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Protein

Serine/threonine kinase-like domain-containing protein STKLD1

Gene

Stkld1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei25 – 251ATPPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi2 – 109ATPPROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine kinase-like domain-containing protein STKLD1
Alternative name(s):
Serine/threonine kinase-like domain-containing protein 1
Sugen kinase 071
Gene namesi
Name:Stkld1
Synonyms:Gm711, Sgk071
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2685557. Stkld1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 662662Serine/threonine kinase-like domain-containing protein STKLD1PRO_0000307899Add
BLAST

Proteomic databases

PaxDbiQ80YS9.
PRIDEiQ80YS9.

PTM databases

PhosphoSiteiQ80YS9.

Expressioni

Gene expression databases

BgeeiQ80YS9.
CleanExiMM_GM711.
ExpressionAtlasiQ80YS9. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000062967.

Structurei

3D structure databases

ProteinModelPortaliQ80YS9.
SMRiQ80YS9. Positions 1-300.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 202202Protein kinasePROSITE-ProRule annotationAdd
BLAST

Domaini

The protein kinase domain is predicted to be catalytically inactive.

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STKL subfamily.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0589. Eukaryota.
ENOG410Y7JF. LUCA.
GeneTreeiENSGT00390000018038.
HOGENOMiHOG000054200.
HOVERGENiHBG056774.
InParanoidiQ80YS9.
KOiK17546.
OMAiVIKQVEC.
OrthoDBiEOG7FNC70.
PhylomeDBiQ80YS9.
TreeFamiTF336364.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80YS9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNPGALGVN LVVEELETET KFLIKQVECI DEHHANKALE ELMPLLKLQH
60 70 80 90 100
PNLSLYHEMF IMWNNEISSL FLCLVMDYYS QGTFQNIMEN KRKLKAVVDT
110 120 130 140 150
EWMHTMLSQV LDAIEYLHKL NIVHRNLKPS NIVLVNSGYC KLQDMSSQAL
160 170 180 190 200
MTHEAKWNVR AEEDPCQKSW MAPEALKFSF STKSDIWSLG CIILDMATCS
210 220 230 240 250
FLNDTEAMQL RKAIRHHPGS LKPILKTMEE KQIPGTDVYY LLLPFMLHIN
260 270 280 290 300
PSDRLAIKDV MQVTFMSNSF KSSSVALNMQ RQKVPIFITD VLLEGNMANI
310 320 330 340 350
LDVMQNFSSR PEVQLRAINK LLTMPEDQLG LPWPTELLEE VISIIKQHGR
360 370 380 390 400
ILDILLSTCS LLLRVLGQAL AKDPEAEIPR SSLIISFLMD TLRSHPNSER
410 420 430 440 450
LVNVVYNVLA IISSQGQISE ELEEEGLFQL AQENLEHFQE DRDICLSILS
460 470 480 490 500
LLWSLLVDVV TVDKEPLEQL SGMVTWVLAT HPEDVEIAEA GCAVLWLLSL
510 520 530 540 550
LGCIKESQFE QVVVLLLRSI QLCPGRVLLV NNAFRGLASL AKVSELVAFR
560 570 580 590 600
IVVLEEGSSG LHLIQDIYKL YKDDPEVVEN LCMLLAHLTS YKEILPEMES
610 620 630 640 650
GGIKDLVQVI RGRFTSSLEL ISYADEILQV LEANAQPGLQ EDQLEPPAGQ
660
EAPLQGEPLF RP
Length:662
Mass (Da):74,843
Last modified:October 23, 2007 - v3
Checksum:iB5D6768182C337FF
GO

Sequence cautioni

The sequence BC050806 differs from that shown. Reason: Frameshift at position 74. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL773563 Genomic DNA. Translation: CAM23707.1.
BC050806 mRNA. No translation available.
CCDSiCCDS15818.1.
RefSeqiNP_941030.2. NM_198628.2.
XP_006498176.2. XM_006498113.2.
UniGeneiMm.330079.

Genome annotation databases

EnsembliENSMUST00000055406; ENSMUSP00000062967; ENSMUSG00000049897.
GeneIDi279029.
KEGGimmu:279029.
UCSCiuc008iwm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL773563 Genomic DNA. Translation: CAM23707.1.
BC050806 mRNA. No translation available.
CCDSiCCDS15818.1.
RefSeqiNP_941030.2. NM_198628.2.
XP_006498176.2. XM_006498113.2.
UniGeneiMm.330079.

3D structure databases

ProteinModelPortaliQ80YS9.
SMRiQ80YS9. Positions 1-300.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000062967.

PTM databases

PhosphoSiteiQ80YS9.

Proteomic databases

PaxDbiQ80YS9.
PRIDEiQ80YS9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000055406; ENSMUSP00000062967; ENSMUSG00000049897.
GeneIDi279029.
KEGGimmu:279029.
UCSCiuc008iwm.1. mouse.

Organism-specific databases

CTDi169436.
MGIiMGI:2685557. Stkld1.

Phylogenomic databases

eggNOGiKOG0589. Eukaryota.
ENOG410Y7JF. LUCA.
GeneTreeiENSGT00390000018038.
HOGENOMiHOG000054200.
HOVERGENiHBG056774.
InParanoidiQ80YS9.
KOiK17546.
OMAiVIKQVEC.
OrthoDBiEOG7FNC70.
PhylomeDBiQ80YS9.
TreeFamiTF336364.

Miscellaneous databases

NextBioi393959.
PROiQ80YS9.
SOURCEiSearch...

Gene expression databases

BgeeiQ80YS9.
CleanExiMM_GM711.
ExpressionAtlasiQ80YS9. baseline and differential.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiSTKL1_MOUSE
AccessioniPrimary (citable) accession number: Q80YS9
Secondary accession number(s): A2ALB0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: May 11, 2016
This is version 103 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Asn-126 is present instead of the conserved Asp which is expected to be an active site residue.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.