Q80YT7 - MYOME_MOUSE

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Protein

Myomegalin

Gene
Pde4dip, Kiaa0454
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

May function as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes By similarity.

GO - Molecular functioni

  1. enzyme binding Source: UniProtKB
  2. protein binding Source: MGI

GO - Biological processi

  1. cellular protein complex assembly Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Myomegalin
Alternative name(s):
Phosphodiesterase 4D-interacting protein
Gene namesi
Name:Pde4dip
Synonyms:Kiaa0454
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:1891434. Pde4dip.

Subcellular locationi

Golgi apparatus By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity. Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. centrosome Source: UniProtKB
  2. cytoplasm Source: UniProtKB
  3. Golgi apparatus Source: UniProtKB
  4. myofibril Source: UniProtKB
  5. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Golgi apparatus, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 22242224MyomegalinPRO_0000307691Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei705 – 7051Phosphothreonine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ80YT7.
PaxDbiQ80YT7.
PRIDEiQ80YT7.

Expressioni

Gene expression databases

ArrayExpressiQ80YT7.
BgeeiQ80YT7.
GenevestigatoriQ80YT7.

Interactioni

Subunit structurei

Interacts with PDE4D By similarity.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000088254.

Structurei

3D structure databases

ProteinModelPortaliQ80YT7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1497 – 158892NBPFAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili41 – 9757 Reviewed predictionAdd
BLAST
Coiled coili162 – 20544 Reviewed predictionAdd
BLAST
Coiled coili236 – 31883 Reviewed predictionAdd
BLAST
Coiled coili350 – 682333 Reviewed predictionAdd
BLAST
Coiled coili745 – 82278 Reviewed predictionAdd
BLAST
Coiled coili856 – 88631 Reviewed predictionAdd
BLAST
Coiled coili949 – 98638 Reviewed predictionAdd
BLAST
Coiled coili1159 – 118729 Reviewed predictionAdd
BLAST
Coiled coili1295 – 133137 Reviewed predictionAdd
BLAST
Coiled coili1377 – 140125 Reviewed predictionAdd
BLAST
Coiled coili1769 – 1958190 Reviewed predictionAdd
BLAST
Coiled coili2148 – 219144 Reviewed predictionAdd
BLAST

Sequence similaritiesi

Contains 1 NBPF domain.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG46262.
GeneTreeiENSGT00530000063845.
HOGENOMiHOG000113709.
HOVERGENiHBG108166.
InParanoidiQ80YT7.
KOiK16549.
OMAiINDSHSC.
PhylomeDBiQ80YT7.
TreeFamiTF329233.

