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Protein
Submitted name:

Angiopoietin-1 receptor

Gene

Tek

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, ReceptorSAAS annotation, Transferase, Tyrosine-protein kinaseSAAS annotation
LigandATP-bindingSAAS annotation, Nucleotide-binding

Protein family/group databases

TCDBi1.A.87.2.4. the mechanosensitive calcium channel (mca) family.

Names & Taxonomyi

Protein namesi
Submitted name:
Angiopoietin-1 receptorImported
Submitted name:
Tek proteinImported
Gene namesi
Name:TekImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:98664. Tek.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei694 – 718HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_501110317023 – 1072Sequence analysisAdd BLAST1050

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi191 ↔ 200PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000006386.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini165 – 201EGF-likeInterPro annotationAdd BLAST37
Domaini299 – 389Ig-likeInterPro annotationAdd BLAST91
Domaini393 – 488Fibronectin type-IIIInterPro annotationAdd BLAST96
Domaini492 – 584Fibronectin type-IIIInterPro annotationAdd BLAST93
Domaini589 – 682Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini772 – 1044Protein kinaseInterPro annotationAdd BLAST273

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.SAAS annotation

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotation, Immunoglobulin domainSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0200. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00810000125384.
HOGENOMiHOG000049232.
HOVERGENiHBG007316.

Family and domain databases

CDDicd00063. FN3. 2 hits.
Gene3Di2.60.40.10. 5 hits.
InterProiView protein in InterPro
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR013111. EGF_extracell.
IPR003961. FN3_dom.
IPR036116. FN3_sf.
IPR007110. Ig-like_dom.
IPR036179. Ig-like_dom_sf.
IPR013783. Ig-like_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR018941. Tyr_kin_Tie2_Ig-like_dom-1_N.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
PfamiView protein in Pfam
PF07974. EGF_2. 1 hit.
PF00041. fn3. 3 hits.
PF10430. Ig_Tie2_1. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiView protein in SMART
SM00181. EGF. 2 hits.
SM00060. FN3. 3 hits.
SM00220. S_TKc. 1 hit.
SM00219. TyrKc. 1 hit.
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF49265. SSF49265. 2 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
PS50853. FN3. 3 hits.
PS50835. IG_LIKE. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.

Sequencei

Sequence statusi: Complete.

Q80YS4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSLAGLVLC GVSLLLYGVV EGAMDLILIN SLPLVSDAET SLTCIASGWH
60 70 80 90 100
PHEPITIGRD FEALMNQHQD PLEVTQDVTR EWAKKVVWKR EKASKINGAY
110 120 130 140 150
FCEGRVRGQA IRIRTMKMRQ QASFLPATLT MTVDRGDNVN ISFKKVLIKE
160 170 180 190 200
EDAVIYKNGC EAQKWGPDCS RPCTTCKNNG VCHEDTGECI CPPGFMGRTC
210 220 230 240 250
EKACEPHTFG RTCKERCSGP EGCKSYVFCL PDPYGCSCAT GWRGLQCNEA
260 270 280 290 300
CPSGYYGPDC KLRCHCTNEE ICDRFQGCLC SQGWQGLQCE KEGRPRMTPQ
310 320 330 340 350
IEDLPDHIEV NSGKFNPICK ASGWPLPTSE EMTLVKPDGT VLQPNDFNYT
360 370 380 390 400
DRFSVAIFTV NRVLPPDSGV WVCSVNTVAG MVEKPFNISV KVLPEPLHAP
410 420 430 440 450
NVIDTGHNFA IINISSEPYF GDGPIKSKKL FYKPVNQAWK YIEVTNEIFT
460 470 480 490 500
LNYLEPRTDY ELCVQLARPG EGGEGHPGPV RRFTTASIGL PPPRGLSLLP
510 520 530 540 550
KSQTALNLTW QPIFTNSEDE FYVEVERRSL QTTSDQQNIK VPGNLTSVLL
560 570 580 590 600
SNLVPREQYT VRARVNTKAQ GEWSEELRAW TLSDILPPQP ENIKISNITD
610 620 630 640 650
STAMVSWTIV DGYSISSIII RYKVQGKNED QHIDVKIKNA TVTQYQLKGL
660 670 680 690 700
EPETTYHVDI FAENNIGSSN PAFSHELRTL PHSPASADLG GGKMLLIAIL
710 720 730 740 750
GSAGMTCITV LLAFLIMLQL KRANVQRRMA QAFQNVREEP AVQFNSGTLA
760 770 780 790 800
LNRKAKNNPD PTIYPVLDWN DIKFQDVIGE GNFGQVLKAR IKKDGLRMDA
810 820 830 840 850
AIKRMKEYAS KDDHRDFAGE LEVLCKLGHH PNIINLLGAC EHRGYLYLAI
860 870 880 890 900
EYAPHGNLLD FLRKSRVLET DPAFAIANST ASTLSSQQLL HFAADVARGM
910 920 930 940 950
DYLSQKQFIH RDLAARNILV GENYIAKIAD FGLSRGQEVY VKKTMGRLPV
960 970 980 990 1000
RWMAIESLNY SVYTTNSDVW SYGVLLWEIV SLGGTPYCGM TCAELYEKLP
1010 1020 1030 1040 1050
QGYRLEKPLN CDDEVYDLMR QCWREKPYER PSFAQILVSL NRMLEERKTY
1060 1070
VNTTLYEKFT YAGIDCSAEE AA
Length:1,072
Mass (Da):120,048
Last modified:June 1, 2003 - v1
Checksum:iE652FFB247D1ABB6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL772277 Genomic DNA. No translation available.
AL954716 Genomic DNA. No translation available.
BC050824 mRNA. Translation: AAH50824.1.
RefSeqiNP_001277480.1. NM_001290551.1.
UniGeneiMm.14313.

Genome annotation databases

EnsembliENSMUST00000073939; ENSMUSP00000073595; ENSMUSG00000006386.
GeneIDi21687.
UCSCiuc012dhc.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiQ80YS4_MOUSE
AccessioniPrimary (citable) accession number: Q80YS4
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: October 25, 2017
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported