Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Thrombospondin 1

Gene

Thbs1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalciumPROSITE-ProRule annotation

Enzyme and pathway databases

ReactomeiR-MMU-114608. Platelet degranulation.
R-MMU-186797. Signaling by PDGF.
R-MMU-216083. Integrin cell surface interactions.
R-MMU-5173214. O-glycosylation of TSR domain-containing proteins.

Names & Taxonomyi

Protein namesi
Submitted name:
Thrombospondin 1Imported
Submitted name:
Thrombospondin-1Imported
Gene namesi
Name:Thbs1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:98737. Thbs1.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_500934633119 – 1171Sequence analysisAdd BLAST1153

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000040152.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044903.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini317 – 374VWFCInterPro annotationAdd BLAST58
Domaini548 – 588EGF-likeInterPro annotationAdd BLAST41
Domaini647 – 691EGF-likeInterPro annotationAdd BLAST45
Repeati692 – 727TSP type-3PROSITE-ProRule annotationAdd BLAST36
Repeati728 – 763TSP type-3PROSITE-ProRule annotationAdd BLAST36
Repeati764 – 786TSP type-3PROSITE-ProRule annotationAdd BLAST23
Repeati787 – 822TSP type-3PROSITE-ProRule annotationAdd BLAST36
Repeati823 – 845TSP type-3PROSITE-ProRule annotationAdd BLAST23
Repeati846 – 883TSP type-3PROSITE-ProRule annotationAdd BLAST38
Repeati884 – 919TSP type-3PROSITE-ProRule annotationAdd BLAST36
Repeati920 – 955TSP type-3PROSITE-ProRule annotationAdd BLAST36
Domaini959 – 1171TSP C-terminal (TSPC)InterPro annotationAdd BLAST213

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotation, RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IFQQ. Eukaryota.
ENOG410XQKE. LUCA.
GeneTreeiENSGT00850000132273.
HOGENOMiHOG000007542.
HOVERGENiHBG018006.
KOiK16857.
OMAiTPQFGGK.
OrthoDBiEOG091G00TV.
TreeFamiTF324917.

Family and domain databases

Gene3Di2.60.120.200. 3 hits.
4.10.1080.10. 2 hits.
InterProiView protein in InterPro
IPR013320. ConA-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR001791. Laminin_G.
IPR028499. Thrombospondin-1.
IPR003367. Thrombospondin_3-like_rpt.
IPR017897. Thrombospondin_3_rpt.
IPR008859. Thrombospondin_C.
IPR000884. TSP1_rpt.
IPR028974. TSP_type-3_rpt.
IPR001007. VWF_dom.
PANTHERiPTHR10199:SF101. PTHR10199:SF101. 1 hit.
PfamiView protein in Pfam
PF00090. TSP_1. 3 hits.
PF02412. TSP_3. 7 hits.
PF05735. TSP_C. 1 hit.
PF00093. VWC. 1 hit.
SMARTiView protein in SMART
SM00181. EGF. 3 hits.
SM00179. EGF_CA. 2 hits.
SM00209. TSP1. 3 hits.
SM00210. TSPN. 1 hit.
SM00214. VWC. 1 hit.
SUPFAMiSSF103647. SSF103647. 3 hits.
SSF49899. SSF49899. 2 hits.
SSF82895. SSF82895. 3 hits.
PROSITEiView protein in PROSITE
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 2 hits.
PS50092. TSP1. 3 hits.
PS51234. TSP3. 8 hits.
PS51236. TSP_CTER. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q80YQ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELLRGLGVL FLLHMCGSNR IPESGGDNGV FDIFELIGGA RRGPGRRLVK
60 70 80 90 100
GQDLSSPAFR IENANLIPAV PDDKFQDLLD AVWADKGFIF LASLRQMKKT
110 120 130 140 150
RGTLLAVERK DNTGQIFSVV SNGKAGTLDL SLSLPGKQQV VSVEEALLAT
160 170 180 190 200
GQWKSITLFV QEDRAQLYID CDKMESAELD VPIQSIFTRD LASVARLRVA
210 220 230 240 250
KGDVNDNFQG VLQNVRFVFG TTPEDILRNK GCSSSATNVL LTLDNNVVNG
260 270 280 290 300
SSPAIRTNYI GHKTKDLQAI CGLSCDELSS MVLELKGLRT IVTTLQDSIR
310 320 330 340 350
KVTEENRELV SELKRPPLCF HNGVQYKNNE EWTVDSCTEC HCQNSVTICK
360 370 380 390 400
KVSCPIMPCS NATVPDGECC PRCWPSDSAD DGWSPWSEWT SCSATCGNGI
410 420 430 440 450
QQRGRSCDSL NNRCEGSSVQ TRTCHIQECD KRFKQDGGWS HWSPWSSCSV
460 470 480 490 500
TCGDGVITRI RLCNSPSPQM NGKPCEGEAR ETKACKKDAC PINGGWGPWS
510 520 530 540 550
PWDICSVTCG GGVQRRSRLC NNPTPQFGGK DCVGDVTENQ VCNKQDCPID
560 570 580 590 600
GCLSNPCFAG AKCTSYPDGS WKCGACPPGY SGNGIQCKDV DECKEVPDAC
610 620 630 640 650
FNHNGEHRCK NTDPGYNCLP CPPRFTGSQP FGRGVEHAMA NKQVCKPRNP
660 670 680 690 700
CTDGTHDCNK NAKCNYLGHY SDPMYRCECK PGYAGNGIIC GEDTDLDGWP
710 720 730 740 750
NENLVCVANA TYHCKKDNCP NLPNSGQEDY DKDGIGDACD DDDDNDKIPD
760 770 780 790 800
DRDNCPFHYN PAQYDYDRDD VGDRCDNCPY NHNPDQADTD KNGEGDACAV
810 820 830 840 850
DIDGDGILNE RDNCQYVYNV DQRDTDMDGV GDQCDNCPLE HNPDQLDSDS
860 870 880 890 900
DLIGDTCDNN QDIDEDGHQN NLDNCPYVPN ANQADHDKDG KGDACDHDDD
910 920 930 940 950
NDGIPDDRDN CRLVPNPDQK DSDGDGRGDA CKDDFDHDNV PDIDDICPEN
960 970 980 990 1000
FDISETDFRQ FQMIPLDPKG TSQNDPNWVV RHQGKELVQT VNCDPGLAVG
1010 1020 1030 1040 1050
YDEFNAVDFS GTFFINTERD DDYAGFVFGY QSSSRFYVVM WKQVTQSYWD
1060 1070 1080 1090 1100
TNPTRAQGYS GLSVKVVNST TGPGEHLRNA LWHTGNTPGQ VRTLWHDPRH
1110 1120 1130 1140 1150
IGWKDFTAYR WRLSHRPKTG YIRVVMYEGK KIMADSGPIY DKTYAGGRLG
1160 1170
LFVFSQEMVF FSDMKYECRD S
Length:1,171
Mass (Da):129,690
Last modified:June 1, 2003 - v1
Checksum:i12E077B50C64E2D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL845495 Genomic DNA. No translation available.
AL928957 Genomic DNA. No translation available.
BC050917 mRNA. Translation: AAH50917.1.
RefSeqiNP_001300843.1. NM_001313914.1.
NP_035710.2. NM_011580.4.
UniGeneiMm.4159.