Family and domain databases

InterProiIPR010630. NBPF_dom.
IPR012943. Spindle_assoc.
[Graphical view]
PfamiPF06758. DUF1220. 1 hit.
PF07989. Microtub_assoc. 1 hit.
[Graphical view]
PROSITEiPS51316. NBPF. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q80YT7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSNGYRTLSQ HLNDLKKENF SLKLRIYFLE ERMQQKYEVS REDVYKRNIE     50
LKVEVESLKR ELQDRKQHLD KTWADAEDLN SQNEAELRRQ VEERQQETEH 100
VYELLGNKIQ LLQEEPRLAK NEATEMETLV EAEKRCNLEL SERWTNAAKN 150
REDAAGDQEK PDQYSEALAQ RDRRIEELRQ SLAAQEGLVE QLSQEKRQLL 200
HLLEEPASME VQPVPKGLPT QQKPDLHETP TTQPPVSESH LAELQDKIQQ 250
TEATNKILQE KLNDLSCELK SAQESSQKQD TTIQSLKEML KSRESETEEL 300
YQVIEGQNDT MAKLREMLHQ SQLGQLHSSE GIAPAQQQVA LLDLQSALFC 350
SQLEIQRLQR LVRQKERQLA DGKRCVQLVE AAAQEREHQK EAAWKHNQEL 400
RKALQHLQGE LHSKSQQLHV LEAEKYNEIR TQGQNIQHLS HSLSHKEQLI 450
QELQELLQYR DNADKTLDTN EVFLEKLRQR IQDRAVALER VIDEKFSALE 500
EKDKELRQLR LAVRDRDHDL ERLRCVLSAN EATMQSMESL LRARGLEVEQ 550
LTATCQNLQW LKEELETKFG HWQKEQESII QQLQTSLHDR NKEVEDLSAT 600
LLCKLGPGQS EVAEELCQRL QRKERMLQDL LSDRNKQAVE HEMEIQGLLQ 650
SMGTREQERQ AAAEKMVQAF MERNSELQAL RQYLGGKELM TSSQTFISNQ 700
PAGVTSIGPH HGEQTDQGSM QMPSRDDSTS LTAREEASIP RSTLGDSDTV 750
AGLEKELSNA KEELELMAKK ERESQMELSA LQSMMAMQEE ELQVQAADLE 800
SLTRNVQIKE DLIKDLQMQL VDPEDIPAME RLTQEVLLLR EKVASVEPQG 850
QEVSGNKRQQ LLLMLEGLVD ERSRLNEALQ AERQLYSSLV KFHAQPENSE 900
RDGTLQVELE GAQVLRTRLE EVLGRSLERL SRLESLAAIG GGELESVQAQ 950
EMLHLRAEIH QHLEEKRKAE VELKELKAQI EEAGFSSVSH ISRNTMLSLC 1000
LENAELKEQM GEAMSDGWEV EEDKEKGEVM LETVVAKGCL NENSLQAEFR 1050
KVQGKLKSAY NIINLLKEQL LLRSSEGNSK EMPELLVRLA REVDRMNTGL 1100
PSLGKHQHQE QENTTTARPG SRPQSLPLGA ALSVDGYQLE NKSQAQDSGH 1150
QPEFSLPGST KHLRSQLAQC RQRYQDLQEK LLISEATVFA QANQLEKYRA 1200
VFSESLVKQD SKQIQVDLQD LGYETCGRSE NEAEREETTS PECEEHNNLR 1250
PVVLMEGLCS EQGYLDPVLV SPPAKKPLEN KPGKQEEFRA HGTPDDSSLL 1300
RKDIRDLKAQ LQNANKVIQN LRSRVRSLSA TSDYSSSLER PRKLRAVATL 1350
EGASPHSVTD EDEGWLSDGT GAFYPPGLQA KKDLESLIQR VSQLEAQLPK 1400
TGLEGKLAEE LRCASWPGKY DSLIQDQARE LSYLRQKIRE GRGICYLLTQ 1450
HAKDTVKSFE DLLRSNDIDY YLGQSFREQL AQGGQLTERL TSKLSTKDHK 1500
SEKEEAGLEP LALRLSRELQ EKEKVIEVLQ AKLDTRSLSP PSSHAVSDSH 1550
RSASTTSFLS DDIEACSDMD VASEYTHYDE KKPSPSHSAA SASQGLKGES 1600
SSSPISLPTP QNPPKEASQA HPGFHFHSIP KPASLSQTPM HSALPSFVPF 1650
SPSGPPLLGC CETPMVSLAE AQQELQMLQK QLGESVSIAP PASTSTLLSN 1700
QTEASSPHYI NPAQPHTPTR STIELGRILE PGYLGSSGQW DMMRPQKGSV 1750
SGELSSGSSM YQLNSKPTGA DLLEEHLGEI RNLRQRLEES ICVNDRLREQ 1800
LQHRLSSTAR ENGSTSHFYS QGLESMPQLY NENRALREEN QSLQTRLSHA 1850
SRGHSQEVDH LREALLSSRS QLQELEKELE QQKAERQQLS LQSELQIYES 1900
LCENPKKALK AFSLDSCHQV PGELSCLVAE IRALRGQLEQ SIEVNNRLRL 1950
QLEQQMDRGA GKASLGPIAV GQSFPDKAEP ANLHQGSAAS PPVRDVGLNS 2000
PAMVLPNSSC SAPGSDHAIV TRTNNELSSD DSAAMKNPPK LEVDATDGPF 2050
ANKHGRHVIG HVDDYDALQQ QIGEGKLLIQ KILSLMRSAR SIPGQEAQDT 2100
EAPGNISAHE LRSSAKALNH ALEESTSLLN MFWRAALPNT HGPVLVGKEG 2150
QLMEKELLDL RAQVSQQEQI LQNTAARLKR ANQRKKSMEQ FIVSHLTRTH 2200
DVLKKARTNL EMKSFRALTC TPAL 2224
Length:2,224
Mass (Da):250,631
Last modified:October 23, 2007 - v2
Checksum:iD3EA6F593ACD2445
GO
Isoform 2 (identifier: Q80YT7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-211: MSNGYRTLSQ...LLEEPASMEV → MKEICRICAR...LCDEYLPIGF
     950-955: QEMLHL → RHKHAF
     956-2224: Missing.

