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Protein
Submitted name:

Thrombospondin-1

Gene

Thbs1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalciumPROSITE-ProRule annotation

Enzyme and pathway databases

ReactomeiR-MMU-114608 Platelet degranulation
R-MMU-186797 Signaling by PDGF
R-MMU-216083 Integrin cell surface interactions
R-MMU-5173214 O-glycosylation of TSR domain-containing proteins

Names & Taxonomyi

Protein namesi
Submitted name:
Thrombospondin-1Imported
Gene namesi
Name:Thbs1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi

Organism-specific databases

MGIiMGI:98737 Thbs1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_501458873619 – 1171Sequence analysisAdd BLAST1153

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000040152

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini317 – 374VWFCInterPro annotationAdd BLAST58
Domaini548 – 588EGF-likeInterPro annotationAdd BLAST41
Domaini647 – 691EGF-likeInterPro annotationAdd BLAST45
Repeati692 – 727TSP type-3PROSITE-ProRule annotationAdd BLAST36
Repeati728 – 763TSP type-3PROSITE-ProRule annotationAdd BLAST36
Repeati764 – 786TSP type-3PROSITE-ProRule annotationAdd BLAST23
Repeati787 – 822TSP type-3PROSITE-ProRule annotationAdd BLAST36
Repeati823 – 845TSP type-3PROSITE-ProRule annotationAdd BLAST23
Repeati846 – 883TSP type-3PROSITE-ProRule annotationAdd BLAST38
Repeati884 – 919TSP type-3PROSITE-ProRule annotationAdd BLAST36
Repeati920 – 955TSP type-3PROSITE-ProRule annotationAdd BLAST36
Domaini959 – 1171TSP C-terminalInterPro annotationAdd BLAST213

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili292 – 312Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, EGF-like domainPROSITE-ProRule annotation, RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IFQQ Eukaryota
ENOG410XQKE LUCA
GeneTreeiENSGT00850000132273
HOGENOMiHOG000007542
HOVERGENiHBG018006
KOiK16857
OMAiNKQVCKP
OrthoDBiEOG091G00TV
TreeFamiTF324917

Family and domain databases

Gene3Di2.20.100.10, 3 hits
4.10.1080.10, 2 hits
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR001791 Laminin_G
IPR037349 Thrombospondin
IPR028499 Thrombospondin-1
IPR003367 Thrombospondin_3-like_rpt
IPR017897 Thrombospondin_3_rpt
IPR008859 Thrombospondin_C
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
IPR028974 TSP_type-3_rpt
IPR001007 VWF_dom
PANTHERiPTHR10199 PTHR10199, 5 hits
PTHR10199:SF78 PTHR10199:SF78, 5 hits
PfamiView protein in Pfam
PF00090 TSP_1, 3 hits
PF02412 TSP_3, 7 hits
PF05735 TSP_C, 1 hit
PF00093 VWC, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 3 hits
SM00179 EGF_CA, 2 hits
SM00209 TSP1, 3 hits
SM00210 TSPN, 1 hit
SM00214 VWC, 1 hit
SUPFAMiSSF103647 SSF103647, 3 hits
SSF49899 SSF49899, 2 hits
SSF82895 SSF82895, 3 hits
PROSITEiView protein in PROSITE
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 2 hits
PS50092 TSP1, 3 hits
PS51234 TSP3, 8 hits
PS51236 TSP_CTER, 1 hit
PS01208 VWFC_1, 1 hit
PS50184 VWFC_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q80YQ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELLRGLGVL FLLHMCGSNR IPESGGDNGV FDIFELIGGA RRGPGRRLVK
60 70 80 90 100
GQDLSSPAFR IENANLIPAV PDDKFQDLLD AVWADKGFIF LASLRQMKKT
110 120 130 140 150
RGTLLAVERK DNTGQIFSVV SNGKAGTLDL SLSLPGKQQV VSVEEALLAT
160 170 180 190 200
GQWKSITLFV QEDRAQLYID CDKMESAELD VPIQSIFTRD LASVARLRVA
210 220 230 240 250
KGDVNDNFQG VLQNVRFVFG TTPEDILRNK GCSSSATNVL LTLDNNVVNG
260 270 280 290 300
SSPAIRTNYI GHKTKDLQAI CGLSCDELSS MVLELKGLRT IVTTLQDSIR
310 320 330 340 350
KVTEENRELV SELKRPPLCF HNGVQYKNNE EWTVDSCTEC HCQNSVTICK
360 370 380 390 400
KVSCPIMPCS NATVPDGECC PRCWPSDSAD DGWSPWSEWT SCSATCGNGI
410 420 430 440 450
QQRGRSCDSL NNRCEGSSVQ TRTCHIQECD KRFKQDGGWS HWSPWSSCSV
460 470 480 490 500
TCGDGVITRI RLCNSPSPQM NGKPCEGEAR ETKACKKDAC PINGGWGPWS
510 520 530 540 550
PWDICSVTCG GGVQRRSRLC NNPTPQFGGK DCVGDVTENQ VCNKQDCPID
560 570 580 590 600
GCLSNPCFAG AKCTSYPDGS WKCGACPPGY SGNGIQCKDV DECKEVPDAC
610 620 630 640 650
FNHNGEHRCK NTDPGYNCLP CPPRFTGSQP FGRGVEHAMA NKQVCKPRNP
660 670 680 690 700
CTDGTHDCNK NAKCNYLGHY SDPMYRCECK PGYAGNGIIC GEDTDLDGWP
710 720 730 740 750
NENLVCVANA TYHCKKDNCP NLPNSGQEDY DKDGIGDACD DDDDNDKIPD
760 770 780 790 800
DRDNCPFHYN PAQYDYDRDD VGDRCDNCPY NHNPDQADTD KNGEGDACAV
810 820 830 840 850
DIDGDGILNE RDNCQYVYNV DQRDTDMDGV GDQCDNCPLE HNPDQLDSDS
860 870 880 890 900
DLIGDTCDNN QDIDEDGHQN NLDNCPYVPN ANQADHDKDG KGDACDHDDD
910 920 930 940 950
NDGIPDDRDN CRLVPNPDQK DSDGDGRGDA CKDDFDHDNV PDIDDICPEN
960 970 980 990 1000
FDISETDFRQ FQMIPLDPKG TSQNDPNWVV RHQGKELVQT VNCDPGLAVG
1010 1020 1030 1040 1050
YDEFNAVDFS GTFFINTERD DDYAGFVFGY QSSSRFYVVM WKQVTQSYWD
1060 1070 1080 1090 1100
TNPTRAQGYS GLSVKVVNST TGPGEHLRNA LWHTGNTPGQ VRTLWHDPRH
1110 1120 1130 1140 1150
IGWKDFTAYR WRLSHRPKTG YIRVVMYEGK KIMADSGPIY DKTYAGGRLG
1160 1170
LFVFSQEMVF FSDMKYECRD S
Length:1,171
Mass (Da):129,690
Last modified:June 1, 2003 - v1
Checksum:i12E077B50C64E2D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL845495 Genomic DNA No translation available.
AL928957 Genomic DNA No translation available.
BC050917 mRNA Translation: AAH50917.1
RefSeqiNP_001300843.1, NM_001313914.1
NP_035710.2, NM_011580.4
UniGeneiMm.4159

Genome annotation databases

EnsembliENSMUST00000039559; ENSMUSP00000044903; ENSMUSG00000040152
GeneIDi21825
KEGGimmu:21825
UCSCiuc008lrq.1 mouse

Entry informationi

Entry nameiQ80YQ1_MOUSE
AccessioniPrimary (citable) accession number: Q80YQ1
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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