Genome annotation databases

EnsembliENSMUST00000039559; ENSMUSP00000044903; ENSMUSG00000040152.
GeneIDi21825.
KEGGimmu:21825.
UCSCiuc008lrq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL845495 Genomic DNA. No translation available.
AL928957 Genomic DNA. No translation available.
BC050917 mRNA. Translation: AAH50917.1.
RefSeqiNP_001300843.1. NM_001313914.1.
NP_035710.2. NM_011580.4.
UniGeneiMm.4159.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044903.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000039559; ENSMUSP00000044903; ENSMUSG00000040152.
GeneIDi21825.
KEGGimmu:21825.
UCSCiuc008lrq.1. mouse.

Organism-specific databases

CTDi7057.
MGIiMGI:98737. Thbs1.

Phylogenomic databases

eggNOGiENOG410IFQQ. Eukaryota.
ENOG410XQKE. LUCA.
GeneTreeiENSGT00850000132273.
HOGENOMiHOG000007542.
HOVERGENiHBG018006.
KOiK16857.
OMAiTPQFGGK.
OrthoDBiEOG091G00TV.
TreeFamiTF324917.

Enzyme and pathway databases

ReactomeiR-MMU-114608. Platelet degranulation.
R-MMU-186797. Signaling by PDGF.
R-MMU-216083. Integrin cell surface interactions.
R-MMU-5173214. O-glycosylation of TSR domain-containing proteins.

Miscellaneous databases

ChiTaRSiThbs1. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040152.

Family and domain databases

Gene3Di2.60.120.200. 3 hits.
4.10.1080.10. 2 hits.
InterProiView protein in InterPro
IPR013320. ConA-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR001791. Laminin_G.
IPR028499. Thrombospondin-1.
IPR003367. Thrombospondin_3-like_rpt.
IPR017897. Thrombospondin_3_rpt.
IPR008859. Thrombospondin_C.
IPR000884. TSP1_rpt.
IPR028974. TSP_type-3_rpt.
IPR001007. VWF_dom.
PANTHERiPTHR10199:SF101. PTHR10199:SF101. 1 hit.
PfamiView protein in Pfam
PF00090. TSP_1. 3 hits.
PF02412. TSP_3. 7 hits.
PF05735. TSP_C. 1 hit.
PF00093. VWC. 1 hit.
SMARTiView protein in SMART
SM00181. EGF. 3 hits.
SM00179. EGF_CA. 2 hits.
SM00209. TSP1. 3 hits.
SM00210. TSPN. 1 hit.
SM00214. VWC. 1 hit.
SUPFAMiSSF103647. SSF103647. 3 hits.
SSF49899. SSF49899. 2 hits.
SSF82895. SSF82895. 3 hits.
PROSITEiView protein in PROSITE
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 2 hits.
PS50092. TSP1. 3 hits.
PS51234. TSP3. 8 hits.
PS51236. TSP_CTER. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ80YQ1_MOUSE
AccessioniPrimary (citable) accession number: Q80YQ1
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: February 15, 2017
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.