Show »
Length:1,118
Mass (Da):126,615
Checksum:iDC39815A9629AD96
GO

Sequence cautioni

The sequence AAH25653.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
The sequence BAC65568.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 211211MSNGY…ASMEV → MKEICRICARELCGNQRRWI FHTASKLNLQVLLSHVLGKD VSRDGKAEFACSKCAFMLDR IYRFDTVIARIEALSLERLQ KLLLEKDRLKFCIASMYRKN NDDSGEENKAGSGTVDISGL PDMRYAALLQEDFAYSGFEC WVENEDQINDSHSCHASEGP GNRPRRCRGCAALRVADSDY EAICKVPRKVARSISYAPSS RWSTSICTEEPALSEVGPPD LASTKVPPDGESMEEGTPGS SVESLDASVQASPPQQKDEE TERSAKELVKCDYCSDEQAP QHLCNHKLELALSMIKGLDY KPIQSPRGSKLPIPVKSILP GAKPGHILTNGVSSSFLNRP LKPLYRTPVSYPWEISDGQE LWDDLCDEYLPIGF in isoform 2. VSP_028784Add
BLAST
Alternative sequencei950 – 9556QEMLHL → RHKHAF in isoform 2. VSP_028785
Alternative sequencei956 – 22241269Missing in isoform 2. VSP_028786Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK122286 mRNA. Translation: BAC65568.1. Different initiation.
AC130541 Genomic DNA. No translation available.
AC153661 Genomic DNA. No translation available.
BC025653 mRNA. Translation: AAH25653.1. Sequence problems.
BC034266 mRNA. Translation: AAH34266.1.
BC050783 mRNA. Translation: AAH50783.1.
CCDSiCCDS38562.1. [Q80YT7-2]
RefSeqiNP_001034465.2. NM_001039376.2.
NP_835181.2. NM_178080.4. [Q80YT7-2]
UniGeneiMm.129840.

Genome annotation databases

EnsembliENSMUST00000045243; ENSMUSP00000040905; ENSMUSG00000038170. [Q80YT7-2]
GeneIDi83679.
KEGGimmu:83679.
UCSCiuc008qpg.1. mouse. [Q80YT7-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK122286 mRNA. Translation: BAC65568.1 . Different initiation.
AC130541 Genomic DNA. No translation available.
AC153661 Genomic DNA. No translation available.
BC025653 mRNA. Translation: AAH25653.1 . Sequence problems.
BC034266 mRNA. Translation: AAH34266.1 .
BC050783 mRNA. Translation: AAH50783.1 .
CCDSi CCDS38562.1. [Q80YT7-2 ]
RefSeqi NP_001034465.2. NM_001039376.2.
NP_835181.2. NM_178080.4. [Q80YT7-2 ]
UniGenei Mm.129840.

3D structure databases

ProteinModelPortali Q80YT7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000088254.

Proteomic databases

MaxQBi Q80YT7.
PaxDbi Q80YT7.
PRIDEi Q80YT7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000045243 ; ENSMUSP00000040905 ; ENSMUSG00000038170 . [Q80YT7-2 ]
GeneIDi 83679.
KEGGi mmu:83679.
UCSCi uc008qpg.1. mouse. [Q80YT7-2 ]

Organism-specific databases

CTDi 9659.
MGIi MGI:1891434. Pde4dip.
Rougei Search...

Phylogenomic databases

eggNOGi NOG46262.
GeneTreei ENSGT00530000063845.
HOGENOMi HOG000113709.
HOVERGENi HBG108166.
InParanoidi Q80YT7.
KOi K16549.
OMAi INDSHSC.
PhylomeDBi Q80YT7.
TreeFami TF329233.

Miscellaneous databases

ChiTaRSi PDE4DIP. mouse.
NextBioi 350723.
PROi Q80YT7.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q80YT7.
Bgeei Q80YT7.
Genevestigatori Q80YT7.

Family and domain databases

InterProi IPR010630. NBPF_dom.
IPR012943. Spindle_assoc.
[Graphical view ]
Pfami PF06758. DUF1220. 1 hit.
PF07989. Microtub_assoc. 1 hit.
[Graphical view ]
PROSITEi PS51316. NBPF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
    DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: FVB/N.
    Tissue: Brain and Mammary tumor.

Entry informationi

Entry nameiMYOME_MOUSE
AccessioniPrimary (citable) accession number: Q80YT7
Secondary accession number(s): Q05CH5, Q80U00, Q8K240
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: July 9, 2014
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi